WERAM Information


Tag Content
WERAM ID WERAM-Mae-0029
Ensembl Protein ID ENSMEUP00000002095.1
Gene Name HDAC10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMEUG00000002286.1 ENSMEUT00000002298.1 ENSMEUP00000002095.1
Status Unreviewed
Classification
Type Family E-value Score Start End
HDAC Class-II 1.20e-127 425.2 3 464
HDAC Class-I 1.80e-31 109.4 8 297
Organism Macropus eugenii
Domain Profile
  HDAC Class-II

           class-2.txt  22 khpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsdsiylesksikaarlavGavl 110
+ +E peR++a + rl ++gl++++++l ar+at+eel+lvHs e+v ++ +++++keel++l++++d++y++++++++ar+avGa+l
ENSMEUP00000002095.1 3 CAIEGPERLTATYARLCHRGLAQRCVRLPAREATEEELELVHSPEYVAVVKGTQTMNKEELHNLAQQYDAVYFHPSTFSCARMAVGATL 91
5789************************************************************************************* PP
class-2.txt 111 elvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykdpkvlylSlHRydkg 199
+lvd+vl+g + ng+a+vRPPGHH+++++a+GFC+fnnva+aa+++++++ ++++livDwD+HhG+Gtq if++dp+vly+S+HRy++
ENSMEUP00000002095.1 92 QLVDAVLTGAVGNGMALVRPPGHHSQRDAANGFCVFNNVAIAAEHAKRRHGLQRVLIVDWDIHHGQGTQGIFENDPSVLYFSWHRYEHQ 180
***************************************************************************************** PP
class-2.txt 200 sffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkql 288
sf+p++ ++++d vg+g+g gf+vNv+wn+ +mg+a+y +f +v+lp+a eF+P+lvlvsaGfD+ gdp+g+++ t++c+a+lt l
ENSMEUP00000002095.1 181 SFWPRLRESDYDVVGQGPGRGFTVNVPWNKVGMGNADYVSVFLHVLLPLAIEFDPELVLVSAGFDSGIGDPEGQMQATPECFAHLTLLL 269
***************************************************************************************** PP
class-2.txt 289 lklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
l la+gr+++vlEGGy+l+++ae+v ++++Llg
ENSMEUP00000002095.1 270 LPLARGRLCAVLEGGYHLQSLAECVCLTLQTLLG 303
********************************96 PP
class-2.txt 97 ksikaarlavGavlelvdkvlkgel 121
+ ++a a G +l l dk+l+g++
ENSMEUP00000002095.1 339 HEQDQALAALGKLLALLDKILAGQA 363
456678899999*******999986 PP
class-2.txt 236 eylaafrevvlpiakeFkPdlvlvsaG 262
+l a + ++lp+a++F+P+lvlv G
ENSMEUP00000002095.1 438 TFLLALTSLILPVAYSFQPELVLVVLG 464
5889999*****************877 PP

  HDAC Class-I

           class-1.txt  24 pkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGaslea 112
p+rl+ t +++ gl ++ ++ +++a+ eel +hs ey+ ++k ++ n+eel++ ++++ + P f+ +++ Ga+l+
ENSMEUP00000002095.1 8 PERLTATYARLCHRGLAQRCVRLPAREATEEELELVHSPEYVAVVKGTQTMNKEELHNLAQQYDAVYFHP---STFSCARMAVGATLQL 93
788899999999999**********************************999999999999987665544...6799999********* PP
class-1.txt 113 akkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdrvmtvsfhkygee. 196
++ + ++ +a+ hh++++ a Gfc n++ +a + ++ h +rvl +d d+hhG g + f++ v+ s h+y+++
ENSMEUP00000002095.1 94 VDAVLTGAVGngMALVRPP-GHHSQRDAANGFCVFNNVAIAAEHAKRRHglQRVLIVDWDIHHGQGTQGIFENDPSVLYFSWHRYEHQs 181
*999888765115555554.49********************9988865449*********************************9753 PP
class-1.txt 197 ffPg..tGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvk 282
f+P d + vg++ g+ ++vnvP ++ g+ + y ++f +v+ ++ f+Pe v++ G Ds gD+ g+ + + + +a+ ++
ENSMEUP00000002095.1 182 FWPRlrESDYDVVGQGPGRGFTVNVPWNKvGMGNADYVSVFLHVLLPLAIEFDPELVLVSAGFDSGIGDPEGQMQATPECFAHLTLLLL 270
8886225678889*************96549****************************************************777776 PP
class-1.txt 283 sf.nlpllvlGGGGYtlrnvaRcwtye 308
+ l + GGY l+ +a c +
ENSMEUP00000002095.1 271 PLaRGRLCAVLEGGYHLQSLAECVCLT 297
664888999999*********998865 PP

Protein Sequence
(Fasta)
PECAIEGPER LTATYARLCH RGLAQRCVRL PAREATEEEL ELVHSPEYVA VVKGTQTMNK 60
EELHNLAQQY DAVYFHPSTF SCARMAVGAT LQLVDAVLTG AVGNGMALVR PPGHHSQRDA 120
ANGFCVFNNV AIAAEHAKRR HGLQRVLIVD WDIHHGQGTQ GIFENDPSVL YFSWHRYEHQ 180
SFWPRLRESD YDVVGQGPGR GFTVNVPWNK VGMGNADYVS VFLHVLLPLA IEFDPELVLV 240
SAGFDSGIGD PEGQMQATPE CFAHLTLLLL PLARGRLCAV LEGGYHLQSL AECVCLTLQT 300
LLGDPVPALS GDPAPCLSSL ESIQNVRAAH APHWASLRHE QDQALAALGK LLALLDKILA 360
GQAVAPEVSA AMAVAIRKGL SWGAQRLLCV AIGDLDIPED LRDNGXXXXX XXXXXXXXXX 420
XXXXXXXXXX XXXXXXXTFL LALTSLILPV AYSFQPELVL VVLGPGCGLR SLDMELLTRL 480
LQGPVEGRML LLLQVDAELP LVEALAWALA GRALSSTLGP FFSASPKQAS AITHLCRQRQ 540
LYWPMLQ 547
Nucleotide Sequence
(Fasta)
CCTGAGTGTG CCATTGAGGG TCCTGAGCGT CTGACAGCCA CATATGCCCG GCTTTGTCAT 60
CGAGGACTGG CACAGAGGTG TGTGAGGCTG CCAGCCCGGG AGGCCACTGA GGAGGAGCTG 120
GAGCTGGTAC ACAGCCCAGA GTATGTGGCT GTGGTGAAGG GCACCCAGAC CATGAACAAA 180
GAAGAGCTCC ACAACCTGGC CCAGCAGTAT GACGCTGTCT ACTTTCACCC GAGCACGTTC 240
TCCTGTGCGC GAATGGCCGT GGGAGCCACC TTGCAGCTGG TGGACGCGGT ACTGACTGGA 300
GCCGTAGGCA ACGGGATGGC GCTGGTGAGG CCTCCCGGAC ACCACAGCCA GCGGGATGCT 360
GCCAACGGCT TCTGTGTATT TAACAATGTG GCTATTGCTG CAGAACATGC CAAGAGGAGA 420
CATGGGCTGC AGAGGGTCCT CATTGTTGAC TGGGATATTC ACCATGGGCA GGGGACCCAG 480
GGCATCTTTG AAAATGATCC CAGTGTCCTC TATTTCTCCT GGCATCGATA TGAGCACCAA 540
AGCTTCTGGC CTCGACTCCG GGAATCCGAT TACGATGTGG TGGGTCAGGG CCCCGGCAGA 600
GGCTTTACTG TCAACGTGCC CTGGAACAAG GTTGGGATGG GAAATGCTGA CTATGTGTCC 660
