| Tag |
Content |
| WERAM ID |
WERAM-Scp-0016 |
| Ensembl Protein ID |
SPAC3G9.07c.1:pep |
| Uniprot Accession |
O13298; PHD1_SCHPO
|
| Genbank Protein ID |
NP_594079.1
|
| Protein Name |
Histone deacetylase phd1 |
| Genbank Nucleotide ID |
NM_001019506.2
|
| Gene Name |
PHD1;hda1;SPAC3G9.07c |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
12466527
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
7.60e-156 |
516.5 |
26 |
338 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Is not essential. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Is not essential.
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedc 92
k+v+y+ de+vg+yhyg+khpmkp+r+++t++Lv+ ygl++k+++++p++a++ e+++fh+e+y++flk+v+p+nae++++++++fn+g+dc
SPAC3G9.07c.1:pep 26 KRVTYHLDEQVGNYHYGDKHPMKPHRITITNHLVMGYGLHNKMSVFSPRMATFGEMSEFHREDYLDFLKRVTPDNAEQFADKFQQFNIGDDC 117
589***************************************************************************************** PP
class-1.txt 93 PvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdr 184
Pvfdg +e++q ++Gasl+a++kL ++++diainw+GGlhhak+ easGfcyvnDivlail++l+ ++rvlyidid+hhGDgv++afy++dr
SPAC3G9.07c.1:pep 118 PVFDGTYEFSQRSAGASLDASRKLVQGQTDIAINWSGGLHHAKRGEASGFCYVNDIVLAILNMLRFFPRVLYIDIDIHHGDGVQQAFYESDR 209
******************************************************************************************** PP
class-1.txt 185 vmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae 276
v+tvsfhky+ +ffP+tG++++ g++ gky+a+nvPl+dgi De+y+++fks+i++ i++f+P+a+vlqcGaDsl Drlg+fnlsi++h+e
SPAC3G9.07c.1:pep 210 VLTVSFHKYNGDFFPATGNFDENGVKGGKYFALNVPLEDGIGDEQYTSLFKSIIEPTINTFQPSAIVLQCGADSLGYDRLGVFNLSIHAHGE 301
******************************************************************************************** PP
class-1.txt 277 cvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
cv+f +sfn+p+lv+GGGGYtlrnvaR+w+yet++++
SPAC3G9.07c.1:pep 302 CVRFTRSFNIPMLVVGGGGYTLRNVARAWCYETSICV 338
**********************************987 PP
|
Protein Sequence
(Fasta) | MDTPETSTPY EQVEKGSFFS FRPQKKRVTY HLDEQVGNYH YGDKHPMKPH RITITNHLVM 60
GYGLHNKMSV FSPRMATFGE MSEFHREDYL DFLKRVTPDN AEQFADKFQQ FNIGDDCPVF 120
DGTYEFSQRS AGASLDASRK LVQGQTDIAI NWSGGLHHAK RGEASGFCYV NDIVLAILNM 180
LRFFPRVLYI DIDIHHGDGV QQAFYESDRV LTVSFHKYNG DFFPATGNFD ENGVKGGKYF 240
ALNVPLEDGI GDEQYTSLFK SIIEPTINTF QPSAIVLQCG ADSLGYDRLG VFNLSIHAHG 300
ECVRFTRSFN IPMLVVGGGG YTLRNVARAW CYETSICVNE QIPSELPRET LYYEFFAPDY 360
TLHPRLTTKI ENKNTPKALE DLRIRALEQL RYLGGAPSVQ MQQIPPDLTG HLEEEDERLN 420
DEYLDKAVDV RVRG 434Protein Fasta Sequence
>SPAC3G9.07c.1:pep|PHD1;hda1;SPAC3G9.07c|Schizosaccharomyces pombe
MDTPETSTPYEQVEKGSFFSFRPQKKRVTYHLDEQVGNYHYGDKHPMKPHRITITNHLVMGYGLHNKMSVFSPRMATFGEMSEFHREDYLDFLKRVTPDNAEQFADKFQQFNIGDDCPVFDGTYEFSQRSAGASLDASRKLVQGQTDIAINWSGGLHHAKRGEASGFCYVNDIVLAILNMLRFFPRVLYIDIDIHHGDGVQQAFYESDRVLTVSFHKYNGDFFPATGNFDENGVKGGKYFALNVPLEDGIGDEQYTSLFKSIIEPTINTFQPSAIVLQCGADSLGYDRLGVFNLSIHAHGECVRFTRSFNIPMLVVGGGGYTLRNVARAWCYETSICVNEQIPSELPRETLYYEFFAPDYTLHPRLTTKIENKNTPKALEDLRIRALEQLRYLGGAPSVQMQQIPPDLTGHLEEEDERLNDEYLDKAVDVRVRG |
Nucleotide Sequence
(Fasta) | ACATTTTTAA GTTATAAGAA TGAACCAGCA CTAGCAATTC TTCAAAAAAT TGTAAATCCT 60
ATTTGTTCTT GTGTTTATGG GCTTCAAAGA GTTTGAATTA ACGCTTTGTT GAAGTTGTAC 120
ATTTTATCTA ATAAGGTATC GGGTTTAGCG ACCTTTTGCT ACGTATTCTG CGCTCGACGT 180
AAAAATAAAG TATTTACAGT TCGTGTTGCT GTTTATTATT TGGATTGAAT TCTTTTCTAT 240
AAAAAAATCT GGGTTGTTTT TCGATTTATA TTAATTTGGC ATTGGTCAAT AACTTTCATT 300
TCTCTTGTTT CTTCTGAAAC AGTTATTAAT TTGTTTCTTA ATTTTATTTA TTCTTTTCTT 360
GTTCTTTCTT TAGAAAAGAT ATTTTCATTT AATTTGTCTC GCGGTTTTTT TTAGTATAAT 420
AGTCTGTATA TCATGGATAC TCCTGAGACA TCCACACCTT ATGAACAAGT TGAAAAGGGG 480
TCTTTTTTTA GCTTTCGACC TCAAAAAAAG CGTGTCACAT ATCACTTAGA TGAACAGGTG 540
GGAAACTACC ACTATGGTGA CAAACATCCA ATGAAGCCCC ATCGAATTAC CATTACAAAT 600
CATTTAGTGA TGGGTTATGG GTTGCATAAC AAAATGAGTG TATTCAGCCC CCGGATGGCA 660
ACTTTTGGTG AAATGTCAGA ATTTCATAGG GAGGATTATT TGGATTTCCT TAAGCGCGTT 720
ACTCCTGATA ATGCTGAACA ATTTGCTGAT AAGTTCCAAC AATTCAATAT TGGTGATGAC 780
TGTCCGGTCT TTGACGGCAC TTATGAATTT TCTCAAAGGT CGGCAGGCGC TAGTTTGGAT 840
GCTTCTCGGA AGTTAGTGCA AGGTCAAACA GACATTGCTA TCAATTGGAG CGGTGGTCTC 900
CATCATGCAA AGCGTGGTGA GGCTAGTGGA TTCTGCTATG TTAATGATAT TGTTCTAGCA 960
ATTTTGAACA TGCTACGGTT TTTTCCTCGC GTTTTGTATA TCGATATCGA TATTCATCAT 1020
GGAGATGGTG TGCAGCAAGC ATTCTATGAA TCTGACCGCG TGTTGACGGT TTCTTTTCAC 1080
AAGTATAATG GTGATTTTTT TCCTGCAACT GGTAATTTTG ATGAAAATGG CGTGAAAGGA 1140
GGGAAATATT TTGCTTTAAA CGTTCCTTTG GAAGATGGTA TTGGTGATGA ACAGTACACT 1200
AGTCTTTTCA AATCCATAAT TGAACCAACT ATCAATACTT TTCAACCTTC TGCAATTGTC 1260
CTTCAGTGTG GTGCTGATTC GCTTGGTTAT GATCGGCTCG GCGTGTTCAA TCTGAGCATC 1320
CATGCACATG GGGAATGTGT TAGATTTACC CGTTCATTCA ATATACCCAT GCTTGTAGTT 1380
GGAGGTGGTG GTTATACTCT TAGAAATGTT GCTAGAGCGT GGTGTTATGA AACTTCCATA 1440
TGTGTAAACG AACAAATACC TTCAGAATTA CCTCGTGAAA CTTTGTATTA CGAATTTTTC 1500
GCACCAGATT ACACCCTCCA TCCGCGATTA ACCACGAAGA TAGAAAATAA AAATACACCG 1560
AAAGCTCTTG AAGATCTTCG AATACGGGCC TTGGAGCAAT TACGTTACTT AGGAGGAGCG 1620
CCAAGCGTTC AGATGCAGCA AATTCCACCA GACTTAACTG GGCATTTGGA AGAAGAAGAC 1680
GAACGGTTGA ATGATGAATA CTTAGACAAA GCTGTGGATG TTCGCGTTCG AGGCTGATAT 1740
TAATGAATTT TCGACTTTTT ATTTGATATC CGTACAAACA TCAAATAATT TTAGTTAATG 1800
TTTATAGACA TTGTAAATAT TAATAATTGA CCCTA
1836Nucleotide Fasta Sequence
>SPAC3G9.07c.1:pep|Class-I|Schizosaccharomyces pombe
ACATTTTTAAGTTATAAGAATGAACCAGCACTAGCAATTCTTCAAAAAATTGTAAATCCTATTTGTTCTTGTGTTTATGGGCTTCAAAGAGTTTGAATTAACGCTTTGTTGAAGTTGTACATTTTATCTAATAAGGTATCGGGTTTAGCGACCTTTTGCTACGTATTCTGCGCTCGACGTAAAAATAAAGTATTTACAGTTCGTGTTGCTGTTTATTATTTGGATTGAATTCTTTTCTATAAAAAAATCTGGGTTGTTTTTCGATTTATATTAATTTGGCATTGGTCAATAACTTTCATTTCTCTTGTTTCTTCTGAAACAGTTATTAATTTGTTTCTTAATTTTATTTATTCTTTTCTTGTTCTTTCTTTAGAAAAGATATTTTCATTTAATTTGTCTCGCGGTTTTTTTTAGTATAATAGTCTGTATATCATGGATACTCCTGAGACATCCACACCTTATGAACAAGTTGAAAAGGGGTCTTTTTTTAGCTTTCGACCTCAAAAAAAGCGTGTCACATATCACTTAGATGAACAGGTGGGAAACTACCACTATGGTGACAAACATCCAATGAAGCCCCATCGAATTACCATTACAAATCATTTAGTGATGGGTTATGGGTTGCATAACAAAATGAGTGTATTCAGCCCCCGGATGGCAACTTTTGGTGAAATGTCAGAATTTCATAGGGAGGATTATTTGGATTTCCTTAAGCGCGTTACTCCTGATAATGCTGAACAATTTGCTGATAAGTTCCAACAATTCAATATTGGTGATGACTGTCCGGTCTTTGACGGCACTTATGAATTTTCTCAAAGGTCGGCAGGCGCTAGTTTGGATGCTTCTCGGAAGTTAGTGCAAGGTCAAACAGACATTGCTATCAATTGGAGCGGTGGTCTCCATCATGCAAAGCGTGGTGAGGCTAGTGGATTCTGCTATGTTAATGATATTGTTCTAGCAATTTTGAACATGCTACGGTTTTTTCCTCGCGTTTTGTATATCGATATCGATATTCATCATGGAGATGGTGTGCAGCAAGCATTCTATGAATCTGACCGCGTGTTGACGGTTTCTTTTCACAAGTATAATGGTGATTTTTTTCCTGCAACTGGTAATTTTGATGAAAATGGCGTGAAAGGAGGGAAATATTTTGCTTTAAACGTTCCTTTGGAAGATGGTATTGGTGATGAACAGTACACTAGTCTTTTCAAATCCATAATTGAACCAACTATCAATACTTTTCAACCTTCTGCAATTGTCCTTCAGTGTGGTGCTGATTCGCTTGGTTATGATCGGCTCGGCGTGTTCAATCTGAGCATCCATGCACATGGGGAATGTGTTAGATTTACCCGTTCATTCAATATACCCATGCTTGTAGTTGGAGGTGGTGGTTATACTCTTAGAAATGTTGCTAGAGCGTGGTGTTATGAAACTTCCATATGTGTAAACGAACAAATACCTTCAGAATTACCTCGTGAAACTTTGTATTACGAATTTTTCGCACCAGATTACACCCTCCATCCGCGATTAACCACGAAGATAGAAAATAAAAATACACCGAAAGCTCTTGAAGATCTTCGAATACGGGCCTTGGAGCAATTACGTTACTTAGGAGGAGCGCCAAGCGTTCAGATGCAGCAAATTCCACCAGACTTAACTGGGCATTTGGAAGAAGAAGACGAACGGTTGAATGATGAATACTTAGACAAAGCTGTGGATGTTCGCGTTCGAGGCTGATATTAATGAATTTTCGACTTTTTATTTGATATCCGTACAAACATCAAATAATTTTAGTTAATGTTTATAGACATTGTAAATATTAATAATTGACCCTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0070210--C:Rpd3L-Expanded complex
GO:0034967--C:Set3 complex
GO:0004407--F:histone deacetylase activity
GO:0034739--F:histone deacetylase activity (H4-K16 specific)
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0070869--P:heterochromatin assembly involved in chromatin silencing
GO:0016575--P:histone deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0060303--P:regulation of nucleosome density
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
