Tag |
Content |
WERAM ID |
WERAM-Scp-0036 |
Ensembl Protein ID |
SPBC800.03.1:pep |
Uniprot Accession |
P56523; CLR3_SCHPO |
Genbank Protein ID |
NP_595104.1 |
Protein Name |
Histone deacetylase clr3 |
Genbank Nucleotide ID |
NM_001021011.2 |
Gene Name |
Clr3;SPBC800.03 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
3.90e-127 |
422 |
57 |
385 |
HDAC |
Class-I |
1.40e-35 |
121.5 |
110 |
373 |
|
Organism |
Schizosaccharomyces pombe |
NCBI Taxa ID |
284812 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeaglle.......kleelkarkatkeelqlvHseehvelletaeklekeelesltv 87 +gl+yd++m h++l+e + hpE+p+R+ ++++++++ag+++ ++++ ar+at+eel++vHs+e++++++++ek+++e+l++l++ SPBC800.03.1:pep 57 SGLCYDPRMRFHATLSEVD-DHPEDPRRVLRVFEAIKKAGYVSnvpspsdVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEK 148 689*********9999887.7*******************9996666665599**************************************** PP class-2.txt 88 dsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk..vkkilivDwDvHhGnGt 178 sds+y++++s+ +arla+G+++e++++v++g++kn+favvRPPGHHae++++ GFClfnnv+v+a+ ++q+++ +k++livDwD+HhGnGt SPBC800.03.1:pep 149 ISDSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPdkIKRVLIVDWDIHHGNGT 241 ************************************************************************9888***************** PP class-2.txt 179 qeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdpl 271 q +fy+dp+vly+SlHRy++g+f+p ++ g ++++geg+g+g +vN++w++++mgd +y++af++vv+p+a+eF+Pdlv+vs+GfDaa+gd++ SPBC800.03.1:pep 242 QMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHI 334 *************************9999**************************************************************** PP class-2.txt 272 gglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 g++ +t+++ya++t++l++la+g+v++ lEGGynl++i++++ av+++Llg SPBC800.03.1:pep 335 GQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLG 385 *************************************************96 PP
HDAC Class-I
class-1.txt 46 vkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycql.itGasleaakkLnkkeadiainw.aGGlhhakk 136 + +++a+ eell++hs+e + +++ e+ ++e+l ++ + +d+ +++ +c+ +G+++e+ + + +++ + a hha SPBC800.03.1:pep 110 IPAREATLEELLQVHSQEMYDRVTNTEKMSHEDL----ANLEKISDSLYYNNESAFCARlACGSAIETCTAVVTGQVKNAFAVvRPPGHHAEP 198 56789999********999888777666555554....455556799999*******86156889**999999888776554313455***** PP class-1.txt 137 seasGfcyvnDivlailellk....khkrvlyididlhhGDgveeafyttdrvmtvsfhkygee.ffPgt..GdlsdvgaekgkyyavnvPlk 222 ++ Gfc n++ ++ +l+ k krvl +d d+hhG+g + afy v+ vs+h+y+++ f+Pgt G ++ g++ g +vn+P + SPBC800.03.1:pep 199 HKPGGFCLFNNVSVTARSMLQrfpdKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGrFYPGTnyGCAENCGEGPGLGRTVNIPWS 291 *************999988873444568*********************************985499**9778999***************97 PP class-1.txt 223 .dgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf.nlpllvlGGGGYtlrnva 302 g+ D y f++v+ +v f+P+ v++ cG D+ agD +g+f l+ ++a++ +++ + ++++ GGY+l ++ SPBC800.03.1:pep 292 cAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLaDGKVFISLEGGYNLDSIS 373 589******************************************************9999886889999999***998776 PP
