| Tag |
Content |
| WERAM ID |
WERAM-Drm-0018 |
| Ensembl Protein ID |
FBpp0073173 |
| Uniprot Accession |
Q94517; HDAC1_DROME; O17429; O77213; Q9VZA1
|
| Genbank Protein ID |
NP_647918.2
|
| Protein Name |
Histone deacetylase Rpd3 |
| Genbank Nucleotide ID |
NM_139661.4
|
| Gene Name |
RPD3;HDAC1;CG7471 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26647291
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
7.10e-173 |
575 |
7 |
318 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). |
Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV).
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdgl 98
k+v+y+yd+d+g+y+ygq+hpmkp+r+++th+L+lnygl++k+ei++p+ka+a+e++kfhs+ey++fl++++p+n++e++k++++fnvgedcPvfdgl
FBpp0073173 7 KRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGL 104
589*********************************************************************************************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
+e+cql++G+s++aa kLnk+ ++i+inw GGlhhakkseasGfcyvnDivl+ilellk+h+rvlyidid+hhGDgveeafyttdrvmtvsfhkyge
FBpp0073173 105 YEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGE- 201
*************************************************************************************************. PP
class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
+fPgtGdl+d+ga+kgkyyavn+Pl+dg+dD+ ye+if ++iskv+e+f+P avvlqcGaDsl+gDrlg+fnl++kgh++cv+fvk++nlp+l++GGG
FBpp0073173 202 YFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGG 299
************************************************************************************************** PP
class-1.txt 295 GYtlrnvaRcwtyetavvl 313
GYt+rnv+Rcwtyet+v+l
FBpp0073173 300 GYTIRNVSRCWTYETSVAL 318
****************975 PP
|
Protein Sequence
(Fasta) | MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME IYRPHKATAD 60
EMTKFHSDEY VRFLRSIRPD NMSEYNKQMQ RFNVGEDCPV FDGLYEFCQL SAGGSVAAAV 120
KLNKQASEIC INWGGGLHHA KKSEASGFCY VNDIVLGILE LLKYHQRVLY IDIDVHHGDG 180
VEEAFYTTDR VMTVSFHKYG EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV 240
PIISKVMETF QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVEFVKKYN LPFLMVGGGG 300
YTIRNVSRCW TYETSVALAV EIANELPYND YFEYFGPDFK LHISPSNMTN QNTSEYLEKI 360
KNRLFENLRM LPHAPGVQIQ AIPEDAINDE SDDEDKVDKD DRLPQSDKDK RIVPENEYSD 420
SEDEGEGGRR DNRSYKGQRK RPRLDKDTNS NKASSETSSE IKDEKEKGDG ADGEESTASN 480
TNSNNNSNNK SDNDAGATAN AGSGSGSGSG AGAKGAKENN I 521Protein Fasta Sequence
>FBpp0073173|RPD3;HDAC1;CG7471|Drosophila melanogaster
MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI |
Nucleotide Sequence
(Fasta) | CGGTCACACT GCCCATCTGC AGAGGTTTCC TCTTCGCGAA TTTGTCTTGT GCGCTCCGAT 60
TTTGGCTATA TAGTTGCGCC AAAGTGCCAA AAATCGGACC GGCACCAAAG TAAACCATCT 120
TCTGAGCTCG CAAGTTCATC CGATCGACGA AGGATAGAAA AACATCGACT TTAAGGGGAT 180
TTAAGACCCG CCAACAGCAC CGCAAAATGC AGTCTCACAG CAAAAAGCGC GTTTGTTACT 240
ACTACGACAG CGACATTGGC AACTACTACT ATGGCCAGGG TCATCCCATG AAGCCCCATC 300
GCATACGCAT GACCCACAAC CTGCTGCTCA ACTATGGGCT CTATCGAAAA ATGGAAATAT 360
ACCGTCCCCA TAAAGCCACT GCCGATGAGA TGACCAAGTT CCACTCGGAC GAGTACGTCC 420
GGTTCTTGCG ATCCATTCGG CCGGACAACA TGTCGGAGTA CAACAAGCAG ATGCAGCGTT 480
TCAATGTCGG CGAAGATTGT CCCGTCTTCG ATGGACTATA CGAGTTTTGC CAACTCTCCG 540
CCGGAGGATC CGTAGCTGCG GCCGTAAAAC TGAATAAGCA AGCCTCGGAG ATCTGCATCA 600
ATTGGGGCGG TGGGCTGCAT CACGCCAAAA AATCGGAAGC CTCGGGCTTC TGCTACGTCA 660
ACGACATTGT TCTGGGAATT CTGGAACTGC TTAAATACCA TCAGCGTGTT CTCTACATAG 720
ATATAGACGT CCATCACGGC GATGGCGTGG AGGAGGCGTT CTATACCACC GATCGTGTGA 780
TGACTGTCAG CTTCCACAAG TACGGAGAGT ATTTCCCGGG CACTGGCGAT CTGCGAGACA 840
TTGGCGCCGG CAAGGGAAAG TACTATGCGG TGAATATACC CCTGCGTGAT GGCATGGATG 900
ATGATGCGTA CGAGAGCATA TTTGTGCCCA TTATCAGCAA GGTGATGGAA ACATTCCAGC 960
CGGCAGCCGT GGTGTTGCAG TGTGGCGCCG ATTCGCTGAC TGGCGATCGG TTAGGCTGCT 1020
TCAATCTCAC CGTCAAGGGT CACGGCAAGT GCGTGGAGTT CGTGAAGAAA TATAACCTGC 1080
CATTCCTGAT GGTCGGCGGT GGTGGTTATA CCATTCGTAA TGTATCCCGC TGCTGGACCT 1140
ATGAGACCTC CGTTGCACTG GCCGTGGAGA TAGCCAACGA ACTGCCCTAC AACGATTACT 1200
TCGAGTACTT TGGGCCCGAT TTTAAGCTGC ACATTAGTCC CAGCAATATG ACGAATCAGA 1260
ATACATCCGA GTACCTGGAG AAGATCAAGA ACCGTCTGTT CGAGAACCTG CGCATGCTGC 1320
CTCACGCTCC GGGCGTTCAA ATCCAAGCGA TTCCCGAGGA TGCCATCAAC GATGAGTCCG 1380
ACGACGAGGA CAAGGTCGAC AAGGATGATC GCCTGCCGCA GAGCGACAAG GACAAGCGCA 1440
TTGTGCCCGA GAACGAGTAC TCCGATTCGG AGGATGAGGG CGAAGGCGGT CGCAGGGATA 1500
ACCGTTCGTA CAAGGGTCAG CGGAAGCGGC CGCGTCTCGA CAAGGACACC AACAGCAACA 1560
AGGCATCCTC AGAGACGTCC AGCGAGATCA AGGACGAAAA GGAAAAGGGC GACGGAGCTG 1620
ATGGCGAGGA ATCGACGGCG TCTAATACCA ATAGCAACAA CAACAGTAAC AACAAGAGCG 1680
ATAATGATGC CGGAGCGACA GCTAATGCCG GATCCGGTTC GGGATCAGGT TCCGGTGCCG 1740
GGGCCAAGGG CGCCAAGGAG AACAACATTT GACGTGGCGG CCGCAATTGG TTATAGAAGC 1800
CAATTAAGCG ACCGCCGAAG TACAAGCCAC CGGATTTCAC CTAGTGTCGT CTCATTCCCG 1860
CGCCCCCCTT CACCAACACG CCCCGTAGCC ATGTCCAGGG CTTTTTCTAC ACGCCCCTAC 1920
ACAAGGTCCC ACTGCGATCG GCTCCTTTTT TTCAGTGGGA ATATTCCCAA AGGGGGATAA 1980
ATCAGTAATC AGTGGGCGGA AACACAATTT ATTTTAAGAT CGAAAGTGTA TAGCTAAGCA 2040
AAAAGTGAAT GCATACTTAC AAGCGATCCA ATGTGGCGAA TAACGCAGAA ACTAATTTAA 2100
TCAAATAAAA ATATTTATAC ATTT
2125Nucleotide Fasta Sequence
>FBpp0073173|Class-I|Drosophila melanogaster
CGGTCACACTGCCCATCTGCAGAGGTTTCCTCTTCGCGAATTTGTCTTGTGCGCTCCGATTTTGGCTATATAGTTGCGCCAAAGTGCCAAAAATCGGACCGGCACCAAAGTAAACCATCTTCTGAGCTCGCAAGTTCATCCGATCGACGAAGGATAGAAAAACATCGACTTTAAGGGGATTTAAGACCCGCCAACAGCACCGCAAAATGCAGTCTCACAGCAAAAAGCGCGTTTGTTACTACTACGACAGCGACATTGGCAACTACTACTATGGCCAGGGTCATCCCATGAAGCCCCATCGCATACGCATGACCCACAACCTGCTGCTCAACTATGGGCTCTATCGAAAAATGGAAATATACCGTCCCCATAAAGCCACTGCCGATGAGATGACCAAGTTCCACTCGGACGAGTACGTCCGGTTCTTGCGATCCATTCGGCCGGACAACATGTCGGAGTACAACAAGCAGATGCAGCGTTTCAATGTCGGCGAAGATTGTCCCGTCTTCGATGGACTATACGAGTTTTGCCAACTCTCCGCCGGAGGATCCGTAGCTGCGGCCGTAAAACTGAATAAGCAAGCCTCGGAGATCTGCATCAATTGGGGCGGTGGGCTGCATCACGCCAAAAAATCGGAAGCCTCGGGCTTCTGCTACGTCAACGACATTGTTCTGGGAATTCTGGAACTGCTTAAATACCATCAGCGTGTTCTCTACATAGATATAGACGTCCATCACGGCGATGGCGTGGAGGAGGCGTTCTATACCACCGATCGTGTGATGACTGTCAGCTTCCACAAGTACGGAGAGTATTTCCCGGGCACTGGCGATCTGCGAGACATTGGCGCCGGCAAGGGAAAGTACTATGCGGTGAATATACCCCTGCGTGATGGCATGGATGATGATGCGTACGAGAGCATATTTGTGCCCATTATCAGCAAGGTGATGGAAACATTCCAGCCGGCAGCCGTGGTGTTGCAGTGTGGCGCCGATTCGCTGACTGGCGATCGGTTAGGCTGCTTCAATCTCACCGTCAAGGGTCACGGCAAGTGCGTGGAGTTCGTGAAGAAATATAACCTGCCATTCCTGATGGTCGGCGGTGGTGGTTATACCATTCGTAATGTATCCCGCTGCTGGACCTATGAGACCTCCGTTGCACTGGCCGTGGAGATAGCCAACGAACTGCCCTACAACGATTACTTCGAGTACTTTGGGCCCGATTTTAAGCTGCACATTAGTCCCAGCAATATGACGAATCAGAATACATCCGAGTACCTGGAGAAGATCAAGAACCGTCTGTTCGAGAACCTGCGCATGCTGCCTCACGCTCCGGGCGTTCAAATCCAAGCGATTCCCGAGGATGCCATCAACGATGAGTCCGACGACGAGGACAAGGTCGACAAGGATGATCGCCTGCCGCAGAGCGACAAGGACAAGCGCATTGTGCCCGAGAACGAGTACTCCGATTCGGAGGATGAGGGCGAAGGCGGTCGCAGGGATAACCGTTCGTACAAGGGTCAGCGGAAGCGGCCGCGTCTCGACAAGGACACCAACAGCAACAAGGCATCCTCAGAGACGTCCAGCGAGATCAAGGACGAAAAGGAAAAGGGCGACGGAGCTGATGGCGAGGAATCGACGGCGTCTAATACCAATAGCAACAACAACAGTAACAACAAGAGCGATAATGATGCCGGAGCGACAGCTAATGCCGGATCCGGTTCGGGATCAGGTTCCGGTGCCGGGGCCAAGGGCGCCAAGGAGAACAACATTTGACGTGGCGGCCGCAATTGGTTATAGAAGCCAATTAAGCGACCGCCGAAGTACAAGCCACCGGATTTCACCTAGTGTCGTCTCATTCCCGCGCCCCCCTTCACCAACACGCCCCGTAGCCATGTCCAGGGCTTTTTCTACACGCCCCTACACAAGGTCCCACTGCGATCGGCTCCTTTTTTTCAGTGGGAATATTCCCAAAGGGGGATAAATCAGTAATCAGTGGGCGGAAACACAATTTATTTTAAGATCGAAAGTGTATAGCTAAGCAAAAAGTGAATGCATACTTACAAGCGATCCAATGTGGCGAATAACGCAGAAACTAATTTAATCAAATAAAAATATTTATACATTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0000118--C:histone deacetylase complex
GO:0031523--C:Myb complex
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005700--C:polytene chromosome
GO:0005705--C:polytene chromosome interband
GO:0016580--C:Sin3 complex
GO:0070822--C:Sin3-type complex
GO:0017053--C:transcriptional repressor complex
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0007350--P:blastoderm segmentation
GO:0016568--P:chromatin modification
GO:0006342--P:chromatin silencing
GO:0070983--P:dendrite guidance
GO:0048813--P:dendrite morphogenesis
GO:0008340--P:determination of adult lifespan
GO:0016458--P:gene silencing
GO:0016575--P:histone deacetylation
GO:0007517--P:muscle organ development
GO:0050771--P:negative regulation of axonogenesis
GO:2001229--P:negative regulation of response to gamma radiation
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0022008--P:neurogenesis
GO:0048477--P:oogenesis
GO:0035065--P:regulation of histone acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0022904--P:respiratory electron transport chain
GO:0006351--P:transcription, DNA-templated
GO:0006099--P:tricarboxylic acid cycle
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
