Tag |
Content |
WERAM ID |
WERAM-Ran-0240 |
Ensembl Protein ID |
ENSRNOP00000073744.1 |
Uniprot Accession |
A0A0G2K6B1; A0A0G2K6B1_RAT |
Genbank Protein ID |
XP_008764065.1 |
Protein Name |
Histone deacetylase |
Genbank Nucleotide ID |
XM_008765843.1 |
Gene Name |
HDAC7 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Hist_deacetyl |
H2A; H2B; H3; H4 |
K |
26395029; 26365275 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
2.00e-147 |
491 |
544 |
885 |
HDAC |
Class-I |
2.50e-30 |
106.6 |
562 |
863 |
|
Organism |
Rattus norvegicus |
NCBI Taxa ID |
10116 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
|
Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles...... 84 +glvyd+ mlkhq+ +++++khpE+++Riq+i+srlqe+gl++++e+l++rka++eelq+vHse+hv l++t+ +l++ +l++ ENSRNOP00000073744.1 544 TGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTN-PLSRLKLDNgkltgl 631 78***********************************************************************.*************** PP class-2.txt 85 .............ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqkl 160 ++vd+d+i++e +s++aar+a+G+v++l++kv++ elkngfavvRPPGHHa++stamGFC+fn+va+a+++lqq+ ENSRNOP00000073744.1 632 laqrtfvmlpcggVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHG 720 ***************************************************************************************** PP class-2.txt 161 kvkkilivDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvl 246 k++kilivDwDvHhGnGtq++fy+dp+vly+SlHR+d+g+ffp gsgavdevg+g+gegfnvNvaw ggl mgd eylaafr vv+ ENSRNOP00000073744.1 721 KASKILIVDWDVHHGNGTQQTFYQDPRVLYISLHRHDDGNFFP--GSGAVDEVGTGSGEGFNVNVAWAGGLdppMGDPEYLAAFRIVVM 807 *******************************************..******************************************** PP class-2.txt 247 piakeFkPdlvlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLlg 322 pia+eF+PdlvlvsaGfDaaeg +plgg++v+akc++++t+ql++lagg vvl+lEGG++l+ai++a+ea+v aLlg ENSRNOP00000073744.1 808 PIAREFAPDLVLVSAGFDAAEGhpAPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLG 885 **********************999***************************************************96 PP
HDAC Class-I
class-1.txt 17 gqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyi.....eflkkvepenae........elskelkkfnvgedc 92 ++khp r++ + + + + gl + e ++ +kas eel+++hse ++ + l++ + +n + ++ l +vg d+ ENSRNOP00000073744.1 562 NSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVllygtNPLSRLKLDNGKltgllaqrTF-VMLPCGGVGVDT 649 4578888888888888889999999999999999999999999998877333334577777777776555432211.122223455555 PP class-1.txt 93 .Pvfdglfey..cqlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDg 174 + ++l++ ++ +G+ + a k+ ++e + a+ G hha +s a Gfc+ n + +a +l++ k +++l +d d+hhG+g ENSRNOP00000073744.1 650 dTIWNELHSSnaARWAAGSVTDLAFKVASRELKngFAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQhgKASKILIVDWDVHHGNG 737 2367777653113445566667788888776651155555555.************************9977889************** PP class-1.txt 175 veeafyttdrvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDs 258 +++fy+ rv+ +s+h++++ +ffPg+G +++vg+++g + vnv g+d D +y + f+ v+ ++ + f P+ v++ G D+ ENSRNOP00000073744.1 738 TQQTFYQDPRVLYISLHRHDDgNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDppmgDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDA 826 *******************8746***********************9888876555599****************************** PP class-1.txt 259 lagD..rlgefnlsikghaecvkfvksf..nlpllvl 291 g +lg +++s k ++ + + + s + +l l ENSRNOP00000073744.1 827 AEGHpaPLGGYHVSAKCFGYMTQQLMSLagGAVVLAL 863 998633699****999999988877777433333334 PP
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Protein Sequence (Fasta) | MHSPGAGCPA LQPDTPGSQP QPMDLRVGQR PTVEPPPEPA LLTLQHPQRL HRHLFLAGLQ 60 QQQRSAEPMR LSMDPPLPEL QGAQQEQELR QLLNKDKSKR SAVASSVVKQ KLAEVILKKQ 120 QAALERTVHP SSPSIPYRTL EPLDTEGAAR SVLSSFLPPV PSLPTEPPEH FPLRKTVSEP 180 NLKLRYKPKK SLERRKNPLL RKESAPPSLR RRPAETLGDS SPSSSSTPAS GCSSPNDSEH 240 GPNPALGSEA LLGQRLRLQE TSLAPFALPT VSLLPAITLG LPAPARADGD RRTHSTLGPR 300 GPVLGNPHAP LFLHHGLEPE AGGTLPSRLQ PILLLDPSVS HAPLWTVPGL GPLPFHFAQP 360 LLTTERLSGS GLHRPLNRTR SEPLPPSATA SPLLGPLQPR QDRLKPHVQL IKTAISPPQR 420 PAKPSEKPRL RQIPSAEDLE TDGGGVGPMA NDGLEHRESG RGPPEGRGAV SLQQHQQVPL 480 WEQQHLAGRL SQGGPGDSVL LPLAQIGHRP LSRTQSSPAA PVSLLSPEPT CQTQVLNSSE 540 APATGLVYDS VMLKHQCSCG DNSKHPEHAG RIQSIWSRLQ ERGLRSQCEC LRGRKASLEE 600 LQSVHSERHV LLYGTNPLSR LKLDNGKLTG LLAQRTFVML PCGGVGVDTD TIWNELHSSN 660 AARWAAGSVT DLAFKVASRE LKNGFAVVRP PGHHADHSTA MGFCFFNSVA IACRQLQQHG 720 KASKILIVDW DVHHGNGTQQ TFYQDPRVLY ISLHRHDDGN FFPGSGAVDE VGTGSGEGFN 780 VNVAWAGGLD PPMGDPEYLA AFRIVVMPIA REFAPDLVLV SAGFDAAEGH PAPLGGYHVS 840 AKCFGYMTQQ LMSLAGGAVV LALEGGHDLT AICDASEACV AALLGNKVDP LSQESWKQKP 900 NLNAIRSLEA VVRVHRKYWG CMQRLASCPD PWLPRVPGAD AEVEAVTALA SLSVGILAED 960 RPSKELMEEE EPMNL 975Protein Fasta Sequence
>ENSRNOP00000073744.1|HDAC7|Rattus norvegicus MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGAQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEALLGQRLRLQETSLAPFALPTVSLLPAITLGLPAPARADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGGTLPSRLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASPLLGPLQPRQDRLKPHVQLIKTAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMANDGLEHRESGRGPPEGRGAVSLQQHQQVPLWEQQHLAGRLSQGGPGDSVLLPLAQIGHRPLSRTQSSPAAPVSLLSPEPTCQTQVLNSSEAPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQTFYQDPRVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKVDPLSQESWKQKPNLNAIRSLEAVVRVHRKYWGCMQRLASCPDPWLPRVPGADAEVEAVTALASLSVGILAEDRPSKELMEEEEPMNL
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Nucleotide Sequence (Fasta) | GCCAGGCTGC CAGGGCCCTC CCCCTCCCGG CCCCCTCCCT TCCTCTCGCC GTCTCACAGT 60 CGCTCTGCAG CCTCCGGCGA CCGGGGGGAT GTGAGGCCGG CGCCCCGGCC CCCCGCCCGC 120 CATGAGCCCC CGGCTCTGAG GGCCCCGGCC CCTGGATGCA CAGCCCCGGC GCGGGCTGCC 180 CTGCCCTCCA GCCAGACACA CCAGGCTCTC AGCCCCAGCC CATGGACCTG CGAGTGGGCC 240 AAAGGCCCAC AGTGGAGCCG CCACCAGAGC CTGCACTGCT GACCCTGCAG CACCCTCAGC 300 GCCTGCACCG CCATCTCTTC CTAGCAGGCT TGCAACAGCA ACAGCGCTCA GCTGAGCCCA 360 TGAGGCTCTC CATGGACCCA CCGCTGCCGG AGCTGCAGGG GGCACAGCAG GAGCAAGAAC 420 TTCGGCAACT TCTCAATAAA GACAAGAGCA AGCGAAGTGC CGTAGCCAGC AGTGTGGTCA 480 AGCAGAAACT GGCTGAAGTG ATCCTGAAGA AACAGCAGGC AGCCCTTGAG AGAACAGTCC 540 ACCCCAGCAG CCCCAGTATC CCCTACAGAA CTCTTGAGCC CTTGGACACA GAGGGTGCTG 600 CCCGCTCCGT GCTTAGCAGC TTCCTGCCTC CTGTTCCCAG CCTGCCCACT GAACCCCCGG 660 AACATTTTCC CCTGCGTAAA ACAGTGTCTG AGCCGAACCT GAAGCTGCGC TACAAACCCA 720 AGAAATCCCT GGAGAGGCGT AAGAATCCCC TGCTCAGGAA GGAGAGCGCC CCACCCAGTC 780 TTCGGAGGAG GCCTGCTGAG ACTCTTGGAG ATTCCTCCCC CAGTAGTAGC AGCACACCTG 840 CGTCAGGGTG CAGCTCCCCC AATGACAGCG AGCATGGCCC TAACCCTGCC CTGGGCTCAG 900 AGGCGCTCTT GGGCCAGCGG CTGCGGCTGC AGGAGACTTC TTTGGCCCCG TTCGCTTTGC 960 CGACAGTGTC CTTGCTGCCC GCAATCACAC TGGGGCTGCC TGCCCCTGCC AGGGCTGATG 1020 GTGACCGCAG GACCCATTCA ACTTTGGGCC CTCGGGGTCC TGTCCTAGGG AACCCCCATG 1080 CTCCCCTCTT CCTGCACCAT GGTTTGGAGC CAGAGGCTGG GGGCACCTTA CCCTCTCGCC 1140 TGCAGCCCAT TCTCCTGCTG GATCCCTCAG TCTCTCATGC CCCACTGTGG ACTGTGCCCG 1200 GGCTCGGGCC CTTGCCCTTC CACTTTGCCC AGCCCTTACT GACCACCGAG CGGCTCTCTG 1260 GGTCAGGCCT CCATCGGCCA CTTAACCGGA CCCGCTCAGA GCCCCTGCCC CCCAGCGCCA 1320 CTGCCTCCCC TCTGCTGGGC CCCCTCCAGC CCCGCCAGGA TCGGCTCAAA CCTCATGTCC 1380 AGCTGATCAA GACAGCCATC TCCCCTCCCC AGAGGCCTGC CAAGCCCAGT GAGAAGCCCC 1440 GACTGCGGCA GATACCCTCG GCTGAGGACC TAGAGACAGA TGGTGGGGGA GTGGGACCTA 1500 TGGCGAATGA TGGCCTGGAA CATAGGGAGT CAGGCCGTGG GCCGCCTGAG GGCAGAGGGG 1560 CCGTTTCTCT GCAGCAACAC CAACAGGTGC CACTCTGGGA GCAGCAGCAT CTTGCTGGGC 1620 GGCTCTCCCA GGGAGGCCCC GGGGACTCTG TGCTGCTACC TCTGGCCCAG ATTGGACACC 1680 GGCCCCTGTC CAGAACCCAG TCTTCCCCAG CCGCACCTGT CTCCCTGCTG AGCCCAGAGC 1740 CCACCTGTCA GACCCAAGTC CTCAACAGCT CAGAGGCACC TGCCACAGGG CTGGTCTATG 1800 ACTCGGTGAT GCTGAAACAC CAATGTTCCT GTGGAGACAA CAGCAAGCAT CCCGAGCACG 1860 CAGGCCGCAT CCAGAGCATC TGGTCCCGGC TGCAGGAACG GGGTCTCCGC AGCCAGTGTG 1920 AGTGTCTCCG AGGCCGAAAG GCTTCCCTAG AAGAGCTGCA GTCAGTCCAC TCTGAAAGGC 1980 ACGTGCTCCT CTACGGCACA AACCCACTCA GCCGCCTCAA ACTGGATAAC GGGAAGCTTA 2040 CAGGACTCCT GGCCCAGCGG ACGTTTGTGA TGCTACCCTG TGGCGGGGTT GGGGTAGATA 2100 CTGACACCAT CTGGAATGAG CTGCATTCCT CCAATGCAGC CCGCTGGGCT GCAGGCAGCG 2160 TCACCGACCT TGCCTTCAAA GTCGCTTCCC GAGAGCTAAA GAATGGCTTT GCTGTGGTGC 2220 GGCCTCCAGG ACACCATGCA GATCATTCTA CAGCCATGGG CTTTTGCTTC TTCAACTCTG 2280 TGGCCATCGC CTGCCGACAG CTGCAGCAAC ACGGCAAAGC CAGCAAGATC CTCATTGTCG 2340 ACTGGGATGT TCACCATGGC AACGGCACAC AGCAGACTTT CTATCAGGAC CCCAGGGTGC 2400 TCTACATATC CCTTCATCGC CATGACGATG GCAACTTCTT CCCGGGCAGT GGGGCCGTGG 2460 ATGAGGTGGG AACCGGCAGT GGCGAGGGCT TCAACGTCAA TGTGGCTTGG GCTGGGGGCT 2520 TGGATCCACC CATGGGGGAT CCTGAGTACC TGGCTGCTTT CAGGATAGTG GTGATGCCCA 2580 TTGCCCGCGA GTTTGCTCCA GACCTGGTCC TGGTGTCCGC TGGGTTTGAC GCTGCAGAGG 2640 GTCATCCAGC CCCGCTGGGC GGCTACCATG TTTCTGCCAA ATGCTTTGGG TACATGACAC 2700 AGCAGCTGAT GAGCTTGGCA GGAGGTGCGG TGGTGTTGGC CTTGGAGGGC GGCCATGACC 2760 TCACAGCCAT CTGTGATGCC TCTGAGGCCT GTGTGGCAGC TCTTCTGGGC AACAAGGTGG 2820 ATCCCCTTTC ACAAGAAAGC TGGAAACAGA AACCCAACCT CAATGCCATC CGCTCTCTGG 2880 AAGCCGTGGT CAGGGTGCAC AGGAAATACT GGGGCTGCAT GCAGCGCTTG GCCTCCTGTC 2940 CAGACCCCTG GCTGCCCAGG GTGCCGGGAG CTGATGCAGA AGTGGAGGCC GTGACTGCAC 3000 TGGCATCCCT TTCCGTTGGC ATCCTGGCTG AAGACAGGCC CTCGAAGGAG CTGATGGAAG 3060 AGGAAGAACC CATGAACCTC TAGGGTCTCA GAACAGATCA GCCTGCAGAT GTGGCTCTCC 3120 TCATCACTGT TGTCAACCCT GCTCCTGGGT CTTCAGAGAT CCCCTGGGCA GGTAGTCAGG 3180 TCCAGAGCAC AGCCTACCCT GACGGCTATC CCAGGGAACT TGAGAAGACC ACTGGGTCTG 3240 GGATGGGGGT GAGGGAGGAC TCTGGGAGGA GGCAGGCTGG GC
3283Nucleotide Fasta Sequence
>ENSRNOP00000073744.1|Class-I|Rattus norvegicus GCCAGGCTGCCAGGGCCCTCCCCCTCCCGGCCCCCTCCCTTCCTCTCGCCGTCTCACAGTCGCTCTGCAGCCTCCGGCGACCGGGGGGATGTGAGGCCGGCGCCCCGGCCCCCCGCCCGCCATGAGCCCCCGGCTCTGAGGGCCCCGGCCCCTGGATGCACAGCCCCGGCGCGGGCTGCCCTGCCCTCCAGCCAGACACACCAGGCTCTCAGCCCCAGCCCATGGACCTGCGAGTGGGCCAAAGGCCCACAGTGGAGCCGCCACCAGAGCCTGCACTGCTGACCCTGCAGCACCCTCAGCGCCTGCACCGCCATCTCTTCCTAGCAGGCTTGCAACAGCAACAGCGCTCAGCTGAGCCCATGAGGCTCTCCATGGACCCACCGCTGCCGGAGCTGCAGGGGGCACAGCAGGAGCAAGAACTTCGGCAACTTCTCAATAAAGACAAGAGCAAGCGAAGTGCCGTAGCCAGCAGTGTGGTCAAGCAGAAACTGGCTGAAGTGATCCTGAAGAAACAGCAGGCAGCCCTTGAGAGAACAGTCCACCCCAGCAGCCCCAGTATCCCCTACAGAACTCTTGAGCCCTTGGACACAGAGGGTGCTGCCCGCTCCGTGCTTAGCAGCTTCCTGCCTCCTGTTCCCAGCCTGCCCACTGAACCCCCGGAACATTTTCCCCTGCGTAAAACAGTGTCTGAGCCGAACCTGAAGCTGCGCTACAAACCCAAGAAATCCCTGGAGAGGCGTAAGAATCCCCTGCTCAGGAAGGAGAGCGCCCCACCCAGTCTTCGGAGGAGGCCTGCTGAGACTCTTGGAGATTCCTCCCCCAGTAGTAGCAGCACACCTGCGTCAGGGTGCAGCTCCCCCAATGACAGCGAGCATGGCCCTAACCCTGCCCTGGGCTCAGAGGCGCTCTTGGGCCAGCGGCTGCGGCTGCAGGAGACTTCTTTGGCCCCGTTCGCTTTGCCGACAGTGTCCTTGCTGCCCGCAATCACACTGGGGCTGCCTGCCCCTGCCAGGGCTGATGGTGACCGCAGGACCCATTCAACTTTGGGCCCTCGGGGTCCTGTCCTAGGGAACCCCCATGCTCCCCTCTTCCTGCACCATGGTTTGGAGCCAGAGGCTGGGGGCACCTTACCCTCTCGCCTGCAGCCCATTCTCCTGCTGGATCCCTCAGTCTCTCATGCCCCACTGTGGACTGTGCCCGGGCTCGGGCCCTTGCCCTTCCACTTTGCCCAGCCCTTACTGACCACCGAGCGGCTCTCTGGGTCAGGCCTCCATCGGCCACTTAACCGGACCCGCTCAGAGCCCCTGCCCCCCAGCGCCACTGCCTCCCCTCTGCTGGGCCCCCTCCAGCCCCGCCAGGATCGGCTCAAACCTCATGTCCAGCTGATCAAGACAGCCATCTCCCCTCCCCAGAGGCCTGCCAAGCCCAGTGAGAAGCCCCGACTGCGGCAGATACCCTCGGCTGAGGACCTAGAGACAGATGGTGGGGGAGTGGGACCTATGGCGAATGATGGCCTGGAACATAGGGAGTCAGGCCGTGGGCCGCCTGAGGGCAGAGGGGCCGTTTCTCTGCAGCAACACCAACAGGTGCCACTCTGGGAGCAGCAGCATCTTGCTGGGCGGCTCTCCCAGGGAGGCCCCGGGGACTCTGTGCTGCTACCTCTGGCCCAGATTGGACACCGGCCCCTGTCCAGAACCCAGTCTTCCCCAGCCGCACCTGTCTCCCTGCTGAGCCCAGAGCCCACCTGTCAGACCCAAGTCCTCAACAGCTCAGAGGCACCTGCCACAGGGCTGGTCTATGACTCGGTGATGCTGAAACACCAATGTTCCTGTGGAGACAACAGCAAGCATCCCGAGCACGCAGGCCGCATCCAGAGCATCTGGTCCCGGCTGCAGGAACGGGGTCTCCGCAGCCAGTGTGAGTGTCTCCGAGGCCGAAAGGCTTCCCTAGAAGAGCTGCAGTCAGTCCACTCTGAAAGGCACGTGCTCCTCTACGGCACAAACCCACTCAGCCGCCTCAAACTGGATAACGGGAAGCTTACAGGACTCCTGGCCCAGCGGACGTTTGTGATGCTACCCTGTGGCGGGGTTGGGGTAGATACTGACACCATCTGGAATGAGCTGCATTCCTCCAATGCAGCCCGCTGGGCTGCAGGCAGCGTCACCGACCTTGCCTTCAAAGTCGCTTCCCGAGAGCTAAAGAATGGCTTTGCTGTGGTGCGGCCTCCAGGACACCATGCAGATCATTCTACAGCCATGGGCTTTTGCTTCTTCAACTCTGTGGCCATCGCCTGCCGACAGCTGCAGCAACACGGCAAAGCCAGCAAGATCCTCATTGTCGACTGGGATGTTCACCATGGCAACGGCACACAGCAGACTTTCTATCAGGACCCCAGGGTGCTCTACATATCCCTTCATCGCCATGACGATGGCAACTTCTTCCCGGGCAGTGGGGCCGTGGATGAGGTGGGAACCGGCAGTGGCGAGGGCTTCAACGTCAATGTGGCTTGGGCTGGGGGCTTGGATCCACCCATGGGGGATCCTGAGTACCTGGCTGCTTTCAGGATAGTGGTGATGCCCATTGCCCGCGAGTTTGCTCCAGACCTGGTCCTGGTGTCCGCTGGGTTTGACGCTGCAGAGGGTCATCCAGCCCCGCTGGGCGGCTACCATGTTTCTGCCAAATGCTTTGGGTACATGACACAGCAGCTGATGAGCTTGGCAGGAGGTGCGGTGGTGTTGGCCTTGGAGGGCGGCCATGACCTCACAGCCATCTGTGATGCCTCTGAGGCCTGTGTGGCAGCTCTTCTGGGCAACAAGGTGGATCCCCTTTCACAAGAAAGCTGGAAACAGAAACCCAACCTCAATGCCATCCGCTCTCTGGAAGCCGTGGTCAGGGTGCACAGGAAATACTGGGGCTGCATGCAGCGCTTGGCCTCCTGTCCAGACCCCTGGCTGCCCAGGGTGCCGGGAGCTGATGCAGAAGTGGAGGCCGTGACTGCACTGGCATCCCTTTCCGTTGGCATCCTGGCTGAAGACAGGCCCTCGAAGGAGCTGATGGAAGAGGAAGAACCCATGAACCTCTAGGGTCTCAGAACAGATCAGCCTGCAGATGTGGCTCTCCTCATCACTGTTGTCAACCCTGCTCCTGGGTCTTCAGAGATCCCCTGGGCAGGTAGTCAGGTCCAGAGCACAGCCTACCCTGACGGCTATCCCAGGGAACTTGAGAAGACCACTGGGTCTGGGATGGGGGTGAGGGAGGACTCTGGGAGGAGGCAGGCTGGGC
|
Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0479--Metal-binding KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR017320--Histone_deAcase_II_euk
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PROSITE |
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Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0000118--C:histone deacetylase complex GO:0003682--F:chromatin binding GO:0046872--F:metal ion binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0003714--F:transcription corepressor activity GO:0007043--P:cell-cell junction assembly GO:0032703--P:negative regulation of interleukin-2 production GO:1901223--P:negative regulation of NIK/NF-kappaB signaling GO:0045668--P:negative regulation of osteoblast differentiation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis GO:0006351--P:transcription, DNA-templated GO:0001570--P:vasculogenesis
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Orthology |
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Created Date |
25-Jun-2016 |