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Protein Sequence (Fasta) | MLASNSDGAS TSVKPSDDAV NTVTPWSILL TNNKPMSGSE NTLNNESHEM SQILKKSGLC 60 YDPRMRFHAT LSEVDDHPED PRRVLRVFEA IKKAGYVSNV PSPSDVFLRI PAREATLEEL 120 LQVHSQEMYD RVTNTEKMSH EDLANLEKIS DSLYYNNESA FCARLACGSA IETCTAVVTG 180 QVKNAFAVVR PPGHHAEPHK PGGFCLFNNV SVTARSMLQR FPDKIKRVLI VDWDIHHGNG 240 TQMAFYDDPN VLYVSLHRYE NGRFYPGTNY GCAENCGEGP GLGRTVNIPW SCAGMGDGDY 300 IYAFQRVVMP VAYEFDPDLV IVSCGFDAAA GDHIGQFLLT PAAYAHMTQM LMGLADGKVF 360 ISLEGGYNLD SISTSALAVA QSLLGIPPGR LHTTYACPQA VATINHVTKI QSQYWRCMRP 420 KHFDANPKDA HVDRLHDVIR TYQAKKLFED WKITNMPILR DSVSNVFNNQ VLCSSNFFQK 480 DNLLVIVHES PRVLGNGTSE TNVLNLNDSL LVDPVSLYVE WAMQQDWGLI DINIPEVVTD 540 GENAPVDILS EVKELCLYVW DNYVELSISK NIFFIGGGKA VHGLVNLASS RNVSDRVKCM 600 VNFLGTEPLV GLKTASEEDL PTWYYRHSLV FVSSSNECWK KAKRAKRRYG RLMQSEHTET 660 SDMMEQHYRA VTQYLLHLLQ KARPTSQ 687Protein Fasta Sequence
>SPBC800.03.1:pep|Clr3;SPBC800.03|Schizosaccharomyces pombe MLASNSDGASTSVKPSDDAVNTVTPWSILLTNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFEDWKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISKNIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLVFVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ
|
Nucleotide Sequence (Fasta) | CCGCGCTTCA AAAAGTGTTT CGACAGTTTT ATGAGGGAGT TGTTTAATAG GAGATTTTTT 60 TATTAATTTA TTAATTGATT GACCTTTTTA AGGGCGATAG AAAACGAATG CTGGCCTCTA 120 ATTCTGATGG TGCATCTACT TCTGTAAAAC CATCCGATGA TGCTGTAAAC ACGGTAACTC 180 CATGGTCTAT TCTTTTGACA AACAATAAAC CAATGTCTGG AAGTGAAAAT ACATTAAATA 240 ACGAATCCCA TGAAATGTCG CAAATCTTGA AAAAATCTGG ATTATGCTAT GATCCTCGAA 300 TGAGATTCCA TGCCACTCTA AGTGAAGTGG ATGACCATCC TGAAGATCCA AGACGCGTCC 360 TTCGTGTTTT TGAAGCTATA AAGAAGGCCG GTTATGTATC TAATGTGCCG AGTCCGTCAG 420 ATGTATTTTT ACGGATTCCG GCTAGAGAAG CTACTTTAGA AGAGTTATTA CAAGTTCATT 480 CACAGGAAAT GTATGATAGG GTTACTAATA CCGAAAAAAT GTCTCATGAG GATTTGGCCA 540 ATCTCGAAAA AATCAGTGAT TCTCTATACT ATAATAACGA AAGTGCGTTT TGTGCTCGAT 600 TGGCTTGTGG TAGCGCAATT GAAACATGTA CGGCTGTCGT AACTGGTCAA GTAAAAAATG 660 CCTTCGCAGT TGTTCGCCCT CCTGGCCATC ATGCAGAACC CCATAAACCT GGTGGCTTTT 720 GTTTATTCAA CAATGTTTCT GTAACCGCAA GGAGTATGCT ACAACGCTTT CCGGATAAAA 780 TAAAAAGAGT ATTGATTGTC GACTGGGATA TACACCATGG AAATGGTACG CAAATGGCTT 840 TTTATGACGA TCCAAATGTT CTATACGTTT CTTTGCATCG ATATGAAAAT GGTCGTTTCT 900 ATCCTGGCAC CAATTATGGG TGTGCAGAAA ATTGTGGAGA GGGCCCGGGA TTGGGTAGAA 960 CTGTAAATAT TCCTTGGAGT TGTGCTGGCA TGGGAGATGG TGATTATATA TACGCTTTTC 1020 AGCGCGTCGT AATGCCTGTT GCTTATGAAT