| Tag |
Content |
| WERAM ID |
WERAM-Ran-0006 |
| Ensembl Protein ID |
ENSRNOP00000000742.6 |
| Uniprot Accession |
F7ENH8; F7ENH8_RAT
|
| Genbank Protein ID |
NP_445899.1
|
| Protein Name |
Histone deacetylase |
| Genbank Nucleotide ID |
NM_053447.1
|
| Gene Name |
HDAC2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Hist_deacetyl |
H2A; H2B; H3; H4 |
K |
26395029; 26365275
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
1.20e-174 |
580.7 |
10 |
321 |
|
| Organism |
Rattus norvegicus |
| NCBI Taxa ID |
10116 |
Functional Description
(View) |
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvg 89
kkv+y+yd d+g+y+ygq+hpmkp+r+++th+L+lnygl++k+ei++p+ka+aee++k+hs+eyi+fl++++p+n++e+sk++++fnvg
ENSRNOP00000000742.6 10 KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVG 98
589************************************************************************************** PP
class-1.txt 90 edcPvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveea 178
edcPvfdglfe+cql+tG+s+++a kLn++++d+a+nwaGGlhhakkseasGfcyvnDivla+lellk+h+rvlyidid+hhGDgveea
ENSRNOP00000000742.6 99 EDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAVLELLKYHQRVLYIDIDIHHGDGVEEA 187
***************************************************************************************** PP
class-1.txt 179 fyttdrvmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgef 267
fyttdrvmtvsfhkyge +fPgtGdl+d+ga+kgkyyavn+P++dgidDesy +ifk++iskv+e+++P+avvlqcGaDsl+gDrlg+f
ENSRNOP00000000742.6 188 FYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCF 275
*****************.*********************************************************************** PP
class-1.txt 268 nlsikghaecvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
nl++kgha+cv++vk+fnlpll+lGGGGYt+rnvaRcwtyetav+l
ENSRNOP00000000742.6 276 NLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVAL 321
*******************************************987 PP
|
Protein Sequence
(Fasta) | MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 60
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 120
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA VLELLKYHQR VLYIDIDIHH 180
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 240
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 300
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 360
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 420
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKEAEDKRTD VKEEDKSKDN SGEKTDTKGA 480
KSEQLNNP 488Protein Fasta Sequence
>ENSRNOP00000000742.6|HDAC2|Rattus norvegicus
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAVLELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKEAEDKRTDVKEEDKSKDNSGEKTDTKGAKSEQLNNP |
Nucleotide Sequence
(Fasta) | CGCGCGTCGG CGCCGCTGCC AACCCCGCTC TGCGATCTCG GGCCCTCCCG GCACCCGCTC 60
GCCGTCCCGC TCCGGGCTGT CCTTGCTGCG AGGGCCGCCG CGCCCGCCGT CTCCCTCAGC 120
CCTCTTGTCT GGCCGCCGGG CCGCGGCGGG CGAGAGCAGC CGGAGGAGGA GCCGCAGCCA 180
GGAGGCGGCG GCCGGAGCCC ATGGCGTACA GTCAAGGAGG CGGCAAGAAG AAAGTGTGCT 240
ACTATTATGA CGGTGATATC GGGAATTATT ATTACGGCCA GGGTCATCCC ATGAAGCCCC 300
ATAGGATCCG GATGACTCAT AACTTGCTTC TAAATTATGG TTTATACCGA AAAATGGAAA 360
TATATAGGCC TCATAAGGCC ACTGCTGAAG AAATGACAAA ATACCACAGT GATGAGTATA 420
TCAAGTTTCT ACGATCAATA AGGCCAGATA ACATGTCAGA GTATAGTAAG CAGATGCAGA 480
GATTTAATGT CGGAGAAGAC TGTCCAGTGT TCGATGGACT CTTTGAGTTT TGTCAGCTCT 540
CCACCGGTGG CTCAGTTGCT GGGGCCGTGA AGCTGAACCG TCAACAGACT GACATGGCTG 600
TCAACTGGGC GGGAGGACTG CACCACGCCA AGAAGTCAGA GGCCTCAGGA TTCTGCTACG 660
TTAATGACAT TGTGCTTGCT GTCCTCGAGC TACTGAAATA TCATCAGAGA GTCTTATATA 720
TTGACATAGA CATCCACCAT GGTGATGGTG TTGAGGAAGC TTTTTATACA ACAGATCGCG 780
TGATGACCGT CTCATTCCAT AAATACGGAG AATACTTTCC TGGAACAGGA GACTTGAGGG 840
ATATTGGTGC TGGAAAAGGA AAGTACTACG CTGTCAACTT TCCCATGAGG GACGGTATAG 900
ATGACGAGTC ATATGGACAG ATATTTAAGC CTATAATCTC AAAAGTGATG GAGATGTACC 960
AGCCGAGCGC GGTGGTGCTG CAGTGTGGCG CTGACTCCCT CTCTGGTGAC AGGCTGGGCT 1020
GCTTCAACCT AACTGTCAAA GGTCACGCTA AATGTGTAGA AGTAGTGAAA ACTTTTAACT 1080
TGCCGTTGCT GATGCTTGGC GGAGGTGGCT ACACAATCCG GAATGTTGCT CGATGTTGGA 1140
CGTATGAGAC TGCAGTTGCC CTTGATTGTG AAATTCCCAA TGAGTTGCCA TATAATGATT 1200
ACTTCGAGTA TTTTGGACCA GACTTCAAAC TGCATATTAG TCCCTCAAAC ATGACAAACC 1260
AGAACACTCC AGAATATATG GAAAAGATAA AACAGCGTTT ATTTGAAAAT CTGCGAATGT 1320
TACCACATGC GCCTGGTGTT CAAATGCAAG CTATTCCAGA AGATGCTGTT CATGAAGACA 1380
GTGGTGATGA GGATGGAGAA GACCCTGACA AGAGAATTTC TATTCGAGCA TCAGACAAGC 1440
GGATAGCTTG TGATGAAGAG TTCTCAGATT CTGAGGATGA AGGTGAAGGA GGTCGTAGGA 1500
ATGTCGCTGA TCATAAGAAG GGAGCCAAAA AAGCCAGGAT TGAGGAAGAC AAGAAGGAGG 1560
CGGAGGACAA GAGGACAGAT GTTAAGGAAG AAGACAAATC CAAGGACAAT AGTGGTGAGA 1620
AAACAGACAC CAAAGGAGCC AAATCAGAAC AACTCAACAA CCCTTGAATT TGACTCCCCA 1680
ACCTTAGGAA CCTCGAAAAG TGAGACGATT CTGGGATAAG AAACCTTCGC TGTTTGAGGA 1740
AGTTTGGCTT CATTTTATAC TGTTTTGGCA TGGACTGTAT TTATTTTCAA AATGGCTTGT 1800
TTTTGGTTTT CCTTGGCAAG TTTTATTGTG AGTTTTTCTA ATTATGAAGC AAATTTTTTT 1860
CCACCATGCT TTATGTGATT GTATTTAAAT TGATGTGTTA TTATGTCAAA AAAAAAAAAC 1920
CGGATCTATT AAAGAAACAA TTGGCCTTTC TGAGCTGATT TTTCCATCTT TTGTAATTAT 1980
CTTTATTAAA AAATTGTACT TGGATGGTCT TCTGTCTGTT TATTATGAAG GCTTGTTTCC 2040
AAGCCCGACT GTGAGACTGG AGCATACTCA TGGTGATTTC AGTGGCAGAG ACCCTCTCAC 2100
TGAGTCTGTA CGTGCTTACT GGCTCTAACA GGTATTTCCT ATTTCAATAA AAATGACACC 2160
ATGTCACCTT GTATAGTT
2179Nucleotide Fasta Sequence
>ENSRNOP00000000742.6|Class-I|Rattus norvegicus
CGCGCGTCGGCGCCGCTGCCAACCCCGCTCTGCGATCTCGGGCCCTCCCGGCACCCGCTCGCCGTCCCGCTCCGGGCTGTCCTTGCTGCGAGGGCCGCCGCGCCCGCCGTCTCCCTCAGCCCTCTTGTCTGGCCGCCGGGCCGCGGCGGGCGAGAGCAGCCGGAGGAGGAGCCGCAGCCAGGAGGCGGCGGCCGGAGCCCATGGCGTACAGTCAAGGAGGCGGCAAGAAGAAAGTGTGCTACTATTATGACGGTGATATCGGGAATTATTATTACGGCCAGGGTCATCCCATGAAGCCCCATAGGATCCGGATGACTCATAACTTGCTTCTAAATTATGGTTTATACCGAAAAATGGAAATATATAGGCCTCATAAGGCCACTGCTGAAGAAATGACAAAATACCACAGTGATGAGTATATCAAGTTTCTACGATCAATAAGGCCAGATAACATGTCAGAGTATAGTAAGCAGATGCAGAGATTTAATGTCGGAGAAGACTGTCCAGTGTTCGATGGACTCTTTGAGTTTTGTCAGCTCTCCACCGGTGGCTCAGTTGCTGGGGCCGTGAAGCTGAACCGTCAACAGACTGACATGGCTGTCAACTGGGCGGGAGGACTGCACCACGCCAAGAAGTCAGAGGCCTCAGGATTCTGCTACGTTAATGACATTGTGCTTGCTGTCCTCGAGCTACTGAAATATCATCAGAGAGTCTTATATATTGACATAGACATCCACCATGGTGATGGTGTTGAGGAAGCTTTTTATACAACAGATCGCGTGATGACCGTCTCATTCCATAAATACGGAGAATACTTTCCTGGAACAGGAGACTTGAGGGATATTGGTGCTGGAAAAGGAAAGTACTACGCTGTCAACTTTCCCATGAGGGACGGTATAGATGACGAGTCATATGGACAGATATTTAAGCCTATAATCTCAAAAGTGATGGAGATGTACCAGCCGAGCGCGGTGGTGCTGCAGTGTGGCGCTGACTCCCTCTCTGGTGACAGGCTGGGCTGCTTCAACCTAACTGTCAAAGGTCACGCTAAATGTGTAGAAGTAGTGAAAACTTTTAACTTGCCGTTGCTGATGCTTGGCGGAGGTGGCTACACAATCCGGAATGTTGCTCGATGTTGGACGTATGAGACTGCAGTTGCCCTTGATTGTGAAATTCCCAATGAGTTGCCATATAATGATTACTTCGAGTATTTTGGACCAGACTTCAAACTGCATATTAGTCCCTCAAACATGACAAACCAGAACACTCCAGAATATATGGAAAAGATAAAACAGCGTTTATTTGAAAATCTGCGAATGTTACCACATGCGCCTGGTGTTCAAATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGTGATGAGGATGGAGAAGACCCTGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAAGAGTTCTCAGATTCTGAGGATGAAGGTGAAGGAGGTCGTAGGAATGTCGCTGATCATAAGAAGGGAGCCAAAAAAGCCAGGATTGAGGAAGACAAGAAGGAGGCGGAGGACAAGAGGACAGATGTTAAGGAAGAAGACAAATCCAAGGACAATAGTGGTGAGAAAACAGACACCAAAGGAGCCAAATCAGAACAACTCAACAACCCTTGAATTTGACTCCCCAACCTTAGGAACCTCGAAAAGTGAGACGATTCTGGGATAAGAAACCTTCGCTGTTTGAGGAAGTTTGGCTTCATTTTATACTGTTTTGGCATGGACTGTATTTATTTTCAAAATGGCTTGTTTTTGGTTTTCCTTGGCAAGTTTTATTGTGAGTTTTTCTAATTATGAAGCAAATTTTTTTCCACCATGCTTTATGTGATTGTATTTAAATTGATGTGTTATTATGTCAAAAAAAAAAAACCGGATCTATTAAAGAAACAATTGGCCTTTCTGAGCTGATTTTTCCATCTTTTGTAATTATCTTTATTAAAAAATTGTACTTGGATGGTCTTCTGTCTGTTTATTATGAAGGCTTGTTTCCAAGCCCGACTGTGAGACTGGAGCATACTCATGGTGATTTCAGTGGCAGAGACCCTCTCACTGAGTCTGTACGTGCTTACTGGCTCTAACAGGTATTTCCTATTTCAATAAAAATGACACCATGTCACCTTGTATAGTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0016580--C:Sin3 complex
GO:0001047--F:core promoter binding
GO:0019899--F:enzyme binding
GO:0031072--F:heat shock protein binding
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0044822--F:poly(A) RNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0048149--P:behavioral response to ethanol
GO:0003300--P:cardiac muscle hypertrophy
GO:1903351--P:cellular response to dopamine
GO:0034605--P:cellular response to heat
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0006344--P:maintenance of chromatin silencing
GO:0061000--P:negative regulation of dendritic spine development
GO:0043392--P:negative regulation of DNA binding
GO:0010977--P:negative regulation of neuron projection development
GO:2000757--P:negative regulation of peptidyl-lysine acetylation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:0032732--P:positive regulation of interleukin-1 production
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0045862--P:positive regulation of proteolysis
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0042517--P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0001975--P:response to amphetamine
GO:0031000--P:response to caffeine
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0055093--P:response to hyperoxia
GO:0032496--P:response to lipopolysaccharide
GO:0035094--P:response to nicotine
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
