| Tag |
Content |
| WERAM ID |
WERAM-Art-0110 |
| Ensembl Protein ID |
AT4G33470.1 |
| Uniprot Accession |
Q941D6; HDA14_ARATH; Q9SZC4
|
| Genbank Protein ID |
NP_567921.1
|
| Protein Name |
Histone deacetylase 14 |
| Genbank Nucleotide ID |
NM_119501.3
|
| Gene Name |
HDA14;At4g33470;F17M5.230 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689639; 22404109
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-II |
5.90e-98 |
328.8 |
70 |
388 |
| HDAC |
Class-I |
2.70e-30 |
106.8 |
94 |
356 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
| Domain Profile |
HDAC Class-II
class-2.txt 13 hqaleenkekhpEkpeRiqailsrlqeaglle.....kleelka.rkatkeelqlvHseehvelletae.klekeelesltvdsdsiylesksikaar 103
++al +nke+hpE+++R+ ai+++l++++l++ +++el++ ++at e++++vH++++v le+a+ +++++ l + + s+ +y++s++++ +
AT4G33470.1 70 SAALGHNKESHPECSARVPAIVNALEMNELTPkfrgsQILELANfKTATVEDIANVHDKAYVFGLEKAMdEASDSGLI-FIEGSGPTYATSTTFQDSL 166
556788999***********************555555888877799*********************9667777766.899**************** PP
class-2.txt 104 lavGavlelvdkvlkgelkn.....gfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifykdpkvlylSlHRy 196
+a+Ga + lvd+v++++ + gfa++RPPGHHa ++ +mGFC+f nva+aa+++q+++ +k+i+i+D+DvHhGnGt+++f++dp++++lS+H
AT4G33470.1 167 IAAGAGMALVDSVIAASRNSvdppiGFALIRPPGHHAVPKGPMGFCVFGNVAIAARHAQRTHGLKRIFIIDFDVHHGNGTNDAFTEDPDIFFLSTH-- 262
**************99965477888***********************************************************************.. PP
class-2.txt 197 dkgsffpesgsgavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakcyatltkqllkl... 291
++gs +p g+g+++++g+gkgeg+++N++++gg+ gd ++++f+e+++p+a++FkPd++lvsaG+Da+ dpl++l++t+++y +l+k++++l
AT4G33470.1 263 QDGS-YP--GTGKISDIGKGKGEGTTLNLPLPGGS-GDIAMRTVFEEIIVPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRLake 356
9***.78..8***********************99.**********************************************************9999 PP
class-2.txt 292 .aggrvvlvlEGGynlkaiaeaveavvkaLlg 322
+ggr+v++lEGGynl++++++v+ +++aLlg
AT4G33470.1 357 vCGGRCVFFLEGGYNLESLSSSVADSFRALLG 388
9*****************************96 PP
HDAC Class-I
class-1.txt 28 sltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdg..lfeycqlitGasleaakkLn...kke 120
+++eL ++ s+ le+ + k+a++e+++++h ++y+ l+k e +++ ++ P + f+ + + +Ga ++ ++ ++ +++
AT4G33470.1 94 LEMNELTPKFRGSQILELANFKTATVEDIANVHDKAYVFGLEKAMDEASDSGL-----IFIEGSGPTYATstTFQDSLIAAGAGMALVDSVIaasRNS 186
3567888999999****************************998776655443.....4588888877651155667788999998888775111455 PP
class-1.txt 121 adiainwa...GGlhhakkseasGfcyvnDivlailellkkh..krvlyididlhhGDgveeafyttdrvmtvsfhkygeeffPgtGdlsdvgaekgk 213
d i +a hha + Gfc ++ +a + +++h kr+ id+d+hhG+g ++af++ ++ +s h+ g +PgtG++sd+g++kg
AT4G33470.1 187 VDPPIGFAlirPPGHHAVPKGPMGFCVFGNVAIAARHAQRTHglKRIFIIDFDVHHGNGTNDAFTEDPDIFFLSTHQDGS--YPGTGKISDIGKGKGE 282
56567765222456**********************999976459*******************************9998..9*************** PP
class-1.txt 214 yyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlp 287
++n+Pl g D ++++f+++i + ++f+P+++++ G D+ D+l++ ++++ ++ + k +k+ +
AT4G33470.1 283 GTTLNLPLPGGSGDIAMRTVFEEIIVPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRLAKE 356
********************************************************999887777777766443 PP
|
Protein Sequence
(Fasta) | MSMALIVRPF FVPGSAGISG SRNICKKNQW RKYLLKPSGS SINCSFSTEK NPLLPSIQQL 60
ADARLIYSVS AALGHNKESH PECSARVPAI VNALEMNELT PKFRGSQILE LANFKTATVE 120
DIANVHDKAY VFGLEKAMDE ASDSGLIFIE GSGPTYATST TFQDSLIAAG AGMALVDSVI 180
AASRNSVDPP IGFALIRPPG HHAVPKGPMG FCVFGNVAIA ARHAQRTHGL KRIFIIDFDV 240
HHGNGTNDAF TEDPDIFFLS THQDGSYPGT GKISDIGKGK GEGTTLNLPL PGGSGDIAMR 300
TVFEEIIVPC AQRFKPDIIL VSAGYDAHVL DPLANLQFTT ATYYSLAKDI KRLAKEVCGG 360
RCVFFLEGGY NLESLSSSVA DSFRALLGED SLASEFDNPA YLYDEPMRKV RDAIQRAKSI 420
HCL 423Protein Fasta Sequence
>AT4G33470.1|HDA14;At4g33470;F17M5.230|Arabidopsis thaliana
MSMALIVRPFFVPGSAGISGSRNICKKNQWRKYLLKPSGSSINCSFSTEKNPLLPSIQQLADARLIYSVSAALGHNKESHPECSARVPAIVNALEMNELTPKFRGSQILELANFKTATVEDIANVHDKAYVFGLEKAMDEASDSGLIFIEGSGPTYATSTTFQDSLIAAGAGMALVDSVIAASRNSVDPPIGFALIRPPGHHAVPKGPMGFCVFGNVAIAARHAQRTHGLKRIFIIDFDVHHGNGTNDAFTEDPDIFFLSTHQDGSYPGTGKISDIGKGKGEGTTLNLPLPGGSGDIAMRTVFEEIIVPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRLAKEVCGGRCVFFLEGGYNLESLSSSVADSFRALLGEDSLASEFDNPAYLYDEPMRKVRDAIQRAKSIHCL |
Nucleotide Sequence
(Fasta) | ATCTTTTTTT TTATGGCTGC CTTCAGTAGT AACCTCTGAG CTTGAGGGAA ACTCATGTCC 60
ATGGCGCTAA TTGTCCGGCC ATTCTTTGTT CCTGGAAGTG CTGGAATTTC TGGGAGTAGA 120
AACATATGCA AGAAAAATCA ATGGAGGAAG TATCTTCTGA AACCCAGTGG ATCATCCATT 180
AATTGCTCAT TTAGTACAGA GAAGAATCCT CTATTACCAT CTATCCAGCA GTTAGCCGAT 240
GCTCGTCTCA TATACAGTGT ATCTGCAGCA TTGGGTCATA ACAAGGAATC ACATCCAGAA 300
TGCAGCGCTA GAGTTCCTGC CATTGTTAAT GCTCTCGAGA TGAATGAGCT CACTCCTAAG 360
TTCCGTGGCT CACAGATTCT TGAACTCGCA AATTTCAAGA CTGCAACTGT AGAAGACATT 420
GCAAATGTTC ACGACAAGGC TTATGTCTTT GGCCTAGAAA AGGCAATGGA TGAGGCTTCA 480
GATTCGGGAC TAATTTTCAT TGAAGGCTCT GGACCAACAT ATGCCACTTC AACGACATTC 540
CAAGATTCAC TTATCGCAGC AGGAGCCGGA ATGGCTTTAG TTGATTCAGT GATCGCAGCA 600
TCCAGAAACA GCGTAGATCC ACCCATTGGT TTTGCATTGA TAAGACCTCC TGGGCACCAC 660
GCCGTGCCAA AAGGTCCGAT GGGGTTCTGT GTTTTTGGTA ATGTGGCAAT CGCAGCTCGT 720
CATGCCCAAC GCACACATGG TCTGAAGCGC ATCTTCATAA TTGACTTCGA TGTTCACCAC 780
GGGAATGGCA CAAATGATGC ATTTACTGAG GACCCTGATA TATTCTTTTT GTCAACTCAT 840
CAGGACGGAA GCTACCCTGG AACAGGGAAA ATCAGTGACA TAGGTAAAGG AAAAGGTGAA 900
GGTACCACTC TAAATTTACC TTTGCCTGGA GGTTCAGGTG ATATTGCAAT GAGAACCGTT 960
TTTGAAGAAA TCATTGTTCC ATGTGCTCAA CGGTTCAAGC CAGATATTAT TCTTGTTTCT 1020
GCTGGGTATG ATGCTCATGT CCTGGATCCA CTAGCAAATT TACAGTTCAC GACCGCAACA 1080
TACTACTCAT TGGCAAAAGA TATAAAGCGG TTAGCAAAAG AAGTATGCGG AGGGCGGTGT 1140
GTGTTTTTCT TGGAAGGAGG ATACAATCTT GAATCACTTT CATCATCTGT GGCAGACTCG 1200
TTTCGAGCAT TGCTTGGAGA AGATAGCTTG GCATCAGAGT TTGATAACCC AGCTTACTTG 1260
TACGATGAAC CAATGAGAAA GGTGCGAGAT GCAATTCAGA GAGCCAAAAG CATTCATTGC 1320
TTATAAGGTG AATTTGTTTG AGAAGTTCTG CATCTTAGTC GTCTTAAACT GCCTGCCTAC 1380
TTATGTTTTC TTTTGTAAAA ATATCATTGT AAACATTGTT GATTAGAAAA TTAAAGTTAT 1440
GTAAACAGAA ATGATTATGG TTTTTGCTTA TATATTTAAA TCAGGGACAG CTATTTCTAG 1500
TGACC
1506Nucleotide Fasta Sequence
>AT4G33470.1|Class-I|Arabidopsis thaliana
ATCTTTTTTTTTATGGCTGCCTTCAGTAGTAACCTCTGAGCTTGAGGGAAACTCATGTCCATGGCGCTAATTGTCCGGCCATTCTTTGTTCCTGGAAGTGCTGGAATTTCTGGGAGTAGAAACATATGCAAGAAAAATCAATGGAGGAAGTATCTTCTGAAACCCAGTGGATCATCCATTAATTGCTCATTTAGTACAGAGAAGAATCCTCTATTACCATCTATCCAGCAGTTAGCCGATGCTCGTCTCATATACAGTGTATCTGCAGCATTGGGTCATAACAAGGAATCACATCCAGAATGCAGCGCTAGAGTTCCTGCCATTGTTAATGCTCTCGAGATGAATGAGCTCACTCCTAAGTTCCGTGGCTCACAGATTCTTGAACTCGCAAATTTCAAGACTGCAACTGTAGAAGACATTGCAAATGTTCACGACAAGGCTTATGTCTTTGGCCTAGAAAAGGCAATGGATGAGGCTTCAGATTCGGGACTAATTTTCATTGAAGGCTCTGGACCAACATATGCCACTTCAACGACATTCCAAGATTCACTTATCGCAGCAGGAGCCGGAATGGCTTTAGTTGATTCAGTGATCGCAGCATCCAGAAACAGCGTAGATCCACCCATTGGTTTTGCATTGATAAGACCTCCTGGGCACCACGCCGTGCCAAAAGGTCCGATGGGGTTCTGTGTTTTTGGTAATGTGGCAATCGCAGCTCGTCATGCCCAACGCACACATGGTCTGAAGCGCATCTTCATAATTGACTTCGATGTTCACCACGGGAATGGCACAAATGATGCATTTACTGAGGACCCTGATATATTCTTTTTGTCAACTCATCAGGACGGAAGCTACCCTGGAACAGGGAAAATCAGTGACATAGGTAAAGGAAAAGGTGAAGGTACCACTCTAAATTTACCTTTGCCTGGAGGTTCAGGTGATATTGCAATGAGAACCGTTTTTGAAGAAATCATTGTTCCATGTGCTCAACGGTTCAAGCCAGATATTATTCTTGTTTCTGCTGGGTATGATGCTCATGTCCTGGATCCACTAGCAAATTTACAGTTCACGACCGCAACATACTACTCATTGGCAAAAGATATAAAGCGGTTAGCAAAAGAAGTATGCGGAGGGCGGTGTGTGTTTTTCTTGGAAGGAGGATACAATCTTGAATCACTTTCATCATCTGTGGCAGACTCGTTTCGAGCATTGCTTGGAGAAGATAGCTTGGCATCAGAGTTTGATAACCCAGCTTACTTGTACGATGAACCAATGAGAAAGGTGCGAGATGCAATTCAGAGAGCCAAAAGCATTCATTGCTTATAAGGTGAATTTGTTTGAGAAGTTCTGCATCTTAGTCGTCTTAAACTGCCTGCCTACTTATGTTTTCTTTTGTAAAAATATCATTGTAAACATTGTTGATTAGAAAATTAAAGTTATGTAAACAGAAATGATTATGGTTTTTGCTTATATATTTAAATCAGGGACAGCTATTTCTAGTGACC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0009507--C:chloroplast
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043014--F:alpha-tubulin binding
GO:0048487--F:beta-tubulin binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051721--F:protein phosphatase 2A binding
GO:0043621--F:protein self-association
GO:0042903--F:tubulin deacetylase activity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