TTGATCCAGA TTTAGTTATT GTAAGTTGCG 1080 GCTTTGATGC TGCTGCAGGA GATCACATTG GTCAATTCTT GTTAACTCCA GCTGCCTATG 1140 CTCATATGAC ACAAATGTTA ATGGGATTAG CAGATGGGAA AGTTTTTATC TCCCTTGAGG 1200 GAGGTTATAA TTTGGATTCT ATAAGCACAT CAGCCTTAGC TGTAGCCCAA AGTTTGTTGG 1260 GAATTCCTCC TGGACGATTG CATACAACAT ATGCATGTCC ACAGGCCGTT GCTACCATCA 1320 ACCATGTAAC CAAAATACAA TCCCAATACT GGAGATGTAT GAGGCCGAAA CACTTCGACG 1380 CAAATCCTAA GGATGCCCAT GTAGATCGAT TACATGATGT TATTCGAACT TATCAAGCTA 1440 AAAAACTTTT CGAAGACTGG AAAATTACCA ATATGCCAAT ACTAAGGGAT TCCGTTTCCA 1500 ATGTATTCAA CAATCAAGTA CTGTGCTCTA GCAATTTCTT TCAAAAAGAT AACCTTCTCG 1560 TTATTGTCCA TGAATCTCCT AGAGTCCTGG GTAATGGAAC TAGTGAAACG AACGTTTTGA 1620 ATTTAAATGA TTCGCTTTTA GTAGATCCCG TGAGCCTTTA TGTTGAATGG GCTATGCAAC 1680 AGGACTGGGG GCTTATCGAC ATAAATATAC CTGAAGTGGT TACGGACGGT GAAAATGCAC 1740 CGGTTGACAT TCTTTCTGAA GTGAAAGAAC TTTGTCTTTA TGTATGGGAT AATTATGTTG 1800 AGTTGTCGAT TTCAAAAAAT ATTTTTTTCA TCGGTGGAGG CAAAGCGGTA CATGGATTGG 1860 TTAATTTGGC ATCTTCCAGG AATGTGTCAG ACAGAGTTAA GTGTATGGTG AATTTCCTTG 1920 GCACTGAACC TTTGGTGGGT CTTAAAACGG CATCAGAGGA AGATCTTCCA ACGTGGTATT 1980 ATCGTCATTC ACTCGTGTTT GTGAGTTCTA GTAATGAGTG CTGGAAAAAG GCAAAGCGTG 2040 CTAAAAGAAG ATATGGACGA CTTATGCAAA GTGAACATAC TGAAACTTCG GACATGATGG 2100 AGCAACACTA TCGAGCGGTT ACTCAATACT TGCTGCATTT GCTTCAAAAG GCCCGACCAA 2160 CTTCTCAGTA ACATTCGTTA TTGACTTATG ATTTTTTCAT GGTTTTCTAT TCTTTTAATT 2220 GTCACACATT TAACCTCCTT AAGTTATCTA CGTTAAAATT TATAACGGAC ATTCATGATT 2280 TGCCAAACCC GCTGAATGAT TCGTACTCAA TCTGCTAAGC TGCTTTGTCT CTTTTACTTA 2340 TACTTTAATT CGAGCTCATT ATTCTCAAGG TTGGTGGATT TTGACTTTAT TTTCCAGTAG 2400 AATGTATACA CAAATGGTTT ATTG
2425Nucleotide Fasta Sequence
>SPBC800.03.1:pep|Class-I|Schizosaccharomyces pombe CCGCGCTTCAAAAAGTGTTTCGACAGTTTTATGAGGGAGTTGTTTAATAGGAGATTTTTTTATTAATTTATTAATTGATTGACCTTTTTAAGGGCGATAGAAAACGAATGCTGGCCTCTAATTCTGATGGTGCATCTACTTCTGTAAAACCATCCGATGATGCTGTAAACACGGTAACTCCATGGTCTATTCTTTTGACAAACAATAAACCAATGTCTGGAAGTGAAAATACATTAAATAACGAATCCCATGAAATGTCGCAAATCTTGAAAAAATCTGGATTATGCTATGATCCTCGAATGAGATTCCATGCCACTCTAAGTGAAGTGGATGACCATCCTGAAGATCCAAGACGCGTCCTTCGTGTTTTTGAAGCTATAAAGAAGGCCGGTTATGTATCTAATGTGCCGAGTCCGTCAGATGTATTTTTACGGATTCCGGCTAGAGAAGCTACTTTAGAAGAGTTATTACAAGTTCATTCACAGGAAATGTATGATAGGGTTACTAATACCGAAAAAATGTCTCATGAGGATTTGGCCAATCTCGAAAAAATCAGTGATTCTCTATACTATAATAACGAAAGTGCGTTTTGTGCTCGATTGGCTTGTGGTAGCGCAATTGAAACATGTACGGCTGTCGTAACTGGTCAAGTAAAAAATGCCTTCGCAGTTGTTCGCCCTCCTGGCCATCATGCAGAACCCCATAAACCTGGTGGCTTTTGTTTATTCAACAATGTTTCTGTAACCGCAAGGAGTATGCTACAACGCTTTCCGGATAAAATAAAAAGAGTATTGATTGTCGACTGGGATATACACCATGGAAATGGTACGCAAATGGCTTTTTATGACGATCCAAATGTTCTATACGTTTCTTTGCATCGATATGAAAATGGTCGTTTCTATCCTGGCACCAATTATGGGTGTGCAGAAAATTGTGGAGAGGGCCCGGGATTGGGTAGAACTGTAAATATTCCTTGGAGTTGTGCTGGCATGGGAGATGGTGATTATATATACGCTTTTCAGCGCGTCGTAATGCCTGTTGCTTATGAATTTGATCCAGATTTAGTTATTGTAAGTTGCGGCTTTGATGCTGCTGCAGGAGATCACATTGGTCAATTCTTGTTAACTCCAGCTGCCTATGCTCATATGACACAAATGTTAATGGGATTAGCAGATGGGAAAGTTTTTATCTCCCTTGAGGGAGGTTATAATTTGGATTCTATAAGCACATCAGCCTTAGCTGTAGCCCAAAGTTTGTTGGGAATTCCTCCTGGACGATTGCATACAACATATGCATGTCCACAGGCCGTTGCTACCATCAACCATGTAACCAAAATACAATCCCAATACTGGAGATGTATGAGGCCGAAACACTTCGACGCAAATCCTAAGGATGCCCATGTAGATCGATTACATGATGTTATTCGAACTTATCAAGCTAAAAAACTTTTCGAAGACTGGAAAATTACCAATATGCCAATACTAAGGGATTCCGTTTCCAATGTATTCAACAATCAAGTACTGTGCTCTAGCAATTTCTTTCAAAAAGATAACCTTCTCGTTATTGTCCATGAATCTCCTAGAGTCCTGGGTAATGGAACTAGTGAAACGAACGTTTTGAATTTAAATGATTCGCTTTTAGTAGATCCCGTGAGCCTTTATGTTGAATGGGCTATGCAACAGGACTGGGGGCTTATCGACATAAATATACCTGAAGTGGTTACGGACGGTGAAAATGCACCGGTTGACATTCTTTCTGAAGTGAAAGAACTTTGTCTTTATGTATGGGATAATTATGTTGAGTTGTCGATTTCAAAAAATATTTTTTTCATCGGTGGAGGCAAAGCGGTACATGGATTGGTTAATTTGGCATCTTCCAGGAATGTGTCAGACAGAGTTAAGTGTATGGTGAATTTCCTTGGCACTGAACCTTTGGTGGGTCTTAAAACGGCATCAGAGGAAGATCTTCCAACGTGGTATTATCGTCATTCACTCGTGTTTGTGAGTTCTAGTAATGAGTGCTGGAAAAAGGCAAAGCGTGCTAAAAGAAGATATGGACGACTTATGCAAAGTGAACATACTGAAACTTCGGACATGATGGAGCAACACTATCGAGCGGTTACTCAATACTTGCTGCATTTGCTTCAAAAGGCCCGACCAACTTCTCAGTAACATTCGTTATTGACTTATGATTTTTTCATGGTTTTCTATTCTTTTAATTGTCACACATTTAACCTCCTTAAGTTATCTACGTTAAAATTTATAACGGACATTCATGATTTGCCAAACCCGCTGAATGATTCGTACTCAATCTGCTAAGCTGCTTTGTCTCTTTTACTTATACTTTAATTCGAGCTCATTATTCTCAAGGTTGGTGGATTTTGACTTTATTTTCCAGTAGAATGTATACACAAATGGTTTATTG
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0137--Centromere KW-0156--Chromatin regulator KW-0158--Chromosome KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0779--Telomere KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR019154--Arb2_domain IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR017321--Hist_deAcase_II_yeast
|
PROSITE |
|
Pfam |
PF09757--Arb2 PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0000781--C:chromosome, telomeric region GO:0031934--C:mating-type region heterochromatin GO:0000790--C:nuclear chromatin GO:0031618--C:nuclear pericentric heterochromatin GO:1990707--C:nuclear subtelomeric heterochromatin GO:0030874--C:nucleolar chromatin GO:0005634--C:nucleus GO:0033553--C:rDNA heterochromatin GO:0070824--C:SHREC complex GO:0004407--F:histone deacetylase activity GO:0031078--F:histone deacetylase activity (H3-K14 specific) GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0030702--P:chromatin silencing at centromere GO:0000183--P:chromatin silencing at rDNA GO:0030466--P:chromatin silencing at silent mating-type cassette GO:0006348--P:chromatin silencing at telomere GO:0016575--P:histone deacetylation GO:0070932--P:histone H3 deacetylation GO:0035391--P:maintenance of chromatin silencing at silent mating-type cassette GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0016584--P:nucleosome positioning GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |