| Tag |
Content |
| WERAM ID |
WERAM-Scp-0033 |
| Ensembl Protein ID |
SPBC36.05c.1:pep |
| Uniprot Accession |
O59702; CLR6_SCHPO
|
| Genbank Protein ID |
NP_595333.1
|
| Protein Name |
Histone deacetylase clr6 |
| Genbank Nucleotide ID |
NM_001021241.2
|
| Gene Name |
Clr6;SPBC36.05c |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
5.40e-163 |
540 |
6 |
366 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation.
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcP 93
kkv+y+ydedvg+yhyg +hpmkp+r++++h+Lv+ny+l++kl++++p +a++++++++h++eyiefl +v+p+++e+++ ++ kfnvg+dcP
SPBC36.05c.1:pep 6 KKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCP 98
589****************************************************************************************** PP
class-1.txt 94 vfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvm 186
vfdgl+e+c++++G+s+ aa++Ln+++a+iainwaGGlhhakk+easGfcyvnDi la lellk+h+rvlyidid+hhGDgvee fyttdrvm
SPBC36.05c.1:pep 99 VFDGLYEFCSISAGGSIGAAQELNSGNAEIAINWAGGLHHAKKREASGFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVM 191
********************************************************************************************* PP
class-1.txt 187 tvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvk 279
t+sfhk+ge +fPgtG+++d+g ++gk+yavnvPl+dgidDesye++fk+vis+++++f+Peav+lqcG+DslagDrlg+fnls+kgh+ cv+
SPBC36.05c.1:pep 192 TCSFHKFGE-YFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQCGTDSLAGDRLGCFNLSMKGHSMCVD 283
*********.*********************************************************************************** PP
class-1.txt 280 fvksfnlpllvlGGGGYtlrnvaRcwtyetavv 312
fvksfnlp++++GGGGYt+rnvaR+wtyet+++
SPBC36.05c.1:pep 284 FVKSFNLPMICVGGGGYTVRNVARVWTYETGLL 316
******************************987 PP
class-1.txt 53 aeellkfhseeyieflkkvepen 75
+++ ++++ +y++ +++ en
SPBC36.05c.1:pep 344 SNNMENHNTRQYLDSITSEIIEN 366
34555555555555554433333 PP
|
Protein Sequence
(Fasta) | MGFGKKKVSY FYDEDVGNYH YGPQHPMKPH RVRMVHNLVV NYNLYEKLNV ITPVRATRND 60
MTRCHTDEYI EFLWRVTPDT MEKFQPHQLK FNVGDDCPVF DGLYEFCSIS AGGSIGAAQE 120
LNSGNAEIAI NWAGGLHHAK KREASGFCYV NDIALAALEL LKYHQRVLYI DIDVHHGDGV 180
EEFFYTTDRV MTCSFHKFGE YFPGTGHIKD TGIGTGKNYA VNVPLRDGID DESYESVFKP 240
VISHIMQWFR PEAVILQCGT DSLAGDRLGC FNLSMKGHSM CVDFVKSFNL PMICVGGGGY 300
TVRNVARVWT YETGLLAGEE LDENLPYNDY LQYYGPDYKL NVLSNNMENH NTRQYLDSIT 360
SEIIENLRNL SFAPSVQMHK TPGDFTFENA EKQNIAKEEI MDERV 405Protein Fasta Sequence
>SPBC36.05c.1:pep|Clr6;SPBC36.05c|Schizosaccharomyces pombe
MGFGKKKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDGLYEFCSISAGGSIGAAQELNSGNAEIAINWAGGLHHAKKREASGFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHKFGEYFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQCGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGGGGYTVRNVARVWTYETGLLAGEELDENLPYNDYLQYYGPDYKLNVLSNNMENHNTRQYLDSITSEIIENLRNLSFAPSVQMHKTPGDFTFENAEKQNIAKEEIMDERV |
Nucleotide Sequence
(Fasta) | GAAATATTCA ATAGAACCAG GCTGCTGCTT CAGCTTCTGA CCACTCCATC ATAGCAACAA 60
TTCTACGCGA AAGCGCTCCG AACCTAACAT TTTTAATTGA TAACATAAGG AAACTGTTTG 120
CCTTATTAAA TAATTGGGAA AGAAAATCCT ATTTGAAACT ATGGGGTTCG GGAAGAAAAA 180
GGTTTCTTAT TTCTATGATG AGGATGTTGG AAATTATCAC TATGGTCCTC AGCATCCAAT 240
GAAGCCTCAT CGCGTTCGCA TGGTTCATAA TCTGGTCGTT AATTACAACT TGTATGAGAA 300
GTTGAACGTT ATTACACCTG TTAGAGCAAC AAGGAATGAC ATGACTCGTT GTCATACCGA 360
TGAGTATATT GAATTTCTTT GGAGAGTTAC ACCTGACACG ATGGAAAAAT TTCAACCGCA 420
TCAGCTGAAA TTTAACGTCG GTGATGATTG TCCTGTTTTT GATGGGCTGT ACGAATTTTG 480
TTCAATTTCT GCTGGCGGTT CAATTGGTGC TGCTCAAGAA CTTAACTCGG GAAACGCAGA 540
AATTGCTATT AATTGGGCTG GAGGCCTACA TCACGCTAAA AAACGTGAAG CTTCTGGTTT 600
CTGCTATGTT AATGATATCG CGTTGGCTGC TTTAGAATTG CTGAAATATC ATCAACGTGT 660
TCTTTACATT GATATTGATG TTCACCACGG AGACGGTGTA GAAGAATTTT TCTACACTAC 720
GGATCGCGTT ATGACTTGTT CATTCCACAA ATTCGGTGAA TATTTTCCAG GAACCGGTCA 780
TATCAAGGAC ACCGGAATTG GAACAGGAAA AAACTATGCT GTTAACGTTC CTTTGAGAGA 840
TGGTATTGAC GATGAATCTT ATGAAAGCGT ATTTAAGCCT GTTATAAGTC ACATAATGCA 900
ATGGTTTCGA CCGGAAGCTG TTATTTTACA ATGTGGAACA GATTCTCTCG CTGGTGATCG 960
ACTAGGCTGC TTCAATCTGT CAATGAAGGG ACATTCAATG TGCGTTGATT TTGTTAAGAG 1020
CTTTAATTTG CCAATGATAT GCGTTGGAGG AGGTGGATAT ACTGTACGGA ATGTTGCCCG 1080
TGTCTGGACT TATGAAACTG GTCTTTTAGC CGGCGAAGAG CTTGATGAAA ACCTTCCTTA 1140
TAATGACTAT TTACAATATT ACGGTCCCGA TTACAAGCTC AATGTTCTTT CAAACAATAT 1200
GGAAAACCAT AACACTCGGC AGTATCTTGA TTCGATAACC TCTGAAATCA TCGAAAATTT 1260
GAGAAACTTA TCTTTTGCAC CTAGCGTTCA AATGCATAAA ACTCCCGGTG ACTTTACGTT 1320
TGAAAATGCC GAAAAGCAGA ACATTGCGAA AGAAGAGATT ATGGATGAGC GCGTATAGAC 1380
CTATATAAAA TTTTGTATGT TCATGGTGTT TGAATCCATT ATACTCGGTT TTTTTGTGTT 1440
ATTTGAATCA TGAATACTAT AAAAGCTATT ATGTTTAAAT ACCCTTATTT ATAAGAATTC 1500
TCCAGCATAA TTAGACTTCA GCATTAAATT GAAAATGCTC AT
1543Nucleotide Fasta Sequence
>SPBC36.05c.1:pep|Class-I|Schizosaccharomyces pombe
