WERAM Information


Tag Content
WERAM ID WERAM-Mum-0115
Ensembl Protein ID ENSMUSP00000033501.8
Uniprot Accession Q9Z2V5; HDAC6_MOUSE; B1AUA6
Genbank Protein ID NP_001123888.1; NP_034543.3; XP_006527630.1
Protein Name Histone deacetylase 6
Genbank Nucleotide ID NM_001130416.1; NM_010413.3; XM_006527567.1
Gene Name HDAC6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031161.15 ENSMUST00000033501.14 ENSMUSP00000033501.8
ENSMUSG00000031161.15 ENSMUST00000115642.7 ENSMUSP00000111306.1
ENSMUSG00000031161.15 ENSMUST00000145675.7 ENSMUSP00000121653.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-II Histone deacetylase H2A; H2B; H3; H4 K 18292778
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-II 9.00e-265 877.7 85 799
HDAC Class-I 2.10e-67 229.4 88 792
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Domain Profile
  HDAC Class-II

           class-2.txt   2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsd 90 
+glv+de+ ++ ++l++++ pE+peR++ai ++l +gll+++++++ar a+keel+lvHs e+++l+et++ +++ el++l++++d
ENSMUSP00000033501.8 85 TGLVFDEQLNDFHCLWDDS--FPESPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYD 171
689*******999999988..******************************************************************** PP
class-2.txt 91 siylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtq 179
s+yl+++s+++a la+G+vl+lvd+++ +e++ng+av+RPPGHHa+++ ++G+C+fn+ avaa+++q+k++++++livDwDvHhG+Gtq
ENSMUSP00000033501.8 172 SVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQ 260
***************************************************************************************** PP
class-2.txt 180 eifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaeg 268
if +dp+vly+S+HRy++g+f+p+++ ++++++g g+g+g+++Nv+wn+++m+da+y+aaf +++lp+a+eF+P+lvlv+aGfDa +g
ENSMUSP00000033501.8 261 FIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHG 349
***************************************************************************************** PP
class-2.txt 269 dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
dp+g++ t++++a+lt+ l++lagg+++l lEGGynl+a+a++v+a++++Llg
ENSMUSP00000033501.8 350 DPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLG 403
****************************************************96 PP
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsd 90
+glvydekm++h +l++n+ hpE+p+Ri +i+ +l+e gl+ +++ l ar a ++el+++Hs+e+ve+l+t+ek+++++l++++ ++d
ENSMUSP00000033501.8 480 TGLVYDEKMMSHCNLWDNH--HPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFD 566
79**************999..******************************************************************** PP
class-2.txt 91 siylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk.vkkilivDwDvHhGnGt 178
siy+ ++++++a+la+Ga+++lv++vl+ge+ ng+avvRPPGHHae+++a+GFC+fn+vavaa+++q + +ilivDwDvHhGnGt
ENSMUSP00000033501.8 567 SIYICPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGrALRILIVDWDVHHGNGT 655
******************************************************************9876659**************** PP
class-2.txt 179 qeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaae 267
q+if++dp+vly+SlHRyd+g+ffp+ ++ga ++vg+++g gf+vNv+wng mgda+ylaa++++vlpia+eF+P+lvl+saGfDaa+
ENSMUSP00000033501.8 656 QHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQ 744
***************************************************************************************** PP
class-2.txt 268 gdplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
gdplgg++vt+++ya+lt+ l++laggr++l+lEGGynl +i+e+++a++++Llg
ENSMUSP00000033501.8 745 GDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLG 799
*****************************************************96 PP

  HDAC Class-I

           class-1.txt   6 aydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedc 92 
++de++ ++h +++ p p+rl+ + e ++ gl + ++++ a++eel+ +hs eyi+++++ + n+ el + ++
ENSMUSP00000033501.8 88 VFDEQLNDFHClwDDSFPESPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDS---V 173
57888999986558999*******9998877777888888999***********************9999999998877777754...4 PP
class-1.txt 93 PvfdglfeycqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgvee 177
+ + ++ + l tG+ l+ ++ L e +a+ G hha+++ G+c n + +a +kkh +rvl +d d+hhG g +
ENSMUSP00000033501.8 174 YLHPNSYSCACLATGSVLRLVDALMGAEIRngMAVIRPPG-HHAQHNLMDGYCMFNHLAVAARYAQKKHriQRVLIVDWDVHHGQGTQF 261
566688999999************9776541266665555.9*******************99998876448***************** PP
class-1.txt 178 afyttdrvmtvsfhkygee.ffPg..tGdlsdvgaekgkyyavnvPlk.dgidDesyekifksviskvieafePeavvlqcGaDslagD 262
f + v+ s+h+y+++ f+P + + s +g ++g+ y++nvP + g++D y + f +++ +v + f+P+ v++ G D+l gD
ENSMUSP00000033501.8 262 IFDQDPSVLYFSIHRYEHGrFWPHlkASNWSTIGFGQGQGYTINVPWNqTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGD 350
****************985388853378999***************96269************************************** PP
class-1.txt 263 rlgefnlsikghaecvkfvksf.nlpllvlGGGGYtlrnvaR 303
+ ge + g+a+ +++ +l++ GGY+lr +a+
ENSMUSP00000033501.8 351 PKGEMAATPAGFAHLTHLLMGLaGGKLILSLEGGYNLRALAK 392
*****************9999945566666689****99886 PP
class-1.txt 15 hygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycq 103
+++hp p+r+ + + + gl + i+ ++ a +ell++hs ey+e+l++ e+ ++++l++e ++f+ + cP f ++
ENSMUSP00000033501.8 494 LWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICP---STFACAK 579
348899*******9999999****************************************************9999999...569999* PP
class-1.txt 104 litGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellk...khkrvlyididlhhGDgveeafyttdrvmt 187
l tGa+ + ++ + ++e ia+ G hha + a Gfc+ n + +a + + r+l +d d+hhG+g ++ f+ v+
ENSMUSP00000033501.8 580 LATGAACRLVEAVLSGEVLngIAVVRPPG-HHAEPNAACGFCFFNSVAVAARHAQIiagRALRILIVDWDVHHGNGTQHIFEDDPSVLY 667
********999998887651266665555.9*****************998654331137889************************** PP
class-1.txt 188 vsfhkyge.effP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsik 272
vs+h+y+ +ffP G s+vg + g ++vnvP + + D y + ++++ ++ f+Pe v++ G D+ +gD+lg +++ +
ENSMUSP00000033501.8 668 VSLHRYDRgTFFPmgDEGASSQVGRDAGIGFTVNVPWNGpRMGDADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPE 756
******973599943368999***************9863699********************************************** PP
class-1.txt 273 ghaecvkfvksf.nlpllvlGGGGYtlrnvaRcwty 307
g+a+ +++ ++++ GGY+l+ ++ +
ENSMUSP00000033501.8 757 GYAHLTHLLMGLaGGRIILILEGGYNLASISESMAA 792
*****999998866788888899****999876655 PP

Protein Sequence
(Fasta)
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK KKGKMKKLSQ 60
PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW DDSFPESPER LHAIREQLIL 120
EGLLGRCVSF QARFAEKEEL MLVHSLEYID LMETTQYMNE GELRVLAETY DSVYLHPNSY 180
SCACLATGSV LRLVDALMGA EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK 240
HRIQRVLIVD WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 300
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD PKGEMAATPA 360
GFAHLTHLLM GLAGGKLILS LEGGYNLRAL AKGVSASLHT LLGDPCPMLE SCVVPCASAQ 420
TSIYCTLEAL EPFWEVLERS VETQEEDEVE EAVLEEEEEE GGWEATALPM DTWPLLQNRT 480
GLVYDEKMMS HCNLWDNHHP ETPQRILRIM CHLEEVGLAA RCLILPARPA LDSELLTCHS 540
AEYVEHLRTT EKMKTRDLHR EGANFDSIYI CPSTFACAKL ATGAACRLVE AVLSGEVLNG 600
IAVVRPPGHH AEPNAACGFC FFNSVAVAAR HAQIIAGRAL RILIVDWDVH HGNGTQHIFE 660
DDPSVLYVSL HRYDRGTFFP MGDEGASSQV GRDAGIGFTV NVPWNGPRMG DADYLAAWHR 720
LVLPIAYEFN PELVLISAGF DAAQGDPLGG CQVTPEGYAH LTHLLMGLAG GRIILILEGG 780
YNLASISESM AACTHSLLGD PPPQLTLLRP PQSGALVSIS EVIQVHRKYW RSLRLMKMED 840
KEECSSSRLV IKKLPPTASP VSAKEMTTPK GKVPEESVRK TIAALPGKES TLGQAKSKMA 900
KAVLAQGQSS EQAAKGTTLD LATSKETVGG ATTDLWASAA APENFPNQTT SVEALGETEP 960
TPPASHTNKQ TTGASPLQGV TAQQSLQLGV LSTLELSREA EEAHDSEEGL LGEAAGGQDM 1020
NSLMLTQGFG DFNTQDVFYA VTPLSWCPHL MAVCPIPAAG LDVSQPCKTC GTVQENWVCL 1080
TCYQVYCSRY VNAHMVCHHE ASEHPLVLSC VDLSTWCYVC QAYVHHEDLQ DVKNAAHQNK 1140
FGEDMPHSH 1149
Nucleotide Sequence
(Fasta)
GGGCGGAGGC TTGGAAGGGG CTGAGGGAGC CTGGTTAAAC GGTAGGCGTC TGGGAAGGGG 60
GTGGGGTCTG AAGGATTCTG ATCGAAAGGG GCAGTCCTCG GAGCAGCGGG GCACGGGGAA 120
AGCTCGGGGC GAGATCTGCG CGAGTGGAAG GCGCTGGTTC GGCCCTGCAG GAGGTGGAGT 180
TGAGTGAGTC TTTAAAGGTG CTGCCGAGGC CGCGGCAGCC CGGTCTGGCG GACTAGAAAG 240
GTGGGTGATT TTTCTGGGGA AATAGGCTGA AGCGGGCAGG TTGCAGAAGC CAAGCGTTCC 300
GGGCGCAGAT TAGAGAGCCT TTCCAGGAGC TGAGGCTCTT CAGCCATGAC CTCCACCGGC 360
CAAGATTCTT CTACTAGACA GCGAAAGAGT AGGCACAATC CCCAGTCACC CCTTCAGGAA 420
TCCAGCGCCA CCTTGAAGCG TGGTGGAAAG AAGTGTGCTG TACCCCACTC CAGCCCCAAT 480
CTAGCGGAGG TAAAGAAGAA AGGCAAAATG AAGAAGCTGA GCCAACCAGC TGAAGAGGAC 540
CTAGTTGTGG GGCTTCAAGG GCTGGATCTG AACCCTGAGA CAAGAGTGCC AGTTGGTACT 600
GGATTGGTGT TTGATGAACA ACTAAATGAC TTCCATTGCC TTTGGGATGA CAGCTTCCCT 660
GAAAGCCCTG AGCGGCTCCA TGCCATCAGA GAGCAACTGA TCCTGGAGGG CCTCCTGGGC 720
CGCTGTGTGT CCTTTCAGGC CCGGTTCGCT GAGAAGGAGG AGCTGATGTT GGTTCACAGC 780
CTGGAATACA TTGATCTGAT GGAGACAACC CAGTACATGA ATGAAGGGGA GCTTCGAGTA 840
CTGGCAGAAA CCTATGATTC AGTGTATCTG CATCCGAACT CATATTCCTG TGCCTGCCTG 900
GCTACAGGCT CTGTCCTCCG GCTGGTAGAT GCACTCATGG GGGCTGAGAT TCGGAATGGC 960
ATGGCCGTCA TCAGGCCTCC TGGACACCAT GCTCAGCACA ATCTTATGGA TGGGTATTGC 1020
ATGTTCAACC ATCTGGCTGT GGCTGCCCGC TATGCGCAAA AGAAGCACCG CATTCAGAGG 1080
GTTCTCATCG TGGACTGGGA TGTGCACCAT GGTCAAGGAA CACAGTTCAT CTTCGACCAG 1140
GACCCCAGTG TCCTTTATTT CTCCATCCAC CGATATGAAC ATGGTCGCTT CTGGCCCCAC 1200
CTTAAGGCTT CTAACTGGTC CACTATAGGT TTTGGCCAAG GCCAAGGATA TACCATCAAT 1260
GTACCTTGGA ACCAGACGGG CATGCGGGAC GCTGACTACA TTGCTGCTTT CCTGCACATC 1320
CTGCTGCCAG TTGCCTCGGA GTTTCAGCCT CAACTGGTCT TGGTGGCCGC TGGATTTGAT 1380
GCCCTCCACG GAGACCCCAA GGGAGAGATG GCTGCCACGC CAGCAGGATT TGCCCACCTA 1440
ACCCATTTGC TCATGGGTTT GGCAGGAGGC AAGTTGATTC TGTCCCTGGA GGGTGGCTAT 1500
AACCTCCGTG CCCTGGCTAA GGGAGTCAGT GCTTCACTCC ACACCCTTCT TGGAGACCCT 1560
TGCCCCATGC TGGAGTCCTG TGTTGTACCT TGTGCAAGCG CCCAGACTTC CATCTACTGC 1620
ACTCTAGAAG CCCTTGAACC CTTCTGGGAG GTCCTGGAGA GATCAGTTGA GACCCAGGAG 1680
GAAGATGAAG TGGAAGAAGC CGTGCTAGAA GAGGAGGAGG AGGAAGGTGG CTGGGAGGCC 1740
ACTGCACTGC CCATGGATAC ATGGCCACTG CTCCAGAACC GCACTGGGCT GGTCTATGAT 1800
GAGAAGATGA TGAGTCACTG CAACCTCTGG GACAATCATC ACCCTGAGAC ACCTCAGCGC 1860
ATCTTACGCA TCATGTGTCA CCTGGAGGAG GTGGGCCTTG CGGCTCGCTG TCTCATCCTA 1920
CCTGCTCGGC CTGCCCTGGA CTCTGAGCTC CTTACCTGCC ACAGTGCTGA GTACGTGGAG 1980
CATCTCCGCA CCACAGAAAA GATGAAAACC CGGGATCTGC ACCGTGAAGG TGCCAACTTT 2040
GACTCCATCT ACATCTGCCC CAGCACCTTT GCCTGCGCAA AGCTTGCCAC AGGCGCTGCC 2100
TGCCGCCTGG TGGAAGCTGT GCTCTCGGGA GAGGTTCTAA ATGGCATTGC AGTAGTGCGC 2160
CCTCCAGGAC ACCACGCGGA GCCAAATGCT GCCTGTGGTT TCTGCTTTTT CAACTCAGTA 2220
GCTGTAGCTG CTCGCCATGC CCAGATCATT GCTGGACGTG CCCTGCGGAT CCTAATCGTG 2280
GATTGGGATG TTCATCATGG TAATGGAACT CAGCACATAT TTGAGGATGA CCCTAGTGTA 2340
TTATACGTGT CCCTGCACCG GTATGACCGT GGCACTTTCT TCCCCATGGG GGATGAGGGT 2400
GCCAGTAGCC AAGTAGGCCG AGATGCAGGT ATAGGCTTCA CTGTCAATGT GCCCTGGAAT 2460
GGGCCCCGCA TGGGTGATGC TGATTACCTG GCTGCATGGC ATCGTCTGGT ACTTCCCATC 2520
GCCTATGAGT TTAACCCAGA ACTGGTGCTG ATCTCAGCTG GCTTTGATGC TGCACAAGGG 2580
GATCCGCTGG GGGGCTGCCA AGTAACACCG GAGGGTTATG CCCACCTCAC CCACCTACTG 2640
ATGGGCCTTG CTGGTGGCCG TATTATTCTT ATTCTAGAGG GTGGATACAA TTTGGCATCT 2700
ATCTCTGAGT CTATGGCTGC CTGCACCCAT TCCCTCCTTG GAGACCCACC ACCCCAGCTT 2760
ACTTTGCTGC GACCGCCACA GTCAGGAGCC CTGGTTTCAA TCAGTGAGGT CATCCAAGTC 2820
CATCGCAAAT ACTGGCGCAG TTTGCGGTTG ATGAAAATGG AAGACAAGGA AGAATGCTCT 2880
AGTTCTAGGC TTGTCATCAA GAAGTTGCCC CCAACAGCCA GTCCTGTATC AGCTAAGGAA 2940
ATGACCACAC CGAAAGGAAA GGTTCCTGAA GAAAGCGTGA GGAAGACCAT AGCAGCACTA 3000
CCTGGGAAAG AGTCTACTCT AGGCCAGGCT AAATCAAAGA TGGCTAAGGC TGTGCTTGCT 3060
CAGGGCCAGT CCTCAGAACA AGCTGCTAAG GGAACTACAC TGGATCTGGC TACCTCAAAG 3120
GAGACTGTGG GAGGAGCCAC GACGGACCTG TGGGCCTCAG CAGCTGCTCC TGAAAACTTC 3180
CCTAACCAGA CCACCTCTGT GGAGGCTTTG GGAGAAACTG AGCCAACGCC TCCAGCCTCG 3240
CATACAAACA AGCAGACCAC AGGGGCTTCA CCTCTGCAGG GAGTCACGGC TCAGCAGTCC 3300
CTACAGCTTG GGGTTCTCAG CACTTTGGAG CTAAGCAGAG AAGCAGAGGA AGCCCATGAT 3360
TCTGAGGAGG GCCTGCTAGG GGAAGCCGCT GGAGGTCAGG ACATGAACAG CTTGATGCTG 3420
ACACAAGGAT TTGGGGACTT TAATACCCAG GATGTATTTT ATGCTGTGAC CCCACTATCC 3480
TGGTGTCCCC ATTTGATGGC AGTATGCCCC ATTCCTGCAG CAGGCCTAGA TGTGTCCCAA 3540
CCTTGTAAGA CCTGTGGAAC AGTCCAGGAG AACTGGGTGT GTCTGACTTG CTATCAGGTG 3600
TACTGCAGTC GCTATGTCAA TGCCCATATG GTCTGCCACC ATGAAGCCTC TGAACACCCG 3660
CTGGTCCTCA GCTGTGTTGA CCTGTCTACC TGGTGTTATG TCTGTCAGGC TTATGTCCAC 3720
CACGAGGATC TCCAAGATGT GAAGAACGCT GCCCACCAGA ACAAGTTTGG GGAGGACATG 3780
CCCCACTCAC ACTAAATCCC AGACCACACT GCCTGTTTCC CTTCTGAGGC CACAGGCAGG 3840
GCAGCTTAGT TCACCGCAGT CCGTACCTTG GATAAGGGGC CTCACTTGAA CCCATCTTGA 3900
ATACCCTTTG CCAGGTGCTT ATTTAAGTAC AAATCCTTTT CAAAGGACTC TAGTGTTCAG 3960
TTGTTGATGT GCCCCTGCCC ACTGCCTGCT CGAGGAATAC CTCTGTTCTA CCCAGAAGGA 4020
GGGAGGGACA GCTTAGTAGC CCTAGGAAGG AGCTGAGATC ACAAGGATGA CATTGAAGGA 4080
GACAACGGGG CAGTGGCAGC AGGTCAGCAT ATTTAATAAA GTTGGAGTTG CTACAAAACC 4140
TG 4143
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0966--Cell projection
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50271--ZF_UBP

Pfam

PF00850--Hist_deacetyl
PF02148--zf-UBP

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005901--C:caveola
GO:0044297--C:cell body
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0030286--C:dynein complex
GO:0000118--C:histone deacetylase complex
GO:0016234--C:inclusion body
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0043014--F:alpha-tubulin binding
GO:0008013--F:beta-catenin binding
GO:0048487--F:beta-tubulin binding
GO:0001047--F:core promoter binding
GO:0070840--F:dynein complex binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0051879--F:Hsp90 protein binding
GO:0008017--F:microtubule binding
GO:0051787--F:misfolded protein binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0031593--F:polyubiquitin binding
GO:0048156--F:tau protein binding
GO:0042903--F:tubulin deacetylase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071218--P:cellular response to misfolded protein
GO:0035967--P:cellular response to topologically incorrect protein
GO:0048668--P:collateral sprouting
GO:0060997--P:dendritic spine morphogenesis
GO:0016575--P:histone deacetylation
GO:0070846--P:Hsp90 deacetylation
GO:0006886--P:intracellular protein transport
GO:0032418--P:lysosome localization
GO:0016236--P:macroautophagy
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0051646--P:mitochondrion localization
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0043242--P:negative regulation of protein complex disassembly
GO:0045861--P:negative regulation of proteolysis
GO:0034983--P:peptidyl-lysine deacetylation
GO:0070845--P:polyubiquitinated misfolded protein transport
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0010634--P:positive regulation of epithelial cell migration
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0009967--P:positive regulation of signal transduction
GO:0043241--P:protein complex disassembly
GO:0006476--P:protein deacetylation
GO:0000209--P:protein polyubiquitination
GO:0070201--P:regulation of establishment of protein localization
GO:0045598--P:regulation of fat cell differentiation
GO:0040029--P:regulation of gene expression, epigenetic
GO:0031647--P:regulation of protein stability
GO:0010469--P:regulation of receptor activity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0070848--P:response to growth factor
GO:0051788--P:response to misfolded protein
GO:0010033--P:response to organic substance
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0209 ENSRNOP00000009295.5 Rattus norvegicus 92 0.0 2076
WERAM-Ict-0125 ENSSTOP00000012693.2 Ictidomys tridecemlineatus 79 0.0 1785
WERAM-Mam-0153 ENSMMUP00000021637.2 Macaca mulatta 75 0.0 1723
WERAM-Paa-0049 ENSPANP00000006915.1 Papio anubis 75 0.0 1722
WERAM-Gog-0047 ENSGGOP00000004443.2 Gorilla gorilla 74 0.0 1721
WERAM-Chs-0158 ENSCSAP00000009365.1 Chlorocebus sabaeus 75 0.0 1720
WERAM-Hos-0047 ENSP00000365804.2 Homo sapiens 75 0.0 1717
WERAM-Eqc-0001 ENSECAP00000001121.1 Equus caballus 73 0.0 1713
WERAM-Cap-0109 ENSCPOP00000008049.2 Cavia porcellus 76 0.0 1713
WERAM-Fec-0031 ENSFCAP00000002366.3 Felis catus 75 0.0 1708
WERAM-Aim-0139 ENSAMEP00000013236.1 Ailuropoda melanoleuca 74 0.0 1706
WERAM-Caf-0161 ENSCAFP00000022990.3 Canis familiaris 75 0.0 1697
WERAM-Poa-0196 ENSPPYP00000022747.2 Pongo abelii 73 0.0 1682
WERAM-Orc-0102 ENSOCUP00000008741.3 Oryctolagus cuniculus 75 0.0 1677
WERAM-Otg-0144 ENSOGAP00000012420.2 Otolemur garnettii 72 0.0 1672
WERAM-Mup-0158 ENSMPUP00000013557.1 Mustela putorius furo 74 0.0 1667
WERAM-Myl-0104 ENSMLUP00000008295.2 Myotis lucifugus 73 0.0 1655
WERAM-Tut-0056 ENSTTRP00000004443.1 Tursiops truncatus 73 0.0 1646
WERAM-Caj-0022 ENSCJAP00000004409.2 Callithrix jacchus 72 0.0 1634
WERAM-Sus-0177 ENSSSCP00000022636.1 Sus scrofa 73 0.0 1626
WERAM-Dio-0075 ENSDORP00000007462.1 Dipodomys ordii 71 0.0 1616
WERAM-Bot-0122 ENSBTAP00000017618.5 Bos taurus 72 0.0 1605
WERAM-Loa-0047 ENSLAFP00000003196.3 Loxodonta africana 72 0.0 1603
WERAM-Ova-0124 ENSOARP00000012678.1 Ovis aries 72 0.0 1595
WERAM-Ptv-0077 ENSPVAP00000007213.1 Pteropus vampyrus 69 0.0 1507
WERAM-Dan-0022 ENSDNOP00000002136.3 Dasypus novemcinctus 67 0.0 1484
WERAM-Prc-0036 ENSPCAP00000003334.1 Procavia capensis 68 0.0 1468
WERAM-Mod-0081 ENSMODP00000012731.2 Monodelphis domestica 58 0.0 1258
WERAM-Pat-0185 ENSPTRP00000037550.5 Pan troglodytes 85 0.0 1242
WERAM-Dar-0023 ENSDARP00000124246.1 Danio rerio 50 0.0 1064
WERAM-Xet-0155 ENSXETP00000050501.3 Xenopus tropicalis 49 0.0 1058
WERAM-Ten-0019 ENSTNIP00000004593.1 Tetraodon nigroviridis 48 0.0 993
WERAM-Anc-0082 ENSACAP00000007918.3 Anolis carolinensis 57 0.0 987
WERAM-Orn-0011 ENSONIP00000001061.1 Oreochromis niloticus 47 0.0 980
WERAM-Tar-0042 ENSTRUP00000010127.1 Takifugu rubripes 48 0.0 978
WERAM-Mae-0111 ENSMEUP00000010640.1 Macropus eugenii 68 0.0 962
WERAM-Ocp-0057 ENSOPRP00000005096.1 Ochotona princeps 62 0.0 937
WERAM-Asm-0181 ENSAMXP00000017644.1 Astyanax mexicanus 45 0.0 915
WERAM-Xim-0160 ENSXMAP00000013063.1 Xiphophorus maculatus 43 0.0 860
WERAM-Lac-0055 ENSLACP00000007918.1 Latimeria chalumnae 53 0.0 836
WERAM-Pof-0022 ENSPFOP00000001799.2 Poecilia formosa 50 0.0 836
WERAM-Sah-0012 ENSSHAP00000001165.1 Sarcophilus harrisii 49 0.0 830
WERAM-Pem-0058 ENSPMAP00000006830.1 Petromyzon marinus 54 0.0 819
WERAM-Tas-0021 ENSTSYP00000002661.1 Tarsius syrichta 63 0.0 793
WERAM-Soa-0022 ENSSARP00000002183.1 Sorex araneus 65 0.0 750
WERAM-Nol-0078 ENSNLEP00000009627.2 Nomascus leucogenys 88 0.0 712
WERAM-Ora-0024 ENSOANP00000003575.1 Ornithorhynchus anatinus 58 0.0 682
WERAM-Drm-0028 FBpp0290988 Drosophila melanogaster 44 0.0 673
WERAM-Tag-0059 ENSTGUP00000004152.1 Taeniopygia guttata 48 0.0 671
WERAM-Mim-0053 ENSMICP00000005439.1 Microcebus murinus 52 2e-180 630
WERAM-Ere-0025 ENSEEUP00000001892.1 Erinaceus europaeus 75 4e-169 593
WERAM-Cae-0060 F41H10.6b Caenorhabditis elegans 40 7e-153 539
WERAM-Ect-0051 ENSETEP00000005266.1 Echinops telfairi 63 4e-147 520
WERAM-Fia-0117 ENSFALP00000010126.1 Ficedula albicollis 37 2e-121 435
WERAM-Pes-0141 ENSPSIP00000016742.1 Pelodiscus sinensis 52 1e-115 415
WERAM-Gaga-0090 ENSGALP00000014065.4 Gallus gallus 36 1e-114 412
WERAM-Anp-0022 ENSAPLP00000003127.1 Anas platyrhynchos 53 8e-114 409
WERAM-Meg-0084 ENSMGAP00000008226.2 Meleagris gallopavo 53 1e-113 409
WERAM-Gaa-0030 ENSGACP00000005071.1 Gasterosteus aculeatus 52 3e-112 404
WERAM-Gam-0051 ENSGMOP00000005244.1 Gadus morhua 51 1e-108 392
WERAM-Orla-0095 ENSORLP00000011723.1 Oryzias latipes 34 1e-107 389
WERAM-Leo-0157 ENSLOCP00000018907.1 Lepisosteus oculatus 52 1e-94 345
WERAM-Tub-0095 ENSTBEP00000011284.1 Tupaia belangeri 51 2e-94 344
WERAM-Glm-0045 GLYMA05G00460.1 Glycine max 50 1e-91 336
WERAM-Sem-0022 EFJ08599 Selaginella moellendorffii 44 1e-90 332
WERAM-Scp-0036 SPBC800.03.1:pep Schizosaccharomyces pombe 46 3e-89 328
WERAM-Scj-0031 EEB08679 Schizosaccharomyces japonicus 43 7e-89 326
WERAM-Yal-0023 CAG79971 Yarrowia lipolytica 41 9e-89 326
WERAM-Caa-0034 KGT64501 Candida albicans 44 1e-88 325
WERAM-Crn-0010 AAW42071 Cryptococcus neoformans 46 2e-88 325
WERAM-Php-0085 PP1S34_252V6.1 Physcomitrella patens 48 4e-88 324
WERAM-Met-0112 KEH32016 Medicago truncatula 48 3e-87 321
WERAM-Prp-0049 EMJ12067 Prunus persica 40 8e-87 319
WERAM-Bro-0168 Bo9g014470.1 Brassica oleracea 45 1e-86 319
WERAM-Brr-0181 Bra035942.1-P Brassica rapa 46 2e-86 318
WERAM-Lep-0079 LPERR07G18450.1 Leersia perrieri 47 2e-86 318
WERAM-Coi-0028 EAS30926 Coccidioides immitis 46 1e-85 316
WERAM-Arl-0149 scaffold_802745.1 Arabidopsis lyrata 45 1e-85 315
WERAM-Orbr-0087 OB07G26850.1 Oryza brachyantha 48 1e-85 315
WERAM-Orgl-0076 OGLUM07G21150.1 Oryza glumaepatula 48 1e-85 315
WERAM-Ori-0088 BGIOSGA026083-PA Oryza indica 48 2e-85 315
WERAM-Ors-0072 OS07T0602200-01 Oryza sativa 48 2e-85 315
WERAM-Orr-0082 ORUFI07G22240.1 Oryza rufipogon 48 2e-85 315
WERAM-Orni-0078 ONIVA07G19970.1 Oryza nivara 48 2e-85 315
WERAM-Amt-0091 ERM99985 Amborella trichopoda 47 4e-85 314
WERAM-Brd-0010 BRADI1G22240.1 Brachypodium distachyon 44 4e-85 314
WERAM-Viv-0107 VIT_17s0000g07280.t01 Vitis vinifera 44 7e-85 313
WERAM-Lem-0023 CBX90551 Leptosphaeria maculans 45 8e-85 313
WERAM-Org-0078 ORGLA07G0164500.1 Oryza glaberrima 47 9e-85 313
WERAM-Orp-0076 OPUNC07G19850.1 Oryza punctata 46 1e-84 312
WERAM-Orb-0079 OBART07G21300.1 Oryza barthii 47 2e-84 311
WERAM-Tra-0099 Traes_2DS_DFCAF1EA5.1 Triticum aestivum 40 4e-84 310
WERAM-Zem-0143 GRMZM2G457889_P01 Zea mays 46 5e-84 310
WERAM-Art-0146 AT5G61060.1 Arabidopsis thaliana 46 9e-84 309
WERAM-Sei-0109 Si029091m Setaria italica 46 1e-83 309
WERAM-Ast-0014 CADATEAP00005667 Aspergillus terreus 45 1e-83 309
WERAM-Asc-0002 CADACLAP00000048 Aspergillus clavatus 46 2e-83 308
WERAM-Mua-0066 GSMUA_Achr4P03250_001 Musa acuminata 47 3e-83 308
WERAM-Thc-0031 EOY22062 Theobroma cacao 47 3e-83 307
WERAM-Sob-0036 Sb02g038550.1 Sorghum bicolor 46 6e-83 306
WERAM-Kop-0012 CAY68916 Komagataella pastoris 42 6e-83 306
WERAM-Spr-0021 CBQ72644 Sporisorium reilianum 44 1e-82 306
WERAM-Sol-0055 Solyc03g115150.2.1 Solanum lycopersicum 40 4e-82 304
WERAM-Hov-0018 MLOC_16422.1 Hordeum vulgare 45 7e-82 303
WERAM-Miv-0034 MVLG_04888T0 Microbotryum violaceum 43 1e-81 302
WERAM-Pug-0031 EFP89333 Puccinia graminis 40 1e-81 302
WERAM-Pytr-0015 EDU46537 Pyrenophora triticirepentis 45 3e-81 301
WERAM-Pyt-0023 EFQ89752 Pyrenophora teres 44 3e-81 301
WERAM-Usm-0012 UM02102P0 Ustilago maydis 44 6e-81 300
WERAM-Mel-0037 EGG03660 Melampsora laricipopulina 42 7e-81 300
WERAM-Asn-0017 CADANIAP00004063 Aspergillus nidulans 44 1e-80 299
WERAM-Cag-0018 CAG60803 Candida glabrata 43 2e-80 298
WERAM-Tum-0026 CAZ84932 Tuber melanosporum 44 2e-80 298
WERAM-Sac-0037 YNL021W Saccharomyces cerevisiae 42 2e-80 298
WERAM-Put-0014 PTTG_07163P0 Puccinia triticina 40 3e-80 297
WERAM-Asg-0010 AAS51704 Ashbya gossypii 43 4e-80 297
WERAM-Lab-0047 EDQ99497 Laccaria bicolor 44 3e-79 295
WERAM-Pot-0045 POPTR_0004s09180.1 Populus trichocarpa 43 9e-79 293
WERAM-Trv-0041 EHK18675 Trichoderma virens 41 1e-78 292
WERAM-Kll-0020 CAG99415 Kluyveromyces lactis 41 1e-77 289
Created Date 25-Jun-2016