| Tag |
Content |
| WERAM ID |
WERAM-Mum-0213 |
| Ensembl Protein ID |
ENSMUSP00000080832.5 |
| Uniprot Accession |
Q6P3E7; HDA10_MOUSE; G3X9I8
|
| Genbank Protein ID |
NP_954668.2
|
| Protein Name |
Histone deacetylase 10 |
| Genbank Nucleotide ID |
NM_199198.2
|
| Gene Name |
HDAC10 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-II |
2.50e-136 |
455.6 |
3 |
578 |
| HDAC |
Class-I |
7.80e-30 |
106 |
28 |
317 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
| Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsd 90
++lvy+e m++++ l+++ e+++E+peR++a l+ l+++gl e++++l+a +a++eel lvHs e++ l++++++l+keel++l+++++
ENSMUSP00000080832.5 3 TALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYN 91
689************************************************************************************** PP
class-2.txt 91 siylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtq 179
++y++++++++arla+Ga+l+lvd+vl+g ++ng+a+vRPPGHH+++++a+GFC+fnnva+aak+++qk+ +++ilivDwDvHhG+G+q
ENSMUSP00000080832.5 92 AVYFHPDTFHCARLAAGAALQLVDAVLTGAVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQKYGLQRILIVDWDVHHGQGIQ 180
***************************************************************************************** PP
class-2.txt 180 eifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaeg 268
if++dp+vly+S+HRy++gsf+p + ++++d+vg+g+g+gf+vN++wn+ +mg+a+ylaaf +v+lp+a eF+P+lvlvsaGfD+a g
ENSMUSP00000080832.5 181 YIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIG 269
***************************************************************************************** PP
class-2.txt 269 dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322
dp+g+++ t++c+a+lt+ l+ laggr+++vlEGGy+l+++a++v ++v++Llg
ENSMUSP00000080832.5 270 DPEGQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLG 323
****************************************************96 PP
class-2.txt 104 lavGavlelvdkvlkgelkngfa 126
+ G +l l d +++g+++n++a
ENSMUSP00000080832.5 456 ATLGKILCLLDGIMDGQIRNAIA 478
467999999999*****999998 PP
class-2.txt 236 eylaafrevvlpiakeFkPdlvlvsaG 262
+l ++ +vlp+a+ F+Pd+vl++ G
ENSMUSP00000080832.5 552 GFLSLILGLVLPLAYGFQPDMVLMALG 578
577888899**************9877 PP
HDAC Class-I
class-1.txt 24 pkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGaslea 112
p+rl+ + + + + gl+++ +++ +as eel +hs eyi +++k ++ ++eel+ +k++n + P + f+ ++l +Ga+l+
ENSMUSP00000080832.5 28 PERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYNAVYFHP---DTFHCARLAAGAALQL 113
66666666667778888888899999**************************************877655...78999*********** PP
class-1.txt 113 akkLnkkeadiainw.aGGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdrvmtvsfhkygee.f 197
++ + ++ + ++ hh+++ a Gfc n++ la + ++k+ +r+l +d d+hhG g++ f+ v+ s h+y+++ f
ENSMUSP00000080832.5 114 VDAVLTGAVHNGLALvRPPGHHSQRAAANGFCVFNNVALAAKHAKQKYglQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHRYEHGsF 202
*99988877655554133459********************9998854339*********************************98636 PP
class-1.txt 198 fP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvks 283
+P d + vg+++g+ ++vn+P ++ g+ + y + f +v+ ++ f+Pe v++ G Ds gD+ g+ + + + +a+ ++++
ENSMUSP00000080832.5 203 WPflPESDADAVGQGQGQGFTVNLPWNQvGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQV 291
66324678999**************97659*********************************************************99 PP
class-1.txt 284 f.nlpllvlGGGGYtlrnvaRcwtye 308
+ + GGY l+ +a+ ++
ENSMUSP00000080832.5 292 LaGGRICAVLEGGYHLESLAQSVCMM 317
9667788889999**99999877665 PP
|
Protein Sequence
(Fasta) | MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL SACEASEEEL 60
GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF HCARLAAGAA LQLVDAVLTG 120
AVHNGLALVR PPGHHSQRAA ANGFCVFNNV ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ 180
YIFNDDPSVL YFSWHRYEHG SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA 240
AFLHVLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 300
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ TPYWTSLQQN 360
VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL CLRPAPPICT AVASTVPGAA 420
LCLPPGVLHQ EGSVLREETE AWARLHKSRF QDEDLATLGK ILCLLDGIMD GQIRNAIATT 480
TALATAATLD VLIQRCLARR AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF 540
HFSTPLPQTT GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG 600
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA RLEARWKLLQ 660
VAAPPP 666Protein Fasta Sequence
>ENSMUSP00000080832.5|HDAC10|Mus musculus
MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPEYIALVQKTQTLDKEELHALSKQYNAVYFHPDTFHCARLAAGAALQLVDAVLTGAVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQKYGLQRILIVDWDVHHGQGIQYIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPTPPLLGLMVPCQSALESIQSVQTAQTPYWTSLQQNVAPVLSSSTHSPEERSLRLLGESPTCAVAEDSLSPLLDQLCLRPAPPICTAVASTVPGAALCLPPGVLHQEGSVLREETEAWARLHKSRFQDEDLATLGKILCLLDGIMDGQIRNAIATTTALATAATLDVLIQRCLARRAQRVLCVALGQLDRPLDLADDGRILWLNIRGKDAAIQSMFHFSTPLPQTTGGFLSLILGLVLPLAYGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILAVVEEESIRLLARSLAQALHGETPPSLGPFSKATPEEIQALMFLKARLEARWKLLQVAAPPP |
Nucleotide Sequence
(Fasta) | GGAAGCCGGA AGTTAGGCGT TTGGCGTCAC GCTTAGTTCA GTTTCCAGCG GTTCTCTTCT 60
GACAATCGGG CGGGCTTGAG CCCGGACCTG GGCCTGGGGT GGTTTCCTCT TGCCCAGGTC 120
CAGCGTGCAC AACCCAGTTC GTCCCGAGTG AGGATTGTTT ACGTGCATAG TTAGGTGAGA 180
CCGGGCAGTG CAATTACCTG CCGGCAGAGG GCGTGTTGCG TTAGAGCGGA TCAAAGTGAC 240
CACGGTGTAG CTATGGGCAC AGCACTTGTG TACCACGAGG ACATGACAGC CACTCGACTG 300
CTCTGGGATG ACCCCGAGTG CGAAATTGAG TGCCCAGAGC GCCTGACAGC TGCCCTGGAT 360
GGCCTGCGGC AGCGTGGCCT GGAAGAAAGG TGCCTGTGTT TGTCAGCTTG TGAGGCATCA 420
GAGGAAGAGT TGGGCTTGGT GCACAGCCCG GAATATATAG CCCTGGTGCA GAAGACCCAG 480
ACCCTGGATA AAGAGGAGCT CCACGCACTG TCTAAGCAGT ACAATGCTGT CTACTTTCAC 540
CCGGACACCT TTCACTGTGC CCGGCTGGCA GCGGGGGCTG CACTGCAGCT GGTCGATGCT 600
GTGCTAACAG GAGCTGTGCA CAATGGGCTT GCCCTGGTGA GGCCTCCAGG GCACCACAGT 660
CAGAGGGCAG CTGCCAATGG ATTCTGTGTG TTCAACAATG TGGCTCTAGC AGCCAAACAT 720
GCCAAGCAGA AATATGGGCT GCAGAGGATT CTCATTGTCG ACTGGGATGT CCACCATGGC 780
CAGGGCATCC AGTATATCTT CAACGATGAC CCCAGTGTCC TTTATTTCTC TTGGCACCGC 840
TATGAGCATG GAAGCTTCTG GCCGTTTCTC CCAGAGTCTG ATGCAGATGC AGTTGGCCAA 900
GGGCAGGGCC AAGGTTTCAC TGTCAATTTG CCCTGGAACC AGGTTGGGAT GGGAAATGCC 960
GACTATTTGG CTGCCTTTCT GCATGTGCTG CTCCCACTGG CCTTCGAGTT TGATCCTGAG 1020
TTGGTGCTGG TGTCGGCTGG ATTTGACTCT GCTATCGGGG ACCCTGAGGG GCAGATGCAG 1080
GCCACCCCTG AGTGCTTTGC CCATCTCACA CAGCTGCTGC AGGTGCTGGC TGGTGGCCGG 1140
ATTTGTGCTG TGTTGGAGGG TGGCTACCAC TTGGAGTCCC TAGCACAGTC AGTGTGCATG 1200
ATGGTGCAGA CACTGCTTGG TGACCCCACA CCTCCCCTTC TTGGGCTCAT GGTGCCATGT 1260
CAGAGTGCCC TGGAGTCCAT CCAGAGTGTC CAGACAGCCC AGACCCCTTA CTGGACAAGC 1320
CTCCAGCAAA ATGTGGCCCC AGTTCTGAGT TCCAGCACCC ACTCTCCTGA AGAGAGATCT 1380
CTGCGTCTGC TTGGTGAGAG CCCCACATGT GCAGTAGCAG AGGATTCACT GAGCCCCCTC 1440
CTGGACCAAC TGTGCCTCCG CCCTGCACCT CCAATCTGCA CAGCGGTGGC CTCGACTGTA 1500
CCAGGTGCTG CTCTGTGCTT ACCTCCTGGA GTGCTCCATC AAGAAGGGTC AGTCTTGAGG 1560
GAGGAGACCG AAGCCTGGGC CAGGCTTCAC AAATCCCGGT TCCAGGATGA GGATCTTGCC 1620
ACACTGGGGA AGATTCTGTG TCTCTTAGAT GGAATCATGG ATGGGCAGAT AAGAAATGCC 1680
ATAGCAACCA CAACTGCCCT CGCCACAGCA GCAACATTGG ATGTACTCAT TCAGCGATGC 1740
CTAGCTCGCA GAGCTCAGAG GGTGCTCTGT GTGGCCCTGG GACAACTGGA TCGACCCCTG 1800
GACCTTGCAG ATGATGGGAG AATTCTGTGG CTCAACATCC GGGGCAAGGA TGCAGCCATC 1860
CAGTCCATGT TCCACTTCTC CACTCCACTG CCACAGACAA CTGGAGGGTT TCTGAGCCTC 1920
ATTCTGGGTC TGGTACTGCC CTTGGCCTAT GGTTTCCAGC CTGATATGGT GTTGATGGCA 1980
CTGGGGCCTG CCCATGGCCT GCAGAACGCT CAAGCTGCTC TCTTGGCTGC AATGCTTCGG 2040
AGCCCAGTAG GGGGCCGAAT TCTAGCTGTA GTGGAAGAGG AATCCATACG CCTGCTTGCA 2100
AGGAGCCTGG CGCAGGCATT GCATGGAGAA ACACCTCCCA GTCTGGGTCC TTTCTCGAAG 2160
GCCACTCCAG AGGAGATCCA GGCTCTGATG TTTCTAAAAG CTCGGCTGGA GGCTCGCTGG 2220
AAATTGCTGC AGGTGGCTGC TCCTCCACCA TAATAACAGT GATTGCCAGT CGCTTGAAAT 2280
CGGTCAAGGT GGGCGATTCA CACGTGAAAA ATAGCACACT CGGGCCCCAG CGAACCATGG 2340
CCCGAGACCT ACGTCCCGTC TGCGGCCCAG GCGTCCTCTA CCTCCAGAAC AATAAACATC 2400
GGCCAAACAC AA
2413Nucleotide Fasta Sequence
>ENSMUSP00000080832.5|Class-I|Mus musculus
GGAAGCCGGAAGTTAGGCGTTTGGCGTCACGCTTAGTTCAGTTTCCAGCGGTTCTCTTCTGACAATCGGGCGGGCTTGAGCCCGGACCTGGGCCTGGGGTGGTTTCCTCTTGCCCAGGTCCAGCGTGCACAACCCAGTTCGTCCCGAGTGAGGATTGTTTACGTGCATAGTTAGGTGAGACCGGGCAGTGCAATTACCTGCCGGCAGAGGGCGTGTTGCGTTAGAGCGGATCAAAGTGACCACGGTGTAGCTATGGGCACAGCACTTGTGTACCACGAGGACATGACAGCCACTCGACTGCTCTGGGATGACCCCGAGTGCGAAATTGAGTGCCCAGAGCGCCTGACAGCTGCCCTGGATGGCCTGCGGCAGCGTGGCCTGGAAGAAAGGTGCCTGTGTTTGTCAGCTTGTGAGGCATCAGAGGAAGAGTTGGGCTTGGTGCACAGCCCGGAATATATAGCCCTGGTGCAGAAGACCCAGACCCTGGATAAAGAGGAGCTCCACGCACTGTCTAAGCAGTACAATGCTGTCTACTTTCACCCGGACACCTTTCACTGTGCCCGGCTGGCAGCGGGGGCTGCACTGCAGCTGGTCGATGCTGTGCTAACAGGAGCTGTGCACAATGGGCTTGCCCTGGTGAGGCCTCCAGGGCACCACAGTCAGAGGGCAGCTGCCAATGGATTCTGTGTGTTCAACAATGTGGCTCTAGCAGCCAAACATGCCAAGCAGAAATATGGGCTGCAGAGGATTCTCATTGTCGACTGGGATGTCCACCATGGCCAGGGCATCCAGTATATCTTCAACGATGACCCCAGTGTCCTTTATTTCTCTTGGCACCGCTATGAGCATGGAAGCTTCTGGCCGTTTCTCCCAGAGTCTGATGCAGATGCAGTTGGCCAAGGGCAGGGCCAAGGTTTCACTGTCAATTTGCCCTGGAACCAGGTTGGGATGGGAAATGCCGACTATTTGGCTGCCTTTCTGCATGTGCTGCTCCCACTGGCCTTCGAGTTTGATCCTGAGTTGGTGCTGGTGTCGGCTGGATTTGACTCTGCTATCGGGGACCCTGAGGGGCAGATGCAGGCCACCCCTGAGTGCTTTGCCCATCTCACACAGCTGCTGCAGGTGCTGGCTGGTGGCCGGATTTGTGCTGTGTTGGAGGGTGGCTACCACTTGGAGTCCCTAGCACAGTCAGTGTGCATGATGGTGCAGACACTGCTTGGTGACCCCACACCTCCCCTTCTTGGGCTCATGGTGCCATGTCAGAGTGCCCTGGAGTCCATCCAGAGTGTCCAGACAGCCCAGACCCCTTACTGGACAAGCCTCCAGCAAAATGTGGCCCCAGTTCTGAGTTCCAGCACCCACTCTCCTGAAGAGAGATCTCTGCGTCTGCTTGGTGAGAGCCCCACATGTGCAGTAGCAGAGGATTCACTGAGCCCCCTCCTGGACCAACTGTGCCTCCGCCCTGCACCTCCAATCTGCACAGCGGTGGCCTCGACTGTACCAGGTGCTGCTCTGTGCTTACCTCCTGGAGTGCTCCATCAAGAAGGGTCAGTCTTGAGGGAGGAGACCGAAGCCTGGGCCAGGCTTCACAAATCCCGGTTCCAGGATGAGGATCTTGCCACACTGGGGAAGATTCTGTGTCTCTTAGATGGAATCATGGATGGGCAGATAAGAAATGCCATAGCAACCACAACTGCCCTCGCCACAGCAGCAACATTGGATGTACTCATTCAGCGATGCCTAGCTCGCAGAGCTCAGAGGGTGCTCTGTGTGGCCCTGGGACAACTGGATCGACCCCTGGACCTTGCAGATGATGGGAGAATTCTGTGGCTCAACATCCGGGGCAAGGATGCAGCCATCCAGTCCATGTTCCACTTCTCCACTCCACTGCCACAGACAACTGGAGGGTTTCTGAGCCTCATTCTGGGTCTGGTACTGCCCTTGGCCTATGGTTTCCAGCCTGATATGGTGTTGATGGCACTGGGGCCTGCCCATGGCCTGCAGAACGCTCAAGCTGCTCTCTTGGCTGCAATGCTTCGGAGCCCAGTAGGGGGCCGAATTCTAGCTGTAGTGGAAGAGGAATCCATACGCCTGCTTGCAAGGAGCCTGGCGCAGGCATTGCATGGAGAAACACCTCCCAGTCTGGGTCCTTTCTCGAAGGCCACTCCAGAGGAGATCCAGGCTCTGATGTTTCTAAAAGCTCGGCTGGAGGCTCGCTGGAAATTGCTGCAGGTGGCTGCTCCTCCACCATAATAACAGTGATTGCCAGTCGCTTGAAATCGGTCAAGGTGGGCGATTCACACGTGAAAAATAGCACACTCGGGCCCCAGCGAACCATGGCCCGAGACCTACGTCCCGTCTGCGGCCCAGGCGTCCTCTACCTCCAGAACAATAAACATCGGCCAAACACAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558--F:protein deacetylase activity
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0014003--P:oligodendrocyte development
GO:0006476--P:protein deacetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