GAAATATTCAATAGAACCAGGCTGCTGCTTCAGCTTCTGACCACTCCATCATAGCAACAATTCTACGCGAAAGCGCTCCGAACCTAACATTTTTAATTGATAACATAAGGAAACTGTTTGCCTTATTAAATAATTGGGAAAGAAAATCCTATTTGAAACTATGGGGTTCGGGAAGAAAAAGGTTTCTTATTTCTATGATGAGGATGTTGGAAATTATCACTATGGTCCTCAGCATCCAATGAAGCCTCATCGCGTTCGCATGGTTCATAATCTGGTCGTTAATTACAACTTGTATGAGAAGTTGAACGTTATTACACCTGTTAGAGCAACAAGGAATGACATGACTCGTTGTCATACCGATGAGTATATTGAATTTCTTTGGAGAGTTACACCTGACACGATGGAAAAATTTCAACCGCATCAGCTGAAATTTAACGTCGGTGATGATTGTCCTGTTTTTGATGGGCTGTACGAATTTTGTTCAATTTCTGCTGGCGGTTCAATTGGTGCTGCTCAAGAACTTAACTCGGGAAACGCAGAAATTGCTATTAATTGGGCTGGAGGCCTACATCACGCTAAAAAACGTGAAGCTTCTGGTTTCTGCTATGTTAATGATATCGCGTTGGCTGCTTTAGAATTGCTGAAATATCATCAACGTGTTCTTTACATTGATATTGATGTTCACCACGGAGACGGTGTAGAAGAATTTTTCTACACTACGGATCGCGTTATGACTTGTTCATTCCACAAATTCGGTGAATATTTTCCAGGAACCGGTCATATCAAGGACACCGGAATTGGAACAGGAAAAAACTATGCTGTTAACGTTCCTTTGAGAGATGGTATTGACGATGAATCTTATGAAAGCGTATTTAAGCCTGTTATAAGTCACATAATGCAATGGTTTCGACCGGAAGCTGTTATTTTACAATGTGGAACAGATTCTCTCGCTGGTGATCGACTAGGCTGCTTCAATCTGTCAATGAAGGGACATTCAATGTGCGTTGATTTTGTTAAGAGCTTTAATTTGCCAATGATATGCGTTGGAGGAGGTGGATATACTGTACGGAATGTTGCCCGTGTCTGGACTTATGAAACTGGTCTTTTAGCCGGCGAAGAGCTTGATGAAAACCTTCCTTATAATGACTATTTACAATATTACGGTCCCGATTACAAGCTCAATGTTCTTTCAAACAATATGGAAAACCATAACACTCGGCAGTATCTTGATTCGATAACCTCTGAAATCATCGAAAATTTGAGAAACTTATCTTTTGCACCTAGCGTTCAAATGCATAAAACTCCCGGTGACTTTACGTTTGAAAATGCCGAAAAGCAGAACATTGCGAAAGAAGAGATTATGGATGAGCGCGTATAGACCTATATAAAATTTTGTATGTTCATGGTGTTTGAATCCATTATACTCGGTTTTTTTGTGTTATTTGAATCATGAATACTATAAAAGCTATTATGTTTAAATACCCTTATTTATAAGAATTCTCCAGCATAATTAGACTTCAGCATTAAATTGAAAATGCTCAT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000775--C:chromosome, centromeric region
GO:1990483--C:Clr6 histone deacetylase complex I''
GO:0005829--C:cytosol
GO:0000790--C:nuclear chromatin
GO:0033698--C:Rpd3L complex
GO:0070210--C:Rpd3L-Expanded complex
GO:0032221--C:Rpd3S complex
GO:0004407--F:histone deacetylase activity
GO:0032129--F:histone deacetylase activity (H3-K9 specific)
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0006338--P:chromatin remodeling
GO:0030702--P:chromatin silencing at centromere
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0016575--P:histone deacetylation
GO:1990619--P:histone H3-K9 deacetylation
GO:0061647--P:histone H3-K9 modification
GO:0000070--P:mitotic sister chromatid segregation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051570--P:regulation of histone H3-K9 methylation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
