WERAM Information


Tag Content
WERAM ID WERAM-Hos-0047
Ensembl Protein ID ENSP00000365804.2
Uniprot Accession Q9UBN7; HDAC6_HUMAN; O94975; Q6NT75; Q7L3E5; Q96CY0
Genbank Protein ID NP_006035.2
Protein Name Histone deacetylase 6
Genbank Nucleotide ID NM_006044.3
Gene Name HDAC6;KIAA0901;JM21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000094631.18 ENST00000376619.6 ENSP00000365804.2
ENSG00000094631.18 ENST00000334136.9 ENSP00000334061.5
ENSG00000094631.18 ENST00000426196.5 ENSP00000402189.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-II Histone deacetylase 1 H2A; H2B; H3; H4 K 18292778; 19698979
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-II 1.10e-263 874.9 86 800
HDAC Class-I 2.40e-65 223.5 90 792
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Domain Profile
  HDAC Class-II

        class-2.txt   2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiy 93 
+glv+de+ ++ ++l++++ pE peR++ai ++l ++gll+++++++ar a+keel+lvHs e+++l+et++ +++ el++l+ ++ds+y
ENSP00000365804.2 86 TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVY 175
6899*****9999999988..*********************************************************************** PP
class-2.txt 94 lesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykd 185
l+++s+++a la G+vl+lvd+vl +e++ng+a++RPPGHHa++s ++G+C+fn+vavaa+++qqk++++++livDwDvHhG+Gtq +f +d
ENSP00000365804.2 176 LHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQD 267
******************************************************************************************** PP
class-2.txt 186 pkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvt 277
p+vly+S+HRy++g+f+p+++ ++++++g g+g+g+++Nv+wn+ +m+da+y+aaf +v+lp+a eF+P+lvlv+aGfDa +gdp+g++ t
ENSP00000365804.2 268 PSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAAT 359
******************************************************************************************** PP
class-2.txt 278 akcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
++++a+lt+ l++lagg+++l lEGGynl+a+ae+v+a++++Llg
ENSP00000365804.2 360 PAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG 404
*******************************************96 PP
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiy 93
+glvyd++m++h +l++++ hpE p+Ri +i+ rl+e gl++++++l+ r at+ el+++Hs+e+v +l+ +ek++++el+++++++dsiy
ENSP00000365804.2 481 TGLVYDQNMMNHCNLWDSH--HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIY 570
79*************9999..*********************************************************************** PP
class-2.txt 94 lesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk.vkkilivDwDvHhGnGtqeifyk 184
+ ++++++a+la+Ga+++lv++vl+ge+ ng avvRPPGHHae+++a+GFC+fn+vavaa+++q+ + +ilivDwDvHhGnGtq++f++
ENSP00000365804.2 571 ICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRILIVDWDVHHGNGTQHMFED 662
****************************************************************9776699********************* PP
class-2.txt 185 dpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsv 276
dp+vly+SlHRyd+g+ffp+ ++ga +++g+++g+gf+vNvawng mgda+ylaa++++vlpia+eF+P+lvlvsaGfDaa+gdplgg++v
ENSP00000365804.2 663 DPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQV 754
******************************************************************************************** PP
class-2.txt 277 takcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
++++ya+lt+ l++la+gr++l+lEGGynl++i+e+++a++++Llg
ENSP00000365804.2 755 SPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG 800
********************************************96 PP

  HDAC Class-I

        class-1.txt   7 ydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfd 96 
de++ e+h +++ p p+rl+ ++e +++ gl + ++++ a++eel+ +hs eyi+++++ + n+ el ++ +
ENSP00000365804.2 90 LDEQLNEFHClwDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDS---VYLHP 178
5778888886558999*************************************************9999999888877777754...44556 PP
class-1.txt 97 glfeycqlitGasleaakkLnkk..eadiainwaGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdr 184
+ ++ + l +G+ l+ ++ + ++ +ai G hha++s G+c n + +a ++kh +rvl +d d+hhG g + +f +
ENSP00000365804.2 179 NSYSCACLASGSVLRLVDAVLGAeiRNGMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARYAQQKHriRRVLIVDWDVHHGQGTQFTFDQDPS 269
778888888888888887765441145688877776.9******************998777765337************************ PP
class-1.txt 185 vmtvsfhkygee.ffPg..tGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsik 272
v+ s+h+y+++ f+P + + s +g ++g+ y++nvP ++ g++D y + f +v+ +v f+P+ v++ G D+l+gD+ ge +
ENSP00000365804.2 270 VLYFSIHRYEQGrFWPHlkASNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPA 361
*********986388853378999***************97659************************************************ PP
class-1.txt 273 ghaecvkfvksf.nlpllvlGGGGYtlrnva 302
g+a+ +++ +l++ GGY+lr +a
ENSP00000365804.2 362 GFAQLTHLLMGLaGGKLILSLEGGYNLRALA 392
*******9999945556666689***99877 PP
class-1.txt 7 ydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfd 96
yd+++ ++ +++hp +p+r+ + + + gl + ++p+ a+ +ell++hs ey+ +l+ e+ +++el++e+++f+ + cP
ENSP00000365804.2 485 YDQNMMNHCNlwDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP--- 573
555555543223889***********999*****************************************************9999999... PP
class-1.txt 97 glfeycqlitGasleaakkLnkkea.diainwaGGlhhakkseasGfcyvnDivlailellk...khkrvlyididlhhGDgveeafyttdr 184
f +ql tGa+ + ++ + ++e + a hha ++ a Gfc+ n + +a + + + r+l +d d+hhG+g ++ f+
ENSP00000365804.2 574 STFACAQLATGAACRLVEAVLSGEVlNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTisgHALRILIVDWDVHHGNGTQHMFEDDPS 665
56999**********998877666514444555666******************99865444322778************************ PP
class-1.txt 185 vmtvsfhkyge.effP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsik 272
v+ vs+h+y++ +ffP G s++g g ++vnv + + D y + ++++ ++ f+Pe v++ G D+ gD+lg ++s +
ENSP00000365804.2 666 VLYVSLHRYDHgTFFPmgDEGASSQIGRAAGTGFTVNVAWNGpRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPE 757
*********973599943368999***************9863699********************************************** PP
class-1.txt 273 ghaecvkfvksf.nlpllvlGGGGYtlrnvaRcwt 306
g+a+ +++ ++++ GGY+l+ ++ +
ENSP00000365804.2 758 GYAHLTHLLMGLaSGRIILILEGGYNLTSISESMA 792
*****9999988566788888999**999987665 PP

Protein Sequence
(Fasta)
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG 60
QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI 120
QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS 180
YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ 240
KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG 300
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG DPKGEMAATP 360
AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH TLLGDPCPML ESPGAPCRSA 420
QASVSCALEA LEPFWEVLVR STETVERDNM EEDNVEESEE EGPWEPPVLP ILTWPVLQSR 480
TGLVYDQNMM NHCNLWDSHH PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH 540
SAEYVGHLRA TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN 600
GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV HHGNGTQHMF 660
EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT VNVAWNGPRM GDADYLAAWH 720
RLVLPIAYEF NPELVLVSAG FDAARGDPLG GCQVSPEGYA HLTHLLMGLA SGRIILILEG 780
GYNLTSISES MAACTRSLLG DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE 840
DREGPSSSKL VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET 900
AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ TTSEETVGGA 960
ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME GATLDQTTSE EAPGGTELIQ 1020
TPLASSTDHQ TPPTSPVQGT TPQISPSTLI GSLRTLELGS ESQGASESQA PGEENLLGEA 1080
AGGQDMADSM LMQGSRGLTD QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ 1140
ENWVCLSCYQ VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN 1200
IAHQNKFGED MPHPH 1215
Nucleotide Sequence
(Fasta)
GTTAGCGGTC GGGTCTGGGC AGGGGGTGGA GCTGGTTGAA GGAACGGGGC AGTCCCCTGA 60
GGAGCGGGGC TGGTTGAAAC GCTAGGGGCG GGATCTGGCG GAGTGGAAGG TACCGGTCCG 120
GCCCGATAAG GGGTGGAAAC CGCGGCAGGG GCCAAGCCTC CTCAACTATG ACCTCAACCG 180
GCCAGGATTC CACCACAACC AGGCAGCGAA GAAGTAGGCA GAACCCCCAG TCGCCCCCTC 240
AGGACTCCAG TGTCACTTCG AAGCGAAATA TTAAAAAGGG AGCCGTTCCC CGCTCTATCC 300
CCAATCTAGC GGAGGTAAAG AAGAAAGGCA AAATGAAGAA GCTCGGCCAA GCAATGGAAG 360
AAGACCTAAT CGTGGGACTG CAAGGGATGG ATCTGAACCT TGAGGCTGAA GCACTGGCTG 420
GCACTGGCTT GGTGTTGGAT GAGCAGTTAA ATGAATTCCA TTGCCTCTGG GATGACAGCT 480
TCCCGGAAGG CCCTGAGCGG CTCCATGCCA TCAAGGAGCA ACTGATCCAG GAGGGCCTCC 540
TAGATCGCTG CGTGTCCTTT CAGGCCCGGT TTGCTGAAAA GGAAGAGCTG ATGTTGGTTC 600
ACAGCCTAGA ATATATTGAT CTGATGGAAA CAACCCAGTA CATGAATGAG GGAGAACTCC 660
GTGTCCTAGC AGACACCTAC GACTCAGTTT ATCTGCATCC GAACTCATAC TCCTGTGCCT 720
GCCTGGCCTC AGGCTCTGTC CTCAGGCTGG TGGATGCGGT CCTGGGGGCT GAGATCCGGA 780
ATGGCATGGC CATCATTAGG CCTCCTGGAC ATCACGCCCA GCACAGTCTT ATGGATGGCT 840
ATTGCATGTT CAACCACGTG GCTGTGGCAG CCCGCTATGC TCAACAGAAA CACCGCATCC 900
GGAGGGTCCT TATCGTAGAT TGGGATGTGC ACCACGGTCA AGGAACACAG TTCACCTTCG 960
ACCAGGACCC CAGTGTCCTC TATTTCTCCA TCCACCGCTA CGAGCAGGGT AGGTTCTGGC 1020
CCCACCTGAA GGCCTCTAAC TGGTCCACCA CAGGTTTCGG CCAAGGCCAA GGATATACCA 1080
TCAATGTGCC TTGGAACCAG GTGGGGATGC GGGATGCTGA CTACATTGCT GCTTTCCTGC 1140
ACGTCCTGCT GCCAGTCGCC CTCGAGTTCC AGCCTCAGCT GGTCCTGGTG GCTGCTGGAT 1200
TTGATGCCCT GCAAGGGGAC CCCAAGGGTG AGATGGCCGC CACTCCGGCA GGGTTCGCCC 1260
AGCTAACCCA CCTGCTCATG GGTCTGGCAG GAGGCAAGCT GATCCTGTCT CTGGAGGGTG 1320
GCTACAACCT CCGCGCCCTG GCTGAAGGCG TCAGTGCTTC GCTCCACACC CTTCTGGGAG 1380
ACCCTTGCCC CATGCTGGAG TCACCTGGTG CCCCCTGCCG GAGTGCCCAG GCTTCAGTTT 1440
CCTGTGCTCT GGAAGCCCTT GAGCCCTTCT GGGAGGTTCT TGTGAGATCA ACTGAGACCG 1500
TGGAGAGGGA CAACATGGAG GAGGACAATG TAGAGGAGAG CGAGGAGGAA GGACCCTGGG 1560
AGCCCCCTGT GCTCCCAATC CTGACATGGC CAGTGCTACA GTCTCGCACA GGGCTGGTCT 1620
ATGACCAAAA TATGATGAAT CACTGCAACT TGTGGGACAG CCACCACCCT GAGGTACCCC 1680
AGCGCATCTT GCGGATCATG TGCCGTCTGG AGGAGCTGGG CCTTGCCGGG CGCTGCCTCA 1740
CCCTGACACC GCGCCCTGCC ACAGAGGCTG AGCTGCTCAC CTGTCACAGT GCTGAGTACG 1800
TGGGTCATCT CCGGGCCACA GAGAAAATGA AAACCCGGGA GCTGCACCGT GAGAGTTCCA 1860
ACTTTGACTC CATCTATATC TGCCCCAGTA CCTTCGCCTG TGCACAGCTT GCCACTGGCG 1920
CTGCCTGCCG CCTGGTGGAG GCTGTGCTCT CAGGAGAGGT TCTGAATGGT GCTGCTGTGG 1980
TGCGTCCCCC AGGACACCAC GCAGAGCAGG ATGCAGCTTG CGGTTTTTGC TTTTTCAACT 2040
CTGTGGCTGT GGCTGCTCGC CATGCCCAGA CTATCAGTGG GCATGCCCTA CGGATCCTGA 2100
TTGTGGATTG GGATGTCCAC CACGGTAATG GAACTCAGCA CATGTTTGAG GATGACCCCA 2160
GTGTGCTATA TGTGTCCCTG CACCGCTATG ATCATGGCAC CTTCTTCCCC ATGGGGGATG 2220
AGGGTGCCAG CAGCCAGATC GGCCGGGCTG CGGGCACAGG CTTCACCGTC AACGTGGCAT 2280
GGAACGGGCC CCGCATGGGT GATGCTGACT ACCTAGCTGC CTGGCATCGC CTGGTGCTTC 2340
CCATTGCCTA CGAGTTTAAC CCAGAACTGG TGCTGGTCTC AGCTGGCTTT GATGCTGCAC 2400
GGGGGGATCC GCTGGGGGGC TGCCAGGTGT CACCTGAGGG TTATGCCCAC CTCACCCACC 2460
TGCTGATGGG CCTTGCCAGT GGCCGCATTA TCCTTATCCT AGAGGGTGGC TATAACCTGA 2520
CATCCATCTC AGAGTCCATG GCTGCCTGCA CTCGCTCCCT CCTTGGAGAC CCACCACCCC 2580
TGCTGACCCT GCCACGGCCC CCACTATCAG GGGCCCTGGC CTCAATCACT GAGACCATCC 2640
AAGTCCATCG CAGATACTGG CGCAGCTTAC GGGTCATGAA GGTAGAAGAC AGAGAAGGAC 2700
CCTCCAGTTC TAAGTTGGTC ACCAAGAAGG CACCCCAACC AGCCAAACCT AGGTTAGCTG 2760
AGCGGATGAC CACACGAGAA AAGAAGGTTC TGGAAGCAGG CATGGGGAAA GTCACCTCGG 2820
CATCATTTGG GGAAGAGTCC ACTCCAGGCC AGACTAACTC AGAGACAGCT GTGGTGGCCC 2880
TCACTCAGGA CCAGCCCTCA GAGGCAGCCA CAGGGGGAGC CACTCTGGCC CAGACCATTT 2940
CTGAGGCAGC CATTGGGGGA GCCATGCTGG GCCAGACCAC CTCAGAGGAG GCTGTCGGGG 3000
GAGCCACTCC GGACCAGACC ACCTCAGAGG AGACTGTGGG AGGAGCCATT CTGGACCAGA 3060
CCACCTCAGA GGATGCTGTT GGGGGAGCCA CGCTGGGCCA GACTACCTCA GAGGAGGCTG 3120
TAGGAGGAGC TACACTGGCC CAGACCACCT CGGAGGCAGC CATGGAGGGA GCCACACTGG 3180
ACCAGACTAC GTCAGAGGAG GCTCCAGGGG GCACCGAGCT GATCCAAACT CCTCTAGCCT 3240
CGAGCACAGA CCACCAGACC CCCCCAACCT CACCTGTGCA GGGAACTACA CCCCAGATAT 3300
CTCCCAGTAC ACTGATTGGG AGTCTCAGGA CCTTGGAGCT AGGCAGCGAA TCTCAGGGGG 3360
CCTCAGAATC TCAGGCCCCA GGAGAGGAGA ACCTACTAGG AGAGGCAGCT GGAGGTCAGG 3420
ACATGGCTGA TTCGATGCTG ATGCAGGGAT CTAGGGGCCT CACTGATCAG GCCATATTTT 3480
ATGCTGTGAC ACCACTGCCC TGGTGTCCCC ATTTGGTGGC AGTATGCCCC ATACCTGCAG 3540
CAGGCCTAGA CGTGACCCAA CCTTGTGGGG ACTGTGGAAC AATCCAAGAG AATTGGGTGT 3600
GTCTCTCTTG CTATCAGGTC TACTGTGGTC GTTACATCAA TGGCCACATG CTCCAACACC 3660
ATGGAAATTC TGGACACCCG CTGGTCCTCA GCTACATCGA CCTGTCAGCC TGGTGTTACT 3720
ACTGTCAGGC CTATGTCCAC CACCAGGCTC TCCTAGATGT GAAGAACATC GCCCACCAGA 3780
ACAAGTTTGG GGAGGATATG CCCCACCCAC ACTAAGCCCC AGAATACGGT CCCTCTTCAC 3840
CTTCTGAGGC CCACGATAGA CCAGCTGTAG CTCATTCCAG CCTGTACCTT GGATGAGGGG 3900
TAGCCTCCCA CTGCATCCCA TCCTGAATAT CCTTTGCAAC TCCCCAAGAG TGCTTATTTA 3960
AGTGTTAATA CTTTTAAGAG AACTGCGACG ATTAATTGTG GATCTCCCCC TGCCCATTGC 4020
CTGCTTGAGG GGCACCACTA CTCCAGCCCA GAAGGAAAGG GGGGCAGCTC AGTGGCCCCA 4080
AGAGGGAGCT GATATCATGA GGATAACATT GGCGGGAGGG GAGTTAACTG GCAGGCATGG 4140
CAAGGTTGCA TATGTAATAA AGTACAAGCT GTTAAAAAA
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0966--Cell projection
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50271--ZF_UBP

Pfam

PF00850--Hist_deacetyl
PF02148--zf-UBP

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005901--C:caveola
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0000118--C:histone deacetylase complex
GO:0016234--C:inclusion body
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005771--C:multivesicular body
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0043014--F:alpha-tubulin binding
GO:0008013--F:beta-catenin binding
GO:0001047--F:core promoter binding
GO:0070840--F:dynein complex binding
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0051879--F:Hsp90 protein binding
GO:0008017--F:microtubule binding
GO:0051787--F:misfolded protein binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0031593--F:polyubiquitin binding
GO:0048156--F:tau protein binding
GO:0042903--F:tubulin deacetylase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071218--P:cellular response to misfolded protein
GO:0035967--P:cellular response to topologically incorrect protein
GO:0016575--P:histone deacetylation
GO:0070846--P:Hsp90 deacetylation
GO:0006886--P:intracellular protein transport
GO:0032418--P:lysosome localization
GO:0016236--P:macroautophagy
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0051646--P:mitochondrion localization
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0010727--P:negative regulation of hydrogen peroxide metabolic process
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0051354--P:negative regulation of oxidoreductase activity
GO:0043242--P:negative regulation of protein complex disassembly
GO:0045861--P:negative regulation of proteolysis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006996--P:organelle organization
GO:0034983--P:peptidyl-lysine deacetylation
GO:0070845--P:polyubiquitinated misfolded protein transport
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0010634--P:positive regulation of epithelial cell migration
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0009967--P:positive regulation of signal transduction
GO:0043241--P:protein complex disassembly
GO:0006476--P:protein deacetylation
GO:0000209--P:protein polyubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0010506--P:regulation of autophagy
GO:0070201--P:regulation of establishment of protein localization
GO:0045598--P:regulation of fat cell differentiation
GO:0040029--P:regulation of gene expression, epigenetic
GO:0060632--P:regulation of microtubule-based movement
GO:1903146--P:regulation of mitophagy
GO:0031647--P:regulation of protein stability
GO:0010469--P:regulation of receptor activity
GO:0070848--P:response to growth factor
GO:0051788--P:response to misfolded protein
GO:0010033--P:response to organic substance
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0047 ENSGGOP00000004443.2 Gorilla gorilla 99 0.0 2312
WERAM-Paa-0049 ENSPANP00000006915.1 Papio anubis 99 0.0 2295
WERAM-Mam-0153 ENSMMUP00000021637.2 Macaca mulatta 98 0.0 2288
WERAM-Chs-0158 ENSCSAP00000009365.1 Chlorocebus sabaeus 98 0.0 2286
WERAM-Poa-0196 ENSPPYP00000022747.2 Pongo abelii 98 0.0 2247
WERAM-Caj-0022 ENSCJAP00000004409.2 Callithrix jacchus 92 0.0 2115
WERAM-Otg-0144 ENSOGAP00000012420.2 Otolemur garnettii 85 0.0 1959
WERAM-Eqc-0001 ENSECAP00000001121.1 Equus caballus 83 0.0 1909
WERAM-Mup-0158 ENSMPUP00000013557.1 Mustela putorius furo 79 0.0 1791
WERAM-Ict-0125 ENSSTOP00000012693.2 Ictidomys tridecemlineatus 78 0.0 1790
WERAM-Orc-0102 ENSOCUP00000008741.3 Oryctolagus cuniculus 79 0.0 1790
WERAM-Aim-0139 ENSAMEP00000013236.1 Ailuropoda melanoleuca 79 0.0 1788
WERAM-Cap-0109 ENSCPOP00000008049.2 Cavia porcellus 78 0.0 1761
WERAM-Caf-0161 ENSCAFP00000022990.3 Canis familiaris 78 0.0 1755
WERAM-Myl-0104 ENSMLUP00000008295.2 Myotis lucifugus 77 0.0 1748
WERAM-Tut-0056 ENSTTRP00000004443.1 Tursiops truncatus 76 0.0 1738
WERAM-Ran-0209 ENSRNOP00000009295.5 Rattus norvegicus 75 0.0 1702
WERAM-Mum-0115 ENSMUSP00000033501.8 Mus musculus 74 0.0 1673
WERAM-Ptv-0077 ENSPVAP00000007213.1 Pteropus vampyrus 74 0.0 1652
WERAM-Ova-0124 ENSOARP00000012678.1 Ovis aries 74 0.0 1646
WERAM-Dio-0075 ENSDORP00000007462.1 Dipodomys ordii 71 0.0 1645
WERAM-Bot-0122 ENSBTAP00000017618.5 Bos taurus 73 0.0 1633
WERAM-Dan-0022 ENSDNOP00000002136.3 Dasypus novemcinctus 70 0.0 1571
WERAM-Fec-0031 ENSFCAP00000002366.3 Felis catus 86 0.0 1538
WERAM-Sus-0177 ENSSSCP00000022636.1 Sus scrofa 84 0.0 1497
WERAM-Loa-0047 ENSLAFP00000003196.3 Loxodonta africana 79 0.0 1439
WERAM-Pat-0185 ENSPTRP00000037550.5 Pan troglodytes 99 0.0 1396
WERAM-Prc-0036 ENSPCAP00000003334.1 Procavia capensis 75 0.0 1393
WERAM-Anc-0082 ENSACAP00000007918.3 Anolis carolinensis 52 0.0 1167
WERAM-Ocp-0057 ENSOPRP00000005096.1 Ochotona princeps 72 0.0 1136
WERAM-Mod-0081 ENSMODP00000012731.2 Monodelphis domestica 67 0.0 1095
WERAM-Tas-0021 ENSTSYP00000002661.1 Tarsius syrichta 80 0.0 1077
WERAM-Xet-0155 ENSXETP00000050501.3 Xenopus tropicalis 49 0.0 1037
WERAM-Lac-0055 ENSLACP00000007918.1 Latimeria chalumnae 46 0.0 990
WERAM-Pem-0058 ENSPMAP00000006830.1 Petromyzon marinus 46 0.0 977
WERAM-Mae-0111 ENSMEUP00000010640.1 Macropus eugenii 68 0.0 957
WERAM-Dar-0023 ENSDARP00000124246.1 Danio rerio 50 0.0 908
WERAM-Mim-0053 ENSMICP00000005439.1 Microcebus murinus 68 0.0 888
WERAM-Tar-0042 ENSTRUP00000010127.1 Takifugu rubripes 56 0.0 851
WERAM-Orn-0011 ENSONIP00000001061.1 Oreochromis niloticus 49 0.0 850
WERAM-Ten-0019 ENSTNIP00000004593.1 Tetraodon nigroviridis 52 0.0 840
WERAM-Sah-0012 ENSSHAP00000001165.1 Sarcophilus harrisii 56 0.0 797
WERAM-Nol-0078 ENSNLEP00000009627.2 Nomascus leucogenys 99 0.0 786
WERAM-Asm-0181 ENSAMXP00000017644.1 Astyanax mexicanus 50 0.0 778
WERAM-Soa-0022 ENSSARP00000002183.1 Sorex araneus 67 0.0 758
WERAM-Xim-0160 ENSXMAP00000013063.1 Xiphophorus maculatus 50 0.0 713
WERAM-Pof-0022 ENSPFOP00000001799.2 Poecilia formosa 58 0.0 701
WERAM-Ora-0024 ENSOANP00000003575.1 Ornithorhynchus anatinus 58 0.0 694
WERAM-Tag-0059 ENSTGUP00000004152.1 Taeniopygia guttata 48 0.0 674
WERAM-Drm-0028 FBpp0290988 Drosophila melanogaster 45 0.0 667
WERAM-Ere-0025 ENSEEUP00000001892.1 Erinaceus europaeus 77 3e-169 593
WERAM-Ect-0051 ENSETEP00000005266.1 Echinops telfairi 66 4e-151 533
WERAM-Cae-0060 F41H10.6b Caenorhabditis elegans 39 2e-145 514
WERAM-Tub-0082 ENSTBEP00000009586.1 Tupaia belangeri 69 8e-135 479
WERAM-Pes-0141 ENSPSIP00000016742.1 Pelodiscus sinensis 35 4e-119 427
WERAM-Fia-0117 ENSFALP00000010126.1 Ficedula albicollis 35 2e-118 425
WERAM-Anp-0022 ENSAPLP00000003127.1 Anas platyrhynchos 52 5e-114 410
WERAM-Gaa-0030 ENSGACP00000005071.1 Gasterosteus aculeatus 51 1e-113 409
WERAM-Meg-0084 ENSMGAP00000008226.2 Meleagris gallopavo 52 1e-112 405
WERAM-Gaga-0090 ENSGALP00000014065.4 Gallus gallus 42 3e-111 400
WERAM-Gam-0051 ENSGMOP00000005244.1 Gadus morhua 52 4e-110 397
WERAM-Orla-0095 ENSORLP00000011723.1 Oryzias latipes 52 5e-109 393
WERAM-Leo-0157 ENSLOCP00000018907.1 Lepisosteus oculatus 52 2e-93 341
WERAM-Glm-0045 GLYMA05G00460.1 Glycine max 50 3e-89 327
WERAM-Php-0085 PP1S34_252V6.1 Physcomitrella patens 49 9e-89 326
WERAM-Sem-0022 EFJ08599 Selaginella moellendorffii 44 1e-87 322
WERAM-Lem-0023 CBX90551 Leptosphaeria maculans 45 2e-85 315
WERAM-Brr-0068 Bra012984.1-P Brassica rapa 45 5e-85 313
WERAM-Bro-0134 Bo7g098310.1 Brassica oleracea 45 6e-85 313
WERAM-Caa-0034 KGT64501 Candida albicans 42 1e-84 312
WERAM-Prp-0049 EMJ12067 Prunus persica 43 1e-84 312
WERAM-Met-0112 KEH32016 Medicago truncatula 47 3e-84 311
WERAM-Arl-0149 scaffold_802745.1 Arabidopsis lyrata 42 5e-84 310
WERAM-Crn-0010 AAW42071 Cryptococcus neoformans 47 3e-83 308
WERAM-Scj-0031 EEB08679 Schizosaccharomyces japonicus 42 4e-83 307
WERAM-Art-0146 AT5G61060.1 Arabidopsis thaliana 43 7e-83 306
WERAM-Viv-0107 VIT_17s0000g07280.t01 Vitis vinifera 45 8e-83 306
WERAM-Lep-0079 LPERR07G18450.1 Leersia perrieri 45 2e-82 305
WERAM-Coi-0028 EAS30926 Coccidioides immitis 45 3e-82 305
WERAM-Spr-0021 CBQ72644 Sporisorium reilianum 44 3e-82 304
WERAM-Yal-0023 CAG79971 Yarrowia lipolytica 42 9e-82 303
WERAM-Scp-0036 SPBC800.03.1:pep Schizosaccharomyces pombe 45 1e-81 303
WERAM-Asc-0002 CADACLAP00000048 Aspergillus clavatus 45 1e-81 302
WERAM-Mua-0066 GSMUA_Achr4P03250_001 Musa acuminata 45 3e-81 301
WERAM-Thc-0031 EOY22062 Theobroma cacao 46 4e-81 301
WERAM-Orgl-0076 OGLUM07G21150.1 Oryza glumaepatula 45 4e-81 300
WERAM-Ori-0088 BGIOSGA026083-PA Oryza indica 45 5e-81 300
WERAM-Ors-0072 OS07T0602200-01 Oryza sativa 45 5e-81 300
WERAM-Orr-0082 ORUFI07G22240.1 Oryza rufipogon 45 5e-81 300
WERAM-Orni-0078 ONIVA07G19970.1 Oryza nivara 45 6e-81 300
WERAM-Zem-0143 GRMZM2G457889_P01 Zea mays 45 1e-80 299
WERAM-Orbr-0087 OB07G26850.1 Oryza brachyantha 45 1e-80 299
WERAM-Pytr-0015 EDU46537 Pyrenophora triticirepentis 44 2e-80 298
WERAM-Pyt-0023 EFQ89752 Pyrenophora teres 44 2e-80 298
WERAM-Orp-0076 OPUNC07G19850.1 Oryza punctata 44 2e-80 298
WERAM-Org-0078 ORGLA07G0164500.1 Oryza glaberrima 45 3e-80 298
WERAM-Ast-0014 CADATEAP00005667 Aspergillus terreus 45 3e-80 298
WERAM-Brd-0010 BRADI1G22240.1 Brachypodium distachyon 44 4e-80 297
WERAM-Tra-0099 Traes_2DS_DFCAF1EA5.1 Triticum aestivum 44 4e-80 297
WERAM-Orb-0079 OBART07G21300.1 Oryza barthii 45 5e-80 297
WERAM-Sob-0036 Sb02g038550.1 Sorghum bicolor 45 5e-80 297
WERAM-Sei-0109 Si029091m Setaria italica 45 6e-80 297
WERAM-Hov-0018 MLOC_16422.1 Hordeum vulgare 45 2e-79 295
WERAM-Amt-0091 ERM99985 Amborella trichopoda 44 4e-79 294
WERAM-Mel-0037 EGG03660 Melampsora laricipopulina 45 4e-79 294
WERAM-Asn-0017 CADANIAP00004063 Aspergillus nidulans 42 1e-78 292
WERAM-Kop-0012 CAY68916 Komagataella pastoris 41 3e-78 291
WERAM-Pot-0045 POPTR_0004s09180.1 Populus trichocarpa 45 3e-78 291
WERAM-Usm-0012 UM02102P0 Ustilago maydis 43 4e-78 291
WERAM-Pug-0031 EFP89333 Puccinia graminis 41 5e-78 290
WERAM-Tum-0026 CAZ84932 Tuber melanosporum 43 9e-78 290
WERAM-Cag-0018 CAG60803 Candida glabrata 42 1e-77 289
WERAM-Sol-0055 Solyc03g115150.2.1 Solanum lycopersicum 42 4e-77 287
WERAM-Trv-0041 EHK18675 Trichoderma virens 38 4e-77 287
WERAM-Miv-0034 MVLG_04888T0 Microbotryum violaceum 43 2e-76 285
WERAM-Put-0014 PTTG_07163P0 Puccinia triticina 39 2e-76 285
WERAM-Mao-0002 MGG_01076T0 Magnaporthe oryzae 40 3e-76 285
WERAM-Sac-0037 YNL021W Saccharomyces cerevisiae 39 3e-76 284
WERAM-Tru-0053 TRIUR3_22556-P1 Triticum urartu 41 4e-76 284
WERAM-Asg-0010 AAS51704 Ashbya gossypii 41 7e-76 283
WERAM-Vip-0095 ENSVPAP00000008491.1 Vicugna pacos 81 1e-75 283
WERAM-Lab-0047 EDQ99497 Laccaria bicolor 43 2e-75 282
Created Date 25-Jun-2016