| Tag |
Content |
| WERAM ID |
WERAM-Mum-0059 |
| Ensembl Protein ID |
ENSMUSP00000037981.7 |
| Uniprot Accession |
Q3UM33; Q3UM33_MOUSE
|
| Genbank Protein ID |
NP_034541.2
|
| Protein Name |
Histone deacetylase |
| Genbank Nucleotide ID |
NM_010411.2
|
| Gene Name |
HDAC3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Hist_deacetyl |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
1.40e-169 |
565 |
4 |
390 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View) |
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvge 90
+vay+yd+dvg++hyg++hpmkp+rl+lth+Lvl+ygl+kk+ ++kp +as++++++fhse+yi+fl++v+p+n++ ++k+l+ fnvg+
ENSMUSP00000037981.7 4 TVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGD 92
79*************************************************************************************** PP
class-1.txt 91 dcPvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeaf 179
dcPvf glfe+c+ +tGasl++a++Ln+k +diainwaGGlhhakk easGfcyvnDiv++ilellk+h+rvlyidid+hhGDgv+eaf
ENSMUSP00000037981.7 93 DCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAF 181
***************************************************************************************** PP
class-1.txt 180 yttdrvmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefn 268
y tdrvmtvsfhkyg++ffPgtGd+++vgae+g+yy++nvPl+dgidD+sy+++f++vis+v+++++P+++vlqcGaDsl +Drlg+fn
ENSMUSP00000037981.7 182 YLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFN 270
***************************************************************************************** PP
class-1.txt 269 lsikghaecvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
lsi+gh+ecv++vksfn+pllvlGGGGYt+rnvaRcwtyet++++
ENSMUSP00000037981.7 271 LSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLV 315
******************************************986 PP
class-1.txt 228 esyekifksviskv.ieafePeavvlqcGaDslagDrl 264
+++ +i +++ +++ + + P++ + ++ aD l+ Dr
ENSMUSP00000037981.7 353 QYLDQIRQTIFENLkMLNHAPSVQIHDVPADLLTYDRT 390
67788999999887456799**************9996 PP
|
Protein Sequence
(Fasta) | MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 60
FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 120
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 180
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 240
SQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 360
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 420
DKESDVEI 428Protein Fasta Sequence
>ENSMUSP00000037981.7|HDAC3|Mus musculus
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI |
Nucleotide Sequence
(Fasta) | ACGGCGGGGG TGGGGCTGTC GTCCGGTGGC GGGCGGGCGG GCAGCTGAGG CTCGGGGCCT 60
GGTCCCCCCA GCACCATGGC CAAGACCGTG GCGTATTTCT ACGACCCCGA TGTGGGCAAC 120
TTCCACTATG GAGCTGGACA CCCAATGAAA CCTCATCGCC TGGCATTGAC TCATAGCCTA 180
GTCCTGCATT ATGGTCTCTA TAAGAAGATG ATCGTCTTCA AGCCTTACCA GGCCTCCCAG 240
CATGACATGT GCCGCTTCCA TTCTGAGGAC TACATCGACT TCCTGCAGAG AGTCAGCCCC 300
ACCAATATGC AGGGTTTCAC CAAGAGCCTT AATGCCTTCA ACGTGGGTGA TGACTGCCCA 360
GTGTTTCCAG GACTTTTCGA GTTCTGCTCC CGTTACACAG GCGCATCTCT GCAAGGAGCA 420
ACACAGCTAA ACAACAAGAT CTGTGATATT GCCATCAACT GGGCCGGTGG TCTACATCAT 480
GCCAAGAAAT TTGAGGCCTC TGGCTTCTGC TATGTCAATG ACATAGTAAT TGGTATCCTG 540
GAGCTGCTTA AGTACCACCC TCGGGTGCTC TACATTGATA TCGACATCCA CCATGGTGAC 600
GGGGTTCAGG AAGCCTTCTA CCTCACTGAC CGGGTCATGA CTGTGTCCTT CCACAAATAC 660
GGAAATTACT TCTTTCCTGG AACAGGTGAC ATGTATGAAG TTGGAGCAGA GAGTGGCCGC 720
TACTATTGTC TCAATGTGCC CTTACGAGAT GGCATTGATG ACCAGAGTTA CAAGCACCTT 780
TTCCAGCCAG TCATCAGCCA GGTGGTGGAC TTCTACCAGC CGACGTGCAT CGTGCTCCAG 840
TGTGGCGCTG ACTCCCTGGG CTGTGATCGA TTAGGCTGCT TCAATCTCAG CATTCGAGGA 900
CATGGGGAAT GTGTTGAATA TGTCAAGAGT TTCAATATCC CTCTCCTGGT ACTGGGAGGT 960
GGTGGCTACA CTGTCCGAAA TGTTGCCCGG TGTTGGACAT ATGAAACATC TCTGCTGGTA 1020
GAAGAGGCCA TTAGTGAGGA ACTTCCCTAT AGTGAATACT TCGAGTACTT TGCCCCAGAT 1080
TTCACACTCC ATCCAGATGT CAGCACCCGC ATCGAGAATC AGAACTCACG CCAGTATCTG 1140
GACCAGATCC GCCAGACAAT CTTTGAAAAC TTGAAGATGC TGAACCATGC ACCCAGTGTC 1200
CAGATTCATG ATGTCCCGGC AGACCTCCTG ACGTATGACA GGACTGACGA GGCCGACGCT 1260
GAAGAGAGAG GTCCCGAGGA GAACTACAGC AGGCCAGAAG CACCCAATGA GTTCTATGAT 1320
GGCGACCATG ACAACGACAA GGAAAGTGAT GTGGAGATTT AGAGCAGCAT GGATGCTGTG 1380
TCCCCAAGAG TTCCTTGTCA CCTCTGTGGT GGGAAGGAAA GTATGGTTTC CCCAGGTCTG 1440
AACTGGGTAC CCCCAGGGTG TTTACTAACT CTGGTGAAGG GTTTGGAAAC CATATGTGGT 1500
TCTAGAATTA ACTCCCCTTT CCCTCAAACT CTCACGGCCT GATGATTGTC CCTCTCAGGG 1560
ATGAGACATG GACAGGTCTC TGGAACGTTA TGGGTAATGA GCCCCAGCAA CTGTCCTCAG 1620
CCCCTCTTCC CCTCATTTGT TCCTTCTGTC CTTCCAACAC AGAGACTGTT AGAGATGAAA 1680
GTTTGGACGG TACTAAAGTC ACCTCTGACT TCCTTCTGGG TTCCCCTACT ACAGTTCTTG 1740
CTTCCATGCA AGGTGAACCT GAGGGGAGGA AGGCGTGGCT CTCTGAAACC TTAACTGCAG 1800
ATGAAGTACA GTGGCAAGGA GGAGAGGGTG TGAAGCTCTA ACTGGCTTTA TGTCCATTTT 1860
ACTGTTTTGG ATCTAATAAA CCAATTGGTT TTTTTTTTTT TTTTGTACCT TTCTGGGATT 1920
TTAATTCTTG CTAGTTACCG ATGTATGATG TGAAAAGGAA ACAGATGATG ATGTGTATAA 1980
TAAAATTGTT ACCATTCACT CAGT
2005Nucleotide Fasta Sequence
>ENSMUSP00000037981.7|Class-I|Mus musculus
ACGGCGGGGGTGGGGCTGTCGTCCGGTGGCGGGCGGGCGGGCAGCTGAGGCTCGGGGCCTGGTCCCCCCAGCACCATGGCCAAGACCGTGGCGTATTTCTACGACCCCGATGTGGGCAACTTCCACTATGGAGCTGGACACCCAATGAAACCTCATCGCCTGGCATTGACTCATAGCCTAGTCCTGCATTATGGTCTCTATAAGAAGATGATCGTCTTCAAGCCTTACCAGGCCTCCCAGCATGACATGTGCCGCTTCCATTCTGAGGACTACATCGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAGGGTTTCACCAAGAGCCTTAATGCCTTCAACGTGGGTGATGACTGCCCAGTGTTTCCAGGACTTTTCGAGTTCTGCTCCCGTTACACAGGCGCATCTCTGCAAGGAGCAACACAGCTAAACAACAAGATCTGTGATATTGCCATCAACTGGGCCGGTGGTCTACATCATGCCAAGAAATTTGAGGCCTCTGGCTTCTGCTATGTCAATGACATAGTAATTGGTATCCTGGAGCTGCTTAAGTACCACCCTCGGGTGCTCTACATTGATATCGACATCCACCATGGTGACGGGGTTCAGGAAGCCTTCTACCTCACTGACCGGGTCATGACTGTGTCCTTCCACAAATACGGAAATTACTTCTTTCCTGGAACAGGTGACATGTATGAAGTTGGAGCAGAGAGTGGCCGCTACTATTGTCTCAATGTGCCCTTACGAGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCAGTCATCAGCCAGGTGGTGGACTTCTACCAGCCGACGTGCATCGTGCTCCAGTGTGGCGCTGACTCCCTGGGCTGTGATCGATTAGGCTGCTTCAATCTCAGCATTCGAGGACATGGGGAATGTGTTGAATATGTCAAGAGTTTCAATATCCCTCTCCTGGTACTGGGAGGTGGTGGCTACACTGTCCGAAATGTTGCCCGGTGTTGGACATATGAAACATCTCTGCTGGTAGAAGAGGCCATTAGTGAGGAACTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGATTTCACACTCCATCCAGATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAGACAATCTTTGAAAACTTGAAGATGCTGAACCATGCACCCAGTGTCCAGATTCATGATGTCCCGGCAGACCTCCTGACGTATGACAGGACTGACGAGGCCGACGCTGAAGAGAGAGGTCCCGAGGAGAACTACAGCAGGCCAGAAGCACCCAATGAGTTCTATGATGGCGACCATGACAACGACAAGGAAAGTGATGTGGAGATTTAGAGCAGCATGGATGCTGTGTCCCCAAGAGTTCCTTGTCACCTCTGTGGTGGGAAGGAAAGTATGGTTTCCCCAGGTCTGAACTGGGTACCCCCAGGGTGTTTACTAACTCTGGTGAAGGGTTTGGAAACCATATGTGGTTCTAGAATTAACTCCCCTTTCCCTCAAACTCTCACGGCCTGATGATTGTCCCTCTCAGGGATGAGACATGGACAGGTCTCTGGAACGTTATGGGTAATGAGCCCCAGCAACTGTCCTCAGCCCCTCTTCCCCTCATTTGTTCCTTCTGTCCTTCCAACACAGAGACTGTTAGAGATGAAAGTTTGGACGGTACTAAAGTCACCTCTGACTTCCTTCTGGGTTCCCCTACTACAGTTCTTGCTTCCATGCAAGGTGAACCTGAGGGGAGGAAGGCGTGGCTCTCTGAAACCTTAACTGCAGATGAAGTACAGTGGCAAGGAGGAGAGGGTGTGAAGCTCTAACTGGCTTTATGTCCATTTTACTGTTTTGGATCTAATAAACCAATTGGTTTTTTTTTTTTTTTTGTACCTTTCTGGGATTTTAATTCTTGCTAGTTACCGATGTATGATGTGAAAAGGAAACAGATGATGATGTGTATAATAAAATTGTTACCATTCACTCAGT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003714--F:transcription corepressor activity
GO:0071498--P:cellular response to fluid shear stress
GO:0046329--P:negative regulation of JNK cascade
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001934--P:positive regulation of protein phosphorylation
GO:0032008--P:positive regulation of TOR signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031647--P:regulation of protein stability
GO:0051225--P:spindle assembly
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
