Tag |
Content |
WERAM ID |
WERAM-Art-0147 |
Ensembl Protein ID |
AT5G61070.1 |
Uniprot Accession |
Q8LRK8; HDA18_ARATH; Q9FNQ7 |
Genbank Protein ID |
NP_200915.2 |
Protein Name |
Histone deacetylase 18 |
Genbank Nucleotide ID |
NM_125500.2 |
Gene Name |
HDA18;At5g61070;MAF19.8 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689640; 26689639 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.80e-131 |
439 |
60 |
591 |
HDAC |
Class-I |
1.30e-34 |
121 |
62 |
369 |
|
Organism |
Arabidopsis thaliana |
NCBI Taxa ID |
3702 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletae.klekeelesltvdsdsiylesks 98 +glvyde+m+kh+++++++ +E+p+Ri+ i+++lq ag++++++ l ++ka++++l+lvH+++hv+l+++ + k+++++ ++++++ dsiyl+ s AT5G61070.1 60 VGLVYDETMCKHDTPNGKV--DVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSIStKKKDSRRNKIASQLDSIYLNGGS 155 78***************99..8**************************************************998999999999************** PP class-2.txt 99 ikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklk...vkkilivDwDvHhGnGtqeifykdpkvlylSl 193 ++aa la+G+v+++++kv++gel++gfa+vRPPGHHae+++amGFClfnnvavaa+ l+++ + vkkilivDwD+HhGnGtq++f+kd++vl++S+ AT5G61070.1 156 SEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERPdldVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSV 253 **********************************************************99987777******************************** PP class-2.txt 194 HRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkqllkl 291 HR+d+gsf+p ++g+++ vgeg+gegfn+Nv+w++g++gda+yla+++++++p++keFkPd++l+saGfDaa gdplgg++vt+ +y+ + k+l+++ AT5G61070.1 254 HRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEF 351 ************************************************************************************************** PP class-2.txt 292 aggrvvlvlEGGynlkaiaeaveavvkaLl 321 a+g++vl+lEGGynl+++ +++ a+v++Ll AT5G61070.1 352 AHGKIVLALEGGYNLESLGKSSLACVQVLL 381 *****************************8 PP class-2.txt 19 nkekhpEkpeRiqailsrlqeagllekleelkarkatke.elqlvHseehvelletae.klekeel 82 ++++ E++e + l+r +e ++ k + l+a+++++e l+lvH +e + + ++ ++e+ e AT5G61070.1 526 RSQEFKEDTEFCLSTLRREKELAIMAKNKDLEAKEKELEaRLMLVHAREDKIHAKIERlQQERDEA 591 445577888888888888888899999999999776655279999976654444444323333333 PP
HDAC Class-I
class-1.txt 5 yaydedvgeyhy..gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcP.vfdglf 99 +yde++ ++ + g+ + p r++++ e + g++++ ++ +ka+ ++l +h++++++++k+++++++++ ++++ + d+ + g AT5G61070.1 62 LVYDETMCKHDTpnGKVDVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSISTKKKDSRRNKIA---SQLDSIyLNGGSS 156 56777776666522555677899*****9999999***********************************999887664433...3444440455677 PP class-1.txt 100 eycqlitGasleaakkLnkkeadi..ainwaGGlhhakkseasGfcyvnDivlailellk.....khkrvlyididlhhGDgveeafyttdrvmtvsf 190 e + l +G+ ++ a+k+ ++e d ai hha +ea Gfc n++ +a ll k++l +d d+hhG+g ++ f + +rv+ s+ AT5G61070.1 157 EAAYLAAGSVVKVAEKVAEGELDCgfAIVRPP-GHHAESDEAMGFCLFNNVAVAASFLLNerpdlDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSV 253 888899999**********9988611555554.5*******************999988733333479****************************** PP class-1.txt 191 hkygee.ffP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf 284 h+++++ f+P Gd++ vg++ g + +nvP ++ g+ D y ++ ++++ +v++ f+P++++l G D+ gD+lg ++ g++ ++k + +f AT5G61070.1 254 HRHDHGsFYPfgDDGDFNMVGEGPGEGFNINVPWEQgGCGDADYLAVWNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEF 351 **9875377743579******************98737************************************************************ PP class-1.txt 285 .nlpllvlGGGGYtlrnv 301 + ++++ GGY+l+ + AT5G61070.1 352 aHGKIVLALEGGYNLESL 369 44455556689**99876 PP
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Protein Sequence (Fasta) | MLLKFEASSE LRLVDPSVSL TVLRKIRLSH LPDMTMTSES SGKKCGEGDG KVAGKSQRKV 60 GLVYDETMCK HDTPNGKVDV ECPDRIRVIW EKLQLAGVTQ RCVVLGGSKA EDKHLKLVHT 120 KKHVNLVKSI STKKKDSRRN KIASQLDSIY LNGGSSEAAY LAAGSVVKVA EKVAEGELDC 180 GFAIVRPPGH HAESDEAMGF CLFNNVAVAA SFLLNERPDL DVKKILIVDW DIHHGNGTQK 240 MFWKDSRVLI FSVHRHDHGS FYPFGDDGDF NMVGEGPGEG FNINVPWEQG GCGDADYLAV 300 WNHILIPVTK EFKPDIILLS AGFDAAIGDP LGGCCVTPYG YSVMLKKLME FAHGKIVLAL 360 EGGYNLESLG KSSLACVQVL LEDKQIHGSS ETYPLESTRR VIQAVRERLC TYWPSLDASM 420 ASNENLKNPS AERNSADALL REVEELKSLM AARDGELEAR RKELKAKNKE LEANEKELEA 480 GLMLIRARED VICGLHAKIE SLQQERDEAV AKAERIDKEL QEDRARSQEF KEDTEFCLST 540 LRREKELAIM AKNKDLEAKE KELEARLMLV HAREDKIHAK IERLQQERDE AVAKAERIDK 600 ELQEDRSRSR VGNGSFAFSQ EFYEDMDLDE LEPLSPEFNE DMDSEELEPF QVIKKNMERS 660 HKKFIKDMEC IKFIASERAR VL 682Protein Fasta Sequence
>AT5G61070.1|HDA18;At5g61070;MAF19.8|Arabidopsis thaliana MLLKFEASSELRLVDPSVSLTVLRKIRLSHLPDMTMTSESSGKKCGEGDGKVAGKSQRKVGLVYDETMCKHDTPNGKVDVECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSISTKKKDSRRNKIASQLDSIYLNGGSSEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSVHRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIPVTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLESLGKSSLACVQVLLEDKQIHGSSETYPLESTRRVIQAVRERLCTYWPSLDASMASNENLKNPSAERNSADALLREVEELKSLMAARDGELEARRKELKAKNKELEANEKELEAGLMLIRAREDVICGLHAKIESLQQERDEAVAKAERIDKELQEDRARSQEFKEDTEFCLSTLRREKELAIMAKNKDLEAKEKELEARLMLVHAREDKIHAKIERLQQERDEAVAKAERIDKELQEDRSRSRVGNGSFAFSQEFYEDMDLDELEPLSPEFNEDMDSEELEPFQVIKKNMERSHKKFIKDMECIKFIASERARVL
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Nucleotide Sequence (Fasta) | ATGCTTTTGA AGTTTGAAGC TTCTTCAGAG TTGAGACTAG TTGACCCTTC AGTTTCTCTC 60 ACTGTTCTTC GAAAGATAAG ACTGTCACAT CTCCCGGATA TGACAATGAC CAGCGAATCT 120 TCCGGCAAGA AATGCGGAGA GGGTGACGGC AAAGTCGCCG GTAAAAGCCA GCGAAAGGTG 180 GGTCTTGTTT ATGACGAGAC CATGTGCAAA CACGACACAC CTAACGGTAA GGTTGACGTA 240 GAGTGTCCCG ATCGTATCAG AGTTATCTGG GAGAAGCTTC AGCTCGCCGG AGTCACTCAA 300 AGATGTGTGG TTCTTGGTGG TAGTAAAGCT GAAGATAAGC ATCTCAAATT GGTTCACACA 360 AAGAAACATG TTAATTTAGT GAAGAGTATT AGCACAAAAA AGAAAGATTC TCGGAGAAAC 420 AAGATTGCTT CACAGTTGGA TTCGATTTAT CTGAATGGAG GTTCATCTGA AGCTGCATAT 480 CTTGCAGCTG GATCTGTTGT AAAGGTGGCA GAGAAAGTTG CAGAAGGAGA GTTAGATTGT 540 GGCTTTGCTA TTGTCAGGCC CCCAGGACAC CATGCCGAGT CAGATGAAGC CATGGGTTTT 600 TGTTTATTCA ACAATGTTGC CGTTGCTGCT AGTTTTTTAC TAAACGAAAG ACCTGATCTA 660 GATGTCAAGA AAATTCTGAT TGTCGATTGG GATATCCATC ACGGAAATGG TACACAGAAG 720 ATGTTCTGGA AAGATTCTCG CGTACTAATA TTCTCTGTTC ATAGGCATGA TCACGGAAGT 780 TTCTATCCAT TTGGCGATGA TGGAGACTTT AACATGGTTG GCGAAGGTCC AGGTGAAGGG 840 TTTAACATTA ACGTTCCATG GGAGCAAGGA GGATGTGGAG ATGCAGACTA TCTTGCCGTA 900 TGGAACCACA TCTTGATCCC TGTGACCAAG GAATTCAAAC CAGATATTAT TTTGCTTTCA 960 GCTGGATTTG ATGCAGCTAT TGGTGATCCG CTTGGGGGTT GTTGTGTTAC CCCATATGGA 1020 TATTCAGTTA TGTTGAAGAA GCTGATGGAG TTTGCACATG GAAAGATAGT GCTGGCATTA 1080 GAGGGAGGAT ACAATCTTGA GTCATTGGGA AAGTCTTCAC TCGCATGTGT CCAAGTTTTG 1140 CTTGAAGACA AACAAATTCA TGGTTCATCT GAAACATACC CATTAGAATC TACACGGCGT 1200 GTCATACAAG CGGTACGCGA GAGACTATGC ACATATTGGC CTTCACTTGA CGCGTCAATG 1260 GCGTCTAATG AGAATTTAAA GAACCCAAGT GCAGAAAGAA ACTCCGCTGA CGCCCTCCTT 1320 CGTGAAGTGG AAGAGTTAAA GTCTCTAATG GCTGCCCGAG ATGGAGAACT GGAGGCAAGG 1380 AGAAAAGAGT TAAAGGCCAA AAATAAGGAG CTAGAAGCGA ACGAGAAGGA GCTAGAAGCG 1440 GGACTAATGT TGATTCGCGC TCGGGAGGAT GTAATCTGTG GTCTTCATGC AAAAATAGAG 1500 AGTTTGCAGC AGGAGCGAGA TGAGGCGGTA GCGAAAGCTG AACGCATAGA TAAGGAACTC 1560 CAAGAGGATA GGGCAAGAAG CCAGGAGTTC AAAGAAGACA CAGAGTTTTG CTTGAGTACG 1620 TTAAGGAGGG AGAAGGAGCT TGCCATCATG GCCAAAAATA AGGACCTAGA AGCGAAAGAG 1680 AAGGAGCTAG AAGCGCGGCT AATGTTGGTT CACGCTCGGG AGGATAAAAT TCATGCCAAA 1740 ATAGAGAGGT TGCAGCAGGA GCGAGATGAG GCCGTAGCAA AAGCTGAACG CATAGATAAG 1800 GAACTCCAAG AGGATAGGTC AAGAAGCCGA GTTGGGAATG GATCTTTTGC CTTTTCTCAG 1860 GAGTTCTATG AAGACATGGA CTTAGACGAG CTCGAACCTC TGTCTCCGGA GTTCAATGAA 1920 GACATGGACT CGGAAGAGCT TGAACCGTTT CAGGTCATCA AGAAAAACAT GGAGCGTTCC 1980 CACAAGAAGT TCATAAAAGA TATGGAGTGT ATCAAGTTTA TCGCCAGTGA GAGAGCCAGG 2040 GTACTTTAGG TTGGGAGCTT GAGGCCGTAG CAGAAGACTA CCACAAGTTT CGCGAGATGG 2100 TTGATAAGCT CGGGAAGAGC AACATATACC CTTCTTAGAA AGTACAATGG TGTTTCATTG 2160 TAACCACAGA ACCTT
2176Nucleotide Fasta Sequence
