Tag |
Content |
WERAM ID |
WERAM-Sac-0037 |
Ensembl Protein ID |
YNL021W |
Uniprot Accession |
P53973; HDA1_YEAST; D6W1F8 |
Genbank Protein ID |
NP_014377.1 |
Protein Name |
Histone deacetylase HDA1 |
Genbank Nucleotide ID |
NM_001182860.1 |
Gene Name |
HDA1;YNL021W;N2819 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.30e-124 |
414.1 |
58 |
396 |
HDAC |
Class-I |
2.40e-38 |
130.9 |
74 |
387 |
|
Organism |
Saccharomyces cerevisiae |
NCBI Taxa ID |
559292 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkek....hpEkpeRiqailsrlqeaglle............kleelkarkatkeelqlvHseehvelletaeklekeele 83 +gl+yd +m h+ + ++ + hpE+p+Ri +i++ l+e+gl++ ++++ r+at+ee+++vH++eh+e +e++ek+++eel YNL021W 58 TGLCYDVRMRYHAKIFTSYFEyidpHPEDPRRIYRIYKILAENGLINdptlsgvddlgdLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELL 155 6778888888777666554444555**********************88888888777779************************************* PP class-2.txt 84 sltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk..vkkilivDwDvHhGnGtq 179 ++t++ ds+y++++s+++arl +G ++e++++v++g++kn++avvRPPGHHae+++a GFClf+nvavaak+++++++ v++i+i+DwD+HhGnGtq YNL021W 156 KETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPesVRRIMILDWDIHHGNGTQ 253 ****************************************************************************9889****************** PP class-2.txt 180 eifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvt 277 + fy+d++vly+SlHR+++g+++p + +g++d++gegkgegfn+N++w+ g++gdaey++af++vv+p+ +eFkPdlv++s+GfDaa+gd++g+++vt YNL021W 254 KSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVT 351 ************************9999********************************************************************** PP class-2.txt 278 akcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 ++cy+++t++l++la+g++++vlEGGynl+aia+++ +v+k+L+g YNL021W 352 PSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIG 396 ****************************************99975 PP
HDAC Class-I
class-1.txt 11 vgeyhygqkhpmkpkrlsltheLv............lnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfd 96 ++++y + hp p+r+ + +++ +l + + + a+ ee+l++h++e++ef+++ e+ + eel ke++k g+ + YNL021W 74 TSYFEYIDPHPEDPRRIYRIYKILaenglindptlsGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEK---GDSVYFNN 168 5566667777777777766666553444444444321223334455566678999******************99999999887775...55666667 PP class-1.txt 97 glfeycqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellkkh....krvlyididlhhGDgveeafyttdrvmtv 188 + + ++l +G+++ea k + +++ + +a+ G hha + a Gfc ++ +a ++lk++ +r++ +d d+hhG+g ++ fy+ d+v+ v YNL021W 169 DSYASARLPCGGAIEACKAVVEGRVKnsLAVVRPPG-HHAEPQAAGGFCLFSNVAVAAKNILKNYpesvRRIMILDWDIHHGNGTQKSFYQDDQVLYV 265 899999*************99876541167766666.9*************************76222269*************************** PP class-1.txt 189 sfhkyge.effPgt..GdlsdvgaekgkyyavnvPlk.dgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvk 282 s+h+++ +++Pgt G+ +++g++kg + n+ g+ D +y f++v+ ++ + f+P+ v++ G D+ gD +g+ +++ + ++++ +++k YNL021W 266 SLHRFEMgKYYPGTiqGQYDQTGEGKGEGFNCNITWPvGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLK 363 *****9537****98899***************9764268********************************************************** PP class-1.txt 283 sf.nlpllvlGGGGYtlrnvaRcw 305 s + +l v+ GGY+l +aR YNL021W 364 SLaRGNLCVVLEGGYNLDAIARSA 387 **788999999**********975 PP
|
Protein Sequence (Fasta) | MDSVMVKKEV LENPDHDLKR KLEENKEEEN SLSTTSKSKR QVIVPVCMPK IHYSPLKTGL 60 CYDVRMRYHA KIFTSYFEYI DPHPEDPRRI YRIYKILAEN GLINDPTLSG VDDLGDLMLK 120 IPVRAATSEE ILEVHTKEHL EFIESTEKMS REELLKETEK GDSVYFNNDS YASARLPCGG 180 AIEACKAVVE GRVKNSLAVV RPPGHHAEPQ AAGGFCLFSN VAVAAKNILK NYPESVRRIM 240 ILDWDIHHGN GTQKSFYQDD QVLYVSLHRF EMGKYYPGTI QGQYDQTGEG KGEGFNCNIT 300 WPVGGVGDAE YMWAFEQVVM PMGREFKPDL VIISSGFDAA DGDTIGQCHV TPSCYGHMTH 360 MLKSLARGNL CVVLEGGYNL DAIARSALSV AKVLIGEPPD ELPDPLSDPK PEVIEMIDKV 420 IRLQSKYWNC FRRRHANSGC NFNEPINDSI ISKNFPLQKA IRQQQQHYLS DEFNFVTLPL 480 VSMDLPDNTV LCTPNISESN TIIIVVHDTS DIWAKRNVIS GTIDLSSSVI IDNSLDFIKW 540 GLDRKYGIID VNIPLTLFEP DNYSGMITSQ EVLIYLWDNY IKYFPSVAKI AFIGIGDSYS 600 GIVHLLGHRD TRAVTKTVIN FLGDKQLKPL VPLVDETLSE WYFKNSLIFS NNSHQCWKEN 660 ESRKPRKKFG RVLRCDTDGL NNIIEERFEE ATDFILDSFE EWSDEE 706Protein Fasta Sequence
>YNL021W|HDA1;YNL021W;N2819|Saccharomyces cerevisiae MDSVMVKKEVLENPDHDLKRKLEENKEEENSLSTTSKSKRQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSLDFIKWGLDRKYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDSYSGIVHLLGHRDTRAVTKTVINFLGDKQLKPLVPLVDETLSEWYFKNSLIFSNNSHQCWKENESRKPRKKFGRVLRCDTDGLNNIIEERFEEATDFILDSFEEWSDEE
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Nucleotide Sequence (Fasta) | ATGGATTCTG TAATGGTTAA GAAAGAAGTA CTGGAAAATC CAGACCATGA TTTAAAAAGA 60 AAGCTAGAAG AGAACAAAGA AGAAGAGAAT AGCCTCTCTA CTACTTCTAA AAGTAAAAGG 120 CAGGTTATTG TTCCCGTTTG CATGCCAAAA ATCCATTATT CACCGCTGAA AACTGGTCTT 180 TGCTATGACG TTAGAATGAG GTATCATGCA AAGATTTTCA CATCGTACTT CGAGTACATT 240 GATCCACATC CAGAGGACCC AAGAAGAATA TATCGTATTT ATAAAATACT AGCAGAGAAT 300 GGTCTGATTA ACGACCCCAC TTTAAGCGGC GTGGATGACC TTGGTGATTT AATGCTGAAG 360 ATACCTGTAA GAGCCGCAAC CTCCGAAGAA ATCTTGGAAG TTCATACAAA GGAACATTTA 420 GAGTTTATTG AAAGCACAGA AAAAATGAGC CGAGAAGAGT TATTAAAAGA GACTGAAAAA 480 GGTGATTCCG TATATTTCAA TAATGATTCT TACGCGAGTG CTAGGCTGCC TTGTGGTGGC 540 GCCATTGAAG CATGCAAGGC GGTTGTCGAG GGGCGTGTAA AAAACTCTCT AGCTGTCGTA 600 AGACCACCTG GCCATCATGC AGAGCCTCAA GCTGCGGGTG GTTTTTGTCT CTTCAGTAAT 660 GTTGCTGTTG CTGCCAAGAA TATCTTAAAG AACTACCCAG AAAGTGTAAG AAGGATAATG 720 ATTTTAGATT GGGATATTCA TCATGGTAAT GGCACACAAA AGTCATTCTA TCAAGACGAT 780 CAGGTGCTAT ATGTGTCATT ACACAGATTT GAAATGGGTA AATACTATCC TGGGACCATC 840 CAAGGACAAT ATGATCAAAC TGGTGAGGGT AAGGGTGAAG GATTCAATTG TAATATTACT 900 TGGCCGGTCG GCGGTGTTGG TGATGCAGAA TATATGTGGG CATTTGAACA GGTAGTTATG 960 CCTATGGGGA GAGAATTCAA GCCTGACTTG GTGATTATTT CTTCAGGGTT TGATGCCGCG 1020 GATGGTGATA CTATCGGACA ATGTCATGTC ACCCCAAGTT GTTATGGACA CATGACACAT 1080 ATGTTAAAAT CTCTAGCTAG AGGTAATCTT TGTGTAGTTT TGGAAGGTGG ATATAACTTG 1140 GATGCGATTG CAAGAAGCGC TTTGAGTGTA GCAAAAGTAC TAATAGGGGA GCCTCCTGAT 1200 GAACTACCTG ATCCATTAAG TGATCCCAAG CCTGAGGTCA TAGAAATGAT AGACAAAGTA 1260 ATTCGGTTAC AGTCCAAGTA TTGGAACTGT TTTAGAAGGA GACATGCTAA CTCCGGTTGT 1320 AATTTTAACG AACCTATTAA CGACTCGATA ATATCTAAAA ATTTTCCTCT GCAGAAGGCT 1380 ATTCGTCAAC AACAGCAACA CTATTTAAGC GACGAATTTA ATTTCGTTAC TTTACCGTTA 1440 GTAAGCATGG ATTTACCAGA TAATACAGTG CTATGTACTC CAAACATTTC CGAATCTAAC 1500 ACTATAATTA TAGTCGTTCA TGATACTTCT GATATCTGGG CAAAGAGAAA TGTTATTTCA 1560 GGTACAATTG ACTTATCCTC ATCAGTTATC ATTGATAATT CTCTAGACTT TATCAAATGG 1620 GGACTTGACA GGAAATACGG CATCATTGAT GTAAATATAC CTCTAACTCT GTTTGAACCT 1680 GACAATTACT CAGGAATGAT TACATCCCAA GAAGTTCTAA TATATTTATG GGATAACTAC 1740 ATCAAGTATT TTCCTTCTGT TGCCAAAATT GCTTTTATTG GAATAGGAGA CTCATACTCA 1800 GGTATCGTAC ATCTGCTTGG TCACAGGGAT ACTAGGGCTG TTACTAAAAC GGTAATTAAT 1860 TTCTTGGGAG ACAAGCAGTT AAAGCCACTA GTTCCTCTAG TAGATGAAAC ATTGAGTGAA 1920 TGGTACTTCA AAAACTCACT TATATTTTCA AACAATAGCC ACCAATGCTG GAAAGAAAAT 1980 GAAAGCAGAA AACCAAGAAA AAAATTCGGT AGAGTTTTGA GATGTGATAC GGACGGGTTA 2040 AACAATATAA TTGAAGAAAG ATTTGAAGAG GCTACAGACT TTATACTGGA TTCGTTTGAA 2100 GAATGGAGTG ATGAAGAATG A
2122Nucleotide Fasta Sequence
>YNL021W|Class-I|Saccharomyces cerevisiae ATGGATTCTGTAATGGTTAAGAAAGAAGTACTGGAAAATCCAGACCATGATTTAAAAAGAAAGCTAGAAGAGAACAAAGAAGAAGAGAATAGCCTCTCTACTACTTCTAAAAGTAAAAGGCAGGTTATTGTTCCCGTTTGCATGCCAAAAATCCATTATTCACCGCTGAAAACTGGTCTTTGCTATGACGTTAGAATGAGGTATCATGCAAAGATTTTCACATCGTACTTCGAGTACATTGATCCACATCCAGAGGACCCAAGAAGAATATATCGTATTTATAAAATACTAGCAGAGAATGGTCTGATTAACGACCCCACTTTAAGCGGCGTGGATGACCTTGGTGATTTAATGCTGAAGATACCTGTAAGAGCCGCAACCTCCGAAGAAATCTTGGAAGTTCATACAAAGGAACATTTAGAGTTTATTGAAAGCACAGAAAAAATGAGCCGAGAAGAGTTATTAAAAGAGACTGAAAAAGGTGATTCCGTATATTTCAATAATGATTCTTACGCGAGTGCTAGGCTGCCTTGTGGTGGCGCCATTGAAGCATGCAAGGCGGTTGTCGAGGGGCGTGTAAAAAACTCTCTAGCTGTCGTAAGACCACCTGGCCATCATGCAGAGCCTCAAGCTGCGGGTGGTTTTTGTCTCTTCAGTAATGTTGCTGTTGCTGCCAAGAATATCTTAAAGAACTACCCAGAAAGTGTAAGAAGGATAATGATTTTAGATTGGGATATTCATCATGGTAATGGCACACAAAAGTCATTCTATCAAGACGATCAGGTGCTATATGTGTCATTACACAGATTTGAAATGGGTAAATACTATCCTGGGACCATCCAAGGACAATATGATCAAACTGGTGAGGGTAAGGGTGAAGGATTCAATTGTAATATTACTTGGCCGGTCGGCGGTGTTGGTGATGCAGAATATATGTGGGCATTTGAACAGGTAGTTATGCCTATGGGGAGAGAATTCAAGCCTGACTTGGTGATTATTTCTTCAGGGTTTGATGCCGCGGATGGTGATACTATCGGACAATGTCATGTCACCCCAAGTTGTTATGGACACATGACACATATGTTAAAATCTCTAGCTAGAGGTAATCTTTGTGTAGTTTTGGAAGGTGGATATAACTTGGATGCGATTGCAAGAAGCGCTTTGAGTGTAGCAAAAGTACTAATAGGGGAGCCTCCTGATGAACTACCTGATCCATTAAGTGATCCCAAGCCTGAGGTCATAGAAATGATAGACAAAGTAATTCGGTTACAGTCCAAGTATTGGAACTGTTTTAGAAGGAGACATGCTAACTCCGGTTGTAATTTTAACGAACCTATTAACGACTCGATAATATCTAAAAATTTTCCTCTGCAGAAGGCTATTCGTCAACAACAGCAACACTATTTAAGCGACGAATTTAATTTCGTTACTTTACCGTTAGTAAGCATGGATTTACCAGATAATACAGTGCTATGTACTCCAAACATTTCCGAATCTAACACTATAATTATAGTCGTTCATGATACTTCTGATATCTGGGCAAAGAGAAATGTTATTTCAGGTACAATTGACTTATCCTCATCAGTTATCATTGATAATTCTCTAGACTTTATCAAATGGGGACTTGACAGGAAATACGGCATCATTGATGTAAATATACCTCTAACTCTGTTTGAACCTGACAATTACTCAGGAATGATTACATCCCAAGAAGTTCTAATATATTTATGGGATAACTACATCAAGTATTTTCCTTCTGTTGCCAAAATTGCTTTTATTGGAATAGGAGACTCATACTCAGGTATCGTACATCTGCTTGGTCACAGGGATACTAGGGCTGTTACTAAAACGGTAATTAATTTCTTGGGAGACAAGCAGTTAAAGCCACTAGTTCCTCTAGTAGATGAAACATTGAGTGAATGGTACTTCAAAAACTCACTTATATTTTCAAACAATAGCCACCAATGCTGGAAAGAAAATGAAAGCAGAAAACCAAGAAAAAAATTCGGTAGAGTTTTGAGATGTGATACGGACGGGTTAAACAATATAATTGAAGAAAGATTTGAAGAGGCTACAGACTTTATACTGGATTCGTTTGAAGAATGGAGTGATGAAGAATGA
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Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR019154--Arb2_domain IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR017321--Hist_deAcase_II_yeast
|
PROSITE |
|
Pfam |
PF09757--Arb2 PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0070823--C:HDA1 complex GO:0003682--F:chromatin binding GO:0042802--F:identical protein binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0031047--P:gene silencing by RNA GO:0010978--P:gene silencing involved in chronological cell aging GO:0016575--P:histone deacetylation GO:0001308--P:negative regulation of chromatin silencing involved in replicative cell aging GO:0010621--P:negative regulation of transcription by transcription factor localization GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0031938--P:regulation of chromatin silencing at telomere GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |