Tag |
Content |
WERAM ID |
WERAM-Sac-0048 |
Ensembl Protein ID |
YPL116W |
Uniprot Accession |
Q02959; HOS3_YEAST; D6W3Q2 |
Genbank Protein ID |
NP_015209.1 |
Protein Name |
Histone deacetylase HOS3 |
Genbank Nucleotide ID |
NM_001183930.1 |
Gene Name |
HOS3;YPL116W;LPH11W |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
10535926; 25057019 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
2.10e-93 |
311.5 |
42 |
436 |
HDAC |
Class-I |
4.00e-06 |
25 |
195 |
583 |
|
Organism |
Saccharomyces cerevisiae |
NCBI Taxa ID |
559292 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkek.....hpEkpeRiqailsrlqea.gllekleelkarkatkeelqlvH.........seehvelletae.klekeele 83 a++v+++++l+h +++e+++k ++E+peR+ a+++ +++a +++++l++lk+++++k +l+++H ++e++el+++a+ kl k e+e YPL116W 42 AVVVLSPYSLQHVFPREWVTKsyrktIVERPERLLASSMGISAAiTMYPSLFTLKSSHQRKGSLMAPHvlkvhgsswPAELIELCQMADaKLLKGEIE 139 789***************99999999****************999***************************************************** PP class-2.txt 84 s.ltvdsdsiylesksikaarlavGavlelvdkvlkgelkn.....gfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhG 175 + +t++s++iyl+sk+ika++ ++Ga+ + vd+++kg + +f+++RPPGHH+++ t++GFCl+nn++va+++++++++v++++++D+D+HhG YPL116W 140 VpDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAEhisnrAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNVTHVVVLDFDLHHG 237 989**********************************993334668**************************************************** PP class-2.txt 176 nGtqeifykd........................pkvlylSlHRydkgsffpesgsgavdevgegkge...gfnvNvawnggl...mgdaeylaafr. 242 +Gtq+i++k pkv y+S+H d +sf++esg+++++++++++++ ++++N+ wn++l ++++e+++++r YPL116W 238 DGTQDICWKRagfkpeeepedssyddfgkkfaefPKVGYFSMH--DINSFPTESGFATKENIKNASTCimnSHDLNI-WNIHLskwTTEEEFNVLYRt 332 *********889*******************************..**********************99999*****.*****999***********9 PP class-2.txt 243 ..evvlpiakeF............kP..dlvlvsaGfDaaeg..dplgglsvtakc..yatltkqllkl....aggrvvlvlEGGynlkaiaeaveav 316 ++++++a+eF +P +lv++saGfDa+e+ ++++++sv++ + y+t+tk++lkl ++g+v++++EGGy++kai+++v+a+ YPL116W 333 kyRTLFAKADEFfrsaklemnqqgRPfkGLVVISAGFDASEFeqTSMQRHSVNVPTsfYTTFTKDALKLaqmhCHGKVLSLMEGGYSDKAICSGVFAH 430 999*********************9999**************999********99999***********999************************** PP class-2.txt 317 vkaLlg 322 + +L++ YPL116W 431 LIGLQN 436 **9985 PP
HDAC Class-I
class-1.txt 132 hhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveea 178 hh + sGfc +n+ +ai + +v+ +d+dlhhGDg ++ YPL116W 195 HHCHYGTPSGFCLLNNAHVAIEYAYDtyNVTHVVVLDFDLHHGDGTQDI 243 9********************998873345699************9985 PP class-1.txt 35 lnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnv 88 n ++k+l+ kp++++++e + +s+ ++ l++ + +++++ +++f+ YPL116W 530 SNASPEKELHENKPRSTEKQEQREIRSDTKVKQLSSNNRAAETQIPFLQQEFSS 583 45667899999***********************99998888877766666665 PP
|
Protein Sequence (Fasta) | MSSKHSDPLE RFYKQFQAFV QNNPNVISAA RAAAQIPESA KAVVVLSPYS LQHVFPREWV 60 TKSYRKTIVE RPERLLASSM GISAAITMYP SLFTLKSSHQ RKGSLMAPHV LKVHGSSWPA 120 ELIELCQMAD AKLLKGEIEV PDTWNSGDIY LSSKTIKALQ GTIGAIETGV DSIFKGPSAE 180 HISNRAFVAI RPPGHHCHYG TPSGFCLLNN AHVAIEYAYD TYNVTHVVVL DFDLHHGDGT 240 QDICWKRAGF KPEEEPEDSS YDDFGKKFAE FPKVGYFSMH DINSFPTESG FATKENIKNA 300 STCIMNSHDL NIWNIHLSKW TTEEEFNVLY RTKYRTLFAK ADEFFRSAKL EMNQQGRPFK 360 GLVVISAGFD ASEFEQTSMQ RHSVNVPTSF YTTFTKDALK LAQMHCHGKV LSLMEGGYSD 420 KAICSGVFAH LIGLQNQDWV KEWGSEQVVK EIVRGCKPAW KPYKTKRAKD VIRIWAEEVI 480 RLGRAMIPEF DDIIFKDAVN SAPSNSLLKA TVEPASTSTI AQRIIRSHRS NASPEKELHE 540 NKPRSTEKQE QREIRSDTKV KQLSSNNRAA ETQIPFLQQE FSSEDEDEEY VYDEELNKTF 600 NRTVEDITID DISRHLETLE IEKKGDEDSD HELKEKNWKN SHQRRLQGNG MYKIPSNTKP 660 HRIRQPQNAN TPTYDDSDIS MISHVSRKHT TRSGGRW 697Protein Fasta Sequence
>YPL116W|HOS3;YPL116W;LPH11W|Saccharomyces cerevisiae MSSKHSDPLERFYKQFQAFVQNNPNVISAARAAAQIPESAKAVVVLSPYSLQHVFPREWVTKSYRKTIVERPERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAPHVLKVHGSSWPAELIELCQMADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAEHISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNVTHVVVLDFDLHHGDGTQDICWKRAGFKPEEEPEDSSYDDFGKKFAEFPKVGYFSMHDINSFPTESGFATKENIKNASTCIMNSHDLNIWNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKLEMNQQGRPFKGLVVISAGFDASEFEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHCHGKVLSLMEGGYSDKAICSGVFAHLIGLQNQDWVKEWGSEQVVKEIVRGCKPAWKPYKTKRAKDVIRIWAEEVIRLGRAMIPEFDDIIFKDAVNSAPSNSLLKATVEPASTSTIAQRIIRSHRSNASPEKELHENKPRSTEKQEQREIRSDTKVKQLSSNNRAAETQIPFLQQEFSSEDEDEEYVYDEELNKTFNRTVEDITIDDISRHLETLEIEKKGDEDSDHELKEKNWKNSHQRRLQGNGMYKIPSNTKPHRIRQPQNANTPTYDDSDISMISHVSRKHTTRSGGRW
|
Nucleotide Sequence (Fasta) | ATGTCTTCCA AGCATTCAGA TCCATTGGAG AGATTTTATA AGCAATTTCA AGCATTTGTT 60 CAAAATAACC CTAATGTCAT ATCGGCAGCT CGAGCTGCCG CACAAATACC GGAATCTGCA 120 AAAGCTGTTG TAGTACTATC CCCATATTCT TTACAGCATG TGTTCCCGAG AGAATGGGTA 180 ACAAAATCGT ATAGGAAAAC TATAGTCGAA CGACCAGAAA GATTATTAGC AAGCTCGATG 240 GGTATATCAG CTGCGATTAC AATGTATCCA TCCCTTTTCA CCTTGAAATC CTCGCATCAA 300 AGGAAAGGTT CATTGATGGC ACCTCATGTG CTTAAAGTTC ATGGCAGTAG CTGGCCGGCT 360 GAGTTAATTG AACTTTGCCA AATGGCAGAT GCTAAATTGC TAAAAGGCGA AATCGAAGTC 420 CCAGATACTT GGAACTCAGG TGATATATAC TTGAGCTCAA AGACAATTAA AGCTCTACAG 480 GGAACAATTG GGGCCATTGA AACTGGTGTT GACTCAATTT TCAAAGGACC ATCTGCAGAA 540 CATATTAGTA ACAGAGCTTT TGTTGCTATA CGGCCTCCTG GTCATCATTG CCACTATGGT 600 ACACCATCCG GCTTTTGTCT GTTAAACAAT GCACATGTAG CCATAGAATA TGCGTATGAT 660 ACTTACAACG TCACGCATGT TGTCGTGCTT GATTTCGATC TACACCACGG TGATGGGACC 720 CAAGACATTT GCTGGAAACG TGCGGGTTTC AAACCTGAGG AGGAACCTGA AGATTCATCT 780 TATGATGATT TTGGTAAGAA ATTTGCCGAA TTTCCCAAAG TCGGTTATTT TTCTATGCAT 840 GATATAAATT CATTTCCAAC AGAGTCGGGA TTTGCCACAA AGGAGAACAT TAAAAATGCA 900 TCTACCTGTA TCATGAACTC TCATGACCTA AACATCTGGA ATATTCACTT ATCCAAATGG 960 ACAACCGAAG AAGAATTCAA TGTATTATAC AGGACAAAAT ATAGAACTTT ATTTGCTAAA 1020 GCAGATGAAT TTTTCAGGAG CGCAAAACTA GAAATGAATC AACAAGGGAG ACCATTCAAA 1080 GGTTTGGTTG TCATAAGCGC AGGTTTCGAT GCATCAGAAT TTGAGCAAAC TTCAATGCAA 1140 AGGCATAGTG TCAACGTTCC TACAAGTTTT TATACAACGT TCACCAAAGA TGCATTGAAA 1200 TTAGCACAAA TGCACTGTCA TGGCAAAGTT TTGTCTCTAA TGGAGGGTGG ATATTCTGAT 1260 AAAGCTATAT GTTCTGGTGT TTTCGCACAT TTGATCGGTT TACAAAACCA AGATTGGGTT 1320 AAAGAATGGG GGTCTGAACA AGTCGTTAAA GAGATTGTTC GTGGTTGCAA ACCGGCTTGG 1380 AAACCCTATA AGACAAAAAG AGCAAAAGAT GTCATAAGAA TATGGGCAGA AGAAGTTATC 1440 AGGCTGGGAC GAGCAATGAT ACCGGAATTC GATGATATCA TTTTTAAAGA CGCAGTTAAC 1500 AGCGCACCTT CTAATTCTCT ACTAAAGGCT ACTGTCGAAC CAGCATCCAC GTCGACAATT 1560 GCTCAAAGAA TAATCAGATC TCATAGAAGC AACGCTTCCC CAGAAAAAGA ACTTCATGAA 1620 AACAAGCCGA GAAGCACGGA AAAACAGGAA CAAAGGGAAA TTAGAAGCGA TACCAAGGTC 1680 AAGCAGCTCT CGTCAAATAA TAGAGCAGCT GAAACCCAAA TTCCGTTTTT GCAACAAGAA 1740 TTTTCCAGTG AGGATGAAGA TGAAGAATAC GTTTACGATG AAGAATTGAA CAAAACTTTC 1800 AATCGCACGG TGGAGGATAT TACCATTGAT GATATTTCTA GACATTTGGA GACCTTAGAA 1860 ATTGAAAAAA AAGGTGATGA AGATTCAGAC CATGAGCTAA AAGAAAAAAA TTGGAAAAAC 1920 TCGCACCAAC GCCGTCTACA AGGTAATGGA ATGTATAAAA TTCCCTCCAA TACGAAACCG 1980 CATCGCATAA GACAGCCTCA AAACGCAAAT ACACCAACTT ATGACGATAG TGATATATCA 2040 ATGATTTCTC ATGTTTCAAG AAAACATACA ACAAGAAGTG GTGGAAGATG GTGA
2095Nucleotide Fasta Sequence
>YPL116W|Class-I|Saccharomyces cerevisiae ATGTCTTCCAAGCATTCAGATCCATTGGAGAGATTTTATAAGCAATTTCAAGCATTTGTTCAAAATAACCCTAATGTCATATCGGCAGCTCGAGCTGCCGCACAAATACCGGAATCTGCAAAAGCTGTTGTAGTACTATCCCCATATTCTTTACAGCATGTGTTCCCGAGAGAATGGGTAACAAAATCGTATAGGAAAACTATAGTCGAACGACCAGAAAGATTATTAGCAAGCTCGATGGGTATATCAGCTGCGATTACAATGTATCCATCCCTTTTCACCTTGAAATCCTCGCATCAAAGGAAAGGTTCATTGATGGCACCTCATGTGCTTAAAGTTCATGGCAGTAGCTGGCCGGCTGAGTTAATTGAACTTTGCCAAATGGCAGATGCTAAATTGCTAAAAGGCGAAATCGAAGTCCCAGATACTTGGAACTCAGGTGATATATACTTGAGCTCAAAGACAATTAAAGCTCTACAGGGAACAATTGGGGCCATTGAAACTGGTGTTGACTCAATTTTCAAAGGACCATCTGCAGAACATATTAGTAACAGAGCTTTTGTTGCTATACGGCCTCCTGGTCATCATTGCCACTATGGTACACCATCCGGCTTTTGTCTGTTAAACAATGCACATGTAGCCATAGAATATGCGTATGATACTTACAACGTCACGCATGTTGTCGTGCTTGATTTCGATCTACACCACGGTGATGGGACCCAAGACATTTGCTGGAAACGTGCGGGTTTCAAACCTGAGGAGGAACCTGAAGATTCATCTTATGATGATTTTGGTAAGAAATTTGCCGAATTTCCCAAAGTCGGTTATTTTTCTATGCATGATATAAATTCATTTCCAACAGAGTCGGGATTTGCCACAAAGGAGAACATTAAAAATGCATCTACCTGTATCATGAACTCTCATGACCTAAACATCTGGAATATTCACTTATCCAAATGGACAACCGAAGAAGAATTCAATGTATTATACAGGACAAAATATAGAACTTTATTTGCTAAAGCAGATGAATTTTTCAGGAGCGCAAAACTAGAAATGAATCAACAAGGGAGACCATTCAAAGGTTTGGTTGTCATAAGCGCAGGTTTCGATGCATCAGAATTTGAGCAAACTTCAATGCAAAGGCATAGTGTCAACGTTCCTACAAGTTTTTATACAACGTTCACCAAAGATGCATTGAAATTAGCACAAATGCACTGTCATGGCAAAGTTTTGTCTCTAATGGAGGGTGGATATTCTGATAAAGCTATATGTTCTGGTGTTTTCGCACATTTGATCGGTTTACAAAACCAAGATTGGGTTAAAGAATGGGGGTCTGAACAAGTCGTTAAAGAGATTGTTCGTGGTTGCAAACCGGCTTGGAAACCCTATAAGACAAAAAGAGCAAAAGATGTCATAAGAATATGGGCAGAAGAAGTTATCAGGCTGGGACGAGCAATGATACCGGAATTCGATGATATCATTTTTAAAGACGCAGTTAACAGCGCACCTTCTAATTCTCTACTAAAGGCTACTGTCGAACCAGCATCCACGTCGACAATTGCTCAAAGAATAATCAGATCTCATAGAAGCAACGCTTCCCCAGAAAAAGAACTTCATGAAAACAAGCCGAGAAGCACGGAAAAACAGGAACAAAGGGAAATTAGAAGCGATACCAAGGTCAAGCAGCTCTCGTCAAATAATAGAGCAGCTGAAACCCAAATTCCGTTTTTGCAACAAGAATTTTCCAGTGAGGATGAAGATGAAGAATACGTTTACGATGAAGAATTGAACAAAACTTTCAATCGCACGGTGGAGGATATTACCATTGATGATATTTCTAGACATTTGGAGACCTTAGAAATTGAAAAAAAAGGTGATGAAGATTCAGACCATGAGCTAAAAGAAAAAAATTGGAAAAACTCGCACCAACGCCGTCTACAAGGTAATGGAATGTATAAAATTCCCTCCAATACGAAACCGCATCGCATAAGACAGCCTCAAAACGCAAATACACCAACTTATGACGATAGTGATATATCAATGATTTCTCATGTTTCAAGAAAACATACAACAAGAAGTGGTGGAAGATGGTGA
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Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005634--C:nucleus GO:0004407--F:histone deacetylase activity GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0016575--P:histone deacetylation GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |