Tag |
Content |
WERAM ID |
WERAM-Ran-0176 |
Ensembl Protein ID |
ENSRNOP00000052717.2 |
Uniprot Accession |
Q569C4; HDA10_RAT |
Genbank Protein ID |
NP_001030172.1 |
Protein Name |
Histone deacetylase 10 |
Genbank Nucleotide ID |
NM_001035000.1 |
Gene Name |
HDAC10 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26395029; 26365275 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
8.50e-128 |
426.6 |
3 |
500 |
HDAC |
Class-I |
5.80e-28 |
98.8 |
27 |
289 |
|
Organism |
Rattus norvegicus |
NCBI Taxa ID |
10116 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeelesltvdsd 90 ++lvy+e m++++ l+++ e+++E+peR++a l+ l+++gl e++++l+ +a++eel lvHs e++ l++++++l+keel++l++++d ENSRNOP00000052717.2 3 TALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCQCLSVCEASEEELGLVHSPEYIALVQKTQTLDKEELHTLSKQYD 91 689************************************************************************************** PP class-2.txt 91 siylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtq 179 ++y++++++++arla+Ga+l+lvd+vl+g ++ng+a+vRPPGHH+++++a+GFC+fnnva+aa++++qk+ +++ilivDwDvHhG+G+q ENSRNOP00000052717.2 92 AVYFHPDTFHCARLAAGAALRLVDAVLTGAVHNGVALVRPPGHHSQRAAANGFCVFNNVAIAARHAKQKYGLQRILIVDWDVHHGQGIQ 180 ***************************************************************************************** PP class-2.txt 180 eifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaeg 268 if++dp+vly+S+HRy++g+f+p + ++++d+vg+g+g+gf+vN++wn+ +mg+a+ylaaf +v+lp+a eF+P+lvlvsaGfD+a g ENSRNOP00000052717.2 181 YIFEDDPSVLYFSWHRYEHGNFWPFLPESDADTVGRGRGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIG 269 ***************************************************************************************** PP class-2.txt 269 dplgglsvtakcyatltkqllklaggrvvlvlE 301 dp+g+++ t++c+a+lt+ l+ laggr+++vlE ENSRNOP00000052717.2 270 DPEGQMQATPECFAHLTQLLQVLAGGRICAVLE 302 ********************************9 PP class-2.txt 237 ylaafrevvlpiakeFkPdlvlvsaG 262 +l + +vlp+a+ F+Pd+vl++ G ENSRNOP00000052717.2 475 FLSFILGLVLPLAYGFQPDMVLMALG 500 56666779**************9877 PP
HDAC Class-I
class-1.txt 23 kpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGasle 111 p+rl+ + + + + gl+++ + ++ +as eel +hs eyi +++k ++ ++eel++ +k+++ + + f+ ++l +Ga+l+ ENSRNOP00000052717.2 27 CPERLTAALDGLRQRGLEERCQCLSVCEASEEELGLVHSPEYIALVQKTQTLDKEELHTLSKQYDAVYFH---PDTFHCARLAAGAALR 112 577777777778889999999****************************999999999999998765544...4789999********* PP class-1.txt 112 aakkLnkkeadiainw.aGGlhhakkseasGfcyvnDivlailellkk..hkrvlyididlhhGDgveeafyttdrvmtvsfhkygee. 196 ++ + ++ + ++ hh+++ a Gfc n++ +a + ++k ++r+l +d d+hhG g++ f+ v+ s h+y+++ ENSRNOP00000052717.2 113 LVDAVLTGAVHNGVALvRPPGHHSQRAAANGFCVFNNVAIAARHAKQKygLQRILIVDWDVHHGQGIQYIFEDDPSVLYFSWHRYEHGn 201 **99998877666554134459********************9998852369*********************************9853 PP class-1.txt 197 ffP..gtGdlsdvgaekgkyyavnvPlkd.gidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfv 281 f+P d + vg ++g+ ++vn+P ++ g+ + y + f +v+ ++ f+Pe v++ G Ds gD+ g+ + + + +a+ +++ ENSRNOP00000052717.2 202 FWPflPESDADTVGRGRGQGFTVNLPWNQvGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLL 289 666334678999**************97659********************************************9999988876665 PP
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Protein Sequence (Fasta) | MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCQCL SVCEASEEEL 60 GLVHSPEYIA LVQKTQTLDK EELHTLSKQY DAVYFHPDTF HCARLAAGAA LRLVDAVLTG 120 AVHNGVALVR PPGHHSQRAA ANGFCVFNNV AIAARHAKQK YGLQRILIVD WDVHHGQGIQ 180 YIFEDDPSVL YFSWHRYEHG NFWPFLPESD ADTVGRGRGQ GFTVNLPWNQ VGMGNADYLA 240 AFLHVLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV 300 LECPGVYPEC SDSPDPSLDK PPTNSTCTVA EDSLSPCLDR PCHRPTPPIC IAVALAVSGA 360 ALDLPPGVLH QEGSALREET EAWARLHKSQ FQDDDLAALG KSLCLLDGIL DGQIRSAIAT 420 TTALATAATL GVLIQRCVAH RGQRRILWLS IRGKEADIWS MFHFSTPLPQ TTGGFLSFIL 480 GLVLPLAYGF QPDMVLMALG PAHGLQNAQA ALLAAMLRSP VGGRILALVE EESILQLART 540 LAQVLHGETP PSLGPFSMAS PEEIQALMFL KAQLEPRWKL LQVAAPPP 588Protein Fasta Sequence
>ENSRNOP00000052717.2|HDAC10|Rattus norvegicus MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCQCLSVCEASEEELGLVHSPEYIALVQKTQTLDKEELHTLSKQYDAVYFHPDTFHCARLAAGAALRLVDAVLTGAVHNGVALVRPPGHHSQRAAANGFCVFNNVAIAARHAKQKYGLQRILIVDWDVHHGQGIQYIFEDDPSVLYFSWHRYEHGNFWPFLPESDADTVGRGRGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLECPGVYPECSDSPDPSLDKPPTNSTCTVAEDSLSPCLDRPCHRPTPPICIAVALAVSGAALDLPPGVLHQEGSALREETEAWARLHKSQFQDDDLAALGKSLCLLDGILDGQIRSAIATTTALATAATLGVLIQRCVAHRGQRRILWLSIRGKEADIWSMFHFSTPLPQTTGGFLSFILGLVLPLAYGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVGGRILALVEEESILQLARTLAQVLHGETPPSLGPFSMASPEEIQALMFLKAQLEPRWKLLQVAAPPP
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Nucleotide Sequence (Fasta) | GGCGTTTGGA GCCACGCTTA GCTCAGTTTC CAGCGGTTAG CTTCTGACTA TCGGGCGGGC 60 TTGAGCCGGG ACCTGGTCTT GGGGTGGTTC CCTCTTGCCC AGGTCCAGTG TCCACTACCC 120 GGCTCTGTCC CAAGCGAGGG CTGTTTACGT GCATACTGTT AAGTGAGAGT GGGCAGTGCA 180 ACCACCTGCC GGCAGAGGGC GTGTTGAGTT AGAGCGGATC AAAGTGGCCA TGGGCACAGC 240 ACTTGTGTAC CACGAGGACA TGACAGCCAC CCGACTGCTC TGGGATGACC CTGAGTGCGA 300 AATTGAGTGC CCAGAGCGCC TGACAGCTGC CTTGGATGGC CTGCGGCAGC GTGGCCTGGA 360 AGAAAGGTGC CAGTGTTTGT CAGTTTGTGA GGCATCAGAG GAAGAGTTGG GACTGGTGCA 420 CAGCCCAGAA TATATAGCCC TGGTGCAGAA GACCCAGACC CTGGACAAAG AGGAGCTCCA 480 CACACTGTCT AAGCAGTATG ATGCTGTCTA CTTCCACCCG GATACTTTTC ACTGTGCAAG 540 GCTGGCAGCG GGGGCTGCAC TGCGGCTGGT GGATGCTGTG CTAACAGGAG CTGTGCACAA 600 TGGCGTTGCC CTGGTGAGGC CTCCAGGGCA CCATAGTCAG AGGGCGGCTG CCAATGGCTT 660 CTGTGTGTTC AACAACGTGG CTATAGCAGC CAGACATGCC AAGCAGAAAT ACGGGCTGCA 720 GAGGATTCTC ATTGTCGACT GGGATGTCCA CCATGGCCAG GGCATCCAGT ATATCTTTGA 780 GGATGACCCC AGTGTCCTTT ATTTCTCCTG GCACCGCTAT GAGCATGGAA ACTTCTGGCC 840 GTTCCTCCCA GAGTCTGATG CAGACACAGT TGGCCGAGGG CGGGGCCAAG GTTTCACTGT 900 CAATTTGCCC TGGAACCAGG TTGGGATGGG AAATGCTGAC TATTTGGCTG CCTTCCTGCA 960 TGTGCTGCTC CCGTTGGCCT TTGAGTTTGA CCCTGAGCTG GTGCTGGTGT CAGCTGGATT 1020 CGACTCTGCT ATTGGGGACC CTGAGGGGCA GATGCAGGCC ACCCCTGAGT GCTTTGCCCA 1080 TCTTACACAG CTGCTACAGG TGCTGGCTGG TGGCCGGATT TGTGCTGTGT TGGAGTGCCC 1140 TGGAGTCTAT CCAGAGTGTT CGGACAGCCC AGACCCCTCA CTGGACAAGC CTCCAACAAA 1200 TTCCACATGT ACAGTAGCAG AGGATTCACT GAGCCCCTGC CTGGACAGAC CGTGCCACCG 1260 CCCTACGCCC CCAATCTGCA TAGCTGTTGC CTTGGCTGTG TCAGGTGCTG CCCTGGACTT 1320 ACCTCCTGGA GTGCTCCATC AAGAAGGGTC AGCCTTGAGG GAGGAGACCG AGGCATGGGC 1380 CAGGCTTCAC AAGTCCCAGT TTCAGGACGA CGATCTTGCC GCACTGGGGA AGAGTCTGTG 1440 CCTCTTAGAT GGAATCCTGG ATGGGCAGAT AAGAAGTGCT ATAGCAACCA CAACTGCCCT 1500 TGCCACAGCA GCAACTTTGG GTGTGCTCAT TCAGCGATGT GTAGCCCATA GAGGTCAGAG 1560 GAGAATTCTG TGGCTCAGCA TCCGGGGCAA GGAGGCAGAC ATCTGGTCCA TGTTCCACTT 1620 CTCCACTCCA CTGCCACAGA CAACTGGAGG GTTTCTGAGC TTCATCTTGG GTCTGGTACT 1680 GCCCTTAGCC TATGGCTTCC AGCCTGACAT GGTGTTGATG GCCCTGGGGC CCGCCCATGG 1740 CCTGCAGAAT GCCCAAGCTG CTCTCTTGGC TGCAATGCTT CGGAGCCCAG TAGGGGGCCG 1800 AATTCTAGCT TTAGTGGAAG AGGAATCCAT ACTCCAGCTT GCAAGAACCC TGGCACAGGT 1860 ATTGCATGGA GAAACACCTC CCAGTCTGGG CCCTTTCTCG ATGGCATCTC CAGAGGAGAT 1920 CCAGGCCCTT ATGTTTCTAA AAGCTCAGCT GGAGCCTCGG TGGAAGTTGC TGCAGGTGGC 1980 TGCTCCTCCA CCATAACCGT GATCGCCAGT CGCTTGAAAT CGGCCAAAGA GGGCGATTCC 2040 TAGTTGAAGA GCACACTCTG GCGCCCATGG CCCGAGACCT ACGTCCCGTC TGTGGCCCAG 2100 CTTCCTACCT CCAGAACAAT AAACATCGGC T
2132Nucleotide Fasta Sequence
>ENSRNOP00000052717.2|Class-I|Rattus norvegicus GGCGTTTGGAGCCACGCTTAGCTCAGTTTCCAGCGGTTAGCTTCTGACTATCGGGCGGGCTTGAGCCGGGACCTGGTCTTGGGGTGGTTCCCTCTTGCCCAGGTCCAGTGTCCACTACCCGGCTCTGTCCCAAGCGAGGGCTGTTTACGTGCATACTGTTAAGTGAGAGTGGGCAGTGCAACCACCTGCCGGCAGAGGGCGTGTTGAGTTAGAGCGGATCAAAGTGGCCATGGGCACAGCACTTGTGTACCACGAGGACATGACAGCCACCCGACTGCTCTGGGATGACCCTGAGTGCGAAATTGAGTGCCCAGAGCGCCTGACAGCTGCCTTGGATGGCCTGCGGCAGCGTGGCCTGGAAGAAAGGTGCCAGTGTTTGTCAGTTTGTGAGGCATCAGAGGAAGAGTTGGGACTGGTGCACAGCCCAGAATATATAGCCCTGGTGCAGAAGACCCAGACCCTGGACAAAGAGGAGCTCCACACACTGTCTAAGCAGTATGATGCTGTCTACTTCCACCCGGATACTTTTCACTGTGCAAGGCTGGCAGCGGGGGCTGCACTGCGGCTGGTGGATGCTGTGCTAACAGGAGCTGTGCACAATGGCGTTGCCCTGGTGAGGCCTCCAGGGCACCATAGTCAGAGGGCGGCTGCCAATGGCTTCTGTGTGTTCAACAACGTGGCTATAGCAGCCAGACATGCCAAGCAGAAATACGGGCTGCAGAGGATTCTCATTGTCGACTGGGATGTCCACCATGGCCAGGGCATCCAGTATATCTTTGAGGATGACCCCAGTGTCCTTTATTTCTCCTGGCACCGCTATGAGCATGGAAACTTCTGGCCGTTCCTCCCAGAGTCTGATGCAGACACAGTTGGCCGAGGGCGGGGCCAAGGTTTCACTGTCAATTTGCCCTGGAACCAGGTTGGGATGGGAAATGCTGACTATTTGGCTGCCTTCCTGCATGTGCTGCTCCCGTTGGCCTTTGAGTTTGACCCTGAGCTGGTGCTGGTGTCAGCTGGATTCGACTCTGCTATTGGGGACCCTGAGGGGCAGATGCAGGCCACCCCTGAGTGCTTTGCCCATCTTACACAGCTGCTACAGGTGCTGGCTGGTGGCCGGATTTGTGCTGTGTTGGAGTGCCCTGGAGTCTATCCAGAGTGTTCGGACAGCCCAGACCCCTCACTGGACAAGCCTCCAACAAATTCCACATGTACAGTAGCAGAGGATTCACTGAGCCCCTGCCTGGACAGACCGTGCCACCGCCCTACGCCCCCAATCTGCATAGCTGTTGCCTTGGCTGTGTCAGGTGCTGCCCTGGACTTACCTCCTGGAGTGCTCCATCAAGAAGGGTCAGCCTTGAGGGAGGAGACCGAGGCATGGGCCAGGCTTCACAAGTCCCAGTTTCAGGACGACGATCTTGCCGCACTGGGGAAGAGTCTGTGCCTCTTAGATGGAATCCTGGATGGGCAGATAAGAAGTGCTATAGCAACCACAACTGCCCTTGCCACAGCAGCAACTTTGGGTGTGCTCATTCAGCGATGTGTAGCCCATAGAGGTCAGAGGAGAATTCTGTGGCTCAGCATCCGGGGCAAGGAGGCAGACATCTGGTCCATGTTCCACTTCTCCACTCCACTGCCACAGACAACTGGAGGGTTTCTGAGCTTCATCTTGGGTCTGGTACTGCCCTTAGCCTATGGCTTCCAGCCTGACATGGTGTTGATGGCCCTGGGGCCCGCCCATGGCCTGCAGAATGCCCAAGCTGCTCTCTTGGCTGCAATGCTTCGGAGCCCAGTAGGGGGCCGAATTCTAGCTTTAGTGGAAGAGGAATCCATACTCCAGCTTGCAAGAACCCTGGCACAGGTATTGCATGGAGAAACACCTCCCAGTCTGGGCCCTTTCTCGATGGCATCTCCAGAGGAGATCCAGGCCCTTATGTTTCTAAAAGCTCAGCTGGAGCCTCGGTGGAAGTTGCTGCAGGTGGCTGCTCCTCCACCATAACCGTGATCGCCAGTCGCTTGAAATCGGCCAAAGAGGGCGATTCCTAGTTGAAGAGCACACTCTGGCGCCCATGGCCCGAGACCTACGTCCCGTCTGTGGCCCAGCTTCCTACCTCCAGAACAATAAACATCGGCT
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Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0000118--C:histone deacetylase complex GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0014003--P:oligodendrocyte development GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |