| Tag |
Content |
| WERAM ID |
WERAM-Cae-0007 |
| Ensembl Protein ID |
R06C1.1.2 |
| Uniprot Accession |
G5ECH0; G5ECH0_CAEEL
|
| Genbank Protein ID |
NP_493026.1
|
| Protein Name |
Histone deacetylase |
| Genbank Nucleotide ID |
NM_060625.4
|
| Gene Name |
HDA-3;CELE_R06C1.1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Hist_deacetyl |
H2A; H2B; H3; H4 |
K |
12466527
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
3.10e-164 |
546.6 |
9 |
319 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View) |
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglf 99
+v+y+yd d g+++ygq+hpmkp+r+++th+L++nygl++kl++++p +as++e++++hs++yi+fl++v+++n++++++++++f+vgedcPvfdg++
R06C1.1.2 9 RVSYYYDGDFGNFYYGQGHPMKPHRVRMTHSLIVNYGLYRKLNVMRPARASFSEITRYHSDDYINFLRNVKSDNMSTFTDQMARFSVGEDCPVFDGMY 106
79************************************************************************************************ PP
class-1.txt 100 eycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygeef 197
e+cql++G+sl+aa++Ln++e++iainw+GGlhhakkseasGfcy nDivlailellk+hkrvlyidid+hhGDgveeafyttdrvmtvsfhk+ge +
R06C1.1.2 107 EFCQLSCGGSLAAAARLNRQESEIAINWMGGLHHAKKSEASGFCYSNDIVLAILELLKHHKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKHGE-Y 203
************************************************************************************************.* PP
class-1.txt 198 fPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGGG 295
fPgtGdl+dvga++gkyya+nvPl+dg+dD +ye+if++++ +v+ +f+PeavvlqcGaDslagDrlg+fnl++ gh++cv+++ksfn+pll++GGGG
R06C1.1.2 204 FPGTGDLKDVGAGSGKYYALNVPLRDGVDDVTYERIFRTIMGEVMARFQPEAVVLQCGADSLAGDRLGVFNLTTYGHGKCVEYMKSFNVPLLLVGGGG 301
************************************************************************************************** PP
class-1.txt 296 YtlrnvaRcwtyetavvl 313
Yt+rnv+Rcw yeta++l
R06C1.1.2 302 YTIRNVSRCWLYETAIAL 319
***************986 PP
|
Protein Sequence
(Fasta) | MSLQHSKSRV SYYYDGDFGN FYYGQGHPMK PHRVRMTHSL IVNYGLYRKL NVMRPARASF 60
SEITRYHSDD YINFLRNVKS DNMSTFTDQM ARFSVGEDCP VFDGMYEFCQ LSCGGSLAAA 120
ARLNRQESEI AINWMGGLHH AKKSEASGFC YSNDIVLAIL ELLKHHKRVL YIDIDVHHGD 180
GVEEAFYTTD RVMTVSFHKH GEYFPGTGDL KDVGAGSGKY YALNVPLRDG VDDVTYERIF 240
RTIMGEVMAR FQPEAVVLQC GADSLAGDRL GVFNLTTYGH GKCVEYMKSF NVPLLLVGGG 300
GYTIRNVSRC WLYETAIALN QEVSDDLPLH DYFDYFIPDY KLHIKPLAAL SNFNTPEFID 360
QTIVALLENL KQLPHVPSVQ MQSISTSCDS IVKTFDEKLI RDHQNDDVRV TQFEEDVQVE 420
DSAEFYDGQE PETKNIQSMK RHASPICAAQ EEMKKNRIDG GENVA 465Protein Fasta Sequence
>R06C1.1.2|HDA-3;CELE_R06C1.1|Caenorhabditis elegans
MSLQHSKSRVSYYYDGDFGNFYYGQGHPMKPHRVRMTHSLIVNYGLYRKLNVMRPARASFSEITRYHSDDYINFLRNVKSDNMSTFTDQMARFSVGEDCPVFDGMYEFCQLSCGGSLAAAARLNRQESEIAINWMGGLHHAKKSEASGFCYSNDIVLAILELLKHHKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKHGEYFPGTGDLKDVGAGSGKYYALNVPLRDGVDDVTYERIFRTIMGEVMARFQPEAVVLQCGADSLAGDRLGVFNLTTYGHGKCVEYMKSFNVPLLLVGGGGYTIRNVSRCWLYETAIALNQEVSDDLPLHDYFDYFIPDYKLHIKPLAALSNFNTPEFIDQTIVALLENLKQLPHVPSVQMQSISTSCDSIVKTFDEKLIRDHQNDDVRVTQFEEDVQVEDSAEFYDGQEPETKNIQSMKRHASPICAAQEEMKKNRIDGGENVA |
Nucleotide Sequence
(Fasta) | CTTCCAGATG AGCCTCCAAC ACTCGAAATC TCGAGTTTCC TACTATTATG ATGGAGATTT 60
TGGAAATTTC TACTATGGAC AAGGACATCC AATGAAACCG CATCGTGTTC GAATGACACA 120
TAGCCTTATT GTTAATTATG GATTATATCG GAAGCTTAAT GTCATGCGTC CCGCCCGTGC 180
TTCATTCTCC GAAATCACAC GTTATCACTC TGACGACTAT ATCAATTTCC TTCGTAACGT 240
TAAATCCGAT AATATGTCCA CATTCACAGA TCAAATGGCC CGATTCTCAG TTGGAGAGGA 300
TTGTCCTGTC TTTGATGGAA TGTATGAGTT CTGCCAGCTA TCATGTGGTG GATCACTGGC 360
TGCTGCCGCC CGGCTTAATC GTCAAGAATC AGAAATTGCA ATTAACTGGA TGGGTGGTCT 420
ACATCATGCG AAGAAATCGG AAGCTTCTGG ATTCTGTTAC TCGAATGATA TTGTTCTGGC 480
GATTTTGGAG CTTTTGAAGC ATCATAAAAG AGTTCTTTAT ATTGATATTG ATGTTCATCA 540
TGGTGATGGA GTTGAGGAAG CATTTTATAC GACAGATAGA GTTATGACTG TTTCATTTCA 600
TAAACATGGA GAATATTTCC CTGGAACTGG AGATTTAAAG GACGTTGGCG CTGGAAGTGG 660
CAAGTACTAT GCTCTGAATG TTCCACTTCG TGATGGAGTC GATGACGTCA CTTATGAACG 720
GATTTTCAGA ACAATTATGG GAGAAGTTAT GGCAAGATTT CAACCAGAAG CAGTTGTGCT 780
CCAATGTGGT GCCGATTCAC TGGCAGGAGA TCGGCTAGGA GTATTCAATT TGACTACTTA 840
TGGACACGGA AAATGCGTGG AATACATGAA AAGCTTCAAC GTGCCGCTTC TGTTAGTTGG 900
CGGTGGTGGA TATACGATTC GAAATGTCTC CAGATGTTGG CTGTACGAGA CGGCGATCGC 960
TTTGAATCAA GAAGTTTCAG ATGATCTGCC CCTCCACGAC TACTTTGACT ACTTCATCCC 1020
GGACTACAAA CTACACATAA AGCCGCTCGC CGCTCTTTCG AACTTCAACA CTCCTGAATT 1080
CATTGATCAA ACGATTGTCG CGCTTTTGGA GAATTTAAAG CAACTTCCAC ACGTTCCATC 1140
GGTCCAAATG CAATCGATTT CGACGAGTTG TGACTCAATT GTGAAGACTT TTGACGAGAA 1200
ACTGATCCGA GATCATCAGA ATGATGACGT CAGAGTTACT CAGTTCGAGG AAGACGTTCA 1260
GGTGGAAGAT TCGGCGGAAT TCTACGATGG TCAAGAGCCG GAGACGAAGA ATATTCAATC 1320
GATGAAACGG CACGCGAGTC CGATTTGTGC GGCGCAAGAG GAGATGAAGA AAAATCGGAT 1380
TGATGGCGGC GAAAATGTGG CATAATTTGG TTTTAACTTG ATTTTCTGTA TGCACTAACT 1440
TTGTATTTAT ATCGTCTCTT CAAACTATTT CTTTAATTTA TACGAATCTC AACTTCTCTA 1500
AACCTCTATT GATCCTCAAA TCTATTTAAA TCTTTCGTTA AATCGACAAT TAAAAAATTT 1560
CCGTCGTCAA GTGTGGTGCC GGTGGTGCAT ACACCGCCGC GCACAAATGC ACAGATTTCG 1620
GCGTTTTCGA ATTTTTATCG GATTTCTTTT CTCTATATTT TAAAGGATAT TTTCTATCGT 1680
TTCTTGTCTA AAAACACAGT TTTTATCGAA TTTATCACAA TATAAACCTA TTTATCATC
1740
Nucleotide Fasta Sequence
>R06C1.1.2|Class-I|Caenorhabditis elegans
CTTCCAGATGAGCCTCCAACACTCGAAATCTCGAGTTTCCTACTATTATGATGGAGATTTTGGAAATTTCTACTATGGACAAGGACATCCAATGAAACCGCATCGTGTTCGAATGACACATAGCCTTATTGTTAATTATGGATTATATCGGAAGCTTAATGTCATGCGTCCCGCCCGTGCTTCATTCTCCGAAATCACACGTTATCACTCTGACGACTATATCAATTTCCTTCGTAACGTTAAATCCGATAATATGTCCACATTCACAGATCAAATGGCCCGATTCTCAGTTGGAGAGGATTGTCCTGTCTTTGATGGAATGTATGAGTTCTGCCAGCTATCATGTGGTGGATCACTGGCTGCTGCCGCCCGGCTTAATCGTCAAGAATCAGAAATTGCAATTAACTGGATGGGTGGTCTACATCATGCGAAGAAATCGGAAGCTTCTGGATTCTGTTACTCGAATGATATTGTTCTGGCGATTTTGGAGCTTTTGAAGCATCATAAAAGAGTTCTTTATATTGATATTGATGTTCATCATGGTGATGGAGTTGAGGAAGCATTTTATACGACAGATAGAGTTATGACTGTTTCATTTCATAAACATGGAGAATATTTCCCTGGAACTGGAGATTTAAAGGACGTTGGCGCTGGAAGTGGCAAGTACTATGCTCTGAATGTTCCACTTCGTGATGGAGTCGATGACGTCACTTATGAACGGATTTTCAGAACAATTATGGGAGAAGTTATGGCAAGATTTCAACCAGAAGCAGTTGTGCTCCAATGTGGTGCCGATTCACTGGCAGGAGATCGGCTAGGAGTATTCAATTTGACTACTTATGGACACGGAAAATGCGTGGAATACATGAAAAGCTTCAACGTGCCGCTTCTGTTAGTTGGCGGTGGTGGATATACGATTCGAAATGTCTCCAGATGTTGGCTGTACGAGACGGCGATCGCTTTGAATCAAGAAGTTTCAGATGATCTGCCCCTCCACGACTACTTTGACTACTTCATCCCGGACTACAAACTACACATAAAGCCGCTCGCCGCTCTTTCGAACTTCAACACTCCTGAATTCATTGATCAAACGATTGTCGCGCTTTTGGAGAATTTAAAGCAACTTCCACACGTTCCATCGGTCCAAATGCAATCGATTTCGACGAGTTGTGACTCAATTGTGAAGACTTTTGACGAGAAACTGATCCGAGATCATCAGAATGATGACGTCAGAGTTACTCAGTTCGAGGAAGACGTTCAGGTGGAAGATTCGGCGGAATTCTACGATGGTCAAGAGCCGGAGACGAAGAATATTCAATCGATGAAACGGCACGCGAGTCCGATTTGTGCGGCGCAAGAGGAGATGAAGAAAAATCGGATTGATGGCGGCGAAAATGTGGCATAATTTGGTTTTAACTTGATTTTCTGTATGCACTAACTTTGTATTTATATCGTCTCTTCAAACTATTTCTTTAATTTATACGAATCTCAACTTCTCTAAACCTCTATTGATCCTCAAATCTATTTAAATCTTTCGTTAAATCGACAATTAAAAAATTTCCGTCGTCAAGTGTGGTGCCGGTGGTGCATACACCGCCGCGCACAAATGCACAGATTTCGGCGTTTTCGAATTTTTATCGGATTTCTTTTCTCTATATTTTAAAGGATATTTTCTATCGTTTCTTGTCTAAAAACACAGTTTTTATCGAATTTATCACAATATAAACCTATTTATCATC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003714--F:transcription corepressor activity
GO:0016568--P:chromatin modification
GO:0042262--P:DNA protection
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
