Tag |
Content |
WERAM ID |
WERAM-Hos-0021 |
Ensembl Protein ID |
ENSP00000080059.7 |
Uniprot Accession |
Q8WUI4; HDAC7_HUMAN; B3KY08; B4DWI0; B4E0Q5; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7 |
Genbank Protein ID |
NP_001091886.1; NP_001295019.1; NP_056216.2; XP_011536783.1; XP_011536784.1 |
Protein Name |
Histone deacetylase 7 |
Genbank Nucleotide ID |
NM_001098416.3; NM_001308090.1; NM_015401.4; XM_011538481.1; XM_011538482.1 |
Gene Name |
HDAC7;HDAC7A |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
2.10e-146 |
489.5 |
559 |
900 |
HDAC |
Class-I |
8.00e-29 |
103.5 |
578 |
869 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
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Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles......... 84 +gl+yd+ mlkhq+ ++++++hpE+++Riq+i+srlqe+gl++++e+l++rka++eelq+vHse+hv l++t+ +l++ +l++ ENSP00000080059.7 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTN-PLSRLKLDNgklagllaq 649 789**********************************************************************.****************** PP class-2.txt 85 ..........ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkil 166 ++vd+d+i++e +s++aar+a+G+v++l++kv++ elkngfavvRPPGHHa++stamGFC+fn+va+a+++lqq+ k++kil ENSP00000080059.7 650 rmfvmlpcggVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKIL 741 ******************************************************************************************** PP class-2.txt 167 ivDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvlpiakeFkPd 255 ivDwDvHhGnGtq++fy+dp+vly+SlHR+d+g+ffp gsgavdevg g+gegfnvNvaw ggl mgd eylaafr vv+pia+eF+Pd ENSP00000080059.7 742 IVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNVNVAWAGGLdppMGDPEYLAAFRIVVMPIAREFSPD 831 *************************************..***************************************************** PP class-2.txt 256 lvlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 lvlvsaGfDaaeg +plgg++v+akc++++t+ql++lagg vvl+lEGG++l+ai++a+ea+v aLlg ENSP00000080059.7 832 LVLVSAGFDAAEGhpAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLG 900 *************999***************************************************96 PP
HDAC Class-I
