| Tag |
Content |
| WERAM ID |
WERAM-Art-0072 |
| Ensembl Protein ID |
AT3G18520.1 |
| Uniprot Accession |
Q8GXJ1; HDA15_ARATH; F4J8S2; Q3EB46; Q8LD93; Q9LS38
|
| Genbank Protein ID |
NP_566612.1
|
| Protein Name |
Histone deacetylase 15 |
| Genbank Nucleotide ID |
NM_112737.2
|
| Gene Name |
HDA15;At3g18520;MYF24_23 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689639
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-II |
6.00e-120 |
401.1 |
150 |
462 |
| HDAC |
Class-I |
6.90e-36 |
125.2 |
276 |
456 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
| Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeaglle.kleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiylesks 98
+++ +de+ml h+ e + + hpE+p+R++ai +l++ag+ + +++ ++ar+ tk+elq+vH++ehv+ ++t+++l + + ++y+++ s
AT3G18520.1 150 TAVGFDERMLLHSEFEVKAQPHPERPDRLRAIAASLATAGVFPgRCLPINAREITKQELQMVHTSEHVDAVDTTSQLLYSYFT------SDTYANEYS 241
6799***********************************998769*****************************665555444......478****** PP
class-2.txt 99 ikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykdpkvlylSlHRy 196
++aarla+G + +l++++++g++kngfa+vRPPGHHa ++amGFCl+nn+avaa ++q + kk+livDwDvHhGnGtqeif+++++vly+SlHR+
AT3G18520.1 242 ARAARLAAGLCADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAALVAQAAGA-KKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRH 338
*******************************************************99887766.********************************** PP
class-2.txt 197 dkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkqllklagg 294
+ g+f+p g+ga+devg++ geg+ vNv+w++g++gd++y++af++vvlpia+ F+Pd+v++saGfDaa+gdplg ++vt+++y+++t++l +l+gg
AT3G18520.1 339 EGGNFYP--GTGAADEVGSNGGEGYCVNVPWSCGGVGDKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCCDVTPAGYSRMTQMLGDLCGG 434
*******..***************************************************************************************** PP
class-2.txt 295 rvvlvlEGGynlkaiaeaveavvkaLlg 322
+++++lEGGynl++i+++++av+k+Llg
AT3G18520.1 435 KMLVILEGGYNLRSISASATAVIKVLLG 462
**************************96 PP
HDAC Class-I
class-1.txt 132 hhakkseasGfcyvnDivlailellk.khkrvlyididlhhGDgveeafyttdrvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlk.dgid 226
hha ++a Gfc n+ +a l + k+vl +d d+hhG+g +e f++ + v+ +s+h+++ +f+PgtG ++vg + g y+vnvP + g+
AT3G18520.1 276 HHAGVRHAMGFCLHNNAAVAALVAQAaGAKKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRHEGgNFYPGTGAADEVGSNGGEGYCVNVPWScGGVG 373
9************9998887776665489*********************************97527************************98368** PP
class-1.txt 227 DesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf.nlpllvlGGGGYtlrnvaRcwtye 308
D+ y f++v+ ++ +af+P+ v++ G D+ gD+lg+ +++ g++++ +++ + ++lv+ GGY+lr ++ t
AT3G18520.1 374 DKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCCDVTPAGYSRMTQMLGDLcGGKMLVILEGGYNLRSISASATAV 456
********************************************************998899************999766655 PP
|
Protein Sequence
(Fasta) | MVVETIERSC EGSKRRHVNG GDIAVPCSGE ECSNGDINVA PGVSAKRARV SREMTFEDIY 60
GADALLNDDD DEDDDCDWEP VQAPMEFVKW CCVNCTMSNP GDMVHCCICG EHKESGILRH 120
GYLASPFFKD TGLIEVEEKY GGSSSATSST AVGFDERMLL HSEFEVKAQP HPERPDRLRA 180
IAASLATAGV FPGRCLPINA REITKQELQM VHTSEHVDAV DTTSQLLYSY FTSDTYANEY 240
SARAARLAAG LCADLATDIF TGRVKNGFAL VRPPGHHAGV RHAMGFCLHN NAAVAALVAQ 300
AAGAKKVLIV DWDVHHGNGT QEIFEQNKSV LYISLHRHEG GNFYPGTGAA DEVGSNGGEG 360
YCVNVPWSCG GVGDKDYIFA FQHVVLPIAS AFSPDFVIIS AGFDAARGDP LGCCDVTPAG 420
YSRMTQMLGD LCGGKMLVIL EGGYNLRSIS ASATAVIKVL LGENPENELP IATTPSVAGL 480
QTVLDVLNIQ LEFWPSLAIS YSKLLSELEA RLIENKKNQM KRKVVRVPTW WKWGRKKLLY 540
NFLSARMISR SK 552Protein Fasta Sequence
>AT3G18520.1|HDA15;At3g18520;MYF24_23|Arabidopsis thaliana
MVVETIERSCEGSKRRHVNGGDIAVPCSGEECSNGDINVAPGVSAKRARVSREMTFEDIYGADALLNDDDDEDDDCDWEPVQAPMEFVKWCCVNCTMSNPGDMVHCCICGEHKESGILRHGYLASPFFKDTGLIEVEEKYGGSSSATSSTAVGFDERMLLHSEFEVKAQPHPERPDRLRAIAASLATAGVFPGRCLPINAREITKQELQMVHTSEHVDAVDTTSQLLYSYFTSDTYANEYSARAARLAAGLCADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAALVAQAAGAKKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRHEGGNFYPGTGAADEVGSNGGEGYCVNVPWSCGGVGDKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCCDVTPAGYSRMTQMLGDLCGGKMLVILEGGYNLRSISASATAVIKVLLGENPENELPIATTPSVAGLQTVLDVLNIQLEFWPSLAISYSKLLSELEARLIENKKNQMKRKVVRVPTWWKWGRKKLLYNFLSARMISRSK |
Nucleotide Sequence
(Fasta) | GTTGTCGCCG TCGTCGTTTC TCTCATTTCT GCTCTGTTGT GCTATCGTAG CGTCGCGCTC 60
CTTTAAACGC GACGGACGCA GCCTTCTCTG TTCATCGTTT CGCCGGAAGT TTTCTTCAGC 120
GGAGATTTAT TTTCAGCTGG TTAGTAGTTT TGAGTGACTA CTGAGGTAAC AATGGTTGTA 180
GAAACTATCG AGAGGTCTTG TGAGGGTTCA AAGAGAAGAC ATGTGAACGG TGGAGATATC 240
GCTGTTCCTT GTTCGGGAGA AGAGTGTAGC AATGGAGATA TAAATGTAGC TCCTGGAGTT 300
TCAGCGAAAA GAGCTAGGGT TTCTAGAGAA ATGACGTTTG AAGATATTTA CGGTGCTGAT 360
GCATTACTCA ATGATGACGA TGATGAGGAT GATGATTGTG ATTGGGAACC TGTGCAGGCG 420
CCTATGGAGT TTGTAAAATG GTGTTGTGTC AATTGCACTA TGTCGAACCC TGGTGATATG 480
GTCCACTGTT GTATATGCGG TGAGCACAAG GAATCTGGCA TTTTGAGGCA TGGATATTTA 540
GCGTCTCCCT TTTTTAAAGA CACTGGTCTC ATTGAAGTCG AGGAGAAATA TGGAGGAAGC 600
TCATCTGCAA CCAGCTCGAC AGCTGTTGGG TTCGACGAGA GAATGTTGCT ACACTCAGAA 660
TTTGAAGTGA AGGCACAACC ACATCCAGAG AGACCTGATC GTCTTCGAGC TATAGCTGCT 720
AGTCTTGCCA CAGCTGGTGT TTTTCCTGGA AGATGCTTGC CTATCAATGC AAGGGAAATC 780
ACGAAACAAG AACTCCAGAT GGTCCACACT TCAGAGCATG TTGATGCTGT TGATACTACA 840
AGCCAGCTTC TCTATAGCTA CTTCACCTCT GACACATATG CTAATGAGTA TTCAGCACGT 900
GCTGCTAGAC TTGCAGCAGG TTTGTGCGCT GATCTAGCTA CAGATATTTT CACTGGCCGT 960
GTAAAAAATG GTTTTGCTTT GGTTAGACCT CCCGGTCATC ATGCTGGCGT CAGGCATGCT 1020
ATGGGGTTTT GCCTTCACAA TAATGCAGCC GTTGCTGCAT TAGTAGCACA AGCAGCAGGG 1080
GCAAAGAAGG TGCTGATTGT GGACTGGGAT GTCCATCATG GCAACGGAAC CCAAGAGATA 1140
TTCGAACAAA ACAAATCTGT ATTGTACATA TCCTTGCACA GACATGAGGG AGGAAACTTC 1200
TATCCCGGTA CTGGAGCTGC TGATGAGGTT GGTTCTAATG GTGGGGAAGG TTATTGTGTA 1260
AATGTTCCAT GGAGTTGCGG TGGAGTTGGG GATAAAGACT ATATCTTTGC GTTTCAACAT 1320
GTGGTTCTCC CCATAGCTTC TGCATTTTCT CCAGATTTTG TCATCATATC TGCGGGATTT 1380
GATGCGGCTA GAGGAGACCC ACTAGGATGC TGTGATGTGA CTCCGGCTGG CTATTCTCGA 1440
ATGACACAGA TGTTGGGTGA TCTGTGTGGT GGGAAAATGC TAGTTATTCT CGAGGGCGGC 1500
TACAATCTTC GCTCCATATC TGCTTCTGCA ACAGCAGTGA TCAAGGTGCT TCTGGGTGAA 1560
AATCCGGAGA ACGAGTTGCC CATCGCCACC ACGCCTTCAG TAGCCGGCCT GCAAACTGTT 1620
CTTGATGTAC TGAATATCCA ACTGGAGTTC TGGCCATCAC TTGCTATCAG CTACTCCAAA 1680
TTACTCTCAG AGTTGGAAGC ACGTCTGATC GAAAACAAAA AAAATCAGAT GAAAAGGAAG 1740
GTTGTTCGGG TTCCGACATG GTGGAAATGG GGACGAAAGA AGCTTTTGTA CAACTTTCTC 1800
TCGGCTCGTA TGATTTCAAG ATCAAAGTGA TTTTAGAAAG CATTCTTCCT AATCCGTCGT 1860
AGGAATTGTC TACACTTACT TGTAACCCTA ACTGATCTGG GGGAATTTAT TGCAATTAGG 1920
GAGCTCTGAA CAATCTTTAT CACTTACATT TGGTAGGGTT TTATAGAAAG AACCCTTTTA 1980
ACCTGCTTAC CAACCATCCT CATCAGACCT CTTAAGCTAG GCAATCGGTT TGGATAAACG 2040
AATTCCTACT TTAACCAAAT TTATAGTTCG GTTTGGTT
2079Nucleotide Fasta Sequence
>AT3G18520.1|Class-I|Arabidopsis thaliana
