Tag |
Content |
WERAM ID |
WERAM-Hos-0016 |
Ensembl Protein ID |
ENSP00000410337.2 |
Uniprot Accession |
Q9UKV0; HDAC9_HUMAN; A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0; O94845; O95028; Q2M2R6; Q86SL1; Q86US3 |
Genbank Protein ID |
NP_001191073.1; NP_001191074.1; NP_001191076.1; NP_001191077.1; NP_055522.1; NP_478056.1; NP_848510.1; NP_848512.1; XP_011513940.1; XP_011513941.1 |
Protein Name |
Histone deacetylase 9 |
Genbank Nucleotide ID |
NM_001204144.2; NM_001204145.2; NM_001204147.2; NM_001204148.2; NM_014707.3; NM_058176.2; NM_178423.2; NM_178425.3; XM_011515638.1; XM_011515639.1 |
Gene Name |
HDAC9;HDAC7;HDAC7B;HDRP;KIAA0744;MITR |
Ensembl Information |
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Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
4.90e-145 |
485 |
47 |
974 |
HDAC |
Class-I |
1.70e-31 |
112.3 |
653 |
943 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
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Domain Profile |
HDAC Class-II
class-2.txt 31 qailsrlqeagllekleelkarkatkeelqlvHseehvelletae.klekeeles 84 q+ l +q+++ ++k + +++ ++++e+l+ H++++ e++++ ++++el + ENSP00000410337.2 47 QQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLaIKQQQELLE 101 4555556777777777778888888888888887777777777654444444443 PP class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles......... 84 +g+ yd+ mlkhq++++n+++hpE+++Riq+i+srlqe+gll+k+e++++rka++ee+qlvHse+h l++t+ +l+ ++l+ ENSP00000410337.2 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTN-PLDGQKLDPrillgddsq 723 789**********************************************************************.****************** PP class-2.txt 85 ..........ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkil 166 l+vdsd+i++e +s+ aar+avG+v+el++kv++gelkngfavvRPPGHHaeestamGFC+fn+va++ak+l+++l+++kil ENSP00000410337.2 724 kffsslpcggLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKIL 815 ******************************************************************************************** PP class-2.txt 167 ivDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvlpiakeFkPd 255 ivD+DvHhGnGtq++fy dp++ly+SlHRyd+g+ffp gsga++evg+g geg+n+N+aw+ggl mgd eyl afr++v p+akeF+Pd ENSP00000410337.2 816 IVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYNINIAWTGGLdppMGDVEYLEAFRTIVKPVAKEFDPD 905 *************************************..***************************************************** PP class-2.txt 256 lvlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 +vlvsaGfDa eg plgg++vtakc+++ltkql++la+grvvl+lEGG++l+ai++a+ea+v+aLlg ENSP00000410337.2 906 MVLVSAGFDALEGhtPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLG 974 *************9889**************************************************96 PP
HDAC Class-I
class-1.txt 19 khpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvep.enae............elskelkkfnvgedc.Pvfd 96 +hp r++ + + + + gl +k e+++ +kas ee++ +hse++ l +p + ++ ++ ++l ++g d+ + + ENSP00000410337.2 653 THPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSL-LYGTNPlDGQKldprillgddsqKFFSSLPCGGLGVDSdTIWN 743 566666666666666677777777777777777777777776655432.2222220222233444333332233333333345555423667 PP class-1.txt 97 glfey..cqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveeafytt 182 +l++ +++ G +e a+k+ ++e + a+ G hha s a Gfc+ n + ++ l+ + +++l +d+d+hhG+g ++afy+ ENSP00000410337.2 744 ELHSSgaARMAVGCVIELASKVASGELKngFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDqlNISKILIVDLDVHHGNGTQQAFYAD 834 77654225677899999999999887661245554444.************************9944567********************** PP class-1.txt 183 drvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDslagD..rlgef 267 ++ +s+h+y+e +ffPg+G ++vg++ g y +n+ + g+d D +y + f++++++v + f+P++v++ G D+l g +lg + ENSP00000410337.2 835 PSILYISLHRYDEgNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDppmgDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHtpPLGGY 926 ***********8746***********************998887655559********************************976337**** PP class-1.txt 268 nlsikghaecvkfvksf 284 +++ k +++ k + + ENSP00000410337.2 927 KVTAKCFGHLTKQLMTL 943 *****999988766655 PP
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Protein Sequence (Fasta) | MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ 60 KQLLIAEFQK QHENLTRQHQ AQLQEHIKEL LAIKQQQELL EKEQKLEQQR QEQEVERHRR 120 EQQLPPLRGK DRGRERAVAS TEVKQKLQEF LLSKSATKDT PTNGKNHSVS RHPKLWYTAA 180 HHTSLDQSSP PLSGTSPSYK YTLPGAQDAK DDFPLRKTAS EPNLKVRSRL KQKVAERRSS 240 PLLRRKDGNV VTSFKKRMFE VTESSVSSSS PGSGPSSPNN GPTGSVTENE TSVLPPTPHA 300 EQMVSQQRIL IHEDSMNLLS LYTSPSLPNI TLGLPAVPSQ LNASNSLKEK QKCETQTLRQ 360 GVPLPGQYGG SIPASSSHPH VTLEGKPPNS SHQALLQHLL LKEQMRQQKL LVAGGVPLHP 420 QSPLATKERI SPGIRGTHKL PRHRPLNRTQ SAPLPQSTLA QLVIQQQHQQ FLEKQKQYQQ 480 QIHMNKLLSK SIEQLKQPGS HLEEAEEELQ GDQAMQEDRA PSSGNSTRSD SSACVDDTLG 540 QVGAVKVKEE PVDSDEDAQI QEMESGEQAA FMQQPFLEPT HTRALSVRQA PLAAVGMDGL 600 EKHRLVSRTH SSPAASVLPH PAMDRPLQPG SATGIAYDPL MLKHQCVCGN STTHPEHAGR 660 IQSIWSRLQE TGLLNKCERI QGRKASLEEI QLVHSEHHSL LYGTNPLDGQ KLDPRILLGD 720 DSQKFFSSLP CGGLGVDSDT IWNELHSSGA ARMAVGCVIE LASKVASGEL KNGFAVVRPP 780 GHHAEESTAM GFCFFNSVAI TAKYLRDQLN ISKILIVDLD VHHGNGTQQA FYADPSILYI 840 SLHRYDEGNF FPGSGAPNEV GTGLGEGYNI NIAWTGGLDP PMGDVEYLEA FRTIVKPVAK 900 EFDPDMVLVS AGFDALEGHT PPLGGYKVTA KCFGHLTKQL MTLADGRVVL ALEGGHDLTA 960 ICDASEACVN ALLGNELEPL AEDILHQSPN MNAVISLQKI IEIQSMSLKF S 1011Protein Fasta Sequence
>ENSP00000410337.2|HDAC9;HDAC7;HDAC7B;HDRP;KIAA0744;MITR|Homo sapiens MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
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Nucleotide Sequence (Fasta) | ATGCACAGTA TGATCAGCTC AGTGGATGTG AAGTCAGAAG TTCCTGTGGG CCTGGAGCCC 60 ATCTCACCTT TAGACCTAAG GACAGACCTC AGGATGATGA TGCCCGTGGT GGACCCTGTT 120 GTCCGTGAGA AGCAATTGCA GCAGGAATTA CTTCTTATCC AGCAGCAGCA ACAAATCCAG 180 AAGCAGCTTC TGATAGCAGA GTTTCAGAAA CAGCATGAGA ACTTGACACG GCAGCACCAG 240 GCTCAGCTTC AGGAGCATAT CAAGGAACTT CTAGCCATAA AACAGCAACA AGAACTCCTA 300 GAAAAGGAGC AGAAACTGGA GCAGCAGAGG CAAGAACAGG AAGTAGAGAG GCATCGCAGA 360 GAACAGCAGC TTCCTCCTCT CAGAGGCAAA GATAGAGGAC GAGAAAGGGC AGTGGCAAGT 420 ACAGAAGTAA AGCAGAAGCT TCAAGAGTTC CTACTGAGTA AATCAGCAAC GAAAGACACT 480 CCAACTAATG GAAAAAATCA TTCCGTGAGC CGCCATCCCA AGCTCTGGTA CACGGCTGCC 540 CACCACACAT CATTGGATCA AAGCTCTCCA CCCCTTAGTG GAACATCTCC ATCCTACAAG 600 TACACATTAC CAGGAGCACA AGATGCAAAG GATGATTTCC CCCTTCGAAA AACTGCCTCT 660 GAGCCCAACT TGAAGGTGCG GTCCAGGTTA AAACAGAAAG TGGCAGAGAG GAGAAGCAGC 720 CCCTTACTCA GGCGGAAGGA TGGAAATGTT GTCACTTCAT TCAAGAAGCG AATGTTTGAG 780 GTGACAGAAT CCTCAGTCAG TAGCAGTTCT CCAGGCTCTG GTCCCAGTTC ACCAAACAAT 840 GGGCCAACTG GAAGTGTTAC TGAAAATGAG ACTTCGGTTT TGCCCCCTAC CCCTCATGCC 900 GAGCAAATGG TTTCACAGCA ACGCATTCTA ATTCATGAAG ATTCCATGAA CCTGCTAAGT 960 CTTTATACCT CTCCTTCTTT GCCCAACATT ACCTTGGGGC TTCCCGCAGT GCCATCCCAG 1020 CTCAATGCTT CGAATTCACT CAAAGAAAAG CAGAAGTGTG AGACGCAGAC GCTTAGGCAA 1080 GGTGTTCCTC TGCCTGGGCA GTATGGAGGC AGCATCCCGG CATCTTCCAG CCACCCTCAT 1140 GTTACTTTAG AGGGAAAGCC ACCCAACAGC AGCCACCAGG CTCTCCTGCA GCATTTATTA 1200 TTGAAAGAAC AAATGCGACA GCAAAAGCTT CTTGTAGCTG GTGGAGTTCC CTTACATCCT 1260 CAGTCTCCCT TGGCAACAAA AGAGAGAATT TCACCTGGCA TTAGAGGTAC CCACAAATTG 1320 CCCCGTCACA GACCCCTGAA CCGAACCCAG TCTGCACCTT TGCCTCAGAG CACGTTGGCT 1380 CAGCTGGTCA TTCAACAGCA ACACCAGCAA TTCTTGGAGA AGCAGAAGCA ATACCAGCAG 1440 CAGATCCACA TGAACAAACT GCTTTCGAAA TCTATTGAAC AACTGAAGCA ACCAGGCAGT 1500 CACCTTGAGG AAGCAGAGGA AGAGCTTCAG GGGGACCAGG CGATGCAGGA AGACAGAGCG 1560 CCCTCTAGTG GCAACAGCAC TAGGAGCGAC AGCAGTGCTT GTGTGGATGA CACACTGGGA 1620 CAAGTTGGGG CTGTGAAGGT CAAGGAGGAA CCAGTGGACA GTGATGAAGA TGCTCAGATC 1680 CAGGAAATGG AATCTGGGGA GCAGGCTGCT TTTATGCAAC AGCCTTTCCT GGAACCCACG 1740 CACACACGTG CGCTCTCTGT GCGCCAAGCT CCGCTGGCTG CGGTTGGCAT GGATGGATTA 1800 GAGAAACACC GTCTCGTCTC CAGGACTCAC TCTTCCCCTG CTGCCTCTGT TTTACCTCAC 1860 CCAGCAATGG ACCGCCCCCT CCAGCCTGGC TCTGCAACTG GAATTGCCTA TGACCCCTTG 1920 ATGCTGAAAC ACCAGTGCGT TTGTGGCAAT TCCACCACCC ACCCTGAGCA TGCTGGACGA 1980 ATACAGAGTA TCTGGTCACG ACTGCAAGAA ACTGGGCTGC TAAATAAATG TGAGCGAATT 2040 CAAGGTCGAA AAGCCAGCCT GGAGGAAATA CAGCTTGTTC ATTCTGAACA TCACTCACTG 2100 TTGTATGGCA CCAACCCCCT GGACGGACAG AAGCTGGACC CCAGGATACT CCTAGGTGAT 2160 GACTCTCAAA AGTTTTTTTC CTCATTACCT TGTGGTGGAC TTGGGGTGGA CAGTGACACC 2220 ATTTGGAATG AGCTACACTC GTCCGGTGCT GCACGCATGG CTGTTGGCTG TGTCATCGAG 2280 CTGGCTTCCA AAGTGGCCTC AGGAGAGCTG AAGAATGGGT TTGCTGTTGT GAGGCCCCCT 2340 GGCCATCACG CTGAAGAATC CACAGCCATG GGGTTCTGCT TTTTTAATTC AGTTGCAATT 2400 ACCGCCAAAT ACTTGAGAGA CCAACTAAAT ATAAGCAAGA TATTGATTGT AGATCTGGAT 2460 GTTCACCATG GAAACGGTAC CCAGCAGGCC TTTTATGCTG ACCCCAGCAT CCTGTACATT 2520 TCACTCCATC GCTATGATGA