Tag |
Content |
WERAM ID |
WERAM-Hos-0058 |
Ensembl Protein ID |
ENSP00000216271.5 |
Uniprot Accession |
Q969S8; HDA10_HUMAN; Q08AP4; Q6STF9; Q96P77; Q96P78; Q9H028; Q9UGX1; Q9UGX2 |
Genbank Protein ID |
NP_001152758.1; NP_114408.3 |
Protein Name |
Histone deacetylase 10 |
Genbank Nucleotide ID |
NM_001159286.1; NM_032019.5 |
Gene Name |
HDAC10;HDA10 |
Ensembl Information |
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Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.20e-133 |
447.6 |
3 |
610 |
HDAC |
Class-I |
2.00e-26 |
95.6 |
26 |
316 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiy 93 ++lvy+e m++++ l+++ e+++E+peR++a l+rl+++gl +++++l+ar+a++eel lvHs e+v+l+++++ l keel++l+ ++d+iy ENSP00000216271.5 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIY 94 689***************************************************************************************** PP class-2.txt 94 lesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykd 185 ++++++++arla+Ga l+lvd+vl+g ++ng+a+vRPPGHH ++++a+GFC+fnnva+aa +++qk+ +++il+vDwDvHhG+G+q +f++d ENSP00000216271.5 95 FHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDD 186 ******************************************************************************************** PP class-2.txt 186 pkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvt 277 p+vly+S+HRy++g+f+p + ++++d+vg+g+g+gf+vN++wn+ +mg+a+y aaf +++lp+a eF+P+lvlvsaGfD+a gdp+g+++ t ENSP00000216271.5 187 PSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQAT 278 ******************************************************************************************** PP class-2.txt 278 akcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 ++c+a+lt+ l+ laggrv++vlEGGy+l+++ae+v ++v++Llg ENSP00000216271.5 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG 323 *******************************************96 PP class-2.txt 237 ylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkqllklaggrvvlvlE 301 +l + +vlp+a+ F+Pdlvlv+ G g+ l+ a l+ +l++laggrv+++lE ENSP00000216271.5 555 FLSCILGLVLPLAYGFQPDLVLVALGP----GHGLQ-----GPHAALLAAMLRGLAGGRVLALLE 610 56666779***************9994....22333.....333356788888888888888887 PP
HDAC Class-I
class-1.txt 22 mkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGasleaa 113 +p+rl+ + + + + gl+++ ++++++as eel +hs ey++++++ ++ +eel+ + +f+ + P f+ ++l +Ga l+ + ENSP00000216271.5 26 ERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP---STFHCARLAAGAGLQLV 114 57888888888899999*************************************999999999997665544...67899999********9 PP class-1.txt 114 kkLnkkeadiainw.aGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdrvmtvsfhkygee.ffP.. 199 + + ++ + ++ hh ++ a Gfc n++ +a + ++kh +r+l +d d+hhG g++ f+ v+ s h+y+++ f+P ENSP00000216271.5 115 DAVLTGAVQNGLALvRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHglHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGrFWPfl 206 99988776655544133459*******************99998876448*********************************985377733 PP class-1.txt 200 gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf.nlpll 289 d + vg ++g ++vn+P ++ g+ + y + f +++ ++ f+Pe v++ G Ds gD+ g+ + + + +a+ ++++ + ENSP00000216271.5 207 RESDADAVGRGQGLGFTVNLPWNQvGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLaGGRVC 298 46788999*************97659*****************************************************9999999666777 PP class-1.txt 290 vlGGGGYtlrnvaRcwty 307 + GGY l+ +a ++ ENSP00000216271.5 299 AVLEGGYHLESLAESVCM 316 788899999988865444 PP
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Protein Sequence (Fasta) | MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL SAREASEEEL 60 GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF HCARLAAGAG LQLVDAVLTG 120 AVQNGLALVR PPGHHGQRAA ANGFCVFNNV AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ 180 YLFEDDPSVL YFSWHRYEHG RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA 240 AFLHLLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV 300 LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ APHWKSLQQQ 360 DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD QPCLCPAPSV RTAVALTTPD 420 ITLVLPPDVI QQEASALREE TEAWARPHES LAREEALTAL GKLLYLLDGM LDGQVNSGIA 480 ATPASAAAAT LDVAVRRGLS HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS 540 MFHVSTPLPV MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL 600 AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL RGQLEPQWKM 660 LQCHPHLVA 669Protein Fasta Sequence
>ENSP00000216271.5|HDAC10;HDA10|Homo sapiens MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
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Nucleotide Sequence (Fasta) | GGCTCGGGGC GCCGAGGCTT CCGCGCCCGC TGGTTCCTCG CTCCGGGGCG GAGCTCGCGA 60 TAGCGACCGG GAGCAGGGCG CGGGGCGGGA CCCAGGTCCG AGGCGAGGAA GCCGGAAGCC 120 AGGCGCGGGG AGCCTCCCCC TTCGACTGCA GCCTCGCTCC GTGCCTTCTG CGCGCCTGGG 180 ATCCCGGAGC CTGCCTAGGT TCTGTGCGCT CCCGCCCAGG CCGGTGCCCG CCGCCCGCCT 240 GCGCCCCAGG CAGGTCCCAG GCCTCCGGCT GCTCCCGGCC GAAGGTGGGG ACAGGCAGTG 300 GCAGGCACCA CTAGCGAGGG CGTTTGGGAA CCCAGGGTGA CCACGGCGCA GCCATGGGGA 360 CCGCGCTTGT GTACCATGAG GACATGACGG CCACCCGGCT GCTCTGGGAC GACCCCGAGT 420 GCGAGATCGA GCGTCCTGAG CGCCTGACCG CAGCCCTGGA TCGCCTGCGG CAGCGCGGCC 480 TGGAACAGAG GTGTCTGCGG TTGTCAGCCC GCGAGGCCTC GGAAGAGGAG CTGGGCCTGG 540 TGCACAGCCC AGAGTATGTA TCCCTGGTCA GGGAGACCCA GGTCCTAGGC AAGGAGGAGC 600 TGCAGGCGCT GTCCGGACAG TTCGACGCCA TCTACTTCCA CCCGAGTACC TTTCACTGCG 660 CGCGGCTGGC CGCAGGGGCT GGACTGCAGC TGGTGGACGC TGTGCTCACT GGAGCTGTGC 720 AAAATGGGCT TGCCCTGGTG AGGCCTCCCG GGCACCATGG CCAGAGGGCG GCTGCCAACG 780 GGTTCTGTGT GTTCAACAAC GTGGCCATAG CAGCTGCACA TGCCAAGCAG AAACACGGGC 840 TACACAGGAT CCTCGTCGTG GACTGGGATG TGCACCATGG CCAGGGGATC CAGTATCTCT 900 TTGAGGATGA CCCCAGCGTC CTTTACTTCT CCTGGCACCG CTATGAGCAT GGGCGCTTCT 960 GGCCTTTCCT GCGAGAGTCA GATGCAGACG CAGTGGGGCG GGGACAGGGC CTCGGCTTCA 1020 CTGTCAACCT GCCCTGGAAC CAGGTTGGGA TGGGAAACGC TGACTACGTG GCTGCCTTCC 1080 TGCACCTGCT GCTCCCACTG GCCTTTGAGT TTGACCCTGA GCTGGTGCTG GTCTCGGCAG 1140 GATTTGACTC AGCCATCGGG GACCCTGAGG GGCAAATGCA GGCCACGCCA GAGTGCTTCG 1200 CCCACCTCAC ACAGCTGCTG CAGGTGCTGG CCGGCGGCCG GGTCTGTGCC GTGCTGGAGG 1260 GCGGCTACCA CCTGGAGTCA CTGGCGGAGT CAGTGTGCAT GACAGTACAG ACGCTGCTGG 1320 GTGACCCGGC CCCACCCCTG TCAGGGCCAA TGGCGCCATG TCAGAGTGCC CTAGAGTCCA 1380 TCCAGAGTGC CCGTGCTGCC CAGGCCCCGC ACTGGAAGAG CCTCCAGCAG CAAGATGTGA 1440 CCGCTGTGCC GATGAGCCCC AGCAGCCACT CCCCAGAGGG GAGGCCTCCA CCTCTGCTGC 1500 CTGGGGGTCC AGTGTGTAAG GCAGCTGCAT CTGCACCGAG CTCCCTCCTG GACCAGCCGT 1560 GCCTCTGCCC CGCACCCTCT GTCCGCACCG CTGTTGCCCT GACAACGCCG GATATCACAT 1620 TGGTTCTGCC CCCTGACGTC ATCCAACAGG AAGCGTCAGC CCTGAGGGAG GAGACAGAAG 1680 CCTGGGCCAG GCCACACGAG TCCCTGGCCC GGGAGGAGGC CCTCACTGCA CTTGGGAAGC 1740 TCCTGTACCT CTTAGATGGG ATGCTGGATG GGCAGGTGAA CAGTGGTATA GCAGCCACTC 1800 CAGCCTCTGC TGCAGCAGCC ACCCTGGATG TGGCTGTTCG GAGAGGCCTG TCCCACGGAG 1860 CCCAGAGGCT GCTGTGCGTG GCCCTGGGAC AGCTGGACCG GCCTCCAGAC CTCGCCCATG 1920 ACGGGAGGAG TCTGTGGCTG AACATCAGGG GCAAGGAGGC GGCTGCCCTA TCCATGTTCC 1980 ATGTCTCCAC GCCACTGCCA GTGATGACCG GTGGTTTCCT GAGCTGCATC TTGGGCTTGG 2040 TGCTGCCCCT GGCCTATGGC TTCCAGCCTG ACCTGGTGCT GGTGGCGCTG GGGCCTGGCC 2100 ATGGCCTGCA GGGCCCCCAC GCTGCACTCC TGGCTGCAAT GCTTCGGGGG CTGGCAGGGG 2160 GCCGAGTCCT GGCCCTCCTG GAGGAGAACT CCACACCCCA GCTAGCAGGG ATCCTGGCCC 2220 GGGTGCTGAA TGGAGAGGCA CCTCCTAGCC TAGGCCCTTC CTCTGTGGCC TCCCCAGAGG 2280 ACGTCCAGGC CCTGATGTAC CTGAGAGGGC AGCTGGAGCC TCAGTGGAAG ATGTTGCAGT 2340 GCCATCCTCA CCTGGTGGCT TGAAATCGGC CAAGGTGGGA GCATTTACAC CGCAGAAATG 2400 ACACCGCACG CCAGCGCCCC GCGGCCGCGA TCCGGACCCC AAGCCCACGG CTCCCTCGAC 2460 TCTGGGGCAC GGAACCCCGC CCACTCCCAA TCCCCGCGCC CCGCCCTCTC CCACCCGTGC 2520 TTCCCCCGCT CCACCCCTCA CCTCACCTCG CCCCCGCCCC ACCCATCGCG CCCCGGCCCG 2580 TCCCATCGAG GCCCATGCAA CCCACGCTCG GTCCCGTTCC GGCCCCTGCG CCCCGCTGCG 2640 CTTCGCTCCC CGCCCTTGCG CCGTTAGTAA ACATCGCTCA AACGAAA
2688Nucleotide Fasta Sequence
>ENSP00000216271.5|Class-I|Homo sapiens GGCTCGGGGCGCCGAGGCTTCCGCGCCCGCTGGTTCCTCGCTCCGGGGCGGAGCTCGCGATAGCGACCGGGAGCAGGGCGCGGGGCGGGACCCAGGTCCGAGGCGAGGAAGCCGGAAGCCAGGCGCGGGGAGCCTCCCCCTTCGACTGCAGCCTCGCTCCGTGCCTTCTGCGCGCCTGGGATCCCGGAGCCTGCCTAGGTTCTGTGCGCTCCCGCCCAGGCCGGTGCCCGCCGCCCGCCTGCGCCCCAGGCAGGTCCCAGGCCTCCGGCTGCTCCCGGCCGAAGGTGGGGACAGGCAGTGGCAGGCACCACTAGCGAGGGCGTTTGGGAACCCAGGGTGACCACGGCGCAGCCATGGGGACCGCGCTTGTGTACCATGAGGACATGACGGCCACCCGGCTGCTCTGGGACGACCCCGAGTGCGAGATCGAGCGTCCTGAGCGCCTGACCGCAGCCCTGGATCGCCTGCGGCAGCGCGGCCTGGAACAGAGGTGTCTGCGGTTGTCAGCCCGCGAGGCCTCGGAAGAGGAGCTGGGCCTGGTGCACAGCCCAGAGTATGTATCCCTGGTCAGGGAGACCCAGGTCCTAGGCAAGGAGGAGCTGCAGGCGCTGTCCGGACAGTTCGACGCCATCTACTTCCACCCGAGTACCTTTCACTGCGCGCGGCTGGCCGCAGGGGCTGGACTGCAGCTGGTGGACGCTGTGCTCACTGGAGCTGTGCAAAATGGGCTTGCCCTGGTGAGGCCTCCCGGGCACCATGGCCAGAGGGCGGCTGCCAACGGGTTCTGTGTGTTCAACAACGTGGCCATAGCAGCTGCACATGCCAAGCAGAAACACGGGCTACACAGGATCCTCGTCGTGGACTGGGATGTGCACCATGGCCAGGGGATCCAGTATCTCTTTGAGGATGACCCCAGCGTCCTTTACTTCTCCTGGCACCGCTATGAGCATGGGCGCTTCTGGCCTTTCCTGCGAGAGTCAGATGCAGACGCAGTGGGGCGGGGACAGGGCCTCGGCTTCACTGTCAACCTGCCCTGGAACCAGGTTGGGATGGGAAACGCTGACTACGTGGCTGCCTTCCTGCACCTGCTGCTCCCACTGGCCTTTGAGTTTGACCCTGAGCTGGTGCTGGTCTCGGCAGGATTTGACTCAGCCATCGGGGACCCTGAGGGGCAAATGCAGGCCACGCCAGAGTGCTTCGCCCACCTCACACAGCTGCTGCAGGTGCTGGCCGGCGGCCGGGTCTGTGCCGTGCTGGAGGGCGGCTACCACCTGGAGTCACTGGCGGAGTCAGTGTGCATGACAGTACAGACGCTGCTGGGTGACCCGGCCCCACCCCTGTCAGGGCCAATGGCGCCATGTCAGAGTGCCCTAGAGTCCATCCAGAGTGCCCGTGCTGCCCAGGCCCCGCACTGGAAGAGCCTCCAGCAGCAAGATGTGACCGCTGTGCCGATGAGCCCCAGCAGCCACTCCCCAGAGGGGAGGCCTCCACCTCTGCTGCCTGGGGGTCCAGTGTGTAAGGCAGCTGCATCTGCACCGAGCTCCCTCCTGGACCAGCCGTGCCTCTGCCCCGCACCCTCTGTCCGCACCGCTGTTGCCCTGACAACGCCGGATATCACATTGGTTCTGCCCCCTGACGTCATCCAACAGGAAGCGTCAGCCCTGAGGGAGGAGACAGAAGCCTGGGCCAGGCCACACGAGTCCCTGGCCCGGGAGGAGGCCCTCACTGCACTTGGGAAGCTCCTGTACCTCTTAGATGGGATGCTGGATGGGCAGGTGAACAGTGGTATAGCAGCCACTCCAGCCTCTGCTGCAGCAGCCACCCTGGATGTGGCTGTTCGGAGAGGCCTGTCCCACGGAGCCCAGAGGCTGCTGTGCGTGGCCCTGGGACAGCTGGACCGGCCTCCAGACCTCGCCCATGACGGGAGGAGTCTGTGGCTGAACATCAGGGGCAAGGAGGCGGCTGCCCTATCCATGTTCCATGTCTCCACGCCACTGCCAGTGATGACCGGTGGTTTCCTGAGCTGCATCTTGGGCTTGGTGCTGCCCCTGGCCTATGGCTTCCAGCCTGACCTGGTGCTGGTGGCGCTGGGGCCTGGCCATGGCCTGCAGGGCCCCCACGCTGCACTCCTGGCTGCAATGCTTCGGGGGCTGGCAGGGGGCCGAGTCCTGGCCCTCCTGGAGGAGAACTCCACACCCCAGCTAGCAGGGATCCTGGCCCGGGTGCTGAATGGAGAGGCACCTCCTAGCCTAGGCCCTTCCTCTGTGGCCTCCCCAGAGGACGTCCAGGCCCTGATGTACCTGAGAGGGCAGCTGGAGCCTCAGTGGAAGATGTTGCAGTGCCATCCTCACCTGGTGGCTTGAAATCGGCCAAGGTGGGAGCATTTACACCGCAGAAATGACACCGCACGCCAGCGCCCCGCGGCCGCGATCCGGACCCCAAGCCCACGGCTCCCTCGACTCTGGGGCACGGAACCCCGCCCACTCCCAATCCCCGCGCCCCGCCCTCTCCCACCCGTGCTTCCCCCGCTCCACCCCTCACCTCACCTCGCCCCCGCCCCACCCATCGCGCCCCGGCCCGTCCCATCGAGGCCCATGCAACCCACGCTCGGTCCCGTTCCGGCCCCTGCGCCCCGCTGCGCTTCGCTCCCCGCCCTTGCGCCGTTAGTAAACATCGCTCAAACGAAA
|
Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0378--Hydrolase KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0000118--C:histone deacetylase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0019899--F:enzyme binding GO:0004407--F:histone deacetylase activity GO:0042826--F:histone deacetylase binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558--F:protein deacetylase activity GO:0016568--P:chromatin modification GO:0016575--P:histone deacetylation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0014003--P:oligodendrocyte development GO:0006476--P:protein deacetylation GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |