| Tag |
Content |
| WERAM ID |
WERAM-Hos-0198 |
| Ensembl Protein ID |
ENSP00000302967.3 |
| Uniprot Accession |
O15379; HDAC3_HUMAN; D3DQE1; O43268; Q9UEI5; Q9UEV0
|
| Genbank Protein ID |
NP_003874.2
|
| Protein Name |
Histone deacetylase 3 |
| Genbank Nucleotide ID |
NM_003883.3
|
| Gene Name |
HDAC3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
2.40e-169 |
565.1 |
4 |
390 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcP 93
+vay+yd+dvg++hyg++hpmkp+rl+lth+Lvl+ygl+kk+ ++kp +as++++++fhse+yi+fl++v+p+n++ ++k+l+ fnvg+dcP
ENSP00000302967.3 4 TVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCP 95
79****************************************************************************************** PP
class-1.txt 94 vfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrv 185
vf glfe+c+ +tGasl++a++Ln+k +diainwaGGlhhakk easGfcyvnDiv++ilellk+h+rvlyidid+hhGDgv+eafy tdrv
ENSP00000302967.3 96 VFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRV 187
******************************************************************************************** PP
class-1.txt 186 mtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaec 277
mtvsfhkyg++ffPgtGd+++vgae+g+yy++nvPl+dgidD+sy+++f++vi++v+++++P+++vlqcGaDsl +Drlg+fnlsi+gh+ec
ENSP00000302967.3 188 MTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGEC 279
******************************************************************************************** PP
class-1.txt 278 vkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
v++vksfn+pllvlGGGGYt+rnvaRcwtyet++++
ENSP00000302967.3 280 VEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLV 315
*********************************986 PP
class-1.txt 228 esyekifksviskv.ieafePeavvlqcGaDslagDrl 264
+++ +i +++ +++ + + P++ + ++ aD l+ Dr
ENSP00000302967.3 353 QYLDQIRQTIFENLkMLNHAPSVQIHDVPADLLTYDRT 390
67788999999887456799**************9996 PP
|
Protein Sequence
(Fasta) | MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 60
FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 120
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 180
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 240
NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 360
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 420
DKESDVEI 428Protein Fasta Sequence
>ENSP00000302967.3|HDAC3|Homo sapiens
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI |
Nucleotide Sequence
(Fasta) | AGCACGCACG GCCGGGGAGG GGCTGGCGGC GGCCGCGGGC GGCGGGCGGC GGAGGTGCGG 60
GGCCTGCTCC CGCCGGCACC ATGGCCAAGA CCGTGGCCTA TTTCTACGAC CCCGACGTGG 120
GCAACTTCCA CTACGGAGCT GGACACCCTA TGAAGCCCCA TCGCCTGGCA TTGACCCATA 180
GCCTGGTCCT GCATTACGGT CTCTATAAGA AGATGATCGT CTTCAAGCCA TACCAGGCCT 240
CCCAACATGA CATGTGCCGC TTCCACTCCG AGGACTACAT TGACTTCCTG CAGAGAGTCA 300
GCCCCACCAA TATGCAAGGC TTCACCAAGA GTCTTAATGC CTTCAACGTA GGCGATGACT 360
GCCCAGTGTT TCCCGGGCTC TTTGAGTTCT GCTCGCGTTA CACAGGCGCA TCTCTGCAAG 420
GAGCAACCCA GCTGAACAAC AAGATCTGTG ATATTGCCAT TAACTGGGCT GGTGGTCTGC 480
ACCATGCCAA GAAGTTTGAG GCCTCTGGCT TCTGCTATGT CAACGACATT GTGATTGGCA 540
TCCTGGAGCT GCTCAAGTAC CACCCTCGGG TGCTCTACAT TGACATTGAC ATCCACCATG 600
GTGACGGGGT TCAAGAAGCT TTCTACCTCA CTGACCGGGT CATGACGGTG TCCTTCCACA 660
AATACGGAAA TTACTTCTTC CCTGGCACAG GTGACATGTA TGAAGTCGGG GCAGAGAGTG 720
GCCGCTACTA CTGTCTGAAC GTGCCCCTGC GGGATGGCAT TGATGACCAG AGTTACAAGC 780
ACCTTTTCCA GCCGGTTATC AACCAGGTAG TGGACTTCTA CCAACCCACG TGCATTGTGC 840
TCCAGTGTGG AGCTGACTCT CTGGGCTGTG ATCGATTGGG CTGCTTTAAC CTCAGCATCC 900
GAGGGCATGG GGAATGCGTT GAATATGTCA AGAGCTTCAA TATCCCTCTA CTCGTGCTGG 960
GTGGTGGTGG TTATACTGTC CGAAATGTTG CCCGCTGCTG GACATATGAG ACATCGCTGC 1020
TGGTAGAAGA GGCCATTAGT GAGGAGCTTC CCTATAGTGA ATACTTCGAG TACTTTGCCC 1080
CAGACTTCAC ACTTCATCCA GATGTCAGCA CCCGCATCGA GAATCAGAAC TCACGCCAGT 1140
ATCTGGACCA GATCCGCCAG ACAATCTTTG AAAACCTGAA GATGCTGAAC CATGCACCTA 1200
GTGTCCAGAT TCATGACGTG CCTGCAGACC TCCTGACCTA TGACAGGACT GATGAGGCTG 1260
ATGCAGAGGA GAGGGGTCCT GAGGAGAACT ATAGCAGGCC AGAGGCACCC AATGAGTTCT 1320
ATGATGGAGA CCATGACAAT GACAAGGAAA GCGATGTGGA GATTTAAGAG TGGCTTGGGA 1380
TGCTGTGTCC CAAGGAATTT CTTTTCACCT CTTGGTTGGG CTGGAGGGAA AAGGAGTGGC 1440
TCCTAGAGTC CTGGGGGTCA CCCCAGGGCT TTTGCTGACT CTGGGAAAGA GTCTGGAGAC 1500
CACATTTGGT TCTCGAACCA TCTACCTGCT TTTCCTCTCT CTCCCAAGGC CTGACAATGG 1560
TACCTATTAG GGATGAGATA CAGACAAGGA TAGCTATCTG GGACATTATT GGCAGTGGGC 1620
CCTGGAGGCC AGTCCCTAGC CCCCCTTGCC CCTTATTTCT TCCCTGCTTC CCTCGAACCC 1680
AGAGATTTTT GAGGGATGAA CGGGTAGACA AGGACTGAGA TTGCCTCTGA CTTCCTCCTC 1740
CCCTGGGTTC TGACTTCTTC CTCCCCTTGC TTCCAGGGAA GATGAAGAGA GAGAGATTTG 1800
GAAGGGGCTC TGGCTCCCTA ACACCTGAAT CCCAGATGAT GGGAAGTATG TTTTCAAGTG 1860
TGGGGAGGAT ATGAAAATGT TCTGTTCTCA CTTTTGGCTT TATGTCCATT TTACCACTGT 1920
TTTTATCCAA TAAACTAAGT CGGTATTTTT TGTACCTTT
Nucleotide Fasta Sequence
>ENSP00000302967.3|Class-I|Homo sapiens
AGCACGCACGGCCGGGGAGGGGCTGGCGGCGGCCGCGGGCGGCGGGCGGCGGAGGTGCGGGGCCTGCTCCCGCCGGCACCATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCTGGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGTCTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAACATGACATGTGCCGCTTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGCTTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTCTTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAACAAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAGGCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTACCACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCTTTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTCCCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAACGTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATCAACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCTCTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTTGAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTCCGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGTGAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCAGATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAGACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTGCCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCTGAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAATGACAAGGAAAGCGATGTGGAGATTTAAGAGTGGCTTGGGATGCTGTGTCCCAAGGAATTTCTTTTCACCTCTTGGTTGGGCTGGAGGGAAAAGGAGTGGCTCCTAGAGTCCTGGGGGTCACCCCAGGGCTTTTGCTGACTCTGGGAAAGAGTCTGGAGACCACATTTGGTTCTCGAACCATCTACCTGCTTTTCCTCTCTCTCCCAAGGCCTGACAATGGTACCTATTAGGGATGAGATACAGACAAGGATAGCTATCTGGGACATTATTGGCAGTGGGCCCTGGAGGCCAGTCCCTAGCCCCCCTTGCCCCTTATTTCTTCCCTGCTTCCCTCGAACCCAGAGATTTTTGAGGGATGAACGGGTAGACAAGGACTGAGATTGCCTCTGACTTCCTCCTCCCCTGGGTTCTGACTTCTTCCTCCCCTTGCTTCCAGGGAAGATGAAGAGAGAGAGATTTGGAAGGGGCTCTGGCTCCCTAACACCTGAATCCCAGATGATGGGAAGTATGTTTTCAAGTGTGGGGAGGATATGAAAATGTTCTGTTCTCACTTTTGGCTTTATGTCCATTTTACCACTGTTTTTATCCAATAAACTAAGTCGGTATTTTTTGTACCTTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0030332--F:cyclin binding
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051059--F:NF-kappaB binding
GO:0033558--F:protein deacetylase activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044255--P:cellular lipid metabolic process
GO:0071498--P:cellular response to fluid shear stress
GO:0016568--P:chromatin modification
GO:0007623--P:circadian rhythm
GO:0043066--P:negative regulation of apoptotic process
GO:0046329--P:negative regulation of JNK cascade
GO:1903507--P:negative regulation of nucleic acid-templated transcription
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0001934--P:positive regulation of protein phosphorylation
GO:0032008--P:positive regulation of TOR signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006476--P:protein deacetylation
GO:0031647--P:regulation of protein stability
GO:0051225--P:spindle assembly
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