GTTGTCGCCGTCGTCGTTTCTCTCATTTCTGCTCTGTTGTGCTATCGTAGCGTCGCGCTCCTTTAAACGCGACGGACGCAGCCTTCTCTGTTCATCGTTTCGCCGGAAGTTTTCTTCAGCGGAGATTTATTTTCAGCTGGTTAGTAGTTTTGAGTGACTACTGAGGTAACAATGGTTGTAGAAACTATCGAGAGGTCTTGTGAGGGTTCAAAGAGAAGACATGTGAACGGTGGAGATATCGCTGTTCCTTGTTCGGGAGAAGAGTGTAGCAATGGAGATATAAATGTAGCTCCTGGAGTTTCAGCGAAAAGAGCTAGGGTTTCTAGAGAAATGACGTTTGAAGATATTTACGGTGCTGATGCATTACTCAATGATGACGATGATGAGGATGATGATTGTGATTGGGAACCTGTGCAGGCGCCTATGGAGTTTGTAAAATGGTGTTGTGTCAATTGCACTATGTCGAACCCTGGTGATATGGTCCACTGTTGTATATGCGGTGAGCACAAGGAATCTGGCATTTTGAGGCATGGATATTTAGCGTCTCCCTTTTTTAAAGACACTGGTCTCATTGAAGTCGAGGAGAAATATGGAGGAAGCTCATCTGCAACCAGCTCGACAGCTGTTGGGTTCGACGAGAGAATGTTGCTACACTCAGAATTTGAAGTGAAGGCACAACCACATCCAGAGAGACCTGATCGTCTTCGAGCTATAGCTGCTAGTCTTGCCACAGCTGGTGTTTTTCCTGGAAGATGCTTGCCTATCAATGCAAGGGAAATCACGAAACAAGAACTCCAGATGGTCCACACTTCAGAGCATGTTGATGCTGTTGATACTACAAGCCAGCTTCTCTATAGCTACTTCACCTCTGACACATATGCTAATGAGTATTCAGCACGTGCTGCTAGACTTGCAGCAGGTTTGTGCGCTGATCTAGCTACAGATATTTTCACTGGCCGTGTAAAAAATGGTTTTGCTTTGGTTAGACCTCCCGGTCATCATGCTGGCGTCAGGCATGCTATGGGGTTTTGCCTTCACAATAATGCAGCCGTTGCTGCATTAGTAGCACAAGCAGCAGGGGCAAAGAAGGTGCTGATTGTGGACTGGGATGTCCATCATGGCAACGGAACCCAAGAGATATTCGAACAAAACAAATCTGTATTGTACATATCCTTGCACAGACATGAGGGAGGAAACTTCTATCCCGGTACTGGAGCTGCTGATGAGGTTGGTTCTAATGGTGGGGAAGGTTATTGTGTAAATGTTCCATGGAGTTGCGGTGGAGTTGGGGATAAAGACTATATCTTTGCGTTTCAACATGTGGTTCTCCCCATAGCTTCTGCATTTTCTCCAGATTTTGTCATCATATCTGCGGGATTTGATGCGGCTAGAGGAGACCCACTAGGATGCTGTGATGTGACTCCGGCTGGCTATTCTCGAATGACACAGATGTTGGGTGATCTGTGTGGTGGGAAAATGCTAGTTATTCTCGAGGGCGGCTACAATCTTCGCTCCATATCTGCTTCTGCAACAGCAGTGATCAAGGTGCTTCTGGGTGAAAATCCGGAGAACGAGTTGCCCATCGCCACCACGCCTTCAGTAGCCGGCCTGCAAACTGTTCTTGATGTACTGAATATCCAACTGGAGTTCTGGCCATCACTTGCTATCAGCTACTCCAAATTACTCTCAGAGTTGGAAGCACGTCTGATCGAAAACAAAAAAAATCAGATGAAAAGGAAGGTTGTTCGGGTTCCGACATGGTGGAAATGGGGACGAAAGAAGCTTTTGTACAACTTTCTCTCGGCTCGTATGATTTCAAGATCAAAGTGATTTTAGAAAGCATTCTTCCTAATCCGTCGTAGGAATTGTCTACACTTACTTGTAACCCTAACTGATCTGGGGGAATTTATTGCAATTAGGGAGCTCTGAACAATCTTTATCACTTACATTTGGTAGGGTTTTATAGAAAGAACCCTTTTAACCTGCTTACCAACCATCCTCATCAGACCTCTTAAGCTAGGCAATCGGTTTGGATAAACGAATTCCTACTTTAACCAAATTTATAGTTCGGTTTGGTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR001876--Znf_RanBP2
|
| PROSITE |
PS01358--ZF_RANBP2_1
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
