WERAM Information

Tag Content
WERAM ID WERAM-Hos-0228
Ensembl Protein ID ENSP00000430432.1
Uniprot Accession Q92769; HDAC2_HUMAN; B3KRS5; B4DL58; E1P561; Q5SRI8; Q5SZ86; Q8NEH4
Genbank Protein ID NP_001518.3; XP_011534090.1
Protein Name Histone deacetylase 2
Genbank Nucleotide ID NM_001527.3; XM_011535788.1
Gene Name HDAC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196591.11 ENST00000519065.5 ENSP00000430432.1
ENSG00000196591.11 ENST00000368632.6 ENSP00000357621.2
ENSG00000196591.11 ENST00000425835.6 ENSP00000417026.2
ENSG00000196591.11 ENST00000523628.5 ENSP00000427861.1
ENSG00000196591.11 ENST00000521163.5 ENSP00000428024.1
ENSG00000196591.11 ENST00000522371.5 ENSP00000428599.1
ENSG00000196591.11 ENST00000518690.5 ENSP00000428653.1
ENSG00000196591.11 ENST00000520895.5 ENSP00000428861.1
ENSG00000196591.11 ENST00000524334.1 ENSP00000428989.1
ENSG00000196591.11 ENST00000523240.5 ENSP00000429236.1
ENSG00000196591.11 ENST00000521610.5 ENSP00000429901.1
ENSG00000196591.11 ENST00000519108.5 ENSP00000430008.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-I Histone deacetylase H2A; H2B; H3; H4 K 18292778
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-I 1.70e-174 582 10 321
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Domain Profile
  HDAC Class-I
        class-1.txt   1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedc 92 
                        kkv+y+yd d+g+y+ygq+hpmkp+r+++th+L+lnygl++k+ei++p+ka+aee++k+hs+eyi+fl++++p+n++e+sk++++fnvgedc
  ENSP00000430432.1  10 KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDC 101
                        589***************************************************************************************** PP
        class-1.txt  93 PvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdr 184
                        Pvfdglfe+cql+tG+s+++a kLn++++d+a+nwaGGlhhakkseasGfcyvnDivlailellk+h+rvlyidid+hhGDgveeafyttdr
  ENSP00000430432.1 102 PVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDR 193
                        ******************************************************************************************** PP
        class-1.txt 185 vmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae 276
                        vmtvsfhkyge +fPgtGdl+d+ga+kgkyyavn+P++dgidDesy +ifk++iskv+e+++P+avvlqcGaDsl+gDrlg+fnl++kgha+
  ENSP00000430432.1 194 VMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAK 284
                        ***********.******************************************************************************** PP
        class-1.txt 277 cvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
                        cv++vk+fnlpll+lGGGGYt+rnvaRcwtyetav+l
  ENSP00000430432.1 285 CVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVAL 321
                        **********************************987 PP
Protein Sequence
(Fasta)		MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 60
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 120
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 180
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 240
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 300
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 360
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 420
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT 480
KSEQLSNP 488
Nucleotide Sequence
(Fasta)		GCAGGTTGTT CACCCTAACA GGGCCTCTAA CCTCGAGCCC GAAACGGCCT CCTTCTCCAG 60
CCGTGCCCCT TCCTCCCCCG TGGAGGCCGC AGTGGATGCG CTCACCTCCC TGCGGCCTCC 120
TGAGGTGGTT TGGTGGCCCC CTCCTCGCGA GTTGGTGCCG CTGCCACCTC CGATTCCGAG 180
CTTTCGGCAC CTCTGCCGGG TGGTACCGAG CCTTCCCGGC GCCCCCTCCT CTCCTCCCAC 240
CGGCCTGCCC TTCCCCGCGG GACTATCGCC CCCACGTTTC CCTCAGCCCT TTTCTCTCCC 300
GGCCGAGCCG CGGCGGCAGC AGCAGCAGCA GCAGCAGCAG GAGGAGGAGC CCGGTGGCGG 360
CGGTGGCCGG GGAGCCCATG GCGTACAGTC AAGGAGGCGG CAAAAAAAAA GTCTGCTACT 420
ACTACGACGG TGATATTGGA AATTATTATT ATGGACAGGG TCATCCCATG AAGCCTCATA 480
GAATCCGCAT GACCCATAAC TTGCTGTTAA ATTATGGCTT ATACAGAAAA ATGGAAATAT 540
ATAGGCCCCA TAAAGCCACT GCCGAAGAAA TGACAAAATA TCACAGTGAT GAGTATATCA 600
AATTTCTACG GTCAATAAGA CCAGATAACA TGTCTGAGTA TAGTAAGCAG ATGCAGAGAT 660
TTAATGTTGG AGAAGATTGT CCAGTGTTTG ATGGACTCTT TGAGTTTTGT CAGCTCTCAA 720
CTGGCGGTTC AGTTGCTGGA GCTGTGAAGT TAAACCGACA ACAGACTGAT ATGGCTGTTA 780
ATTGGGCTGG AGGATTACAT CATGCTAAGA AATCAGAAGC ATCAGGATTC TGTTACGTTA 840
ATGATATTGT GCTTGCCATC CTTGAATTAC TAAAGTATCA TCAGAGAGTC TTATATATTG 900
ATATAGATAT TCATCATGGT GATGGTGTTG AAGAAGCTTT TTATACAACA GATCGTGTAA 960
TGACGGTATC ATTCCATAAA TATGGGGAAT ACTTTCCTGG CACAGGAGAC TTGAGGGATA 1020
TTGGTGCTGG AAAAGGCAAA TACTATGCTG TCAATTTTCC AATGAGAGAT GGTATAGATG 1080
ATGAGTCATA TGGGCAGATA TTTAAGCCTA TTATCTCAAA GGTGATGGAG ATGTATCAAC 1140
CTAGTGCTGT GGTATTACAG TGTGGTGCAG ACTCATTATC TGGTGATAGA CTGGGTTGTT 1200
TCAATCTAAC AGTCAAAGGT CATGCTAAAT GTGTAGAAGT TGTAAAAACT TTTAACTTAC 1260
CATTACTGAT GCTTGGAGGA GGTGGCTACA CAATCCGTAA TGTTGCTCGA TGTTGGACAT 1320
ATGAGACTGC AGTTGCCCTT GATTGTGAGA TTCCCAATGA GTTGCCATAT AATGATTACT 1380
TTGAGTATTT TGGACCAGAC TTCAAACTGC ATATTAGTCC TTCAAACATG ACAAACCAGA 1440
ACACTCCAGA ATATATGGAA AAGATAAAAC AGCGTTTGTT TGAAAATTTG CGCATGTTAC 1500
CTCATGCACC TGGTGTCCAG ATGCAAGCTA TTCCAGAAGA TGCTGTTCAT GAAGACAGTG 1560
GAGATGAAGA TGGAGAAGAT CCAGACAAGA GAATTTCTAT TCGAGCATCA GACAAGCGGA 1620
TAGCTTGTGA TGAAGAATTC TCAGATTCTG AGGATGAAGG AGAAGGAGGT CGAAGAAATG 1680
TGGCTGATCA TAAGAAAGGA GCAAAGAAAG CTAGAATTGA AGAAGATAAG AAAGAAACAG 1740
AGGACAAAAA AACAGACGTT AAGGAAGAAG ATAAATCCAA GGACAACAGT GGTGAAAAAA 1800
CAGATACCAA AGGAACCAAA TCAGAACAGC TCAGCAACCC CTGAATTTGA CAGTCTCACC 1860
AATTTCAGAA AATCATTAAA AAGAAAATAT TGAAAGGAAA ATGTTTTCTT TTTGAAGACT 1920
TCTGGCTTCA TTTTATACTA CTTTGGCATG GACTGTATTT ATTTTCAAAT GGCTTTTTCG 1980
TTTTTGTTTT TCTTGGCAAG TTTTATTGTG AGTTTTTCTA ATTATGAAGC AAAATTTCTT 2040
TTCTCCACCA TGCTTTATGT GATAGTATTT AAAATTGATG TGAGTTATTA TGTCAAAAAA 2100
ACTGATCTAT TAAAGAAGTA ATTGGCCTTT CTGAGCTGAT TTTTCCATCT TTTGTAATTA 2160
TCTTTATTAA AAAATTGTAC TTGGATTATC TTTTGTCTGT TTATTACTAC AATATGAAGT 2220
CTTGTTTCAG TGGCTAATGA CATCATTTCT GTAGACTTAC AATACACTCT AGGTGAAAGA 2280
TAATGATTAC AGCTTGAAAG ATAACTATTT GCTGTTTCTT TGGGAAGAGT ATTTATAGTA 2340
ATTATTACTT ATCTTTGCAA TAGAAATTCT ACCACCTTGC CCTCTATAGC TTAGCCAGTT 2400
AGTATCAGTG AAGATTAACA TCCCATTACA ATTTATGAAA TAATACAGAC TCTGCAATTG 2460
AGATGTAGGA GTTCTTTGAG TTGACCCAAA GATTCTCAAA ATTGAAATGG AAATTCTGAA 2520
TTGAAAGAAG AAACTGACCA GAACTTGTAT TGACCAGACT TGCCTATAGT ATATTGCTGG 2580
TTTAAAATGG AACCTGCAGA CAAAACCTGT TTCTTTTACT GCATTTACAT GGCATCCAGG 2640
TTCCATTATT ATTTACGTGA CATCCAGGTT TCTAACTCAA GGAAATAAAC ACAACTGATT 2700
TATCATTCAG CAACTACTTA TTGTGTGTCT GCCCATTTTA AGACTGTAGG AGTGTAACTG 2760
AATATAATGG AAAAATGCTT TCACTCAGAG CTTACACTCA GAGCTTACAT TCTAGTAGCA 2820
GGAAGCAGAC AAATGGGGGT AACTCCTGCT ACTAAGATGT GCAAAGAAGA CAAAACATTT 2880
TAGGAACTTG CCAAAATCAG TGAAATCTCC CTTTTTGTCA GGCCCACATT GATTCTTTTG 2940
AGATTAAAAA TTACAGAATG CCAGAAGATA ATTCAGTCAA AAGTATTTCT CTTCAGTGCA 3000
GTAAAATATT AAAAGAAAAA ATATTTCTCT ACAAGCCTCT TAAATGTTTC AGACATTCAC 3060
AATAGCACCT AGACTTTTGT AATGAACAGC TGTGCACCCA CCCCGACTTA ACAAATATTT 3120
TACTTTTGCT ATATTTGCTT CGGTGTTTTT TTCTTAAAAT ACACCGAAAT TGAAGCTCTC 3180
TTTGTGTACT TTGTCGTTTG TAATCCTCCC TCCCTCCCAG CCTTAAGAAG TAATCACCAT 3240
TGTGATTATT TTATCCATGT TTTTGTGAAT ATTTTACCCA TGTTTTTGTA CTTTTGCTAC 3300
ATATTTGTTA TCAATCTGTA AACCTTTATG ACATTAGGAA CTAAGAAACT TAGTCCCTTC 3360
GTTAGGGGGA TAATGAAATG TATTTAGTGT TTGTGAAACA TAGATGGTAT GTATTTGGAC 3420
AATTCTGTAA CTTTGCTTTT TTTATTTTTA TTTTTCCATA GCTTATTGGG GAACAGGTGG 3480
TGTTTGGTTA CATGATTAAG TTCTTTAGTG GTGATTTGTG GGATTTTGGT GGACCCATCA 3540
CCCAAGCAGT GTACACTGCA CCCTATTTGT AATCTTTTAT CCCTCGCCCC CCTCCCACCA 3600
TGCCTCCCGT CTACCATGAT GATCCTGTTT TAAATAAGAA AATACCATTT CGCAGGCTCC 3660
AGATGTTCTG GCATCCTCCC TGTGGATTTC CCAGTGCCTG CAGCTCACAG GACAACAGGG 3720
GCTGTGGTAG AGTCACCTAT GAGATCCTGG AGTAGTGGAT GGAGGAGATG GAACAGTGAA 3780
GACGGAAACT GAGCTCAGTA TCCGGGTGCC AGGAGACAAA GGCCCTTTGC TTTTTTTCAT 3840
TTAATATTCT GATCTACCCC TGTTGACACA TGTTAAGTAT AGTTCATTTT GACTGCTATG 3900
TATTATGTTC CATTGTGTGA ACATACTGAA ATTGTACACT TCAATACTAT ACTGGATCTC 3960
CTTGGGTGTA TTTAAGAGGT TTTGTTTTTC TAAGTAGTTG GTTATATACA ACTAAAACCT 4020
CAAGAGAACT ATCTAAAGCA ATTTCAGCAA GGTGATTTGG TACAGCATTA ATAAACAGAA 4080
ATCAGTAACA CTTAGTGACC AAGTCTGTTG GAAGAACAAA GACCCCCATT TGTAATAACA 4140
AAATTTTTAG AAATAATATG TAAAGAAGCT ATGGTTCTTG TGTCTAGTAA GGTCAATGTA 4200
ACATAGTAAG ATGTCAGAAT ACCCTAATAC TTTAAAAAAT TCATATAGGA TAAAAATGAT 4260
ATTTGAAATT GGCAAGGAAA GACATTATTT TGTAAGTGGA ATTGGGACAA CAACTGGTAA 4320
CCAAATGGAA AACCCAGTTT TCTGCCCTCC ACTAGAAGAT TTAAATAGGA AAAGATAAAA 4380
CTACCAAAAA CCTAAACTCT TAAAGCAAAT GGATTGAAGA AGGCCTAAGT GTGACACCAA 4440
ACTCAACTAT AAAAGATATA TTTGATAACA AAAAAAAAAT TAGTTCAGTG GACCAACAAA 4500
AACTTAGAAG ACAAGTCAAG AAAAATGACA AAAGACAGAG TGGGAGGCAG ATTTGTAACT 4560
CATCCAGGTC AAAAGGCTCA TATCTAAAGA TAGTAGAGGA ACAAAATGTA TAAGGATGTG 4620
AACTGGGAAA CAAATACATA TAAATAGTTT GTAAATATGA AAAGATCTTT AACCTCAGTA 4680
AATAAAAAGC TATAGAGAGA CTTATTTTTT AACTTAGTTT TTTAAACCTA TTATGTTTAT 4740
TTATTTTTTC TTTTTTTGAG ACGGAGTCTC GCTGTTGCCC AGGCTGGTGT GCAATGGCGC 4800
AATCTCGGCT CACTGCAACC TCCGCCTCCC AGGTTGAAGC CATTCTCCTG CCTCAGCCTC 4860
CTGAGTAGCT GGGATTACAG GCGCCTGTCA CCACGCCCAG CTAATTGTTC GCATTTTTAG 4920
TAGAGACGGG GTTTCACTAT GTTGGCCAGG CTGGCCTCGA ACTCCTGACC TCATGATCCA 4980
CCCACCTTGG CCTTCCAAAG TGCTGGGATT ACAGGTGTGA GCTGCCGCAC CTGGCTGTTT 5040
ATCTCTTTTT TTTAGAGAAA GGATCTCGGT CACCCAGGAT GGAGTGTGGT AGCCTGATCA 5100
TATCTCACTA CATCTTAGAA CTTCTAGGCT TAGGGTATTC TCCCACCTCA GCCTCCCAAG 5160
TAGCTGGGAC TACAAGTGTG CACCATCACA CCTAGCTGAT TTTTACATTT TTATTTTGGA 5220
GAGATGGTGT CTCCCTGTGT TGCCCAGGCT GGTCACAAAC TCCTAGGCTC AAGCGATTCT 5280
CCTGACTCAG GCATGAGCCA CCGTACCCGG CCTAAACCTA TCATGTTACA GACTTAGAAA 5340
GCAACTATTG TCAAGTGTTT GAGGAAACTC AGGTCAGGTT TGGTAAACTA AGATATTAAC 5400
TCAAGTAAAG CTCTTTAATT CATTTAATGA AGGTGCCACA TTGTCTCAGT TCTCTATGGC 5460
ATGGGTGAAT GCTGTTCTAA GTCAGCATTG GTACTCTAAG CTAGTTACAT CATATCTAAG 5520
CTTTGCCCTT CTACCAGAGC TGCTAGCATT CTGTCAATGG GCAATTATTT GAAGTTCTTA 5580
CATTGAAGTT AGTCACCTAC ATCTTCTGTT TTTTATGGTT TTGATGTAGT AATACTGCTG 5640
AAGTTTTTTT GATAACTGCG ATTCATAATA TTTGTTATTC ATATTGTGAT ATAAATGATA 5700
AGGGCTTTTG AAAACAAGTA GTAATCATTT CAATAGCTTA GGATCTCCAC CATAATCTTA 5760
GGAAAATTAC TAACCTCTGT GCCTCAGTTG CTTCATCATT TAAAATGAGG AAAATAATAG 5820
TCCCTACTTA ATAGGTTTGT TGTGAGGATT GAGTTAATAA CATAGTTAAT GCTCAGTAAG 5880
GGTTAGCTGC TATTTTTTTT TCTTTTTTTT TTGAAAGAGT CTCACTCTGT TGCCCAGGTT 5940
GGAGTGCAGT GGCATGATCT TGGCTCACTG CATCCTCTGC TTCCTAGGTT CAGGTGATTC 6000
TCATGCTTCA GCCTCCCAAG CAGCTGGGAG TACAGGTGTG CACCACCACA CCTGGCTAAT 6060
TTTTGTATAT TTAGTAGAGA CGGGTTCTCA CCATATTGTC CAGGCTGGTC TTGAACTCCT 6120
TACCTCAAAT GATCCACCCG CCTGGGCCTC CCAAAGTGCT GGGATTACAA GCATGAGCCA 6180
CCGCGCCTGG CTTGCTATTG TTATGAGGTA AAGGTAGATA GATGGGTGAG AGTGGTGCCA 6240
GGGGAAGTGT TAAATTTTTG AGTGTTCCTT TAGATGCCAG ATGGGTTGTA TCTGAGCCTT 6300
TTATTGCAGT TTGATGCCTA CTAGTGTGAA GACTACTAGG TCATAGTGGA TAGAGAAGCA 6360
ATCTTTTGGA GACCTGATTT TAGCAAGGAT ACGAATAATA TTTGACAACT TTGGGGGGAT 6420
CTTGATGCCT CTGTAATTTA CTCAAGGATA ATCTCAAGAA AAATGGCATT AAGTAGATTA 6480
CAGAAAAAAT AGAACTATCA TATTGTTATT ATTGGCTATT TACATGAGCA ATGCGGAGAA 6540
ATGTTTAGGA TTACAGCATT TAGAAGCTTC TCAATTGCTG CATTTCCTCA CTGTACCACA 6600
AGATGGCAGA TACTGCATTT AAAATTTTTT TTTCTGTGTG TTTTCTCTTA TAGTCACTTG 6660
GTGGCCATGT AACAAGCAGA GCAACATGTA TTAACAGATT CTTTTTGAAT GCAATATTGG 6720
ATTAAAAACT TTGAATTAAA CTACAATTAA GTTTACTGAT TTAGGTTTTC CTATAAGAAT 6780
TATAACACTA ATTTCTAAGT TTTACATCTG CAAAACACAG TAGAGTGTAT CTGGTAGTCA 6840
TTGACTAATT GTGACTTTGC TAGTCAGACA AAATGGAACT GAATATTAGA GCCAGAATAA 6900
TTTTCTGTTT TGACTGGTGG TAAGAATCAG TTAGTATACA GAATGGGAAA GAATTGAAAT 6960
TTATTTCTAG GAATTATAGT TATAGTGAAG TTAATATTCA GGGGCATTGG GTGCTTGTTC 7020
CACGACTTTT GTTTACTGAA CTAAGTACCT AACCCCTTTG GTCTTTGAAC ACTGCAGAGT 7080
TATGATTAGG ATTATTAATG AAAAATTCTT TTTTAGTAGA ACAAACAGTT AAGGACAGAA 7140
GACACCTTGA TTAGATTCTG TTATTTGCTC TTTTTATTAA GATTGTTTTT ACTCTAAATG 7200
TTAAAGAAAT GTATAATTAT TTCTAAGGTA AAATGAGTAG CAGGATTCTG AATAGGAGAT 7260
TTTTTTTGGC CAGACCCATT TTGCAGCCAG TGGTTTGTAT TTAGGAGTGA GTTGAACAAA 7320
GAAGACTCTA ATCTGTTTTT GTGTTGTGGA TTTTTTATTC TATTGATAAA TCAGTAGCTT 7380
CCAGCTTCTC TTGTATCCTC TACTAGTCAT CTTTTTTGTT TCTTCAGAAA TAAACATCCA 7440
GGGTCACTTC CCTGCCCTTG CCATATACTT ACTAGGATGA TGTACAGGTA AAACTTTTAA 7500
AGGAAAGTAC GGACAGGCAA TTCCTAAAGT AAAAGAGAGC ACATTATCAA AACTGGCTGT 7560
ACTTAACAAA TACCAACAAA AAGTCATTAC ACTTCTGGCA ACAAATAATG TTTGATTTAA 7620
AAAGACAAGA ATTTCCCCTT TTGCTCTTAT TTTTTAAATA TGCTATGTCC TTAAGTGAGA 7680
AATGCACTTC AAAAATTTTC TTATTCTGAA GTCTAGCCGG AAAGTTTGAA CTTGTGTTGC 7740
CTTTGGCTAG ACTAGGTGAA ATTAAGGGGC TTAAGAGGGC ACTGTTGTGT GGCCCTGTGG 7800
TAGATAATAG CCCTCCAAGC ATGAGGATGG GAGATCTACC ATTCACCAGT ATTTCCAAAG 7860
TTATATTCTT AAAAAGGCTA GATTTCTAAT TTCCGTAGAA TCTAGGTATG TTCTTTTCAA 7920
CTCAGCATCT GATAAGAAAG TTTGGGCAAG TAGGTGCGAA AAATTTACTC TAGATACCAT 7980
TTTCCAGGAA AAAATATAAT TCAAGTCCAA CGTATTACTA GCTGTCACCT TCCCCAACAA 8040
TCAAATAAGC ATTGTTATTG TCAAACACAT TTACTTGTAT AGTTCAGTGT TATATGTAAT 8100
GGACTTAGGT ATAATTCCTG TGCTATTCCC TTTTGATGCC AAACACCCTT TTGTAAGCTG 8160
TTTTGTTTGA AATCCAAATT TATATGTCTT AAAGTAAATG GCAGCATTGG GCTTTCTTAA 8220
TGTAATGACT CTTCTGCCAT CCTATTTCTA GAGTTAGGCA GAAAATTCTG TAAATCTATC 8280
TTATTTCCAG TCTGTTTGTG ACTATGGTGG GCAATAAATC TGATTTCCCA GAAAAACACA 8340
TCTGGACCCC TATAGGTAAG GTAAACAAGC CTCATCTTAA ATTGTTTGTA CTTCCGACCT 8400
GACCTCAAAA CACCATCATC ATCTAGAGCA GCAACAAGTA AAGAACAATG CACTGGAAAT 8460
CACATATATG GGTCTAGCAC CAGCCTTTAC ATTACACAAC TTTGCTTTGG GCAAGTCATT 8520
TAAATTTCTG TGCTTCAGTT TACTAAATCT ATGAAACTGA CTAGGTAACA GCTGACATGC 8580
TTTTCCAGCA CTCCGTCTTT TACCTGTCTG ATGTCACAAA TTGATCATTC CTTTCTGGCC 8640
TTGAGATGCG TATCAACCCA GATAGTCATT AACCCAGATA GTTGGCATTC AGGATAAAAT 8700
GTTTTTGCCT TTCCTGTCCT GCAAGCTCTT TAAAGTCCAA AATATGCCTT TATATCTTTA 8760
TGTGTAATAG GTATGAAATC TATTTCTTGG TTGTTGAATA GGATAGGCTT ATTAGACATT 8820
CTAAAGTCAA CTTTTTTCTC ATATTTAAAC ATTTACCCGT AGAAATTCAG TTTTTTAAAG 8880
TTTTAAGTCA GTTGATTGTA CCAAACATTA CTATTAAAAA AAAATCAAAG TCAGAGACCA 8940
GAGTTTCCCT GCATCAGCGT TCAGTCAGGA GACAGGAACT ATACTAATTT GAACATGTAA 9000
AGTTAAATAT AATCCTTAAT AATAACAGGA TTGGAATAAG GGATAAAAGA AAGAGAATTC 9060
CTTCTATATA TATGTATACA CACACATATA TATATATACA TGTGTATATA TGTGTGTGTA 9120
TGTATATTAT ATAATATACA TACACACACA CAAAGAATGT CAGACAAGGA GCAGCCACCA 9180
TTCTGCTTAC TTTCACTGGA TTAAGAGTTT CATAAGGGCA AGGGTTTTGT TTGTCTTACA 9240
CTCCACTGGG GATTAATCTC CAGTGTCTAG AACAGTGCCT AACACATAAA TAAAGCCTCA 9300
ATTATTATTT GTGGAATGGA ATGGAATTTG AGTGAAATGG AATGGGAATA GAATGGACTG 9360
GAATGGAAAT AGAAGTGGGA AGGGGAATGG AAGGGGATAG AAGAGGATTG AAGAGGACAG 9420
AAGGAGATGG GATAAGATGG GATGGGATAG GATCGAATCT CAGGTCCAGG AGTCAGAATA 9480
ACTGAATCCT ATTCCAGTTC TGCCATCAAC AAGTCCTGTG AAATTTGGAA AGTCACTTAA 9540
CCCTCTGGCC TTGTAGAATA TCTCAGTGGG CATGTCTGAT GTTTCTTCAT GGTTAGATAT 9600
AGGTTGCATG TTTTGGGCAA GAATATCACA GGAATGATGC TGTGTTCTCA GTGCACCCAG 9660
TCAGGTAATG CATGATTTCA ATTTCTCTCA TTACTGATGA TGTTAACTTT AATCACTTAG 9720
TGAATGAGAA CATGAGCATC ATTTTGAAAG CAAACTGCAA AGTTTTGATG TCAACATTTT 9780
AGCAATTACG TATAATTTCC CCCAAGGATA CTGGCTTTGA GATAATGTAA ATATACATGG 9840
GAAAGACAAA GCTCAAATAA AGGAAAAAGA CCCA 9875
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0702--S-nitrosylation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
Interpro

IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
PROSITE
Pfam

PF00850--Hist_deacetyl
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0043234--C:protein complex
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0019213--F:deacetylase activity
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051059--F:NF-kappaB binding
GO:0044822--F:poly(A) RNA binding
GO:0033558--F:protein deacetylase activity
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0043565--F:sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0048149--P:behavioral response to ethanol
GO:0007596--P:blood coagulation
GO:0003300--P:cardiac muscle hypertrophy
GO:1903351--P:cellular response to dopamine
GO:0034605--P:cellular response to heat
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0006338--P:chromatin remodeling
GO:0032922--P:circadian regulation of gene expression
GO:0016358--P:dendrite development
GO:0042733--P:embryonic digit morphogenesis
GO:0009913--P:epidermal cell differentiation
GO:0061029--P:eyelid development in camera-type eye
GO:0061198--P:fungiform papilla formation
GO:0060789--P:hair follicle placode formation
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0006344--P:maintenance of chromatin silencing
GO:0043066--P:negative regulation of apoptotic process
GO:0061000--P:negative regulation of dendritic spine development
GO:0043392--P:negative regulation of DNA binding
GO:0045347--P:negative regulation of MHC class II biosynthetic process
GO:0010977--P:negative regulation of neuron projection development
GO:2000757--P:negative regulation of peptidyl-lysine acetylation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0008284--P:positive regulation of cell proliferation
GO:0032967--P:positive regulation of collagen biosynthetic process
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:0032732--P:positive regulation of interleukin-1 production
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0045862--P:positive regulation of proteolysis
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0042517--P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0001975--P:response to amphetamine
GO:0031000--P:response to caffeine
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0055093--P:response to hyperoxia
GO:0032496--P:response to lipopolysaccharide
GO:0035094--P:response to nicotine
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Tut-0167 ENSTTRP00000014262.1 Tursiops truncatus 99 0.0 855
WERAM-Paa-0030 ENSPANP00000015145.1 Papio anubis 100 0.0 848
WERAM-Chs-0191 ENSCSAP00000011772.1 Chlorocebus sabaeus 100 0.0 848
WERAM-Mod-0165 ENSMODP00000022264.3 Monodelphis domestica 99 0.0 846
WERAM-Myl-0035 ENSMLUP00000002835.2 Myotis lucifugus 100 0.0 846
WERAM-Ict-0111 ENSSTOP00000011457.2 Ictidomys tridecemlineatus 100 0.0 845
WERAM-Gaga-0137 ENSGALP00000024133.3 Gallus gallus 100 0.0 845
WERAM-Ova-0099 ENSOARP00000010190.1 Ovis aries 100 0.0 845
WERAM-Sus-0028 ENSSSCP00000004781.2 Sus scrofa 100 0.0 845
WERAM-Ran-0006 ENSRNOP00000000742.6 Rattus norvegicus 99 0.0 843
WERAM-Orc-0004 ENSOCUP00000000521.2 Oryctolagus cuniculus 99 0.0 843
WERAM-Poa-0153 ENSPPYP00000018964.2 Pongo abelii 100 0.0 843
WERAM-Pat-0155 ENSPTRP00000049696.3 Pan troglodytes 100 0.0 843
WERAM-Mum-0029 ENSMUSP00000019911.7 Mus musculus 100 0.0 843
WERAM-Cap-0156 ENSCPOP00000012920.2 Cavia porcellus 99 0.0 843
WERAM-Fia-0139 ENSFALP00000011453.1 Ficedula albicollis 99 0.0 842
WERAM-Nol-0145 ENSNLEP00000015855.1 Nomascus leucogenys 100 0.0 842
WERAM-Tag-0146 ENSTGUP00000012328.1 Taeniopygia guttata 99 0.0 842
WERAM-Gog-0059 ENSGGOP00000005320.2 Gorilla gorilla 100 0.0 842
WERAM-Anc-0129 ENSACAP00000012046.2 Anolis carolinensis 98 0.0 841
WERAM-Ect-0064 ENSETEP00000006883.1 Echinops telfairi 99 0.0 840
WERAM-Aim-0151 ENSAMEP00000013919.1 Ailuropoda melanoleuca 99 0.0 840
WERAM-Dan-0143 ENSDNOP00000031144.1 Dasypus novemcinctus 99 0.0 840
WERAM-Loa-0063 ENSLAFP00000004670.4 Loxodonta africana 99 0.0 837
WERAM-Ere-0068 ENSEEUP00000005465.1 Erinaceus europaeus 100 0.0 828
WERAM-Anp-0059 ENSAPLP00000006605.1 Anas platyrhynchos 100 0.0 827
WERAM-Caf-0048 ENSCAFP00000006011.3 Canis familiaris 99 0.0 827
WERAM-Meg-0131 ENSMGAP00000014157.2 Meleagris gallopavo 99 0.0 826
WERAM-Caj-0052 ENSCJAP00000008409.2 Callithrix jacchus 100 0.0 825
WERAM-Xet-0050 ENSXETP00000015978.3 Xenopus tropicalis 97 0.0 825
WERAM-Sah-0134 ENSSHAP00000014467.1 Sarcophilus harrisii 99 0.0 824
WERAM-Eqc-0098 ENSECAP00000011591.1 Equus caballus 100 0.0 823
WERAM-Fec-0156 ENSFCAP00000015379.2 Felis catus 96 0.0 822
WERAM-Pes-0022 ENSPSIP00000004737.1 Pelodiscus sinensis 99 0.0 818
WERAM-Mup-0118 ENSMPUP00000010193.1 Mustela putorius furo 100 0.0 815
WERAM-Tas-0085 ENSTSYP00000008588.1 Tarsius syrichta 97 0.0 806
WERAM-Ora-0034 ENSOANP00000005760.2 Ornithorhynchus anatinus 100 0.0 791
WERAM-Bot-0111 ENSBTAP00000015734.4 Bos taurus 94 0.0 788
WERAM-Dio-0132 ENSDORP00000012520.1 Dipodomys ordii 93 0.0 772
WERAM-Mam-0073 ENSMMUP00000011716.2 Macaca mulatta 94 0.0 770
WERAM-Orn-0136 ENSONIP00000014285.1 Oreochromis niloticus 88 0.0 769
WERAM-Orla-0197 ENSORLP00000022529.1 Oryzias latipes 87 0.0 767
WERAM-Xim-0061 ENSXMAP00000005239.1 Xiphophorus maculatus 88 0.0 765
WERAM-Ptv-0152 ENSPVAP00000012567.1 Pteropus vampyrus 90 0.0 761
WERAM-Ocp-0006 ENSOPRP00000000780.1 Ochotona princeps 91 0.0 761
WERAM-Otg-0072 ENSOGAP00000005101.2 Otolemur garnettii 90 0.0 761
WERAM-Asm-0151 ENSAMXP00000014739.1 Astyanax mexicanus 92 0.0 760
WERAM-Pof-0181 ENSPFOP00000015600.1 Poecilia formosa 86 0.0 758
WERAM-Tar-0085 ENSTRUP00000016627.1 Takifugu rubripes 88 0.0 754
WERAM-Leo-0176 ENSLOCP00000020984.1 Lepisosteus oculatus 89 0.0 753
WERAM-Ten-0060 ENSTNIP00000007837.1 Tetraodon nigroviridis 87 0.0 749
WERAM-Vip-0012 ENSVPAP00000001394.1 Vicugna pacos 90 0.0 746
WERAM-Dar-0035 ENSDARP00000051798.4 Danio rerio 91 0.0 743
WERAM-Gaa-0072 ENSGACP00000009568.1 Gasterosteus aculeatus 91 0.0 739
WERAM-Gam-0033 ENSGMOP00000003469.1 Gadus morhua 91 0.0 739
WERAM-Cii-0014 ENSCINP00000005410.3 Ciona intestinalis 88 0.0 706
WERAM-Drm-0018 FBpp0073173 Drosophila melanogaster 82 0.0 704
WERAM-Prc-0059 ENSPCAP00000005589.1 Procavia capensis 84 0.0 688
WERAM-Tub-0118 ENSTBEP00000013142.1 Tupaia belangeri 82 0.0 656
WERAM-Soa-0003 ENSSARP00000000316.1 Sorex araneus 85 0.0 655
WERAM-Pem-0096 ENSPMAP00000010023.1 Petromyzon marinus 80 0.0 631
WERAM-Chh-0102 ENSCHOP00000011659.1 Choloepus hoffmanni 80 1e-179 627
WERAM-Mim-0092 ENSMICP00000008598.1 Microcebus murinus 81 2e-177 619
WERAM-Mae-0030 ENSMEUP00000002192.1 Macropus eugenii 78 3e-176 615
WERAM-Asf-0020 CADAFLAP00008921 Aspergillus flavus 69 2e-164 575
WERAM-Cae-0005 C53A5.3 Caenorhabditis elegans 70 1e-163 573
WERAM-Asc-0037 CADACLAP00008612 Aspergillus clavatus 69 9e-163 570
WERAM-Asn-0024 CADANIAP00005952 Aspergillus nidulans 68 2e-162 569
WERAM-Asfu-0015 CADAFUAP00003503 Aspergillus fumigatus 69 2e-162 569
WERAM-Asni-0020 CADANGAP00005938 Aspergillus niger 68 3e-162 568
WERAM-Coi-0024 EAS33504 Coccidioides immitis 69 5e-162 568
WERAM-Ved-0020 EGY15146 Verticillium dahliae 68 1e-159 560
WERAM-Scs-0023 EDO03342 Sclerotinia sclerotiorum 68 3e-159 558
WERAM-Tum-0029 CAZ85499 Tuber melanosporum 69 5e-159 558
WERAM-Sem-0128 EFJ38890 Selaginella moellendorffii 68 7e-159 557
WERAM-Osl-0002 ABO94711 Ostreococcus lucimarinus 69 8e-159 557
WERAM-Map-0015 MAPG_05105T0 Magnaporthe poae 68 2e-158 556
WERAM-Gag-0026 GGTG_08607T0 Gaeumannomyces graminis 68 3e-158 555
WERAM-Php-0050 PP1S223_52V6.1 Physcomitrella patens 68 3e-158 555
WERAM-Tra-0318 Traes_7DL_578CF3F0D.2 Triticum aestivum 68 7e-158 554
WERAM-Prp-0060 EMJ10303 Prunus persica 68 1e-157 553
WERAM-Brd-0020 BRADI1G37290.1 Brachypodium distachyon 67 1e-157 553
WERAM-Glm-0046 GLYMA05G02540.1 Glycine max 68 6e-157 551
WERAM-Caa-0018 KGT69072 Candida albicans 66 6e-157 551
WERAM-Thc-0029 EOY20838 Theobroma cacao 68 6e-157 551
WERAM-Viv-0108 VIT_17s0000g09070.t01 Vitis vinifera 68 7e-157 551
WERAM-Yal-0022 CAG79885 Yarrowia lipolytica 67 1e-156 550
WERAM-Zyt-0024 Mycgr3P51809 Zymoseptoria tritici 68 2e-156 550
WERAM-Kll-0018 CAG99124 Kluyveromyces lactis 67 2e-156 550
WERAM-Mao-0017 MGG_05857T0 Magnaporthe oryzae 67 2e-156 549
WERAM-Amt-0072 ERN20455 Amborella trichopoda 67 4e-156 548
WERAM-Kop-0004 CAY67954 Komagataella pastoris 67 4e-156 548
WERAM-Trv-0003 EHK19072 Trichoderma virens 68 7e-156 547
WERAM-Cag-0003 CAG57932 Candida glabrata 67 2e-155 546
WERAM-Pot-0149 POPTR_0015s09400.1 Populus trichocarpa 68 3e-155 545
WERAM-Brr-0180 Bra035858.1-P Brassica rapa 68 3e-155 545
WERAM-Asg-0034 AAS54885 Ashbya gossypii 66 4e-155 545
WERAM-Bro-0169 Bo9g017510.1 Brassica oleracea 68 8e-155 544
WERAM-Met-0068 AES71453 Medicago truncatula 65 9e-155 544
WERAM-Arl-0113 fgenesh2_kg.8__ 2309__ AT5G63110.1 Arabidopsis lyrata 68 1e-154 543
WERAM-Art-0148 AT5G63110.1 Arabidopsis thaliana 68 2e-154 543
WERAM-Trr-0017 EGR48353 Trichoderma reesei 67 2e-154 543
WERAM-Sol-0082 Solyc06g071680.2.1 Solanum lycopersicum 66 3e-154 542
WERAM-Hov-0001 MLOC_10109.1 Hordeum vulgare 67 3e-154 542
WERAM-Sac-0039 YNL330C Saccharomyces cerevisiae 65 6e-153 538
WERAM-Ori-0039 BGIOSGA012324-PA Oryza indica 68 7e-153 538
WERAM-Chg-0005 EAQ93036 Chaetomium globosum 62 8e-153 537
WERAM-Ors-0059 OS06T0583400-01 Oryza sativa 68 9e-153 537
WERAM-Orp-0064 OPUNC06G17670.1 Oryza punctata 68 1e-152 536
WERAM-Orb-0066 OBART06G19560.1 Oryza barthii 68 1e-152 536
WERAM-Orbr-0074 OB06G27130.1 Oryza brachyantha 68 1e-152 536
WERAM-Orr-0068 ORUFI06G20660.1 Oryza rufipogon 68 2e-152 536
WERAM-Ast-0010 CADATEAP00004306 Aspergillus terreus 66 2e-152 536
WERAM-Orgl-0064 OGLUM06G20570.1 Oryza glumaepatula 68 2e-152 536
WERAM-Sob-0135 Sb10g022820.1 Sorghum bicolor 68 2e-151 533
WERAM-Sei-0026 Si006243m Setaria italica 68 2e-151 532
WERAM-Phn-0005 SNOT_00508 Phaeosphaeria nodorum 67 2e-151 532
WERAM-Orm-0063 OMERI06G19730.1 Oryza meridionalis 68 4e-151 531
WERAM-Zem-0056 GRMZM2G081474_P01 Zea mays 68 5e-151 531
WERAM-Orni-0065 ONIVA06G23170.1 Oryza nivara 68 5e-151 531
WERAM-Sot-0088 PGSC0003DMT400076252 Solanum tuberosum 67 1e-150 530
WERAM-Pyt-0025 EFQ89270 Pyrenophora teres 67 2e-150 530
WERAM-Lem-0026 CBX91288 Leptosphaeria maculans 67 3e-150 529
WERAM-Spr-0005 CBQ70764 Sporisorium reilianum 63 3e-150 528
WERAM-Lep-0066 LPERR06G16070.1 Leersia perrieri 68 5e-150 528
WERAM-Aet-0051 EMT16627 Aegilops tauschii 67 6e-150 528
WERAM-Pytr-0033 EDU43668 Pyrenophora triticirepentis 66 8e-150 527
WERAM-Lac-0087 ENSLACP00000011092.1 Latimeria chalumnae 63 2e-149 526
WERAM-Nec-0007 EFNCRP00000000997 Neurospora crassa 65 5e-149 525
WERAM-Usm-0008 UM01352P0 Ustilago maydis 63 8e-149 524
WERAM-Lab-0002 EDR16061 Laccaria bicolor 63 8e-149 524
WERAM-Crn-0023 AAW44291 Cryptococcus neoformans 65 1e-147 520
Created Date 25-Jun-2016