class-1.txt 18 qkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyi.....eflkkvepenae.......elskelkkfnvgedc.Pvfd 96 ++hp r++ + + + + gl + e ++ +kas eel+++hse ++ + l++ + +n + ++ l +vg d+ + + ENSP00000080059.7 578 SRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVllygtNPLSRLKLDNGKlagllaqRMFVMLPCGGVGVDTdTIWN 669 46777777888888888888888888888888888888888888877633333456777777766655443322222233345555423667 PP class-1.txt 97 glfey..cqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveeafytt 182 +l++ ++ +G+ + a k+ ++e + a+ G hha +s a Gfc+ n + +a +l++ k +++l +d d+hhG+g +++fy+ ENSP00000080059.7 670 ELHSSnaARWAAGSVTDLAFKVASRELKngFAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQqsKASKILIVDWDVHHGNGTQQTFYQD 760 77643113445555566777887776551145555544.************************9866788********************** PP class-1.txt 183 drvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDslagD..rlgef 267 v+ +s+h++++ +ffPg+G +++vga++g + vnv g+d D +y + f+ v+ ++ + f+P+ v++ G D+ g +lg + ENSP00000080059.7 761 PSVLYISLHRHDDgNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDppmgDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHpaPLGGY 852 ***********8746***********************9888876555599******************************99863369999 PP class-1.txt 268 nlsikghaecvkfvksf 284 ++s k ++ + + + + ENSP00000080059.7 853 HVSAKCFGYMTQQLMNL 869 99999998877666555 PP
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Protein Sequence (Fasta) | MHSPGADGTQ VSPGAHYCSP TGAGCPRPCA DTPGPQPQPM DLRVGQRPPV EPPPEPTLLA 60 LQRPQRLHHH LFLAGLQQQR SVEPMRLSMD TPMPELQVGP QEQELRQLLH KDKSKRSAVA 120 SSVVKQKLAE VILKKQQAAL ERTVHPNSPG IPYRTLEPLE TEGATRSMLS SFLPPVPSLP 180 SDPPEHFPLR KTVSEPNLKL RYKPKKSLER RKNPLLRKES APPSLRRRPA ETLGDSSPSS 240 SSTPASGCSS PNDSEHGPNP ILGSEALLGQ RLRLQETSVA PFALPTVSLL PAITLGLPAP 300 ARADSDRRTH PTLGPRGPIL GSPHTPLFLP HGLEPEAGGT LPSRLQPILL LDPSGSHAPL 360 LTVPGLGPLP FHFAQSLMTT ERLSGSGLHW PLSRTRSEPL PPSATAPPPP GPMQPRLEQL 420 KTHVQVIKRS AKPSEKPRLR QIPSAEDLET DGGGPGQVVD DGLEHRELGH GQPEARGPAP 480 LQQHPQVLLW EQQRLAGRLP RGSTGDTVLL PLAQGGHRPL SRAQSSPAAP ASLSAPEPAS 540 QARVLSSSET PARTLPFTTG LIYDSVMLKH QCSCGDNSRH PEHAGRIQSI WSRLQERGLR 600 SQCECLRGRK ASLEELQSVH SERHVLLYGT NPLSRLKLDN GKLAGLLAQR MFVMLPCGGV 660 GVDTDTIWNE LHSSNAARWA AGSVTDLAFK VASRELKNGF AVVRPPGHHA DHSTAMGFCF 720 FNSVAIACRQ LQQQSKASKI LIVDWDVHHG NGTQQTFYQD PSVLYISLHR HDDGNFFPGS 780 GAVDEVGAGS GEGFNVNVAW AGGLDPPMGD PEYLAAFRIV VMPIAREFSP DLVLVSAGFD 840 AAEGHPAPLG GYHVSAKCFG YMTQQLMNLA GGAVVLALEG GHDLTAICDA SEACVAALLG 900 NRVDPLSEEG WKQKPNLNAI RSLEAVIRVH SKYWGCMQRL ASCPDSWVPR VPGADKEEVE 960 AVTALASLSV GILAEDRPSE QLVEEEEPMN L 991Protein Fasta Sequence
>ENSP00000080059.7|HDAC7;HDAC7A|Homo sapiens MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
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Nucleotide Sequence (Fasta) | ATGCACAGCC CCGGCGCTGA TGGGACCCAG GTGAGCCCGG GTGCCCACTA CTGCAGCCCC 60 ACTGGCGCAG GCTGCCCCAG GCCCTGTGCA GACACACCAG GCCCTCAGCC GCAGCCCATG 120 GACCTGCGGG TGGGCCAGCG GCCCCCAGTG GAGCCCCCAC CAGAGCCCAC ATTGCTGGCC 180 CTGCAGCGTC CCCAGCGCCT GCACCACCAC CTCTTCCTAG CAGGCCTGCA GCAGCAGCGC 240 TCGGTGGAGC CCATGAGGCT CTCCATGGAC ACGCCGATGC CCGAGTTGCA GGTGGGACCC 300 CAGGAACAAG AGCTGCGGCA GCTTCTCCAC AAGGACAAGA GCAAGCGAAG TGCTGTAGCC 360 AGCAGCGTGG TCAAGCAGAA GCTAGCGGAG GTGATTCTGA AAAAACAGCA GGCGGCCCTA 420 GAAAGAACAG TCCATCCCAA CAGCCCCGGC ATTCCCTACA GAACCCTGGA GCCCCTGGAG 480 ACGGAAGGAG CCACCCGCTC CATGCTCAGC AGCTTTTTGC CTCCTGTTCC CAGCCTGCCC 540 AGTGACCCCC CAGAGCACTT CCCTCTGCGC AAGACAGTCT CTGAGCCCAA CCTGAAGCTG 600 CGCTATAAGC CCAAGAAGTC CCTGGAGCGG AGGAAGAATC CACTGCTCCG AAAGGAGAGT 660 GCGCCCCCCA GCCTCCGGCG GCGGCCCGCA GAGACCCTCG GAGACTCCTC CCCAAGTAGT 720 AGCAGCACGC CCGCATCAGG GTGCAGCTCC CCCAATGACA GCGAGCACGG CCCCAATCCC 780 ATCCTGGGCT CGGAGGCGCT CTTGGGCCAG CGGCTGCGGC TGCAGGAGAC TTCTGTGGCC 840 CCGTTCGCCT TGCCGACAGT GTCCTTGCTG CCCGCAATCA CTCTGGGGCT GCCCGCCCCT 900 GCCAGGGCTG ACAGTGACCG CAGGACCCAT CCGACTCTGG GCCCTCGGGG GCCAATCCTG 960 GGGAGCCCCC ACACTCCCCT CTTCCTGCCC CATGGCTTGG AGCCCGAGGC TGGGGGCACC 1020 TTGCCCTCTC GCCTGCAGCC CATTCTCCTC CTGGACCCCT CAGGCTCTCA TGCCCCGCTG 1080 CTGACTGTGC CCGGGCTTGG GCCCTTGCCC TTCCACTTTG CCCAGTCCTT AATGACCACC 1140 GAGCGGCTCT CTGGGTCAGG CCTCCACTGG CCACTGAGCC GGACTCGCTC AGAGCCCCTG 1200 CCCCCCAGTG CCACCGCTCC CCCACCGCCG GGCCCCATGC AGCCCCGCCT GGAGCAGCTC 1260 AAAACTCACG TCCAGGTGAT CAAGAGGTCA GCCAAGCCGA GTGAGAAGCC CCGGCTGCGG 1320 CAGATACCCT CGGCTGAAGA CCTGGAGACA GATGGCGGGG GACCGGGCCA GGTGGTGGAC 1380 GATGGCCTGG AGCACAGGGA GCTGGGCCAT GGGCAGCCTG AGGCCAGAGG CCCCGCTCCT 1440 CTCCAGCAGC ACCCTCAGGT GTTGCTCTGG GAACAGCAGC GACTGGCTGG GCGGCTCCCC 1500 CGGGGCAGCA CCGGGGACAC TGTGCTGCTT CCTCTGGCCC AGGGTGGGCA CCGGCCTCTG 1560 TCCCGGGCTC AGTCTTCCCC AGCCGCACCT GCCTCACTGT CAGCCCCAGA GCCTGCCAGC 1620 CAGGCCCGAG TCCTCTCCAG CTCAGAGACC CCTGCCAGGA CCCTGCCCTT CACCACAGGG 1680 CTGATCTATG ACTCGGTCAT GCTGAAGCAC CAGTGCTCCT GCGGTGACAA CAGCAGGCAC 1740 CCGGAGCACG CCGGCCGCAT CCAGAGCATC TGGTCCCGGC TGCAGGAGCG GGGGCTCCGG 1800 AGCCAGTGTG AGTGTCTCCG AGGCCGGAAG GCCTCCCTGG AAGAGCTGCA GTCGGTCCAC 1860 TCTGAGCGGC ACGTGCTCCT CTACGGCACC AACCCGCTCA GCCGCCTCAA ACTGGACAAC 1920 GGGAAGCTGG CAGGGCTCCT GGCACAGCGG ATGTTTGTGA TGCTGCCCTG TGGTGGGGTT 1980 GGGGTGGACA CTGACACCAT CTGGAATGAG CTTCATTCCT CCAATGCAGC CCGCTGGGCC 2040 GCTGGCAGTG TCACTGACCT CGCCTTCAAA GTGGCTTCTC GTGAGCTAAA GAATGGTTTC 2100 GCTGTGGTGC GGCCCCCAGG ACACCATGCA GATCATTCAA CAGCCATGGG CTTCTGCTTC 2160 TTCAACTCAG TGGCCATCGC CTGCCGGCAG CTGCAACAGC AGAGCAAGGC CAGCAAGATC 2220 CTCATTGTAG ACTGGGACGT GCACCATGGC AACGGCACCC AGCAAACCTT CTACCAAGAC 2280 CCCAGTGTGC TCTACATCTC CCTGCATCGC CATGACGACG GCAACTTCTT CCCGGGGAGT 2340 GGGGCTGTGG ATGAGGTAGG GGCTGGCAGC GGTGAGGGCT TCAATGTCAA TGTGGCCTGG 2400 GCTGGAGGTC TGGACCCCCC CATGGGGGAT CCTGAGTACC TGGCTGCTTT CAGGATAGTC 2460 GTGATGCCCA TCGCCCGAGA GTTCTCTCCA GACCTAGTCC TGGTGTCTGC TGGATTTGAT 2520 GCTGCTGAGG GTCACCCGGC CCCACTGGGT GGCTACCATG TTTCTGCCAA ATGTTTTGGA 2580 TACATGACGC AGCAACTGAT GAACCTGGCA GGAGGCGCAG TGGTGCTGGC CTTGGAGGGT 2640 GGCCATGACC TCACAGCCAT CTGTGACGCC TCTGAGGCCT GTGTGGCTGC TCTTCTGGGT 2700 AACAGGGTGG ATCCCCTTTC AGAAGAAGGC TGGAAACAGA AACCCAACCT CAATGCCATC 2760 CGCTCTCTGG AGGCCGTGAT CCGGGTGCAC AGTAAATACT GGGGCTGCAT GCAGCGCCTG 2820 GCCTCCTGTC CAGACTCCTG GGTGCCTAGA GTGCCAGGGG CTGACAAAGA AGAAGTGGAG 2880 GCAGTGACCG CACTGGCGTC CCTCTCTGTG GGCATCCTGG CTGAAGATAG GCCCTCGGAG 2940 CAGCTGGTGG AGGAGGAAGA ACCTATGAAT CTCTAAGGCT CTGGAACCAT CTGCCCGCCC 3000 ACCATGCCCT TGGGACCTGG TTCTCTTCTA ACCCCTGGCA ATAGCCCCCA TTCCTGGGTC 3060 TTTAGAGATC CTGTGGGCAA GTAGTTGGAA CCAGAGAACA GCCTGCCTGC TTTGACAGTT 3120 ATCCCAGGGA GCGTGAGAAA ATCCCTGGGT CTAGAATGGG AACTGGAGAG GACCCTGAGA 3180 GGAGACGGGC TGGGCGGCGA CCCCCACAGG GCTCTCGAGA ACAGATTCTC CCCTCCAGTA 3240 TGGGCCCTGG CTGTGGCCCC CATTCCTCAG GACTGCACAG AGGAGGACTG GCTCCGGCTC 3300 CGTCGGGCTC ACCCTTAACC ACTATTCCTG GCTCTGCAAA CCCCAGACTT TGCACACAGC 3360 CTCAGGCTCC ACACAGAAAT GTGAACTTGG CCTCAGACAG GCTGGCCCTT CCTAGGCTCT 3420 AGGGGCTAGG GGGGAGTGGG GAGCCAAGAG GTCCCATATT CCTGAGTGCA GGGGTAGTCC 3480 CTCTCACCTG CTTCCTCAGA CGACTCTGGA AGCTTCCCTC TACCACTGGG CACTGAGACG 3540 AAGCTCCCTG ACAGCCGAGA CTGGCAGCCC TCCATCTGGT CCGTACCCTC GCCAGAGGCC 3600 CCCCTACATC AACCTCCTGG CGATGCCCTG GTGGAGCAGA TGGGTGCTCT GGGAGTCCTG 3660 TGCTTCCTGA TCCAATGGTG CCAAACCCTT CATCTCCCCA AGAAGCGCAG CATACCCCTG 3720 GGACCCCTCG GCCACTGCCC ACTCGGGGAG CCTTCTCTGT TTCTGGGGCC TCCCCCACCA 3780 TAGCTCTGAT TCCCACCCCA CATAGGAGTA GCCTGACTGA GGGGGAAGGG GTGGGAGAGA 3840 AGATACAGAC ATGGAGGAGG GGAGGCTGCT CTGGCAAAGT CTTCAAGGCT TTTGGGGGTC 3900 CAGGCCTGGG GTCAAGAAGG AAAATGTGTG TGAGCATGTG TGTGAGTGAG GCGTGTGTGT 3960 GAGCGTGTGT GTGAGTGAGG CGTGTGTGTG TGTCTTTCCT AGGACCCACC ATACCCTGTG 4020 TATGTATGCA TGTTTTTGTA AAAAGGAAGA AAATGGAAAA AAATCTGAAC AATAAATGTT 4080 TTATTTGCTT TAAAA
4096Nucleotide Fasta Sequence
>ENSP00000080059.7|Class-I|Homo sapiens ATGCACAGCCCCGGCGCTGATGGGACCCAGGTGAGCCCGGGTGCCCACTACTGCAGCCCCACTGGCGCAGGCTGCCCCAGGCCCTGTGCAGACACACCAGGCCCTCAGCCGCAGCCCATGGACCTGCGGGTGGGCCAGCGGCCCCCAGTGGAGCCCCCACCAGAGCCCACATTGCTGGCCCTGCAGCGTCCCCAGCGCCTGCACCACCACCTCTTCCTAGCAGGCCTGCAGCAGCAGCGCTCGGTGGAGCCCATGAGGCTCTCCATGGACACGCCGATGCCCGAGTTGCAGGTGGGACCCCAGGAACAAGAGCTGCGGCAGCTTCTCCACAAGGACAAGAGCAAGCGAAGTGCTGTAGCCAGCAGCGTGGTCAAGCAGAAGCTAGCGGAGGTGATTCTGAAAAAACAGCAGGCGGCCCTAGAAAGAACAGTCCATCCCAACAGCCCCGGCATTCCCTACAGAACCCTGGAGCCCCTGGAGACGGAAGGAGCCACCCGCTCCATGCTCAGCAGCTTTTTGCCTCCTGTTCCCAGCCTGCCCAGTGACCCCCCAGAGCACTTCCCTCTGCGCAAGACAGTCTCTGAGCCCAACCTGAAGCTGCGCTATAAGCCCAAGAAGTCCCTGGAGCGGAGGAAGAATCCACTGCTCCGAAAGGAGAGTGCGCCCCCCAGCCTCCGGCGGCGGCCCGCAGAGACCCTCGGAGACTCCTCCCCAAGTAGTAGCAGCACGCCCGCATCAGGGTGCAGCTCCCCCAATGACAGCGAGCACGGCCCCAATCCCATCCTGGGCTCGGAGGCGCTCTTGGGCCAGCGGCTGCGGCTGCAGGAGACTTCTGTGGCCCCGTTCGCCTTGCCGACAGTGTCCTTGCTGCCCGCAATCACTCTGGGGCTGCCCGCCCCTGCCAGGGCTGACAGTGACCGCAGGACCCATCCGACTCTGGGCCCTCGGGGGCCAATCCTGGGGAGCCCCCACACTCCCCTCTTCCTGCCCCATGGCTTGGAGCCCGAGGCTGGGGGCACCTTGCCCTCTCGCCTGCAGCCCATTCTCCTCCTGGACCCCTCAGGCTCTCATGCCCCGCTGCTGACTGTGCCCGGGCTTGGGCCCTTGCCCTTCCACTTTGCCCAGTCCTTAATGACCACCGAGCGGCTCTCTGGGTCAGGCCTCCACTGGCCACTGAGCCGGACTCGCTCAGAGCCCCTGCCCCCCAGTGCCACCGCTCCCCCACCGCCGGGCCCCATGCAGCCCCGCCTGGAGCAGCTCAAAACTCACGTCCAGGTGATCAAGAGGTCAGCCAAGCCGAGTGAGAAGCCCCGGCTGCGGCAGATACCCTCGGCTGAAGACCTGGAGACAGATGGCGGGGGACCGGGCCAGGTGGTGGACGATGGCCTGGAGCACAGGGAGCTGGGCCATGGGCAGCCTGAGGCCAGAGGCCCCGCTCCTCTCCAGCAGCACCCTCAGGTGTTGCTCTGGGAACAGCAGCGACTGGCTGGGCGGCTCCCCCGGGGCAGCACCGGGGACACTGTGCTGCTTCCTCTGGCCCAGGGTGGGCACCGGCCTCTGTCCCGGGCTCAGTCTTCCCCAGCCGCACCTGCCTCACTGTCAGCCCCAGAGCCTGCCAGCCAGGCCCGAGTCCTCTCCAGCTCAGAGACCCCTGCCAGGACCCTGCCCTTCACCACAGGGCTGATCTATGACTCGGTCATGCTGAAGCACCAGTGCTCCTGCGGTGACAACAGCAGGCACCCGGAGCACGCCGGCCGCATCCAGAGCATCTGGTCCCGGCTGCAGGAGCGGGGGCTCCGGAGCCAGTGTGAGTGTCTCCGAGGCCGGAAGGCCTCCCTGGAAGAGCTGCAGTCGGTCCACTCTGAGCGGCACGTGCTCCTCTACGGCACCAACCCGCTCAGCCGCCTCAAACTGGACAACGGGAAGCTGGCAGGGCTCCTGGCACAGCGGATGTTTGTGATGCTGCCCTGTGGTGGGGTTGGGGTGGACACTGACACCATCTGGAATGAGCTTCATTCCTCCAATGCAGCCCGCTGGGCCGCTGGCAGTGTCACTGACCTCGCCTTCAAAGTGGCTTCTCGTGAGCTAAAGAATGGTTTCGCTGTGGTGCGGCCCCCAGGACACCATGCAGATCATTCAACAGCCATGGGCTTCTGCTTCTTCAACTCAGTGGCCATCGCCTGCCGGCAGCTGCAACAGCAGAGCAAGGCCAGCAAGATCCTCATTGTAGACTGGGACGTGCACCATGGCAACGGCACCCAGCAAACCTTCTACCAAGACCCCAGTGTGCTCTACATCTCCCTGCATCGCCATGACGACGGCAACTTCTTCCCGGGGAGTGGGGCTGTGGATGAGGTAGGGGCTGGCAGCGGTGAGGGCTTCAATGTCAATGTGGCCTGGGCTGGAGGTCTGGACCCCCCCATGGGGGATCCTGAGTACCTGGCTGCTTTCAGGATAGTCGTGATGCCCATCGCCCGAGAGTTCTCTCCAGACCTAGTCCTGGTGTCTGCTGGATTTGATGCTGCTGAGGGTCACCCGGCCCCACTGGGTGGCTACCATGTTTCTGCCAAATGTTTTGGATACATGACGCAGCAACTGATGAACCTGGCAGGAGGCGCAGTGGTGCTGGCCTTGGAGGGTGGCCATGACCTCACAGCCATCTGTGACGCCTCTGAGGCCTGTGTGGCTGCTCTTCTGGGTAACAGGGTGGATCCCCTTTCAGAAGAAGGCTGGAAACAGAAACCCAACCTCAATGCCATCCGCTCTCTGGAGGCCGTGATCCGGGTGCACAGTAAATACTGGGGCTGCATGCAGCGCCTGGCCTCCTGTCCAGACTCCTGGGTGCCTAGAGTGCCAGGGGCTGACAAAGAAGAAGTGGAGGCAGTGACCGCACTGGCGTCCCTCTCTGTGGGCATCCTGGCTGAAGATAGGCCCTCGGAGCAGCTGGTGGAGGAGGAAGAACCTATGAATCTCTAAGGCTCTGGAACCATCTGCCCGCCCACCATGCCCTTGGGACCTGGTTCTCTTCTAACCCCTGGCAATAGCCCCCATTCCTGGGTCTTTAGAGATCCTGTGGGCAAGTAGTTGGAACCAGAGAACAGCCTGCCTGCTTTGACAGTTATCCCAGGGAGCGTGAGAAAATCCCTGGGTCTAGAATGGGAACTGGAGAGGACCCTGAGAGGAGACGGGCTGGGCGGCGACCCCCACAGGGCTCTCGAGAACAGATTCTCCCCTCCAGTATGGGCCCTGGCTGTGGCCCCCATTCCTCAGGACTGCACAGAGGAGGACTGGCTCCGGCTCCGTCGGGCTCACCCTTAACCACTATTCCTGGCTCTGCAAACCCCAGACTTTGCACACAGCCTCAGGCTCCACACAGAAATGTGAACTTGGCCTCAGACAGGCTGGCCCTTCCTAGGCTCTAGGGGCTAGGGGGGAGTGGGGAGCCAAGAGGTCCCATATTCCTGAGTGCAGGGGTAGTCCCTCTCACCTGCTTCCTCAGACGACTCTGGAAGCTTCCCTCTACCACTGGGCACTGAGACGAAGCTCCCTGACAGCCGAGACTGGCAGCCCTCCATCTGGTCCGTACCCTCGCCAGAGGCCCCCCTACATCAACCTCCTGGCGATGCCCTGGTGGAGCAGATGGGTGCTCTGGGAGTCCTGTGCTTCCTGATCCAATGGTGCCAAACCCTTCATCTCCCCAAGAAGCGCAGCATACCCCTGGGACCCCTCGGCCACTGCCCACTCGGGGAGCCTTCTCTGTTTCTGGGGCCTCCCCCACCATAGCTCTGATTCCCACCCCACATAGGAGTAGCCTGACTGAGGGGGAAGGGGTGGGAGAGAAGATACAGACATGGAGGAGGGGAGGCTGCTCTGGCAAAGTCTTCAAGGCTTTTGGGGGTCCAGGCCTGGGGTCAAGAAGGAAAATGTGTGTGAGCATGTGTGTGAGTGAGGCGTGTGTGTGAGCGTGTGTGTGAGTGAGGCGTGTGTGTGTGTCTTTCCTAGGACCCACCATACCCTGTGTATGTATGCATGTTTTTGTAAAAAGGAAGAAAATGGAAAAAAATCTGAACAATAAATGTTTTATTTGCTTTAAAA
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0378--Hydrolase KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc --
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Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR017320--Histone_deAcase_II_euk
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PROSITE |
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Pfam |
PF00850--Hist_deacetyl
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0000118--C:histone deacetylase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0071889--F:14-3-3 protein binding GO:0033613--F:activating transcription factor binding GO:0003682--F:chromatin binding GO:0046872--F:metal ion binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0019901--F:protein kinase binding GO:0005080--F:protein kinase C binding GO:0070491--F:repressing transcription factor binding GO:0019789--F:SUMO transferase activity GO:0003714--F:transcription corepressor activity GO:0007043--P:cell-cell junction assembly GO:0071260--P:cellular response to mechanical stimulus GO:0032703--P:negative regulation of interleukin-2 production GO:1901215--P:negative regulation of neuron death GO:1901223--P:negative regulation of NIK/NF-kappaB signaling GO:0045668--P:negative regulation of osteoblast differentiation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0051402--P:neuron apoptotic process GO:0030182--P:neuron differentiation GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis GO:0016925--P:protein sumoylation GO:0006351--P:transcription, DNA-templated GO:0001570--P:vasculogenesis
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Orthology |
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Created Date |
25-Jun-2016 |