| Tag |
Content |
| WERAM ID |
WERAM-Ran-0128 |
| Ensembl Protein ID |
ENSRNOP00000071791.1 |
| Uniprot Accession |
A0A0G2K1C8; A0A0G2K1C8_RAT
|
| Genbank Protein ID |
|
| Protein Name |
Histone deacetylase |
| Genbank Nucleotide ID |
|
| Gene Name |
HDAC3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26395029; 26365275
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
5.30e-159 |
529.3 |
4 |
390 |
|
| Organism |
Rattus norvegicus |
| NCBI Taxa ID |
10116 |
Functional Description
(View) |
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvge 90
+vay+yd+dvg++hyg++hpmkp+rl+lth+Lvl+ygl+kk+ ++ p +as ++l++ +++ yi +l k+++++ ++++++l+ ++g+
ENSRNOP00000071791.1 4 TVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIFFCPFRASLHYLCRQKTQGYIMILLKISASDLKSFTRSLNGLALGK 92
79*************************************************************************************** PP
class-1.txt 91 dcPvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeaf 179
++Pvf glfe+c+ +tGasl++a++Ln+k +diainwaGGlhhakk easGfcyvnDiv++ilellk+h+rvlyidid+hhGDgv+eaf
ENSRNOP00000071791.1 93 QSPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAF 181
***************************************************************************************** PP
class-1.txt 180 yttdrvmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefn 268
y tdrvmtvsfhkyg++ffPgtGd+++vgae+g+yy++nvPl+dgidD+sy+++f++vis+v+++++P+++vlqcGaDsl +Drlg+fn
ENSRNOP00000071791.1 182 YLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFN 270
***************************************************************************************** PP
class-1.txt 269 lsikghaecvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
lsi+gh+ecv++vksfn+pllvlGGGGYt+rnvaRcwtyet++++
ENSRNOP00000071791.1 271 LSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLV 315
******************************************986 PP
class-1.txt 228 esyekifksviskv.ieafePeavvlqcGaDslagDrl 264
+++ +i +++ +++ + + P++ + ++ aD l+ Dr
ENSRNOP00000071791.1 353 QYLDQIRQTIFENLkMLNHAPSVQIHDVPADLLTYDRT 390
67788999999887456799**************9996 PP
|
Protein Sequence
(Fasta) | MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIFFCP FRASLHYLCR 60
QKTQGYIMIL LKISASDLKS FTRSLNGLAL GKQSPVFPGL FEFCSRYTGA SLQGATQLNN 120
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 180
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 240
SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 360
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 420
DKESDVEI 428Protein Fasta Sequence
>ENSRNOP00000071791.1|HDAC3|Rattus norvegicus
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIFFCPFRASLHYLCRQKTQGYIMILLKISASDLKSFTRSLNGLALGKQSPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI |
Nucleotide Sequence
(Fasta) | ATGGCCAAGA CCGTGGCGTA TTTCTACGAC CCCGATGTGG GCAACTTCCA CTACGGAGCT 60
GGACACCCGA TGAAACCCCA TCGCCTGGCA TTGACTCATA GCCTAGTCCT GCATTATGGT 120
CTCTATAAGA AGATGATCTT CTTTTGCCCA TTCAGGGCCA GCCTACATTA TTTATGTAGG 180
CAGAAGACTC AGGGGTACAT TATGATACTC TTAAAAATAT CAGCATCAGA CCTAAAAAGT 240
TTTACAAGGT CTCTCAATGG CCTGGCACTT GGGAAACAGA GCCCTGTGTT TCCCGGGCTC 300
TTCGAGTTCT GCTCCCGCTA TACAGGCGCA TCTCTGCAAG GGGCAACACA GCTAAACAAC 360
AAGATCTGTG ATATTGCCAT CAACTGGGCT GGTGGTCTAC ATCATGCCAA GAAGTTTGAG 420
GCCTCTGGCT TCTGCTATGT CAATGACATA GTAATTGGTA TCCTGGAGCT GCTCAAGTAC 480
CACCCTCGGG TGCTGTACAT TGATATTGAC ATCCACCATG GTGACGGGGT TCAGGAAGCC 540
TTCTACCTCA CTGACCGGGT CATGACTGTG TCCTTCCACA AATATGGAAA TTACTTCTTT 600
CCTGGAACAG GTGATATGTA TGAAGTTGGA GCAGAGAGTG GCCGCTACTA TTGTCTCAAT 660
GTGCCCTTAC GGGATGGCAT TGATGACCAG AGTTACAAGC ACCTTTTCCA GCCGGTCATC 720
AGCCAGGTGG TGGACTTCTA TCAGCCGACG TGCATCGTGC TGCAGTGTGG CGCTGACTCC 780
CTGGGCTGTG ATCGATTAGG CTGCTTCAAT CTCAGCATTC GAGGACATGG GGAATGTGTT 840
GAATATGTCA AGAGTTTCAA TATCCCTCTC CTGGTGCTGG GAGGTGGTGG TTACACCGTT 900
CGAAATGTTG CCCGGTGCTG GACATATGAA ACATCTCTGC TGGTAGAAGA GGCCATTAGT 960
GAGGAACTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC CAGATTTCAC GCTCCATCCA 1020
GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT ATCTAGACCA GATCCGCCAG 1080
ACCATCTTTG AAAACTTGAA GATGCTGAAC CATGCACCCA GTGTCCAGAT TCATGATGTT 1140
CCAGCAGATC TCCTGACCTA TGACAGGACT GACGAGGCCG ATGCTGAAGA GAGAGGTCCT 1200
GAGGAGAACT ACAGCAGGCC AGAAGCACCC AATGAATTCT ATGATGGAGA CCATGACAAT 1260
GACAAGGAAA GTGATGTGGA GATTTAA
1288Nucleotide Fasta Sequence
>ENSRNOP00000071791.1|Class-I|Rattus norvegicus
ATGGCCAAGACCGTGGCGTATTTCTACGACCCCGATGTGGGCAACTTCCACTACGGAGCTGGACACCCGATGAAACCCCATCGCCTGGCATTGACTCATAGCCTAGTCCTGCATTATGGTCTCTATAAGAAGATGATCTTCTTTTGCCCATTCAGGGCCAGCCTACATTATTTATGTAGGCAGAAGACTCAGGGGTACATTATGATACTCTTAAAAATATCAGCATCAGACCTAAAAAGTTTTACAAGGTCTCTCAATGGCCTGGCACTTGGGAAACAGAGCCCTGTGTTTCCCGGGCTCTTCGAGTTCTGCTCCCGCTATACAGGCGCATCTCTGCAAGGGGCAACACAGCTAAACAACAAGATCTGTGATATTGCCATCAACTGGGCTGGTGGTCTACATCATGCCAAGAAGTTTGAGGCCTCTGGCTTCTGCTATGTCAATGACATAGTAATTGGTATCCTGGAGCTGCTCAAGTACCACCCTCGGGTGCTGTACATTGATATTGACATCCACCATGGTGACGGGGTTCAGGAAGCCTTCTACCTCACTGACCGGGTCATGACTGTGTCCTTCCACAAATATGGAAATTACTTCTTTCCTGGAACAGGTGATATGTATGAAGTTGGAGCAGAGAGTGGCCGCTACTATTGTCTCAATGTGCCCTTACGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTCATCAGCCAGGTGGTGGACTTCTATCAGCCGACGTGCATCGTGCTGCAGTGTGGCGCTGACTCCCTGGGCTGTGATCGATTAGGCTGCTTCAATCTCAGCATTCGAGGACATGGGGAATGTGTTGAATATGTCAAGAGTTTCAATATCCCTCTCCTGGTGCTGGGAGGTGGTGGTTACACCGTTCGAAATGTTGCCCGGTGCTGGACATATGAAACATCTCTGCTGGTAGAAGAGGCCATTAGTGAGGAACTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGATTTCACGCTCCATCCAGATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTAGACCAGATCCGCCAGACCATCTTTGAAAACTTGAAGATGCTGAACCATGCACCCAGTGTCCAGATTCATGATGTTCCAGCAGATCTCCTGACCTATGACAGGACTGACGAGGCCGATGCTGAAGAGAGAGGTCCTGAGGAGAACTACAGCAGGCCAGAAGCACCCAATGAATTCTATGATGGAGACCATGACAATGACAAGGAAAGTGATGTGGAGATTTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003714--F:transcription corepressor activity
GO:0071498--P:cellular response to fluid shear stress
GO:0046329--P:negative regulation of JNK cascade
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001934--P:positive regulation of protein phosphorylation
GO:0032008--P:positive regulation of TOR signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031647--P:regulation of protein stability
GO:0051225--P:spindle assembly
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
