Tag |
Content |
WERAM ID |
WERAM-Hos-0047 |
Ensembl Protein ID |
ENSP00000365804.2 |
Uniprot Accession |
Q9UBN7; HDAC6_HUMAN; O94975; Q6NT75; Q7L3E5; Q96CY0 |
Genbank Protein ID |
NP_006035.2 |
Protein Name |
Histone deacetylase 6 |
Genbank Nucleotide ID |
NM_006044.3 |
Gene Name |
HDAC6;KIAA0901;JM21 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase 1 |
H2A; H2B; H3; H4 |
K |
18292778; 19698979 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.10e-263 |
874.9 |
86 |
800 |
HDAC |
Class-I |
2.40e-65 |
223.5 |
90 |
792 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiy 93 +glv+de+ ++ ++l++++ pE peR++ai ++l ++gll+++++++ar a+keel+lvHs e+++l+et++ +++ el++l+ ++ds+y ENSP00000365804.2 86 TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVY 175 6899*****9999999988..*********************************************************************** PP class-2.txt 94 lesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykd 185 l+++s+++a la G+vl+lvd+vl +e++ng+a++RPPGHHa++s ++G+C+fn+vavaa+++qqk++++++livDwDvHhG+Gtq +f +d ENSP00000365804.2 176 LHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQD 267 ******************************************************************************************** PP class-2.txt 186 pkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvt 277 p+vly+S+HRy++g+f+p+++ ++++++g g+g+g+++Nv+wn+ +m+da+y+aaf +v+lp+a eF+P+lvlv+aGfDa +gdp+g++ t ENSP00000365804.2 268 PSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAAT 359 ******************************************************************************************** PP class-2.txt 278 akcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 ++++a+lt+ l++lagg+++l lEGGynl+a+ae+v+a++++Llg ENSP00000365804.2 360 PAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG 404 *******************************************96 PP class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiy 93 +glvyd++m++h +l++++ hpE p+Ri +i+ rl+e gl++++++l+ r at+ el+++Hs+e+v +l+ +ek++++el+++++++dsiy ENSP00000365804.2 481 TGLVYDQNMMNHCNLWDSH--HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIY 570 79*************9999..*********************************************************************** PP class-2.txt 94 lesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk.vkkilivDwDvHhGnGtqeifyk 184 + ++++++a+la+Ga+++lv++vl+ge+ ng avvRPPGHHae+++a+GFC+fn+vavaa+++q+ + +ilivDwDvHhGnGtq++f++ ENSP00000365804.2 571 ICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRILIVDWDVHHGNGTQHMFED 662 ****************************************************************9776699********************* PP class-2.txt 185 dpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsv 276 dp+vly+SlHRyd+g+ffp+ ++ga +++g+++g+gf+vNvawng mgda+ylaa++++vlpia+eF+P+lvlvsaGfDaa+gdplgg++v ENSP00000365804.2 663 DPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQV 754 ******************************************************************************************** PP class-2.txt 277 takcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 ++++ya+lt+ l++la+gr++l+lEGGynl++i+e+++a++++Llg ENSP00000365804.2 755 SPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG 800 ********************************************96 PP
HDAC Class-I
class-1.txt 7 ydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfd 96 de++ e+h +++ p p+rl+ ++e +++ gl + ++++ a++eel+ +hs eyi+++++ + n+ el ++ + ENSP00000365804.2 90 LDEQLNEFHClwDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDS---VYLHP 178 5778888886558999*************************************************9999999888877777754...44556 PP class-1.txt 97 glfeycqlitGasleaakkLnkk..eadiainwaGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdr 184 + ++ + l +G+ l+ ++ + ++ +ai G hha++s G+c n + +a ++kh +rvl +d d+hhG g + +f + ENSP00000365804.2 179 NSYSCACLASGSVLRLVDAVLGAeiRNGMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARYAQQKHriRRVLIVDWDVHHGQGTQFTFDQDPS 269 778888888888888887765441145688877776.9******************998777765337************************ PP class-1.txt 185 vmtvsfhkygee.ffPg..tGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsik 272 v+ s+h+y+++ f+P + + s +g ++g+ y++nvP ++ g++D y + f +v+ +v f+P+ v++ G D+l+gD+ ge + ENSP00000365804.2 270 VLYFSIHRYEQGrFWPHlkASNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPA 361 *********986388853378999***************97659************************************************ PP class-1.txt 273 ghaecvkfvksf.nlpllvlGGGGYtlrnva 302 g+a+ +++ +l++ GGY+lr +a ENSP00000365804.2 362 GFAQLTHLLMGLaGGKLILSLEGGYNLRALA 392 *******9999945556666689***99877 PP class-1.txt 7 ydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfd 96 yd+++ ++ +++hp +p+r+ + + + gl + ++p+ a+ +ell++hs ey+ +l+ e+ +++el++e+++f+ + cP ENSP00000365804.2 485 YDQNMMNHCNlwDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP--- 573 555555543223889***********999*****************************************************9999999... PP class-1.txt 97 glfeycqlitGasleaakkLnkkea.diainwaGGlhhakkseasGfcyvnDivlailellk...khkrvlyididlhhGDgveeafyttdr 184 f +ql tGa+ + ++ + ++e + a hha ++ a Gfc+ n + +a + + + r+l +d d+hhG+g ++ f+ ENSP00000365804.2 574 STFACAQLATGAACRLVEAVLSGEVlNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTisgHALRILIVDWDVHHGNGTQHMFEDDPS 665 56999**********998877666514444555666******************99865444322778************************ PP class-1.txt 185 vmtvsfhkyge.effP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsik 272 v+ vs+h+y++ +ffP G s++g g ++vnv + + D y + ++++ ++ f+Pe v++ G D+ gD+lg ++s + ENSP00000365804.2 666 VLYVSLHRYDHgTFFPmgDEGASSQIGRAAGTGFTVNVAWNGpRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPE 757 *********973599943368999***************9863699********************************************** PP class-1.txt 273 ghaecvkfvksf.nlpllvlGGGGYtlrnvaRcwt 306 g+a+ +++ ++++ GGY+l+ ++ + ENSP00000365804.2 758 GYAHLTHLLMGLaSGRIILILEGGYNLTSISESMA 792 *****9999988566788888999**999987665 PP
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Protein Sequence (Fasta) | MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG 60 QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI 120 QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS 180 YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ 240 KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG 300 QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG DPKGEMAATP 360 AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH TLLGDPCPML ESPGAPCRSA 420 QASVSCALEA LEPFWEVLVR STETVERDNM EEDNVEESEE EGPWEPPVLP ILTWPVLQSR 480 TGLVYDQNMM NHCNLWDSHH PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH 540 SAEYVGHLRA TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN 600 GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQTISGHA LRILIVDWDV HHGNGTQHMF 660 EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT VNVAWNGPRM GDADYLAAWH 720 RLVLPIAYEF NPELVLVSAG FDAARGDPLG GCQVSPEGYA HLTHLLMGLA SGRIILILEG 780 GYNLTSISES MAACTRSLLG DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE 840 DREGPSSSKL VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KVTSASFGEE STPGQTNSET 900 AVVALTQDQP SEAATGGATL AQTISEAAIG GAMLGQTTSE EAVGGATPDQ TTSEETVGGA 960 ILDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME GATLDQTTSE EAPGGTELIQ 1020 TPLASSTDHQ TPPTSPVQGT TPQISPSTLI GSLRTLELGS ESQGASESQA PGEENLLGEA 1080 AGGQDMADSM LMQGSRGLTD QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ 1140 ENWVCLSCYQ VYCGRYINGH MLQHHGNSGH PLVLSYIDLS AWCYYCQAYV HHQALLDVKN 1200 IAHQNKFGED MPHPH 1215Protein Fasta Sequence
>ENSP00000365804.2|HDAC6;KIAA0901;JM21|Homo sapiens MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH
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Nucleotide Sequence (Fasta) | GTTAGCGGTC GGGTCTGGGC AGGGGGTGGA GCTGGTTGAA GGAACGGGGC AGTCCCCTGA 60 GGAGCGGGGC TGGTTGAAAC GCTAGGGGCG GGATCTGGCG GAGTGGAAGG TACCGGTCCG 120 GCCCGATAAG GGGTGGAAAC CGCGGCAGGG GCCAAGCCTC CTCAACTATG ACCTCAACCG 180 GCCAGGATTC CACCACAACC AGGCAGCGAA GAAGTAGGCA GAACCCCCAG TCGCCCCCTC 240 AGGACTCCAG TGTCACTTCG AAGCGAAATA TTAAAAAGGG AGCCGTTCCC CGCTCTATCC 300 CCAATCTAGC GGAGGTAAAG AAGAAAGGCA AAATGAAGAA GCTCGGCCAA GCAATGGAAG 360 AAGACCTAAT CGTGGGACTG CAAGGGATGG ATCTGAACCT TGAGGCTGAA GCACTGGCTG 420 GCACTGGCTT GGTGTTGGAT GAGCAGTTAA ATGAATTCCA TTGCCTCTGG GATGACAGCT 480 TCCCGGAAGG CCCTGAGCGG CTCCATGCCA TCAAGGAGCA ACTGATCCAG GAGGGCCTCC 540 TAGATCGCTG CGTGTCCTTT CAGGCCCGGT TTGCTGAAAA GGAAGAGCTG ATGTTGGTTC 600 ACAGCCTAGA ATATATTGAT CTGATGGAAA CAACCCAGTA CATGAATGAG GGAGAACTCC 660 GTGTCCTAGC AGACACCTAC GACTCAGTTT ATCTGCATCC GAACTCATAC TCCTGTGCCT 720 GCCTGGCCTC AGGCTCTGTC CTCAGGCTGG TGGATGCGGT CCTGGGGGCT GAGATCCGGA 780 ATGGCATGGC CATCATTAGG CCTCCTGGAC ATCACGCCCA GCACAGTCTT ATGGATGGCT 840 ATTGCATGTT CAACCACGTG GCTGTGGCAG CCCGCTATGC TCAACAGAAA CACCGCATCC 900 GGAGGGTCCT TATCGTAGAT TGGGATGTGC ACCACGGTCA AGGAACACAG TTCACCTTCG 960 ACCAGGACCC CAGTGTCCTC TATTTCTCCA TCCACCGCTA CGAGCAGGGT AGGTTCTGGC 1020 CCCACCTGAA GGCCTCTAAC TGGTCCACCA CAGGTTTCGG CCAAGGCCAA GGATATACCA 1080 TCAATGTGCC TTGGAACCAG GTGGGGATGC GGGATGCTGA CTACATTGCT GCTTTCCTGC 1140 ACGTCCTGCT GCCAGTCGCC CTCGAGTTCC AGCCTCAGCT GGTCCTGGTG GCTGCTGGAT 1200 TTGATGCCCT GCAAGGGGAC CCCAAGGGTG AGATGGCCGC CACTCCGGCA GGGTTCGCCC 1260 AGCTAACCCA CCTGCTCATG GGTCTGGCAG GAGGCAAGCT GATCCTGTCT CTGGAGGGTG 1320 GCTACAACCT CCGCGCCCTG GCTGAAGGCG TCAGTGCTTC GCTCCACACC CTTCTGGGAG 1380 ACCCTTGCCC CATGCTGGAG TCACCTGGTG CCCCCTGCCG GAGTGCCCAG GCTTCAGTTT 1440 CCTGTGCTCT GGAAGCCCTT GAGCCCTTCT GGGAGGTTCT TGTGAGATCA ACTGAGACCG 1500 TGGAGAGGGA CAACATGGAG GAGGACAATG TAGAGGAGAG CGAGGAGGAA GGACCCTGGG 1560 AGCCCCCTGT GCTCCCAATC CTGACATGGC CAGTGCTACA GTCTCGCACA GGGCTGGTCT 1620 ATGACCAAAA TATGATGAAT CACTGCAACT TGTGGGACAG CCACCACCCT GAGGTACCCC 1680 AGCGCATCTT GCGGATCATG TGCCGTCTGG AGGAGCTGGG CCTTGCCGGG CGCTGCCTCA 1740 CCCTGACACC GCGCCCTGCC ACAGAGGCTG AGCTGCTCAC CTGTCACAGT GCTGAGTACG 1800 TGGGTCATCT CCGGGCCACA GAGAAAATGA AAACCCGGGA GCTGCACCGT GAGAGTTCCA 1860 ACTTTGACTC CATCTATATC TGCCCCAGTA CCTTCGCCTG TGCACAGCTT GCCACTGGCG 1920 CTGCCTGCCG CCTGGTGGAG GCTGTGCTCT CAGGAGAGGT TCTGAATGGT GCTGCTGTGG 1980 TGCGTCCCCC AGGACACCAC GCAGAGCAGG ATGCAGCTTG CGGTTTTTGC TTTTTCAACT 2040 CTGTGGCTGT GGCTGCTCGC CATGCCCAGA CTATCAGTGG GCATGCCCTA CGGATCCTGA 2100 TTGTGGATTG GGATGTCCAC CACGGTAATG GAACTCAGCA CATGTTTGAG GATGACCCCA 2160 GTGTGCTATA TGTGTCCCTG CACCGCTATG ATCATGGCAC CTTCTTCCCC ATGGGGGATG 2220 AGGGTGCCAG CAGCCAGATC GGCCGGGCTG CGGGCACAGG CTTCACCGTC AACGTGGCAT 2280 GGAACGGGCC CCGCATGGGT GATGCTGACT ACCTAGCTGC CTGGCATCGC CTGGTGCTTC 2340 CCATTGCCTA CGAGTTTAAC CCAGAACTGG TGCTGGTCTC AGCTGGCTTT GATGCTGCAC 2400 GGGGGGATCC GCTGGGGGGC TGCCAGGTGT CACCTGAGGG TTATGCCCAC CTCACCCACC 2460 TGCTGATGGG CCTTGCCAGT GGCCGCATTA TCCTTATCCT AGAGGGTGGC TATAACCTGA 2520 CATCCATCTC AGAGTCCATG GCTGCCTGCA CTCGCTCCCT CCTTGGAGAC CCACCACCCC 2580 TGCTGACCCT GCCACGGCCC CCACTATCAG GGGCCCTGGC CTCAATCACT GAGACCATCC 2640 AAGTCCATCG CAGATACTGG CGCAGCTTAC GGGTCATGAA GGTAGAAGAC AGAGAAGGAC 2700 CCTCCAGTTC TAAGTTGGTC ACCAAGAAGG CACCCCAACC AGCCAAACCT AGGTTAGCTG 2760 AGCGGATGAC CACACGAGAA AAGAAGGTTC TGGAAGCAGG CATGGGGAAA GTCACCTCGG 2820 CATCATTTGG GGAAGAGTCC ACTCCAGGCC AGACTAACTC AGAGACAGCT GTGGTGGCCC 2880 TCACTCAGGA CCAGCCCTCA GAGGCAGCCA CAGGGGGAGC CACTCTGGCC CAGACCATTT 2940 CTGAGGCAGC CATTGGGGGA GCCATGCTGG GCCAGACCAC CTCAGAGGAG GCTGTCGGGG 3000 GAGCCACTCC GGACCAGACC ACCTCAGAGG AGACTGTGGG AGGAGCCATT CTGGACCAGA 3060 CCACCTCAGA GGATGCTGTT GGGGGAGCCA CGCTGGGCCA GACTACCTCA GAGGAGGCTG 3120 TAGGAGGAGC TACACTGGCC CAGACCACCT CGGAGGCAGC CATGGAGGGA GCCACACTGG 3180 ACCAGACTAC GTCAGAGGAG GCTCCAGGGG GCACCGAGCT GATCCAAACT CCTCTAGCCT 3240 CGAGCACAGA CCACCAGACC CCCCCAACCT CACCTGTGCA GGGAACTACA CCCCAGATAT 3300 CTCCCAGTAC ACTGATTGGG AGTCTCAGGA CCTTGGAGCT AGGCAGCGAA TCTCAGGGGG 3360 CCTCAGAATC TCAGGCCCCA GGAGAGGAGA ACCTACTAGG AGAGGCAGCT GGAGGTCAGG 3420 ACATGGCTGA TTCGATGCTG ATGCAGGGAT CTAGGGGCCT CACTGATCAG GCCATATTTT 3480 ATGCTGTGAC ACCACTGCCC TGGTGTCCCC ATTTGGTGGC AGTATGCCCC ATACCTGCAG 3540 CAGGCCTAGA CGTGACCCAA CCTTGTGGGG ACTGTGGAAC AATCCAAGAG AATTGGGTGT 3600 GTCTCTCTTG CTATCAGGTC TACTGTGGTC GTTACATCAA TGGCCACATG CTCCAACACC 3660 ATGGAAATTC TGGACACCCG CTGGTCCTCA GCTACATCGA CCTGTCAGCC TGGTGTTACT 3720 ACTGTCAGGC CTATGTCCAC CACCAGGCTC TCCTAGATGT GAAGAACATC GCCCACCAGA 3780 ACAAGTTTGG GGAGGATATG CCCCACCCAC ACTAAGCCCC AGAATACGGT CCCTCTTCAC 3840 CTTCTGAGGC CCACGATAGA CCAGCTGTAG CTCATTCCAG CCTGTACCTT GGATGAGGGG 3900 TAGCCTCCCA CTGCATCCCA TCCTGAATAT CCTTTGCAAC TCCCCAAGAG TGCTTATTTA 3960 AGTGTTAATA CTTTTAAGAG AACTGCGACG ATTAATTGTG GATCTCCCCC TGCCCATTGC 4020 CTGCTTGAGG GGCACCACTA CTCCAGCCCA GAAGGAAAGG GGGGCAGCTC AGTGGCCCCA 4080 AGAGGGAGCT GATATCATGA GGATAACATT GGCGGGAGGG GAGTTAACTG GCAGGCATGG 4140 CAAGGTTGCA TATGTAATAA AGTACAAGCT GTTAAAAAA
Nucleotide Fasta Sequence
>ENSP00000365804.2|Class-I|Homo sapiens GTTAGCGGTCGGGTCTGGGCAGGGGGTGGAGCTGGTTGAAGGAACGGGGCAGTCCCCTGAGGAGCGGGGCTGGTTGAAACGCTAGGGGCGGGATCTGGCGGAGTGGAAGGTACCGGTCCGGCCCGATAAGGGGTGGAAACCGCGGCAGGGGCCAAGCCTCCTCAACTATGACCTCAACCGGCCAGGATTCCACCACAACCAGGCAGCGAAGAAGTAGGCAGAACCCCCAGTCGCCCCCTCAGGACTCCAGTGTCACTTCGAAGCGAAATATTAAAAAGGGAGCCGTTCCCCGCTCTATCCCCAATCTAGCGGAGGTAAAGAAGAAAGGCAAAATGAAGAAGCTCGGCCAAGCAATGGAAGAAGACCTAATCGTGGGACTGCAAGGGATGGATCTGAACCTTGAGGCTGAAGCACTGGCTGGCACTGGCTTGGTGTTGGATGAGCAGTTAAATGAATTCCATTGCCTCTGGGATGACAGCTTCCCGGAAGGCCCTGAGCGGCTCCATGCCATCAAGGAGCAACTGATCCAGGAGGGCCTCCTAGATCGCTGCGTGTCCTTTCAGGCCCGGTTTGCTGAAAAGGAAGAGCTGATGTTGGTTCACAGCCTAGAATATATTGATCTGATGGAAACAACCCAGTACATGAATGAGGGAGAACTCCGTGTCCTAGCAGACACCTACGACTCAGTTTATCTGCATCCGAACTCATACTCCTGTGCCTGCCTGGCCTCAGGCTCTGTCCTCAGGCTGGTGGATGCGGTCCTGGGGGCTGAGATCCGGAATGGCATGGCCATCATTAGGCCTCCTGGACATCACGCCCAGCACAGTCTTATGGATGGCTATTGCATGTTCAACCACGTGGCTGTGGCAGCCCGCTATGCTCAACAGAAACACCGCATCCGGAGGGTCCTTATCGTAGATTGGGATGTGCACCACGGTCAAGGAACACAGTTCACCTTCGACCAGGACCCCAGTGTCCTCTATTTCTCCATCCACCGCTACGAGCAGGGTAGGTTCTGGCCCCACCTGAAGGCCTCTAACTGGTCCACCACAGGTTTCGGCCAAGGCCAAGGATATACCATCAATGTGCCTTGGAACCAGGTGGGGATGCGGGATGCTGACTACATTGCTGCTTTCCTGCACGTCCTGCTGCCAGTCGCCCTCGAGTTCCAGCCTCAGCTGGTCCTGGTGGCTGCTGGATTTGATGCCCTGCAAGGGGACCCCAAGGGTGAGATGGCCGCCACTCCGGCAGGGTTCGCCCAGCTAACCCACCTGCTCATGGGTCTGGCAGGAGGCAAGCTGATCCTGTCTCTGGAGGGTGGCTACAACCTCCGCGCCCTGGCTGAAGGCGTCAGTGCTTCGCTCCACACCCTTCTGGGAGACCCTTGCCCCATGCTGGAGTCACCTGGTGCCCCCTGCCGGAGTGCCCAGGCTTCAGTTTCCTGTGCTCTGGAAGCCCTTGAGCCCTTCTGGGAGGTTCTTGTGAGATCAACTGAGACCGTGGAGAGGGACAACATGGAGGAGGACAATGTAGAGGAGAGCGAGGAGGAAGGACCCTGGGAGCCCCCTGTGCTCCCAATCCTGACATGGCCAGTGCTACAGTCTCGCACAGGGCTGGTCTATGACCAAAATATGATGAATCACTGCAACTTGTGGGACAGCCACCACCCTGAGGTACCCCAGCGCATCTTGCGGATCATGTGCCGTCTGGAGGAGCTGGGCCTTGCCGGGCGCTGCCTCACCCTGACACCGCGCCCTGCCACAGAGGCTGAGCTGCTCACCTGTCACAGTGCTGAGTACGTGGGTCATCTCCGGGCCACAGAGAAAATGAAAACCCGGGAGCTGCACCGTGAGAGTTCCAACTTTGACTCCATCTATATCTGCCCCAGTACCTTCGCCTGTGCACAGCTTGCCACTGGCGCTGCCTGCCGCCTGGTGGAGGCTGTGCTCTCAGGAGAGGTTCTGAATGGTGCTGCTGTGGTGCGTCCCCCAGGACACCACGCAGAGCAGGATGCAGCTTGCGGTTTTTGCTTTTTCAACTCTGTGGCTGTGGCTGCTCGCCATGCCCAGACTATCAGTGGGCATGCCCTACGGATCCTGATTGTGGATTGGGATGTCCACCACGGTAATGGAACTCAGCACATGTTTGAGGATGACCCCAGTGTGCTATATGTGTCCCTGCACCGCTATGATCATGGCACCTTCTTCCCCATGGGGGATGAGGGTGCCAGCAGCCAGATCGGCCGGGCTGCGGGCACAGGCTTCACCGTCAACGTGGCATGGAACGGGCCCCGCATGGGTGATGCTGACTACCTAGCTGCCTGGCATCGCCTGGTGCTTCCCATTGCCTACGAGTTTAACCCAGAACTGGTGCTGGTCTCAGCTGGCTTTGATGCTGCACGGGGGGATCCGCTGGGGGGCTGCCAGGTGTCACCTGAGGGTTATGCCCACCTCACCCACCTGCTGATGGGCCTTGCCAGTGGCCGCATTATCCTTATCCTAGAGGGTGGCTATAACCTGACATCCATCTCAGAGTCCATGGCTGCCTGCACTCGCTCCCTCCTTGGAGACCCACCACCCCTGCTGACCCTGCCACGGCCCCCACTATCAGGGGCCCTGGCCTCAATCACTGAGACCATCCAAGTCCATCGCAGATACTGGCGCAGCTTACGGGTCATGAAGGTAGAAGACAGAGAAGGACCCTCCAGTTCTAAGTTGGTCACCAAGAAGGCACCCCAACCAGCCAAACCTAGGTTAGCTGAGCGGATGACCACACGAGAAAAGAAGGTTCTGGAAGCAGGCATGGGGAAAGTCACCTCGGCATCATTTGGGGAAGAGTCCACTCCAGGCCAGACTAACTCAGAGACAGCTGTGGTGGCCCTCACTCAGGACCAGCCCTCAGAGGCAGCCACAGGGGGAGCCACTCTGGCCCAGACCATTTCTGAGGCAGCCATTGGGGGAGCCATGCTGGGCCAGACCACCTCAGAGGAGGCTGTCGGGGGAGCCACTCCGGACCAGACCACCTCAGAGGAGACTGTGGGAGGAGCCATTCTGGACCAGACCACCTCAGAGGATGCTGTTGGGGGAGCCACGCTGGGCCAGACTACCTCAGAGGAGGCTGTAGGAGGAGCTACACTGGCCCAGACCACCTCGGAGGCAGCCATGGAGGGAGCCACACTGGACCAGACTACGTCAGAGGAGGCTCCAGGGGGCACCGAGCTGATCCAAACTCCTCTAGCCTCGAGCACAGACCACCAGACCCCCCCAACCTCACCTGTGCAGGGAACTACACCCCAGATATCTCCCAGTACACTGATTGGGAGTCTCAGGACCTTGGAGCTAGGCAGCGAATCTCAGGGGGCCTCAGAATCTCAGGCCCCAGGAGAGGAGAACCTACTAGGAGAGGCAGCTGGAGGTCAGGACATGGCTGATTCGATGCTGATGCAGGGATCTAGGGGCCTCACTGATCAGGCCATATTTTATGCTGTGACACCACTGCCCTGGTGTCCCCATTTGGTGGCAGTATGCCCCATACCTGCAGCAGGCCTAGACGTGACCCAACCTTGTGGGGACTGTGGAACAATCCAAGAGAATTGGGTGTGTCTCTCTTGCTATCAGGTCTACTGTGGTCGTTACATCAATGGCCACATGCTCCAACACCATGGAAATTCTGGACACCCGCTGGTCCTCAGCTACATCGACCTGTCAGCCTGGTGTTACTACTGTCAGGCCTATGTCCACCACCAGGCTCTCCTAGATGTGAAGAACATCGCCCACCAGAACAAGTTTGGGGAGGATATGCCCCACCCACACTAAGCCCCAGAATACGGTCCCTCTTCACCTTCTGAGGCCCACGATAGACCAGCTGTAGCTCATTCCAGCCTGTACCTTGGATGAGGGGTAGCCTCCCACTGCATCCCATCCTGAATATCCTTTGCAACTCCCCAAGAGTGCTTATTTAAGTGTTAATACTTTTAAGAGAACTGCGACGATTAATTGTGGATCTCCCCCTGCCCATTGCCTGCTTGAGGGGCACCACTACTCCAGCCCAGAAGGAAAGGGGGGCAGCTCAGTGGCCCCAAGAGGGAGCTGATATCATGAGGATAACATTGGCGGGAGGGGAGTTAACTGGCAGGCATGGCAAGGTTGCATATGTAATAAAGTACAAGCTGTTAAAAAA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0009--Actin-binding KW-0025--Alternative splicing KW-0072--Autophagy KW-0966--Cell projection KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0378--Hydrolase KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR013083--Znf_RING/FYVE/PHD IPR001607--Znf_UBP
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PROSITE |
PS50271--ZF_UBP
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Pfam |
PF00850--Hist_deacetyl PF02148--zf-UBP
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Gene Ontology |
GO:0016235--C:aggresome GO:0030424--C:axon GO:0005901--C:caveola GO:0031252--C:cell leading edge GO:0005737--C:cytoplasm GO:0005881--C:cytoplasmic microtubule GO:0005829--C:cytosol GO:0030425--C:dendrite GO:0000118--C:histone deacetylase complex GO:0016234--C:inclusion body GO:0005874--C:microtubule GO:0005875--C:microtubule associated complex GO:0005771--C:multivesicular body GO:0005634--C:nucleus GO:0043204--C:perikaryon GO:0048471--C:perinuclear region of cytoplasm GO:0043014--F:alpha-tubulin binding GO:0008013--F:beta-catenin binding GO:0001047--F:core promoter binding GO:0070840--F:dynein complex binding GO:0019899--F:enzyme binding GO:0004407--F:histone deacetylase activity GO:0042826--F:histone deacetylase binding GO:0051879--F:Hsp90 protein binding GO:0008017--F:microtubule binding GO:0051787--F:misfolded protein binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0031593--F:polyubiquitin binding GO:0048156--F:tau protein binding GO:0042903--F:tubulin deacetylase activity GO:0031625--F:ubiquitin protein ligase binding GO:0008270--F:zinc ion binding GO:0070842--P:aggresome assembly GO:0070301--P:cellular response to hydrogen peroxide GO:0071218--P:cellular response to misfolded protein GO:0035967--P:cellular response to topologically incorrect protein GO:0016575--P:histone deacetylation GO:0070846--P:Hsp90 deacetylation GO:0006886--P:intracellular protein transport GO:0032418--P:lysosome localization GO:0016236--P:macroautophagy GO:0006515--P:misfolded or incompletely synthesized protein catabolic process GO:0051646--P:mitochondrion localization GO:0098779--P:mitophagy in response to mitochondrial depolarization GO:0010727--P:negative regulation of hydrogen peroxide metabolic process GO:0007026--P:negative regulation of microtubule depolymerization GO:0051354--P:negative regulation of oxidoreductase activity GO:0043242--P:negative regulation of protein complex disassembly GO:0045861--P:negative regulation of proteolysis GO:0045892--P:negative regulation of transcription, DNA-templated GO:0006996--P:organelle organization GO:0034983--P:peptidyl-lysine deacetylation GO:0070845--P:polyubiquitinated misfolded protein transport GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly GO:0010634--P:positive regulation of epithelial cell migration GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death GO:0010870--P:positive regulation of receptor biosynthetic process GO:0009967--P:positive regulation of signal transduction GO:0043241--P:protein complex disassembly GO:0006476--P:protein deacetylation GO:0000209--P:protein polyubiquitination GO:0060765--P:regulation of androgen receptor signaling pathway GO:0010506--P:regulation of autophagy GO:0070201--P:regulation of establishment of protein localization GO:0045598--P:regulation of fat cell differentiation GO:0040029--P:regulation of gene expression, epigenetic GO:0060632--P:regulation of microtubule-based movement GO:1903146--P:regulation of mitophagy GO:0031647--P:regulation of protein stability GO:0010469--P:regulation of receptor activity GO:0070848--P:response to growth factor GO:0051788--P:response to misfolded protein GO:0010033--P:response to organic substance GO:0009636--P:response to toxic substance GO:0006351--P:transcription, DNA-templated GO:0090042--P:tubulin deacetylation GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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Orthology |
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Created Date |
25-Jun-2016 |