>AT5G61070.1|Class-I|Arabidopsis thaliana ATGCTTTTGAAGTTTGAAGCTTCTTCAGAGTTGAGACTAGTTGACCCTTCAGTTTCTCTCACTGTTCTTCGAAAGATAAGACTGTCACATCTCCCGGATATGACAATGACCAGCGAATCTTCCGGCAAGAAATGCGGAGAGGGTGACGGCAAAGTCGCCGGTAAAAGCCAGCGAAAGGTGGGTCTTGTTTATGACGAGACCATGTGCAAACACGACACACCTAACGGTAAGGTTGACGTAGAGTGTCCCGATCGTATCAGAGTTATCTGGGAGAAGCTTCAGCTCGCCGGAGTCACTCAAAGATGTGTGGTTCTTGGTGGTAGTAAAGCTGAAGATAAGCATCTCAAATTGGTTCACACAAAGAAACATGTTAATTTAGTGAAGAGTATTAGCACAAAAAAGAAAGATTCTCGGAGAAACAAGATTGCTTCACAGTTGGATTCGATTTATCTGAATGGAGGTTCATCTGAAGCTGCATATCTTGCAGCTGGATCTGTTGTAAAGGTGGCAGAGAAAGTTGCAGAAGGAGAGTTAGATTGTGGCTTTGCTATTGTCAGGCCCCCAGGACACCATGCCGAGTCAGATGAAGCCATGGGTTTTTGTTTATTCAACAATGTTGCCGTTGCTGCTAGTTTTTTACTAAACGAAAGACCTGATCTAGATGTCAAGAAAATTCTGATTGTCGATTGGGATATCCATCACGGAAATGGTACACAGAAGATGTTCTGGAAAGATTCTCGCGTACTAATATTCTCTGTTCATAGGCATGATCACGGAAGTTTCTATCCATTTGGCGATGATGGAGACTTTAACATGGTTGGCGAAGGTCCAGGTGAAGGGTTTAACATTAACGTTCCATGGGAGCAAGGAGGATGTGGAGATGCAGACTATCTTGCCGTATGGAACCACATCTTGATCCCTGTGACCAAGGAATTCAAACCAGATATTATTTTGCTTTCAGCTGGATTTGATGCAGCTATTGGTGATCCGCTTGGGGGTTGTTGTGTTACCCCATATGGATATTCAGTTATGTTGAAGAAGCTGATGGAGTTTGCACATGGAAAGATAGTGCTGGCATTAGAGGGAGGATACAATCTTGAGTCATTGGGAAAGTCTTCACTCGCATGTGTCCAAGTTTTGCTTGAAGACAAACAAATTCATGGTTCATCTGAAACATACCCATTAGAATCTACACGGCGTGTCATACAAGCGGTACGCGAGAGACTATGCACATATTGGCCTTCACTTGACGCGTCAATGGCGTCTAATGAGAATTTAAAGAACCCAAGTGCAGAAAGAAACTCCGCTGACGCCCTCCTTCGTGAAGTGGAAGAGTTAAAGTCTCTAATGGCTGCCCGAGATGGAGAACTGGAGGCAAGGAGAAAAGAGTTAAAGGCCAAAAATAAGGAGCTAGAAGCGAACGAGAAGGAGCTAGAAGCGGGACTAATGTTGATTCGCGCTCGGGAGGATGTAATCTGTGGTCTTCATGCAAAAATAGAGAGTTTGCAGCAGGAGCGAGATGAGGCGGTAGCGAAAGCTGAACGCATAGATAAGGAACTCCAAGAGGATAGGGCAAGAAGCCAGGAGTTCAAAGAAGACACAGAGTTTTGCTTGAGTACGTTAAGGAGGGAGAAGGAGCTTGCCATCATGGCCAAAAATAAGGACCTAGAAGCGAAAGAGAAGGAGCTAGAAGCGCGGCTAATGTTGGTTCACGCTCGGGAGGATAAAATTCATGCCAAAATAGAGAGGTTGCAGCAGGAGCGAGATGAGGCCGTAGCAAAAGCTGAACGCATAGATAAGGAACTCCAAGAGGATAGGTCAAGAAGCCGAGTTGGGAATGGATCTTTTGCCTTTTCTCAGGAGTTCTATGAAGACATGGACTTAGACGAGCTCGAACCTCTGTCTCCGGAGTTCAATGAAGACATGGACTCGGAAGAGCTTGAACCGTTTCAGGTCATCAAGAAAAACATGGAGCGTTCCCACAAGAAGTTCATAAAAGATATGGAGTGTATCAAGTTTATCGCCAGTGAGAGAGCCAGGGTACTTTAGGTTGGGAGCTTGAGGCCGTAGCAGAAGACTACCACAAGTTTCGCGAGATGGTTGATAAGCTCGGGAAGAGCAACATATACCCTTCTTAGAAAGTACAATGGTGTTTCATTGTAACCACAGAACCTT
|
Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0175--Coiled coil KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0005634--C:nucleus GO:0004407--F:histone deacetylase activity GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0006338--P:chromatin remodeling GO:0016575--P:histone deacetylation GO:0045604--P:regulation of epidermal cell differentiation GO:0006355--P:regulation of transcription, DNA-templated GO:0010053--P:root epidermal cell differentiation GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |