| Tag |
Content |
| WERAM ID |
WERAM-Drm-0025 |
| Ensembl Protein ID |
FBpp0078414 |
| Uniprot Accession |
Q7KTS4; Q7KTS4_DROME
|
| Genbank Protein ID |
NP_651978.2
|
| Protein Name |
Histone deacetylase |
| Genbank Nucleotide ID |
NM_143721.4
|
| Gene Name |
HDAC3;CG2128 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Hist_deacetyl |
H2A; H2B; H3; H4 |
K |
12466527
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
6.80e-163 |
542.2 |
4 |
320 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View) |
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae....elskelkkfnvgedcPv 94
++v+y+y+ dvg++hyg++hpmkp+rl++th+Lv+nygl+kk++i++p kasa+++l+fhs+eyi +l++v+p+n + ++k l++f+vgedcPv
FBpp0078414 4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQcnsvAYTKYLAHFSVGEDCPV 101
589************************************************************************998888889************** PP
class-1.txt 95 fdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhk 192
fdglf++c+++tGasle+a+kLn++++di+inw+GGlhhakk easGfcyvnDiv++ilellk+h+rvlyidid+hhGDgv+eafy tdrvmt sfhk
FBpp0078414 102 FDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHK 199
************************************************************************************************** PP
class-1.txt 193 ygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllv 290
yg++ffPgtGd++++gae+g+yy+vnvPlk+gidD+sy ++fk++is ++++++P+a+vlqcGaDslagDrlg+f+ls+kgh+ecvkfvk+ n+p+lv
FBpp0078414 200 YGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLV 297
************************************************************************************************** PP
class-1.txt 291 lGGGGYtlrnvaRcwtyetavvl 313
+GGGGYtlrnvaRcwt+et++++
FBpp0078414 298 VGGGGYTLRNVARCWTHETSLLV 320
********************987 PP
|
Protein Sequence
(Fasta) | MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLHKKMKIYR PYKASAQDML 60
RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP VFDGLFDFCA MYTGASLEGA 120
QKLNHNHSDI CINWSGGLHH AKKFEASGFC YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD 180
GVQEAFYLTD RVMTASFHKY GNYFFPGTGD MYEIGAESGR YYSVNVPLKE GIDDQSYFQV 240
FKPIISAIMD FYRPTAIVLQ CGADSLAGDR LGCFSLSTKG HGECVKFVKE LNVPTLVVGG 300
GGYTLRNVAR CWTHETSLLV DQDIENDLPA TEYYDFFAPD FTLHPEINSR QDNANSKQYL 360
ELIVKHVYEN LKMCQHSPSV QMVQTPPDVD LEELRSNREE ASDPDVRISV ADEDKLVDAK 420
NEFYDGDQDQ DKPDSAES 438Protein Fasta Sequence
>FBpp0078414|HDAC3;CG2128|Drosophila melanogaster
MTDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQDQDKPDSAES |
Nucleotide Sequence
(Fasta) | TTAGTACACT ATCGGCGCAC GCCGCTTTAA GTTGTCTTCA ATTGGCAATA AGTTAGCAAA 60
TTGATATCTC ACGATTAAAC AAAGGTACCC AAAGGTGACC ACGGGAGCGG CATGCTGTTG 120
GGCGAATACG ACACAACCCG GCGACTCCTT TTCATCGTGG CCGTTCTGCT GATTGTCCTG 180
TATGCGAAGA CGTACCTGCT GCCCGGCGAG GATTTGGTCC ACAACTAGGG GACTACGGCG 240
TCCCTGCAAT AACCGATCCA ATTGAGAAGT TGGCGCGATG ACGGACCGTA GGGTGTCGTA 300
CTTCTACAAC GCGGACGTGG GCAACTTCCA CTATGGAGCC GGGCATCCCA TGAAGCCGCA 360
ACGCCTGGCG GTCACTCACA GCCTGGTAAT GAACTACGGA CTGCACAAGA AAATGAAGAT 420
CTACAGGCCG TACAAGGCCA GTGCGCAGGA CATGCTCCGC TTCCACAGCG ACGAGTACAT 480
CGCCTACTTA CAGCAGGTGA CTCCACAAAA CATTCAGTGC AATTCCGTGG CCTATACGAA 540
GTACCTGGCG CACTTCAGCG TAGGCGAGGA CTGTCCCGTG TTCGATGGCC TCTTCGACTT 600
CTGTGCAATG TACACGGGTG CCTCGCTGGA GGGAGCCCAG AAGCTGAACC ACAACCACAG 660
CGACATATGC ATAAACTGGT CGGGCGGACT GCATCACGCC AAGAAGTTCG AGGCAAGCGG 720
ATTCTGCTAC GTGAATGACA TCGTCATCGG CATTCTGGAG CTGCTTAAGT ACCATCCTCG 780
GGTGCTCTAC ATCGACATCG ATGTGCACCA CGGCGACGGG GTGCAGGAGG CGTTCTACCT 840
TACGGACCGA GTGATGACGG CTTCGTTCCA CAAATACGGA AACTACTTTT TTCCCGGCAC 900
GGGAGACATG TACGAGATAG GCGCCGAATC GGGACGATAC TACAGCGTTA ATGTGCCGCT 960
AAAGGAGGGC ATTGATGACC AGAGCTATTT TCAGGTGTTC AAACCCATAA TTTCTGCCAT 1020
TATGGACTTC TACCGGCCCA CGGCTATCGT TTTGCAGTGT GGCGCGGATT CACTAGCTGG 1080
AGATCGACTA GGTTGCTTCT CCCTGAGCAC CAAGGGACAT GGTGAGTGTG TCAAATTTGT 1140
GAAGGAACTG AACGTACCCA CATTGGTGGT CGGAGGCGGT GGCTACACCT TACGGAACGT 1200
GGCCCGCTGC TGGACGCACG AGACCTCGCT GCTGGTGGAC CAAGACATTG AAAATGACCT 1260
ACCCGCCACC GAGTATTACG ACTTTTTCGC CCCCGACTTT ACACTCCATC CAGAGATTAA 1320
CTCACGCCAA GATAATGCTA ACTCAAAGCA GTATCTTGAA CTCATCGTTA AGCATGTGTA 1380
TGAAAACCTT AAGATGTGCC AGCACTCGCC CAGCGTCCAA ATGGTGCAGA CCCCGCCTGA 1440
TGTGGACTTG GAGGAGCTGC GCAGCAACCG GGAGGAGGCG AGTGATCCCG ACGTGCGAAT 1500
ATCCGTAGCC GATGAGGACA AGCTGGTTGA TGCTAAGAAC GAGTTCTACG ACGGCGATCA 1560
GGACCAAGAC AAGCCCGATT CGGCAGAAAG TTAGTATTGG ATAATGTAGA ATAAGGATTC 1620
GAGTTTAGCG TAAGCAGTAA AGAGTATCAG CTTATTTTGT
1661Nucleotide Fasta Sequence
>FBpp0078414|Class-I|Drosophila melanogaster
TTAGTACACTATCGGCGCACGCCGCTTTAAGTTGTCTTCAATTGGCAATAAGTTAGCAAATTGATATCTCACGATTAAACAAAGGTACCCAAAGGTGACCACGGGAGCGGCATGCTGTTGGGCGAATACGACACAACCCGGCGACTCCTTTTCATCGTGGCCGTTCTGCTGATTGTCCTGTATGCGAAGACGTACCTGCTGCCCGGCGAGGATTTGGTCCACAACTAGGGGACTACGGCGTCCCTGCAATAACCGATCCAATTGAGAAGTTGGCGCGATGACGGACCGTAGGGTGTCGTACTTCTACAACGCGGACGTGGGCAACTTCCACTATGGAGCCGGGCATCCCATGAAGCCGCAACGCCTGGCGGTCACTCACAGCCTGGTAATGAACTACGGACTGCACAAGAAAATGAAGATCTACAGGCCGTACAAGGCCAGTGCGCAGGACATGCTCCGCTTCCACAGCGACGAGTACATCGCCTACTTACAGCAGGTGACTCCACAAAACATTCAGTGCAATTCCGTGGCCTATACGAAGTACCTGGCGCACTTCAGCGTAGGCGAGGACTGTCCCGTGTTCGATGGCCTCTTCGACTTCTGTGCAATGTACACGGGTGCCTCGCTGGAGGGAGCCCAGAAGCTGAACCACAACCACAGCGACATATGCATAAACTGGTCGGGCGGACTGCATCACGCCAAGAAGTTCGAGGCAAGCGGATTCTGCTACGTGAATGACATCGTCATCGGCATTCTGGAGCTGCTTAAGTACCATCCTCGGGTGCTCTACATCGACATCGATGTGCACCACGGCGACGGGGTGCAGGAGGCGTTCTACCTTACGGACCGAGTGATGACGGCTTCGTTCCACAAATACGGAAACTACTTTTTTCCCGGCACGGGAGACATGTACGAGATAGGCGCCGAATCGGGACGATACTACAGCGTTAATGTGCCGCTAAAGGAGGGCATTGATGACCAGAGCTATTTTCAGGTGTTCAAACCCATAATTTCTGCCATTATGGACTTCTACCGGCCCACGGCTATCGTTTTGCAGTGTGGCGCGGATTCACTAGCTGGAGATCGACTAGGTTGCTTCTCCCTGAGCACCAAGGGACATGGTGAGTGTGTCAAATTTGTGAAGGAACTGAACGTACCCACATTGGTGGTCGGAGGCGGTGGCTACACCTTACGGAACGTGGCCCGCTGCTGGACGCACGAGACCTCGCTGCTGGTGGACCAAGACATTGAAAATGACCTACCCGCCACCGAGTATTACGACTTTTTCGCCCCCGACTTTACACTCCATCCAGAGATTAACTCACGCCAAGATAATGCTAACTCAAAGCAGTATCTTGAACTCATCGTTAAGCATGTGTATGAAAACCTTAAGATGTGCCAGCACTCGCCCAGCGTCCAAATGGTGCAGACCCCGCCTGATGTGGACTTGGAGGAGCTGCGCAGCAACCGGGAGGAGGCGAGTGATCCCGACGTGCGAATATCCGTAGCCGATGAGGACAAGCTGGTTGATGCTAAGAACGAGTTCTACGACGGCGATCAGGACCAAGACAAGCCCGATTCGGCAGAAAGTTAGTATTGGATAATGTAGAATAAGGATTCGAGTTTAGCGTAAGCAGTAAAGAGTATCAGCTTATTTTGT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0016049--P:cell growth
GO:0006342--P:chromatin silencing
GO:0016573--P:histone acetylation
GO:0016575--P:histone deacetylation
GO:0043066--P:negative regulation of apoptotic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0019233--P:sensory perception of pain
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