GTCTTCCTTC ATGTGCTGCT CCCCCTGGCC ATAGAGTTTG ACCCTGAGCT TGTCCTGGTG 720
TCAGCTGGAT TTGACTCTGG CATTGGGGAC CCTGAGGGGC AAATGCAGGC CACGCCCGAG 780
TGCTTCGCCC ACCTGACTCT TTTGCTGCTG CCACTGGCCC GGGGCCGGCT CTGTGCTGTA 840
CTTGAGGGCG GCTATCACTT GCAGTCTCTG GCTGAATGTG TATGTCTGAC CCTGCAGACT 900
TTGCTGGGAG ATCCTGTGCC AGCTCTCTCC GGGGATCCAG CTCCTTGTTT GAGCTCACTG 960
GAATCAATCC AGAATGTGAG AGCAGCCCAT GCCCCACACT GGGCAAGCCT CAGGCATGAA 1020
CAGGACCAGG CCCTTGCTGC CCTGGGGAAG CTCTTGGCTC TGCTGGACAA GATCCTGGCT 1080
GGGCAGGCTG TGGCCCCTGA AGTTTCAGCA GCCATGGCTG TAGCCATCCG CAAAGGCCTC 1140
AGCTGGGGGG CACAGAGGCT GCTGTGTGTG GCTATAGGAG ATTTGGACAT TCCTGAGGAC 1200
TTAAGGGACA ATGGNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1260
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN GACCTTCCTC 1320
TTGGCCCTCA CCAGCCTCAT CTTACCCGTG GCCTACAGTT TCCAGCCAGA GCTGGTGCTT 1380
GTGGTCCTGG GGCCAGGATG TGGCCTCCGC AGCCTGGACA TGGAGCTGCT CACCAGGCTA 1440
CTCCAGGGGC CAGTGGAGGG CCGAATGCTA CTGCTGCTGC AGGTGGATGC TGAGCTCCCA 1500
CTGGTGGAGG CTCTGGCCTG GGCCTTGGCG GGCCGGGCTC TCTCCAGCAC CCTGGGTCCC 1560
TTCTTCTCGG CCTCCCCAAA GCAAGCCTCG GCCATCACTC ACCTCTGTCG GCAGCGGCAG 1620
CTGTACTGGC CCATGCTGCA A 1642
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Sah-0095 ENSSHAP00000011018.1 Sarcophilus harrisii 93 0.0 653
WERAM-Mod-0049 ENSMODP00000006876.3 Monodelphis domestica 92 0.0 640
WERAM-Pes-0141 ENSPSIP00000016742.1 Pelodiscus sinensis 72 4e-155 545
WERAM-Hos-0058 ENSP00000216271.5 Homo sapiens 76 4e-152 535
WERAM-Pat-0122 ENSPTRP00000025053.4 Pan troglodytes 76 6e-152 535
WERAM-Gog-0159 ENSGGOP00000014095.2 Gorilla gorilla 76 2e-151 533
WERAM-Otg-0149 ENSOGAP00000012689.2 Otolemur garnettii 76 3e-151 532
WERAM-Nol-0005 ENSNLEP00000000692.2 Nomascus leucogenys 76 4e-151 532
WERAM-Chs-0051 ENSCSAP00000001305.1 Chlorocebus sabaeus 76 6e-151 531
WERAM-Fia-0117 ENSFALP00000010126.1 Ficedula albicollis 71 9e-150 527
WERAM-Anc-0012 ENSACAP00000019114.1 Anolis carolinensis 64 2e-149 526
WERAM-Eqc-0086 ENSECAP00000010704.1 Equus caballus 75 5e-149 525
WERAM-Paa-0009 ENSPANP00000013655.1 Papio anubis 75 5e-149 525
WERAM-Tut-0141 ENSTTRP00000011664.1 Tursiops truncatus 75 7e-149 524
WERAM-Fec-0119 ENSFCAP00000011049.3 Felis catus 75 7e-149 524
WERAM-Ere-0078 ENSEEUP00000006690.1 Erinaceus europaeus 75 1e-148 523
WERAM-Caf-0004 ENSCAFP00000000979.4 Canis familiaris 74 1e-148 523
WERAM-Mum-0213 ENSMUSP00000080832.5 Mus musculus 74 1e-147 520
WERAM-Aim-0036 ENSAMEP00000002564.1 Ailuropoda melanoleuca 73 2e-147 519
WERAM-Cap-0164 ENSCPOP00000013386.2 Cavia porcellus 75 1e-146 517
WERAM-Mup-0023 ENSMPUP00000002307.1 Mustela putorius furo 74 1e-146 516
WERAM-Sus-0012 ENSSSCP00000001039.2 Sus scrofa 73 3e-145 513
WERAM-Ict-0132 ENSSTOP00000013675.2 Ictidomys tridecemlineatus 74 3e-145 512
WERAM-Xet-0171 ENSXETP00000064083.1 Xenopus tropicalis 69 9e-145 511
WERAM-Meg-0084 ENSMGAP00000008226.2 Meleagris gallopavo 68 1e-144 511
WERAM-Anp-0022 ENSAPLP00000003127.1 Anas platyrhynchos 69 2e-144 510
WERAM-Bot-0106 ENSBTAP00000014602.4 Bos taurus 73 7e-143 504
WERAM-Gaga-0090 ENSGALP00000014065.4 Gallus gallus 68 8e-143 504
WERAM-Lac-0157 ENSLACP00000018610.1 Latimeria chalumnae 68 4e-140 495
WERAM-Myl-0003 ENSMLUP00000000417.2 Myotis lucifugus 72 9e-140 494
WERAM-Ova-0212 ENSOARP00000021243.1 Ovis aries 72 3e-138 489
WERAM-Orc-0191 ENSOCUP00000020861.2 Oryctolagus cuniculus 73 6e-138 488
WERAM-Caj-0034 ENSCJAP00000006067.1 Callithrix jacchus 73 1e-136 484
WERAM-Asm-0162 ENSAMXP00000016088.1 Astyanax mexicanus 67 1e-134 477
WERAM-Tag-0059 ENSTGUP00000004152.1 Taeniopygia guttata 71 2e-134 477
WERAM-Mam-0123 ENSMMUP00000018537.2 Macaca mulatta 70 3e-134 476
WERAM-Orla-0095 ENSORLP00000011723.1 Oryzias latipes 66 5e-133 472
WERAM-Orn-0102 ENSONIP00000011058.1 Oreochromis niloticus 66 6e-133 471
WERAM-Gaa-0030 ENSGACP00000005071.1 Gasterosteus aculeatus 65 5e-131 465
WERAM-Gam-0051 ENSGMOP00000005244.1 Gadus morhua 65 2e-130 463
WERAM-Tar-0203 ENSTRUP00000042351.1 Takifugu rubripes 65 6e-129 458
WERAM-Dar-0187 ENSDARP00000109870.2 Danio rerio 65 6e-129 458
WERAM-Pof-0123 ENSPFOP00000010612.2 Poecilia formosa 65 8e-129 458
WERAM-Xim-0154 ENSXMAP00000012744.1 Xiphophorus maculatus 65 2e-128 457
WERAM-Ect-0100 ENSETEP00000011415.1 Echinops telfairi 79 1e-127 454
WERAM-Tub-0095 ENSTBEP00000011284.1 Tupaia belangeri 70 8e-127 451
WERAM-Ptv-0046 ENSPVAP00000004918.1 Pteropus vampyrus 66 5e-123 438
WERAM-Poa-0105 ENSPPYP00000013362.1 Pongo abelii 65 2e-120 429
WERAM-Ran-0176 ENSRNOP00000052717.2 Rattus norvegicus 77 9e-120 428
WERAM-Leo-0157 ENSLOCP00000018907.1 Lepisosteus oculatus 61 1e-114 410
WERAM-Loa-0176 ENSLAFP00000017654.2 Loxodonta africana 70 2e-113 407
WERAM-Prc-0036 ENSPCAP00000003334.1 Procavia capensis 56 1e-106 384
WERAM-Dio-0075 ENSDORP00000007462.1 Dipodomys ordii 56 5e-106 382
WERAM-Ten-0019 ENSTNIP00000004593.1 Tetraodon nigroviridis 54 2e-97 353
WERAM-Dan-0147 ENSDNOP00000022283.1 Dasypus novemcinctus 59 1e-94 344
WERAM-Drm-0028 FBpp0290988 Drosophila melanogaster 49 1e-93 341
WERAM-Ocp-0057 ENSOPRP00000005096.1 Ochotona princeps 52 2e-92 337
WERAM-Pem-0058 ENSPMAP00000006830.1 Petromyzon marinus 53 4e-90 329
WERAM-Soa-0022 ENSSARP00000002183.1 Sorex araneus 51 1e-80 298
WERAM-Bro-0134 Bo7g098310.1 Brassica oleracea 42 5e-78 289
WERAM-Brr-0068 Bra012984.1-P Brassica rapa 42 1e-77 288
WERAM-Arl-0149 scaffold_802745.1 Arabidopsis lyrata 41 1e-77 288
WERAM-Tru-0053 TRIUR3_22556-P1 Triticum urartu 41 3e-76 283
WERAM-Brd-0010 BRADI1G22240.1 Brachypodium distachyon 41 4e-76 283
WERAM-Scj-0031 EEB08679 Schizosaccharomyces japonicus 42 5e-75 279
WERAM-Art-0147 AT5G61070.1 Arabidopsis thaliana 41 8e-75 278
WERAM-Asn-0017 CADANIAP00004063 Aspergillus nidulans 40 9e-75 278
WERAM-Tra-0016 Traes_1BL_9084A78D6.1 Triticum aestivum 41 1e-74 278
WERAM-Sei-0109 Si029091m Setaria italica 41 2e-74 277
WERAM-Lem-0023 CBX90551 Leptosphaeria maculans 40 2e-74 277
WERAM-Ors-0072 OS07T0602200-01 Oryza sativa 41 2e-74 277
WERAM-Orr-0082 ORUFI07G22240.1 Oryza rufipogon 41 2e-74 277
WERAM-Lep-0079 LPERR07G18450.1 Leersia perrieri 41 2e-74 277
WERAM-Orgl-0076 OGLUM07G21150.1 Oryza glumaepatula 41 2e-74 277
WERAM-Ori-0088 BGIOSGA026083-PA Oryza indica 41 2e-74 277
WERAM-Orni-0078 ONIVA07G19970.1 Oryza nivara 41 2e-74 277
WERAM-Sob-0036 Sb02g038550.1 Sorghum bicolor 41 2e-74 277
WERAM-Org-0078 ORGLA07G0164500.1 Oryza glaberrima 41 7e-74 275
WERAM-Orbr-0087 OB07G26850.1 Oryza brachyantha 40 2e-73 273
WERAM-Orp-0076 OPUNC07G19850.1 Oryza punctata 41 3e-73 273
WERAM-Hov-0018 MLOC_16422.1 Hordeum vulgare 43 3e-73 273
WERAM-Glm-0221 GLYMA17G08581.1 Glycine max 40 4e-73 273
WERAM-Sem-0022 EFJ08599 Selaginella moellendorffii 43 5e-73 272
WERAM-Zem-0143 GRMZM2G457889_P01 Zea mays 40 7e-73 272
WERAM-Prp-0049 EMJ12067 Prunus persica 40 9e-73 271
WERAM-Thc-0031 EOY22062 Theobroma cacao 40 1e-72 271
WERAM-Pot-0045 POPTR_0004s09180.1 Populus trichocarpa 39 2e-72 271
WERAM-Caa-0034 KGT64501 Candida albicans 37 2e-72 270
WERAM-Scp-0036 SPBC800.03.1:pep Schizosaccharomyces pombe 42 2e-72 270
WERAM-Ast-0014 CADATEAP00005667 Aspergillus terreus 39 2e-72 270
WERAM-Orb-0079 OBART07G21300.1 Oryza barthii 41 2e-72 270
WERAM-Cag-0018 CAG60803 Candida glabrata 39 2e-72 270
WERAM-Ora-0024 ENSOANP00000003575.1 Ornithorhynchus anatinus 59 3e-72 270
WERAM-Coi-0028 EAS30926 Coccidioides immitis 38 5e-72 269
WERAM-Asg-0010 AAS51704 Ashbya gossypii 40 7e-72 268
WERAM-Sac-0037 YNL021W Saccharomyces cerevisiae 39 1e-71 268
WERAM-Viv-0107 VIT_17s0000g07280.t01 Vitis vinifera 39 2e-71 267
WERAM-Asc-0002 CADACLAP00000048 Aspergillus clavatus 42 2e-71 267
WERAM-Php-0085 PP1S34_252V6.1 Physcomitrella patens 40 4e-71 266
WERAM-Pytr-0015 EDU46537 Pyrenophora triticirepentis 39 7e-71 265
WERAM-Kll-0020 CAG99415 Kluyveromyces lactis 38 3e-70 263
WERAM-Cae-0060 F41H10.6b Caenorhabditis elegans 41 6e-70 262
WERAM-Amt-0091 ERM99985 Amborella trichopoda 37 3e-69 260
WERAM-Sol-0055 Solyc03g115150.2.1 Solanum lycopersicum 37 9e-69 258
WERAM-Tum-0026 CAZ84932 Tuber melanosporum 37 1e-68 258
WERAM-Met-0112 KEH32016 Medicago truncatula 38 1e-68 258
WERAM-Pyt-0023 EFQ89752 Pyrenophora teres 38 1e-68 258
WERAM-Spr-0021 CBQ72644 Sporisorium reilianum 42 5e-68 256
WERAM-Mel-0037 EGG03660 Melampsora laricipopulina 39 1e-67 254
WERAM-Mua-0066 GSMUA_Achr4P03250_001 Musa acuminata 38 2e-67 254
WERAM-Aet-0030 EMT21577 Aegilops tauschii 40 2e-67 253
WERAM-Phn-0010 SNOT_01279 Phaeosphaeria nodorum 43 5e-67 253
WERAM-Pug-0031 EFP89333 Puccinia graminis 39 5e-67 252
WERAM-Yal-0023 CAG79971 Yarrowia lipolytica 38 6e-67 252
WERAM-Orl-0040 KN538895.1_FGP007 Oryza longistaminata 41 1e-66 251
WERAM-Tas-0021 ENSTSYP00000002661.1 Tarsius syrichta 40 2e-66 251
WERAM-Kop-0012 CAY68916 Komagataella pastoris 36 2e-66 250
WERAM-Miv-0034 MVLG_04888T0 Microbotryum violaceum 40 2e-66 250
WERAM-Mao-0002 MGG_01076T0 Magnaporthe oryzae 39 2e-65 247
WERAM-Usm-0012 UM02102P0 Ustilago maydis 40 3e-65 246
WERAM-Crn-0010 AAW42071 Cryptococcus neoformans 38 3e-65 246
WERAM-Trr-0039 EGR46026 Trichoderma reesei 39 9e-65 245
WERAM-Trv-0041 EHK18675 Trichoderma virens 39 4e-64 243
WERAM-Gag-0014 GGTG_04308T0 Gaeumannomyces graminis 38 1e-63 241
WERAM-Put-0014 PTTG_07163P0 Puccinia triticina 37 3e-63 240
WERAM-Chg-0033 EAQ86725 Chaetomium globosum 38 2e-62 237
WERAM-Nec-0012 EFNCRP00000001681 Neurospora crassa 38 2e-62 237
WERAM-Map-0033 MAPG_10880T0 Magnaporthe poae 39 3e-62 236
WERAM-Ved-0005 EGY17208 Verticillium dahliae 36 8e-62 235
WERAM-Zyt-0016 Mycgr3P37223 Zymoseptoria tritici 37 1e-61 235
WERAM-Fuo-0035 FOXG_13914P0 Fusarium oxysporum 36 3e-61 233
WERAM-Aso-0015 CADAORAP00001816 Aspergillus oryzae 37 3e-61 233
WERAM-Asfu-0010 CADAFUAP00002902 Aspergillus fumigatus 40 1e-60 231
WERAM-Sot-0015 PGSC0003DMT400014582 Solanum tuberosum 40 3e-60 230
Created Date 25-Jun-2016