AGGGAACTTT TTCCCTGGCA GTGGAGCCCC AAATGAGGTT 2580 GGAACAGGCC TTGGAGAAGG GTACAATATA AATATTGCCT GGACAGGTGG CCTTGATCCT 2640 CCCATGGGAG ATGTTGAGTA CCTTGAAGCA TTCAGGACCA TCGTGAAGCC TGTGGCCAAA 2700 GAGTTTGATC CAGACATGGT CTTAGTATCT GCTGGATTTG ATGCATTGGA AGGCCACACC 2760 CCTCCTCTAG GAGGGTACAA AGTGACGGCA AAATGTTTTG GTCATTTGAC GAAGCAATTG 2820 ATGACATTGG CTGATGGACG TGTGGTGTTG GCTCTAGAAG GAGGACATGA TCTCACAGCC 2880 ATCTGTGATG CATCAGAAGC CTGTGTAAAT GCCCTTCTAG GAAATGAGCT GGAGCCACTT 2940 GCAGAAGATA TTCTCCACCA AAGCCCGAAT ATGAATGCTG TTATTTCTTT ACAGAAGATC 3000 ATTGAAATTC AAAGTATGTC TTTAAAGTTC TCTTAAAAAT TCTAAGCAGG TAAAACTAAC 3060 TAAAATTATA TTGAAAATTA TAGTACAAAG AAACATTTA
Nucleotide Fasta Sequence
>ENSP00000410337.2|Class-I|Homo sapiens ATGCACAGTATGATCAGCTCAGTGGATGTGAAGTCAGAAGTTCCTGTGGGCCTGGAGCCCATCTCACCTTTAGACCTAAGGACAGACCTCAGGATGATGATGCCCGTGGTGGACCCTGTTGTCCGTGAGAAGCAATTGCAGCAGGAATTACTTCTTATCCAGCAGCAGCAACAAATCCAGAAGCAGCTTCTGATAGCAGAGTTTCAGAAACAGCATGAGAACTTGACACGGCAGCACCAGGCTCAGCTTCAGGAGCATATCAAGGAACTTCTAGCCATAAAACAGCAACAAGAACTCCTAGAAAAGGAGCAGAAACTGGAGCAGCAGAGGCAAGAACAGGAAGTAGAGAGGCATCGCAGAGAACAGCAGCTTCCTCCTCTCAGAGGCAAAGATAGAGGACGAGAAAGGGCAGTGGCAAGTACAGAAGTAAAGCAGAAGCTTCAAGAGTTCCTACTGAGTAAATCAGCAACGAAAGACACTCCAACTAATGGAAAAAATCATTCCGTGAGCCGCCATCCCAAGCTCTGGTACACGGCTGCCCACCACACATCATTGGATCAAAGCTCTCCACCCCTTAGTGGAACATCTCCATCCTACAAGTACACATTACCAGGAGCACAAGATGCAAAGGATGATTTCCCCCTTCGAAAAACTGCCTCTGAGCCCAACTTGAAGGTGCGGTCCAGGTTAAAACAGAAAGTGGCAGAGAGGAGAAGCAGCCCCTTACTCAGGCGGAAGGATGGAAATGTTGTCACTTCATTCAAGAAGCGAATGTTTGAGGTGACAGAATCCTCAGTCAGTAGCAGTTCTCCAGGCTCTGGTCCCAGTTCACCAAACAATGGGCCAACTGGAAGTGTTACTGAAAATGAGACTTCGGTTTTGCCCCCTACCCCTCATGCCGAGCAAATGGTTTCACAGCAACGCATTCTAATTCATGAAGATTCCATGAACCTGCTAAGTCTTTATACCTCTCCTTCTTTGCCCAACATTACCTTGGGGCTTCCCGCAGTGCCATCCCAGCTCAATGCTTCGAATTCACTCAAAGAAAAGCAGAAGTGTGAGACGCAGACGCTTAGGCAAGGTGTTCCTCTGCCTGGGCAGTATGGAGGCAGCATCCCGGCATCTTCCAGCCACCCTCATGTTACTTTAGAGGGAAAGCCACCCAACAGCAGCCACCAGGCTCTCCTGCAGCATTTATTATTGAAAGAACAAATGCGACAGCAAAAGCTTCTTGTAGCTGGTGGAGTTCCCTTACATCCTCAGTCTCCCTTGGCAACAAAAGAGAGAATTTCACCTGGCATTAGAGGTACCCACAAATTGCCCCGTCACAGACCCCTGAACCGAACCCAGTCTGCACCTTTGCCTCAGAGCACGTTGGCTCAGCTGGTCATTCAACAGCAACACCAGCAATTCTTGGAGAAGCAGAAGCAATACCAGCAGCAGATCCACATGAACAAACTGCTTTCGAAATCTATTGAACAACTGAAGCAACCAGGCAGTCACCTTGAGGAAGCAGAGGAAGAGCTTCAGGGGGACCAGGCGATGCAGGAAGACAGAGCGCCCTCTAGTGGCAACAGCACTAGGAGCGACAGCAGTGCTTGTGTGGATGACACACTGGGACAAGTTGGGGCTGTGAAGGTCAAGGAGGAACCAGTGGACAGTGATGAAGATGCTCAGATCCAGGAAATGGAATCTGGGGAGCAGGCTGCTTTTATGCAACAGCCTTTCCTGGAACCCACGCACACACGTGCGCTCTCTGTGCGCCAAGCTCCGCTGGCTGCGGTTGGCATGGATGGATTAGAGAAACACCGTCTCGTCTCCAGGACTCACTCTTCCCCTGCTGCCTCTGTTTTACCTCACCCAGCAATGGACCGCCCCCTCCAGCCTGGCTCTGCAACTGGAATTGCCTATGACCCCTTGATGCTGAAACACCAGTGCGTTTGTGGCAATTCCACCACCCACCCTGAGCATGCTGGACGAATACAGAGTATCTGGTCACGACTGCAAGAAACTGGGCTGCTAAATAAATGTGAGCGAATTCAAGGTCGAAAAGCCAGCCTGGAGGAAATACAGCTTGTTCATTCTGAACATCACTCACTGTTGTATGGCACCAACCCCCTGGACGGACAGAAGCTGGACCCCAGGATACTCCTAGGTGATGACTCTCAAAAGTTTTTTTCCTCATTACCTTGTGGTGGACTTGGGGTGGACAGTGACACCATTTGGAATGAGCTACACTCGTCCGGTGCTGCACGCATGGCTGTTGGCTGTGTCATCGAGCTGGCTTCCAAAGTGGCCTCAGGAGAGCTGAAGAATGGGTTTGCTGTTGTGAGGCCCCCTGGCCATCACGCTGAAGAATCCACAGCCATGGGGTTCTGCTTTTTTAATTCAGTTGCAATTACCGCCAAATACTTGAGAGACCAACTAAATATAAGCAAGATATTGATTGTAGATCTGGATGTTCACCATGGAAACGGTACCCAGCAGGCCTTTTATGCTGACCCCAGCATCCTGTACATTTCACTCCATCGCTATGATGAAGGGAACTTTTTCCCTGGCAGTGGAGCCCCAAATGAGGTTGGAACAGGCCTTGGAGAAGGGTACAATATAAATATTGCCTGGACAGGTGGCCTTGATCCTCCCATGGGAGATGTTGAGTACCTTGAAGCATTCAGGACCATCGTGAAGCCTGTGGCCAAAGAGTTTGATCCAGACATGGTCTTAGTATCTGCTGGATTTGATGCATTGGAAGGCCACACCCCTCCTCTAGGAGGGTACAAAGTGACGGCAAAATGTTTTGGTCATTTGACGAAGCAATTGATGACATTGGCTGATGGACGTGTGGTGTTGGCTCTAGAAGGAGGACATGATCTCACAGCCATCTGTGATGCATCAGAAGCCTGTGTAAATGCCCTTCTAGGAAATGAGCTGGAGCCACTTGCAGAAGATATTCTCCACCAAAGCCCGAATATGAATGCTGTTATTTCTTTACAGAAGATCATTGAAATTCAAAGTATGTCTTTAAAGTTCTCTTAAAAATTCTAAGCAGGTAAAACTAACTAAAATTATATTGAAAATTATAGTACAAAGAAACATTTA
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0160--Chromosomal rearrangement KW-0181--Complete proteome KW-0378--Hydrolase KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0862--Zinc --
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Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR024643--Hist_deacetylase_Gln_rich_N IPR017320--Histone_deAcase_II_euk
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PROSITE |
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Pfam |
PF12203--HDAC4_Gln PF00850--Hist_deacetyl
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0000118--C:histone deacetylase complex GO:0035097--C:histone methyltransferase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0005667--C:transcription factor complex GO:0004407--F:histone deacetylase activity GO:0042826--F:histone deacetylase binding GO:0046872--F:metal ion binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558--F:protein deacetylase activity GO:0005080--F:protein kinase C binding GO:0070491--F:repressing transcription factor binding GO:0003714--F:transcription corepressor activity GO:0008134--F:transcription factor binding GO:0042113--P:B cell activation GO:0030183--P:B cell differentiation GO:0032869--P:cellular response to insulin stimulus GO:0007507--P:heart development GO:0016575--P:histone deacetylation GO:0070932--P:histone H3 deacetylation GO:0070933--P:histone H4 deacetylation GO:0006954--P:inflammatory response GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0030182--P:neuron differentiation GO:0034983--P:peptidyl-lysine deacetylation GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis GO:0048742--P:regulation of skeletal muscle fiber development GO:0051153--P:regulation of striated muscle cell differentiation GO:0001975--P:response to amphetamine GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |