| Tag |
Content |
| WERAM ID |
WERAM-Cae-0005 |
| Ensembl Protein ID |
C53A5.3 |
| Uniprot Accession |
O17695; HDA1_CAEEL
|
| Genbank Protein ID |
NP_506599.1
|
| Protein Name |
Histone deacetylase 1 |
| Genbank Nucleotide ID |
NM_074198.7
|
| Gene Name |
HDA-1;C53A5.3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
11940660
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
5.60e-165 |
549.1 |
13 |
324 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression.
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdgl 98
++vay+yd+++g+y+ygq+h+mkp+r+++th+Lvlnygl+++lei++p as+e++++fhs+ey++flk+ +p+n ++++k++ kfnvgedcP+fdgl
C53A5.3 13 RRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGL 110
589*********************************************************************************************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
+e+cql++G+sl+aa+kLnk++ diainw+GGlhhakkseasGfcy nDivl+ilellk+hkrvly+did+hhGDgveeafyttdrvmtvsfhkyg+
C53A5.3 111 YEFCQLSSGGSLAAATKLNKQKVDIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGD- 207
*************************************************************************************************. PP
class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
ffPgtGdl+d+ga+kgk y+vnvPl+dgi D sy++ifk++++kv+e+f+P avvlqcGaDsl+gDrlg fnl++kgh+ec +f++s+n+pl+++GGG
C53A5.3 208 FFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGG 305
************************************************************************************************** PP
class-1.txt 295 GYtlrnvaRcwtyetavvl 313
GYt rnvaRcwtyet++++
C53A5.3 306 GYTPRNVARCWTYETSIAV 324
****************987 PP
|
Protein Sequence
(Fasta) | MNSNGPLMEH GKRRVAYYYD SNIGNYYYGQ GHVMKPHRIR MTHHLVLNYG LYRNLEIFRP 60
FPASFEDMTR FHSDEYMTFL KSANPDNLKS FNKQMLKFNV GEDCPLFDGL YEFCQLSSGG 120
SLAAATKLNK QKVDIAINWM GGLHHAKKSE ASGFCYTNDI VLGILELLKY HKRVLYVDID 180
VHHGDGVEEA FYTTDRVMTV SFHKYGDFFP GTGDLKDIGA GKGKLYSVNV PLRDGITDVS 240
YQSIFKPIMT KVMERFDPCA VVLQCGADSL NGDRLGPFNL TLKGHGECAR FFRSYNVPLM 300
MVGGGGYTPR NVARCWTYET SIAVDKEVPN ELPYNDYFEY FGPNYRLHIE SSNAANENSS 360
DMLAKLQTDV IANLEQLTFV PSVQMRPIPE DALSALNDDS LIADQANPDK RLPPQITDGM 420
IQDDGDFYDG EREGDDRRNE SDAKRAAQFE SEGGEKRQKT E 461Protein Fasta Sequence
>C53A5.3|HDA-1;C53A5.3|Caenorhabditis elegans
MNSNGPLMEHGKRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAATKLNKQKVDIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGGGYTPRNVARCWTYETSIAVDKEVPNELPYNDYFEYFGPNYRLHIESSNAANENSSDMLAKLQTDVIANLEQLTFVPSVQMRPIPEDALSALNDDSLIADQANPDKRLPPQITDGMIQDDGDFYDGEREGDDRRNESDAKRAAQFESEGGEKRQKTE |
Nucleotide Sequence
(Fasta) | TCTACTGCGA CCATCAAACA TGAACTCAAA CGGCCCGTTG ATGGAGCACG GTAAGCGCCG 60
TGTCGCCTAC TACTATGACT CCAACATTGG AAATTACTAT TATGGTCAAG GGCACGTCAT 120
GAAGCCACAT CGTATCAGAA TGACCCATCA TCTCGTTCTC AACTATGGTC TGTACCGGAA 180
TTTAGAGATT TTCCGCCCAT TCCCTGCATC ATTCGAAGAC ATGACTCGTT TTCACAGCGA 240
CGAGTACATG ACGTTTTTGA AGAGTGCGAA TCCAGATAAT CTGAAATCCT TCAACAAACA 300
AATGCTTAAG TTCAATGTTG GAGAAGATTG TCCTCTCTTT GATGGTCTTT ATGAGTTCTG 360
CCAACTCAGT TCGGGAGGTT CTCTGGCTGC TGCCACTAAA TTGAACAAGC AGAAGGTGGA 420
CATTGCTATC AATTGGATGG GAGGCCTCCA TCACGCCAAG AAAAGCGAGG CGTCCGGATT 480
CTGTTACACC AATGACATCG TTCTCGGTAT TCTCGAGCTT CTCAAGTACC ACAAGCGAGT 540
ACTTTACGTC GATATTGATG TTCATCACGG AGATGGAGTA GAGGAGGCGT TCTATACGAC 600
TGATCGAGTA ATGACAGTGT CATTCCATAA ATATGGAGAT TTCTTCCCAG GAACCGGAGA 660
CCTGAAAGAT ATAGGAGCTG GAAAAGGAAA GCTCTATTCA GTCAATGTTC CACTTCGCGA 720
TGGAATCACC GACGTCTCTT ACCAGAGTAT TTTTAAACCA ATCATGACAA AGGTTATGGA 780
GAGATTTGAT CCCTGTGCTG TTGTTCTTCA ATGTGGAGCT GATTCTCTCA ACGGAGATAG 840
ACTTGGACCA TTCAATCTGA CCTTGAAAGG CCACGGAGAA TGTGCTCGTT TCTTCCGAAG 900
CTACAACGTT CCACTTATGA TGGTCGGTGG AGGTGGATAC ACTCCAAGAA ATGTGGCACG 960
TTGTTGGACG TACGAAACCT CGATTGCCGT CGATAAGGAA GTTCCAAATG AGTTGCCATA 1020
CAATGACTAC TTCGAATACT TTGGACCAAA CTACCGACTT CACATCGAGT CGTCGAATGC 1080
AGCAAATGAA AATAGCTCCG ATATGCTGGC TAAATTGCAA ACTGACGTCA TCGCCAATCT 1140
CGAGCAGCTC ACTTTTGTTC CAAGTGTTCA AATGAGACCG ATCCCAGAAG ACGCCCTCTC 1200
TGCATTGAAT GATGACTCAT TGATCGCCGA CCAAGCTAAT CCCGACAAAC GACTACCACC 1260
ACAAATTACC GATGGAATGA TTCAAGACGA TGGAGACTTC TACGATGGTG AGCGTGAGGG 1320
AGATGATCGA AGAAACGAGA GCGATGCGAA GAGAGCAGCT CAGTTTGAGT CGGAAGGTGG 1380
TGAAAAGCGT CAGAAGACAG AGTAAAACAC TAAAATGTGC CGCCGTCGAA TTCAGTATCT 1440
CCTCTGAAAA TAATATTCAA TCACTGTACA CCACTTTTTC CTTGTCAAAT GAGTATTACT 1500
TTTTGATTTT CCTTAAATCT AATTTAATTT TCCGCCCAAA TCCCAACTGT TTTATTTATT 1560
TTTCAAATTC AAGCACTTTT ATTTGGAAGA TCTCTTCACT TTTCCCCATT AATCCTTTTT 1620
TATCTCAGTA TCCTTTACCC GTTTTGCACT TCCTCAACAT CCTTACTCCT CACATCCACA 1680
TCTAATCTAC CCCCTTCAAC GATTTCCATT TCTCTTGTCG TCCCACACTC CCCATTTTAC 1740
TGGCACACAA TTCCAATTCC ACAGTCAGAT CCTGAACACT TTTTTGTATT TTGGTGAATT 1800
TCTTCGTTTT TATTTATTTA ATAAAATTGA CTCGATTGGA A
1842Nucleotide Fasta Sequence
>C53A5.3|Class-I|Caenorhabditis elegans
TCTACTGCGACCATCAAACATGAACTCAAACGGCCCGTTGATGGAGCACGGTAAGCGCCGTGTCGCCTACTACTATGACTCCAACATTGGAAATTACTATTATGGTCAAGGGCACGTCATGAAGCCACATCGTATCAGAATGACCCATCATCTCGTTCTCAACTATGGTCTGTACCGGAATTTAGAGATTTTCCGCCCATTCCCTGCATCATTCGAAGACATGACTCGTTTTCACAGCGACGAGTACATGACGTTTTTGAAGAGTGCGAATCCAGATAATCTGAAATCCTTCAACAAACAAATGCTTAAGTTCAATGTTGGAGAAGATTGTCCTCTCTTTGATGGTCTTTATGAGTTCTGCCAACTCAGTTCGGGAGGTTCTCTGGCTGCTGCCACTAAATTGAACAAGCAGAAGGTGGACATTGCTATCAATTGGATGGGAGGCCTCCATCACGCCAAGAAAAGCGAGGCGTCCGGATTCTGTTACACCAATGACATCGTTCTCGGTATTCTCGAGCTTCTCAAGTACCACAAGCGAGTACTTTACGTCGATATTGATGTTCATCACGGAGATGGAGTAGAGGAGGCGTTCTATACGACTGATCGAGTAATGACAGTGTCATTCCATAAATATGGAGATTTCTTCCCAGGAACCGGAGACCTGAAAGATATAGGAGCTGGAAAAGGAAAGCTCTATTCAGTCAATGTTCCACTTCGCGATGGAATCACCGACGTCTCTTACCAGAGTATTTTTAAACCAATCATGACAAAGGTTATGGAGAGATTTGATCCCTGTGCTGTTGTTCTTCAATGTGGAGCTGATTCTCTCAACGGAGATAGACTTGGACCATTCAATCTGACCTTGAAAGGCCACGGAGAATGTGCTCGTTTCTTCCGAAGCTACAACGTTCCACTTATGATGGTCGGTGGAGGTGGATACACTCCAAGAAATGTGGCACGTTGTTGGACGTACGAAACCTCGATTGCCGTCGATAAGGAAGTTCCAAATGAGTTGCCATACAATGACTACTTCGAATACTTTGGACCAAACTACCGACTTCACATCGAGTCGTCGAATGCAGCAAATGAAAATAGCTCCGATATGCTGGCTAAATTGCAAACTGACGTCATCGCCAATCTCGAGCAGCTCACTTTTGTTCCAAGTGTTCAAATGAGACCGATCCCAGAAGACGCCCTCTCTGCATTGAATGATGACTCATTGATCGCCGACCAAGCTAATCCCGACAAACGACTACCACCACAAATTACCGATGGAATGATTCAAGACGATGGAGACTTCTACGATGGTGAGCGTGAGGGAGATGATCGAAGAAACGAGAGCGATGCGAAGAGAGCAGCTCAGTTTGAGTCGGAAGGTGGTGAAAAGCGTCAGAAGACAGAGTAAAACACTAAAATGTGCCGCCGTCGAATTCAGTATCTCCTCTGAAAATAATATTCAATCACTGTACACCACTTTTTCCTTGTCAAATGAGTATTACTTTTTGATTTTCCTTAAATCTAATTTAATTTTCCGCCCAAATCCCAACTGTTTTATTTATTTTTCAAATTCAAGCACTTTTATTTGGAAGATCTCTTCACTTTTCCCCATTAATCCTTTTTTATCTCAGTATCCTTTACCCGTTTTGCACTTCCTCAACATCCTTACTCCTCACATCCACATCTAATCTACCCCCTTCAACGATTTCCATTTCTCTTGTCGTCCCACACTCCCCATTTTACTGGCACACAATTCCAATTCCACAGTCAGATCCTGAACACTTTTTTGTATTTTGGTGAATTTCTTCGTTTTTATTTATTTAATAAAATTGACTCGATTGGAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0043073--C:germ cell nucleus
GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0030154--P:cell differentiation
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0008406--P:gonad development
GO:0016575--P:histone deacetylation
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:1903854--P:negative regulation of stress response to copper ion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0040027--P:negative regulation of vulval development
GO:0045138--P:nematode male tail tip morphogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045595--P:regulation of cell differentiation
GO:0030334--P:regulation of cell migration
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
