Tag |
Content |
WERAM ID |
WERAM-Art-0146 |
Ensembl Protein ID |
AT5G61060.1 |
Uniprot Accession |
Q8RX28; HDA5_ARATH; Q9FNQ7; Q9FNQ8 |
Genbank Protein ID |
NP_200914.2 |
Protein Name |
Histone deacetylase 5 |
Genbank Nucleotide ID |
NM_125499.4 |
Gene Name |
HDA5;At5g61060;MAF19.7 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26704384 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.80e-131 |
438.9 |
27 |
348 |
HDAC |
Class-I |
4.20e-36 |
125.9 |
27 |
566 |
|
Organism |
Arabidopsis thaliana |
NCBI Taxa ID |
3702 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletae.klekeelesltvdsdsiylesks 98 +gl+yde+m+kh+++ +++ hpE+p+Ri+ i+++lq ag+ ++++ l ++ka++++lqlvH+++hv+l+++ + k+++ + ++++++ +siyl+ s AT5G61060.1 27 VGLIYDETMCKHDTPDGED--HPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVHTKDHVNLVKSIStKQKDYRRNRIASQLNSIYLNGGS 122 789**************99..***************************************************998889999999************** PP class-2.txt 99 ikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk...vkkilivDwDvHhGnGtqeifykdpkvlylSl 193 ++aa la+G+v++l++kv++gel++gfa+vRPPGHHae+++amGFClfnnvavaa+ l+++ + vkkilivDwDvHhGnGtq++f+kdp+vl++S+ AT5G61060.1 123 SEAAYLAAGSVVKLAEKVAEGELDCGFAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPdlgVKKILIVDWDVHHGNGTQKMFWKDPRVLFFSV 220 ***********************************************************9987788******************************** PP class-2.txt 194 HRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkqllkl 291 HR++ g f+p+ ++g+++ vgeg+gegfn+Nv+w++g +gda+ylaa++++++p+a+eF+Pd++++saGfDaa +dplgg++vt+ +y+ + k+l+++ AT5G61060.1 221 HRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWDQGRCGDADYLAAWDHILIPVAREFNPDVIFLSAGFDAAINDPLGGCCVTPYGYSVMLKKLMEF 318 ************************************************************************************************** PP class-2.txt 292 aggrvvlvlEGGynlkaiaeaveavvkaLl 321 a+g++vl+lEGGynl++ia+++ a+v++Ll AT5G61060.1 319 AQGKIVLALEGGYNLDSIAKSSLACVQVLL 348 *****************************8 PP
HDAC Class-I
class-1.txt 3 vayaydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdgl 98 v +yde++ ++ + g++hp p r++++ e + g+s++ ++ ++ka+ ++l+ +h++++++++k++++++++ + +++ + g AT5G61060.1 27 VGLIYDETMCKHDTpdGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVHTKDHVNLVKSISTKQKDYRR-NRIASQLN-SIYLNGGS 122 5567777777766555899*************9999***********************************998776433.33333333.34456677 PP class-1.txt 99 feycqlitGasleaakkLnkkeadi..ainwaGGlhhakkseasGfcyvnDivlailellkk.....hkrvlyididlhhGDgveeafyttdrvmtvs 189 e + l +G+ ++ a+k+ ++e d ai hha +ea Gfc n++ +a ll + k++l +d d+hhG+g ++ f + rv+ s AT5G61060.1 123 SEAAYLAAGSVVKLAEKVAEGELDCgfAIVRPP-GHHAEADEAMGFCLFNNVAVAASFLLNErpdlgVKKILIVDWDVHHGNGTQKMFWKDPRVLFFS 219 8888999*************9988611555554.5********************99998752333368***************************** PP class-1.txt 190 fhkyge.effPg..tGdlsdvgaekgkyyavnvPlkdg.idDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvks 283 +h+++ +f+P+ Gd + vg++ g + +nvP ++g + D y + +++ +v + f+P+++ l G D+ +D+lg ++ g++ ++k + + AT5G61060.1 220 VHRHEYgGFYPAgdDGDYNMVGEGPGEGFNINVPWDQGrCGDADYLAAWDHILIPVAREFNPDVIFLSAGFDAAINDPLGGCCVTPYGYSVMLKKLME 317 *987642599973359999****************99979********************************************************** PP class-1.txt 284 f.nlpllvlGGGGYtlrnvaRc 304 f + ++++ GGY+l +a+ AT5G61060.1 318 FaQGKIVLALEGGYNLDSIAKS 339 *6666777779*****999975 PP class-1.txt 65 ieflkkvepenaeelskelkkfnvgedcPvfd 96 +l +++ e+ +++ ++ + nv++d+Pvfd AT5G61060.1 535 HMCLYRITLEQFNDVLSQENGLNVDSDSPVFD 566 568999*************************8 PP
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Protein Sequence (Fasta) | MAMAGESSGK KIGDCDGKVA GNRQRKVGLI YDETMCKHDT PDGEDHPECP DRIRVIWEKL 60 QLAGVSQRCV VLGSSKAEDK HLQLVHTKDH VNLVKSISTK QKDYRRNRIA SQLNSIYLNG 120 GSSEAAYLAA GSVVKLAEKV AEGELDCGFA IVRPPGHHAE ADEAMGFCLF NNVAVAASFL 180 LNERPDLGVK KILIVDWDVH HGNGTQKMFW KDPRVLFFSV HRHEYGGFYP AGDDGDYNMV 240 GEGPGEGFNI NVPWDQGRCG DADYLAAWDH ILIPVAREFN PDVIFLSAGF DAAINDPLGG 300 CCVTPYGYSV MLKKLMEFAQ GKIVLALEGG YNLDSIAKSS LACVQVLLED KQIQGPPEAY 360 PFESTWRVIQ AVRKRLCTYW PSLADELSWK LINQKTPTPI ILISSSDSET EDNAQGLLDQ 420 MSKLSIENPQ GTLLENHQVE PASTSWRADL AKVDVWYASF GSNMWKPRFL CYIQGGQVDG 480 LKKVCVGSMD KSPPKETVWE TFPHRLFFGR ESSVGWGVGG VAFTNPLANL IDQTHMCLYR 540 ITLEQFNDVL SQENGLNVDS DSPVFDLAAL QLVDNKGSIL EAPLNSWYGN VVCLGKERDI 600 PILTMTCTLS AVEKFKSGEI PIRPPAKAYA NTLIRGLVEG GRLSKEEAEA YIDKAVSKPL 660 Protein Fasta Sequence
>AT5G61060.1|HDA5;At5g61060;MAF19.7|Arabidopsis thaliana MAMAGESSGKKIGDCDGKVAGNRQRKVGLIYDETMCKHDTPDGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVHTKDHVNLVKSISTKQKDYRRNRIASQLNSIYLNGGSSEAAYLAAGSVVKLAEKVAEGELDCGFAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPDLGVKKILIVDWDVHHGNGTQKMFWKDPRVLFFSVHRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWDQGRCGDADYLAAWDHILIPVAREFNPDVIFLSAGFDAAINDPLGGCCVTPYGYSVMLKKLMEFAQGKIVLALEGGYNLDSIAKSSLACVQVLLEDKQIQGPPEAYPFESTWRVIQAVRKRLCTYWPSLADELSWKLINQKTPTPIILISSSDSETEDNAQGLLDQMSKLSIENPQGTLLENHQVEPASTSWRADLAKVDVWYASFGSNMWKPRFLCYIQGGQVDGLKKVCVGSMDKSPPKETVWETFPHRLFFGRESSVGWGVGGVAFTNPLANLIDQTHMCLYRITLEQFNDVLSQENGLNVDSDSPVFDLAALQLVDNKGSILEAPLNSWYGNVVCLGKERDIPILTMTCTLSAVEKFKSGEIPIRPPAKAYANTLIRGLVEGGRLSKEEAEAYIDKAVSKPL
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Nucleotide Sequence (Fasta) | CCTAAAAAAA AAAAAGGAGA GAATGAAAAA AAGAAAGAAT TGAAAAGTAA AAAATACTTG 60 GAAGCTTTAG AAGCTGAGAG CAAAGACTTG ACCTTTTTCA CTTCCTTCTC ACTGATCGTC 120 GAACAATAAG GCCGTCGCAT CTCCCAGTTA TGGCTATGGC CGGAGAATCT TCCGGCAAAA 180 AAATTGGAGA CTGTGACGGT AAAGTCGCGG GGAACAGACA GCGAAAGGTG GGTCTTATTT 240 ACGACGAGAC GATGTGCAAA CACGACACAC CTGACGGCGA GGATCACCCT GAGTGTCCCG 300 ACCGCATCAG AGTTATCTGG GAGAAGCTTC AGCTCGCCGG AGTTTCTCAA AGATGTGTGG 360 TTCTTGGTAG TAGCAAAGCA GAAGATAAGC ATCTCCAATT GGTTCACACA AAGGACCATG 420 TTAATTTAGT TAAGAGTATT AGCACAAAAC AGAAAGATTA TCGGAGAAAC AGGATTGCTT 480 CACAGTTGAA TTCGATTTAT CTGAATGGAG GTTCATCTGA AGCCGCATAT CTTGCAGCTG 540 GTTCTGTTGT AAAGTTGGCA GAAAAAGTTG CAGAAGGAGA GTTAGATTGT GGTTTTGCTA 600 TTGTCAGGCC CCCAGGGCAC CATGCTGAGG CAGATGAAGC CATGGGTTTT TGTTTATTCA 660 ACAATGTTGC CGTTGCTGCT AGTTTTTTAC TAAACGAAAG ACCGGATCTA GGGGTCAAGA 720 AAATTCTGAT CGTTGATTGG GATGTCCATC ACGGAAATGG TACCCAGAAG ATGTTTTGGA 780 AAGATCCTCG TGTACTATTT TTCTCTGTTC ATAGGCATGA GTATGGGGGT TTCTATCCAG 840 CGGGTGATGA TGGCGATTAT AACATGGTTG GGGAAGGTCC AGGTGAAGGG TTTAACATAA 900 ATGTTCCATG GGATCAAGGA CGATGTGGAG ATGCAGATTA TCTTGCTGCA TGGGACCATA 960 TCTTGATTCC TGTGGCGAGG GAATTTAACC CGGATGTTAT TTTTCTTTCA GCTGGATTTG 1020 ATGCAGCTAT TAATGATCCG CTAGGGGGTT GTTGTGTGAC CCCATATGGA TATTCAGTTA 1080 TGTTGAAGAA GCTGATGGAG TTTGCACAAG GAAAGATAGT GCTGGCGTTA GAGGGAGGGT 1140 ACAATCTTGA CTCAATTGCA AAGTCTTCAC TTGCATGTGT CCAAGTTTTG CTTGAAGACA 1200 AACAAATTCA AGGACCTCCG GAAGCATACC CATTCGAGTC GACATGGCGT GTCATACAAG 1260 CGGTGCGCAA GAGGCTATGC ACATATTGGC CTTCACTTGC AGATGAATTA TCGTGGAAGC 1320 TAATTAATCA GAAAACTCCT ACTCCAATCA TCCTTATCTC AAGCTCCGAC TCTGAAACTG 1380 AAGACAACGC CCAAGGACTC CTGGATCAAA TGTCGAAACT CAGCATTGAA AACCCTCAAG 1440 GTACACTACT TGAAAACCAC CAAGTAGAAC CTGCATCTAC ATCTTGGAGA GCTGATCTCG 1500 CAAAGGTTGA CGTTTGGTAT GCCTCTTTTG GATCCAACAT GTGGAAACCA AGGTTTCTTT 1560 GCTATATTCA AGGGGGACAG GTCGATGGAT TGAAAAAGGT ATGTGTTGGC TCAATGGATA 1620 AAAGTCCACC AAAGGAAACA GTGTGGGAAA CATTTCCACA TAGATTGTTC TTTGGCCGTG 1680 AATCTTCAGT TGGTTGGGGT GTAGGAGGAG TTGCTTTCAC CAACCCCCTT GCTAATCTCA 1740 TTGATCAAAC TCACATGTGT TTGTACCGTA TCACGCTTGA GCAGTTCAAT GACGTTCTGT 1800 CTCAAGAAAA TGGTTTGAAT GTGGATTCAG ATTCTCCGGT CTTTGATCTA GCTGCTTTGC 1860 AGTTAGTAGA TAACAAAGGA TCCATTTTAG AAGCTCCTTT GAATAGTTGG TATGGAAATG 1920 TTGTCTGCTT GGGAAAAGAA CGCGACATTC CTATACTTAC AATGACTTGC ACGCTTTCCG 1980 CTGTTGAGAA ATTCAAATCC GGTGAGATCC CTATAAGACC TCCTGCAAAA GCTTATGCCA 2040 ACACTTTAAT AAGGGGACTT GTGGAAGGAG GAAGATTATC TAAAGAAGAA GCTGAGGCTT 2100 ACATAGACAA GGCTGTGTCT AAACCTCTCT AGTGTATAAT TATTTACTCA GAAACCGCCC 2160 GTTTGAACAC GATTTGGAGC TTCGGGTTTC TGAGTTATTC AATTAGGATA AAAACCACAA 2220 GTTTAGGAAT ATTGTGAGAC CTTTGAATTT GTCTTTTGAA AGAGAGGACT GTGTCCTCTG 2280 TTAGCTGTGT TGTGCTTGCT CCCTAAGCAA ACTCTCAATG TATTTTAGTT ATCTTCGGGT 2340 TTTAGGCTTT ACCAAGAAGC TGTATTCGGT AAATGTATTA AAGAACCCTC CAAACTGCTT 2400 TATATTGACC GGAGAGAAAC ATTCTTATTC TTCGGAATGG TACTTTGAAG TTTGAAGAGT 2460 TATTTTAAAA AAAGATTT
2479Nucleotide Fasta Sequence
>AT5G61060.1|Class-I|Arabidopsis thaliana CCTAAAAAAAAAAAAGGAGAGAATGAAAAAAAGAAAGAATTGAAAAGTAAAAAATACTTGGAAGCTTTAGAAGCTGAGAGCAAAGACTTGACCTTTTTCACTTCCTTCTCACTGATCGTCGAACAATAAGGCCGTCGCATCTCCCAGTTATGGCTATGGCCGGAGAATCTTCCGGCAAAAAAATTGGAGACTGTGACGGTAAAGTCGCGGGGAACAGACAGCGAAAGGTGGGTCTTATTTACGACGAGACGATGTGCAAACACGACACACCTGACGGCGAGGATCACCCTGAGTGTCCCGACCGCATCAGAGTTATCTGGGAGAAGCTTCAGCTCGCCGGAGTTTCTCAAAGATGTGTGGTTCTTGGTAGTAGCAAAGCAGAAGATAAGCATCTCCAATTGGTTCACACAAAGGACCATGTTAATTTAGTTAAGAGTATTAGCACAAAACAGAAAGATTATCGGAGAAACAGGATTGCTTCACAGTTGAATTCGATTTATCTGAATGGAGGTTCATCTGAAGCCGCATATCTTGCAGCTGGTTCTGTTGTAAAGTTGGCAGAAAAAGTTGCAGAAGGAGAGTTAGATTGTGGTTTTGCTATTGTCAGGCCCCCAGGGCACCATGCTGAGGCAGATGAAGCCATGGGTTTTTGTTTATTCAACAATGTTGCCGTTGCTGCTAGTTTTTTACTAAACGAAAGACCGGATCTAGGGGTCAAGAAAATTCTGATCGTTGATTGGGATGTCCATCACGGAAATGGTACCCAGAAGATGTTTTGGAAAGATCCTCGTGTACTATTTTTCTCTGTTCATAGGCATGAGTATGGGGGTTTCTATCCAGCGGGTGATGATGGCGATTATAACATGGTTGGGGAAGGTCCAGGTGAAGGGTTTAACATAAATGTTCCATGGGATCAAGGACGATGTGGAGATGCAGATTATCTTGCTGCATGGGACCATATCTTGATTCCTGTGGCGAGGGAATTTAACCCGGATGTTATTTTTCTTTCAGCTGGATTTGATGCAGCTATTAATGATCCGCTAGGGGGTTGTTGTGTGACCCCATATGGATATTCAGTTATGTTGAAGAAGCTGATGGAGTTTGCACAAGGAAAGATAGTGCTGGCGTTAGAGGGAGGGTACAATCTTGACTCAATTGCAAAGTCTTCACTTGCATGTGTCCAAGTTTTGCTTGAAGACAAACAAATTCAAGGACCTCCGGAAGCATACCCATTCGAGTCGACATGGCGTGTCATACAAGCGGTGCGCAAGAGGCTATGCACATATTGGCCTTCACTTGCAGATGAATTATCGTGGAAGCTAATTAATCAGAAAACTCCTACTCCAATCATCCTTATCTCAAGCTCCGACTCTGAAACTGAAGACAACGCCCAAGGACTCCTGGATCAAATGTCGAAACTCAGCATTGAAAACCCTCAAGGTACACTACTTGAAAACCACCAAGTAGAACCTGCATCTACATCTTGGAGAGCTGATCTCGCAAAGGTTGACGTTTGGTATGCCTCTTTTGGATCCAACATGTGGAAACCAAGGTTTCTTTGCTATATTCAAGGGGGACAGGTCGATGGATTGAAAAAGGTATGTGTTGGCTCAATGGATAAAAGTCCACCAAAGGAAACAGTGTGGGAAACATTTCCACATAGATTGTTCTTTGGCCGTGAATCTTCAGTTGGTTGGGGTGTAGGAGGAGTTGCTTTCACCAACCCCCTTGCTAATCTCATTGATCAAACTCACATGTGTTTGTACCGTATCACGCTTGAGCAGTTCAATGACGTTCTGTCTCAAGAAAATGGTTTGAATGTGGATTCAGATTCTCCGGTCTTTGATCTAGCTGCTTTGCAGTTAGTAGATAACAAAGGATCCATTTTAGAAGCTCCTTTGAATAGTTGGTATGGAAATGTTGTCTGCTTGGGAAAAGAACGCGACATTCCTATACTTACAATGACTTGCACGCTTTCCGCTGTTGAGAAATTCAAATCCGGTGAGATCCCTATAAGACCTCCTGCAAAAGCTTATGCCAACACTTTAATAAGGGGACTTGTGGAAGGAGGAAGATTATCTAAAGAAGAAGCTGAGGCTTACATAGACAAGGCTGTGTCTAAACCTCTCTAGTGTATAATTATTTACTCAGAAACCGCCCGTTTGAACACGATTTGGAGCTTCGGGTTTCTGAGTTATTCAATTAGGATAAAAACCACAAGTTTAGGAATATTGTGAGACCTTTGAATTTGTCTTTTGAAAGAGAGGACTGTGTCCTCTGTTAGCTGTGTTGTGCTTGCTCCCTAAGCAAACTCTCAATGTATTTTAGTTATCTTCGGGTTTTAGGCTTTACCAAGAAGCTGTATTCGGTAAATGTATTAAAGAACCCTCCAAACTGCTTTATATTGACCGGAGAGAAACATTCTTATTCTTCGGAATGGTACTTTGAAGTTTGAAGAGTTATTTTAAAAAAAGATTT
|
Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005634--C:nucleus GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
|
Orthology |
|
Created Date |
25-Jun-2016 |