Tag |
Content |
WERAM ID |
WERAM-Art-0007 |
Ensembl Protein ID |
AT1G08460.1 |
Uniprot Accession |
Q94EJ2; HDA8_ARATH; Q944J5; Q9SJE6 |
Genbank Protein ID |
NP_563817.1 |
Protein Name |
Histone deacetylase 8 |
Genbank Nucleotide ID |
NM_100719.3 |
Gene Name |
HDA8;At1g08460;T27G7.14;T27G7_7 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689639 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
5.10e-91 |
306 |
6 |
335 |
HDAC |
Class-I |
4.10e-37 |
129.2 |
37 |
326 |
|
Organism |
Arabidopsis thaliana |
NCBI Taxa ID |
3702 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
Domain Profile |
HDAC Class-II
class-2.txt 2 aglvydekmlkhqaleenkek............hpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletae.klekeeleslt 86 ++++++e ml+h+a+e+ ++ hpE+++R++++ls l++ ++++++++++ a +el+++H++e++e+l +a+ + e++e++ AT1G08460.1 6 VDVFWHEGMLRHDAVEGVFDTgydpgfldvlekHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADkSGERCEIA--- 100 5799**************9999*************************************************************997566666666... PP class-2.txt 87 vdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkvkkilivDwDvHhGnGtqeifyk 184 +++++ s++aa la+G++l++++++l+++ k+++a+vRPPGHH+++++a+G+C++nn+a+a+kl++++ +++++ ++D+DvH+GnGt e fy+ AT1G08460.1 101 ---AGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKIAYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYT 195 ...489******************************************************************************************** PP class-2.txt 185 dpkvlylSlHRydkgsffpesgs..gavdevgegkgegfnvNvawngglmgdaeylaafrevvlpiakeFkPdlvlvsaGfDaaegdplgglsvtakc 280 ++kvl++SlH +++gs+ +s+ g++de+ge+ g+g+n+Nv++++g+ gd+ y++a++e+v+p++++F Pd+v++ +G+D++++dp+g++s+t+++ AT1G08460.1 196 SDKVLTVSLH-MNHGSW-GSSHPqkGSIDELGEDVGLGYNLNVPLPNGT-GDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNG 290 **********.*****5.4443335*********************998.************************************************ PP class-2.txt 281 yatltkqllkl....aggrvvlvlEGGynlkaiaeaveavvkaLl 321 y+++ + ++++ ++gr+++v EGGy++++ a++ +a+++++l AT1G08460.1 291 YRRIGQIMRGVaeehSHGRLLMVQEGGYHVTYAAYCLHAMLEGVL 335 **********988889*************************9987 PP
HDAC Class-I
class-1.txt 18 qkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdglfeycqlitGasleaakk 115 +khp r++ + +++ + +++ ++ a ++ell fh+ eyie l + ++ + ++ ++ + + g +e + l +G++l+a+++ AT1G08460.1 37 EKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADK--------SGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQH 126 6899999999999999999999999999********************99866543........345667788888999******************* PP class-1.txt 116 Lnkkeadiainw.aGGlhhakkseasGfcyvnDivlailellk..khkrvlyididlhhGDgveeafyttdrvmtvsfhkygeef...fPgtGdlsdv 207 + + + +ia hh++ ++a G+c++n+ la+ l + +rv idid+h+G+g e fyt+d+v+tvs+h + ++ P G++++ AT1G08460.1 127 ILDCHGKIAYALvRPPGHHSQPTQADGYCFLNNAALAVKLALNsgSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWgssHPQKGSIDEL 224 ********987624567********************9766554789********************************8766553448********* PP class-1.txt 208 gaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksf.....nlpllvlGGGGYtlrn 300 g++ g y +nvPl +g D+ ye +++++ + +++f P++vvl +G Ds a D+ g +l+++g+ ++ ++++ + ll++ GGY ++ AT1G08460.1 225 GEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVaeehsHGRLLMVQEGGYHVTY 322 ******************************************************************99998888865321134579*********999 PP class-1.txt 301 vaRc 304 a c AT1G08460.1 323 AAYC 326 8877 PP
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Protein Sequence (Fasta) | MVTNRVDVFW HEGMLRHDAV EGVFDTGYDP GFLDVLEKHP ENADRVRNML SILRRGPIAP 60 HVNWFTGLPA IVSELLMFHT SEYIEKLVEA DKSGERCEIA AGTFMSPGSW EAALLAAGTT 120 LSAMQHILDC HGKIAYALVR PPGHHSQPTQ ADGYCFLNNA ALAVKLALNS GSCSRVAVID 180 IDVHYGNGTA EGFYTSDKVL TVSLHMNHGS WGSSHPQKGS IDELGEDVGL GYNLNVPLPN 240 GTGDRGYEYA MNELVVPAVR RFGPDMVVLV VGQDSSAFDP NGRQSLTMNG YRRIGQIMRG 300 VAEEHSHGRL LMVQEGGYHV TYAAYCLHAM LEGVLKIPEP HLSDPIAYYP EEEANAVAAV 360 ESIKTYHTEF VPFLRGT 377Protein Fasta Sequence
>AT1G08460.1|HDA8;At1g08460;T27G7.14;T27G7_7|Arabidopsis thaliana MVTNRVDVFWHEGMLRHDAVEGVFDTGYDPGFLDVLEKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADKSGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKIAYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWGSSHPQKGSIDELGEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVAEEHSHGRLLMVQEGGYHVTYAAYCLHAMLEGVLKIPEPHLSDPIAYYPEEEANAVAAVESIKTYHTEFVPFLRGT
|
Nucleotide Sequence (Fasta) | GTGAGCATCC TCCATTATTA CACCACCGTT GGCCTCCGAC GACGGCTCAA GCCTATCTTC 60 GTCGCCGGCT TCTCCGATGG TTACCAATCG CGTAGACGTC TTCTGGCACG AAGGAATGCT 120 CCGACACGAC GCCGTAGAAG GCGTCTTCGA CACTGGATAC GACCCTGGAT TCCTCGACGT 180 ATTGGAGAAG CACCCGGAGA ACGCCGATCG CGTCAGGAAC ATGCTTTCGA TTCTCCGACG 240 CGGTCCCATC GCTCCTCATG TCAATTGGTT TACCGGTCTT CCAGCAATCG TTTCGGAGCT 300 TCTAATGTTT CACACTTCAG AGTACATTGA GAAGCTAGTG GAGGCAGATA AATCAGGAGA 360 AAGGTGTGAA ATTGCCGCAG GTACTTTCAT GAGCCCAGGC TCGTGGGAAG CTGCTCTTCT 420 TGCAGCTGGA ACAACTCTTT CAGCAATGCA ACATATTCTT GATTGCCATG GGAAAATTGC 480 ATATGCTCTG GTACGCCCAC CAGGTCACCA CTCACAGCCT ACTCAGGCTG ATGGGTATTG 540 CTTCCTCAAC AACGCTGCTC TTGCTGTCAA GCTGGCATTG AATTCGGGTT CTTGTTCCCG 600 AGTTGCGGTT ATTGACATCG ATGTACATTA TGGAAATGGC ACAGCTGAAG GGTTTTATAC 660 ATCTGATAAG GTTCTTACGG TGTCACTCCA TATGAACCAT GGATCATGGG GATCGTCCCA 720 CCCGCAGAAA GGGTCGATTG ATGAACTTGG TGAAGACGTG GGATTGGGTT ACAATCTGAA 780 TGTCCCTTTA CCGAATGGCA CGGGTGACCG GGGATATGAA TATGCCATGA ATGAGCTGGT 840 GGTTCCTGCA GTTAGAAGGT TTGGACCCGA TATGGTTGTT CTCGTTGTTG GTCAAGACTC 900 TAGCGCTTTT GATCCAAACG GGAGACAAAG CCTGACAATG AATGGATACA GAAGGATTGG 960 GCAGATAATG AGGGGAGTTG CAGAGGAGCA CAGCCATGGA AGGTTGCTTA TGGTGCAAGA 1020 AGGCGGGTAT CATGTAACAT ATGCAGCTTA CTGCCTCCAC GCCATGCTCG AAGGGGTGCT 1080 GAAGATTCCA GAACCGCATC TATCTGATCC GATCGCTTAT TATCCCGAAG AAGAAGCTAA 1140 TGCTGTTGCT GCTGTGGAGT CAATCAAAAC ATATCACACC GAATTTGTTC CATTTCTCAG 1200 AGGAACTTGA AAATGGGACG TATGAATGAG TTTATGTTAT TCCTCGTTGT CTTGTGACCT 1260 TTTGGAACAC AGATCCAAAT CAATCAGGTC AAACCGTATA TATCAAAATA CTTGTTGATC 1320 AAACTATCTT TTGTATGAAA ACTTATTCAC ACGATCCGAC TTTGTTTTT
Nucleotide Fasta Sequence
>AT1G08460.1|Class-I|Arabidopsis thaliana GTGAGCATCCTCCATTATTACACCACCGTTGGCCTCCGACGACGGCTCAAGCCTATCTTCGTCGCCGGCTTCTCCGATGGTTACCAATCGCGTAGACGTCTTCTGGCACGAAGGAATGCTCCGACACGACGCCGTAGAAGGCGTCTTCGACACTGGATACGACCCTGGATTCCTCGACGTATTGGAGAAGCACCCGGAGAACGCCGATCGCGTCAGGAACATGCTTTCGATTCTCCGACGCGGTCCCATCGCTCCTCATGTCAATTGGTTTACCGGTCTTCCAGCAATCGTTTCGGAGCTTCTAATGTTTCACACTTCAGAGTACATTGAGAAGCTAGTGGAGGCAGATAAATCAGGAGAAAGGTGTGAAATTGCCGCAGGTACTTTCATGAGCCCAGGCTCGTGGGAAGCTGCTCTTCTTGCAGCTGGAACAACTCTTTCAGCAATGCAACATATTCTTGATTGCCATGGGAAAATTGCATATGCTCTGGTACGCCCACCAGGTCACCACTCACAGCCTACTCAGGCTGATGGGTATTGCTTCCTCAACAACGCTGCTCTTGCTGTCAAGCTGGCATTGAATTCGGGTTCTTGTTCCCGAGTTGCGGTTATTGACATCGATGTACATTATGGAAATGGCACAGCTGAAGGGTTTTATACATCTGATAAGGTTCTTACGGTGTCACTCCATATGAACCATGGATCATGGGGATCGTCCCACCCGCAGAAAGGGTCGATTGATGAACTTGGTGAAGACGTGGGATTGGGTTACAATCTGAATGTCCCTTTACCGAATGGCACGGGTGACCGGGGATATGAATATGCCATGAATGAGCTGGTGGTTCCTGCAGTTAGAAGGTTTGGACCCGATATGGTTGTTCTCGTTGTTGGTCAAGACTCTAGCGCTTTTGATCCAAACGGGAGACAAAGCCTGACAATGAATGGATACAGAAGGATTGGGCAGATAATGAGGGGAGTTGCAGAGGAGCACAGCCATGGAAGGTTGCTTATGGTGCAAGAAGGCGGGTATCATGTAACATATGCAGCTTACTGCCTCCACGCCATGCTCGAAGGGGTGCTGAAGATTCCAGAACCGCATCTATCTGATCCGATCGCTTATTATCCCGAAGAAGAAGCTAATGCTGTTGCTGCTGTGGAGTCAATCAAAACATATCACACCGAATTTGTTCCATTTCTCAGAGGAACTTGAAAATGGGACGTATGAATGAGTTTATGTTATTCCTCGTTGTCTTGTGACCTTTTGGAACACAGATCCAAATCAATCAGGTCAAACCGTATATATCAAAATACTTGTTGATCAAACTATCTTTTGTATGAAAACTTATTCACACGATCCGACTTTGTTTTT
|
Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005634--C:nucleus GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
|
Orthology |
|
Created Date |
25-Jun-2016 |