| Tag |
Content |
| WERAM ID |
WERAM-Sac-0016 |
| Ensembl Protein ID |
YGL194C |
| Uniprot Accession |
P53096; HOS2_YEAST; D6VTW0
|
| Genbank Protein ID |
NP_011321.1
|
| Protein Name |
Probable histone deacetylase HOS2 |
| Genbank Nucleotide ID |
NM_001181059.1
|
| Gene Name |
HOS2;YGL194C;G1330 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
25288981
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
4.60e-154 |
511 |
27 |
339 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation.
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelsk.elkkfnvgedcPvfdgl 98
+v+y+++++v++yhyg+khpmkp rl+lt++Lv +ygl+k ++++++++a+++ell+fhse+y++fl+kv+pena++l++ +l++fn+g+dcP+f++l
YGL194C 27 RVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRgTLENFNIGDDCPIFQNL 124
699***************************************************************************97599*************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
++y++l+tGasl+a++kL+++++diainw+GGlhhakk++ sGfcyvnDivl+il+ll++h+r+lyididlhhGDgv+eafyttdrv+t+sfhky+ e
YGL194C 125 YDYTTLYTGASLDATRKLINNQSDIAINWSGGLHHAKKNSPSGFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYNGE 222
************************************************************************************************** PP
class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
ffPgtGdl+++g++kgk++a+nvPl+dgidD+sy ++fks+++++i +f+P+ +v qcGaDsl +Drlg+fnl+ik+h+ecvkfvksf lp+lv+GGG
YGL194C 223 FFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGG 320
************************************************************************************************** PP
class-1.txt 295 GYtlrnvaRcwtyetavvl 313
GYt rnv+R+wtyet++++
YGL194C 321 GYTPRNVSRLWTYETGILN 339
****************986 PP
|
Protein Sequence
(Fasta) | MSGTFSYDVK TKENEPLFEF NSAYSPRVSY HFNSKVSHYH YGVKHPMKPF RLMLTDHLVS 60
SYGLHKIMDL YETRSATRDE LLQFHSEDYV NFLSKVSPEN ANKLPRGTLE NFNIGDDCPI 120
FQNLYDYTTL YTGASLDATR KLINNQSDIA INWSGGLHHA KKNSPSGFCY VNDIVLSILN 180
LLRYHPRILY IDIDLHHGDG VQEAFYTTDR VFTLSFHKYN GEFFPGTGDL TEIGCDKGKH 240
FALNVPLEDG IDDDSYINLF KSIVDPLIMT FKPTLIVQQC GADSLGHDRL GCFNLNIKAH 300
GECVKFVKSF GLPMLVVGGG GYTPRNVSRL WTYETGILND VLLPEDIPED IPFRDSFGPD 360
YSLYPMLDDL YENKNSKKLL EDIRIRCLEN IRYLQGAPSV RMDAECIPTQ DISALTEEED 420
KIIQEMNEET EADSSNRLEE MEKENSGLIA FS 452Protein Fasta Sequence
>YGL194C|HOS2;YGL194C;G1330|Saccharomyces cerevisiae
MSGTFSYDVKTKENEPLFEFNSAYSPRVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLINNQSDIAINWSGGLHHAKKNSPSGFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYNGEFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYTPRNVSRLWTYETGILNDVLLPEDIPEDIPFRDSFGPDYSLYPMLDDLYENKNSKKLLEDIRIRCLENIRYLQGAPSVRMDAECIPTQDISALTEEEDKIIQEMNEETEADSSNRLEEMEKENSGLIAFS |
Nucleotide Sequence
(Fasta) | ATGTCTGGAA CATTTAGTTA TGATGTGAAA ACAAAGGAGA ACGAACCATT ATTTGAGTTT 60
AATTCTGCTT ATTCTCCCAG GGTATCGTAT CATTTTAACT CCAAAGTTTC ACATTACCAT 120
TATGGTGTTA AGCATCCAAT GAAGCCGTTT CGGTTAATGC TAACGGATCA CCTAGTTTCC 180
TCTTATGGAT TGCACAAGAT TATGGACCTT TATGAAACAA GAAGCGCTAC CAGAGACGAA 240
TTACTACAAT TTCACTCGGA AGACTACGTG AATTTTCTCT CGAAGGTTTC ACCAGAAAAT 300
GCAAACAAAC TGCCCAGAGG CACACTTGAA AATTTTAACA TTGGAGACGA CTGTCCTATT 360
TTTCAAAATT TATATGATTA TACAACACTA TACACTGGTG CGAGCCTTGA CGCCACCAGG 420
AAACTAATCA ACAATCAATC GGACATAGCG ATAAATTGGT CTGGTGGTCT TCATCATGCA 480
AAAAAGAATA GTCCATCTGG GTTTTGCTAT GTAAATGATA TTGTGCTTTC TATTTTGAAC 540
TTATTACGAT ATCACCCAAG AATCCTTTAT ATCGATATCG ACTTACATCA CGGCGATGGT 600
GTCCAGGAGG CATTTTACAC CACAGATAGG GTCTTCACGT TGTCTTTTCA TAAATATAAT 660
GGCGAATTTT TCCCAGGAAC TGGTGATCTG ACAGAAATTG GTTGCGACAA AGGAAAACAT 720
TTCGCATTAA ATGTACCCCT AGAAGATGGC ATAGATGACG ACTCATATAT AAACCTTTTC 780
AAGTCAATTG TAGATCCTCT AATAATGACT TTCAAACCAA CACTTATTGT CCAACAATGC 840
GGTGCGGATT CCTTAGGTCA TGATCGCTTA GGATGCTTCA ATTTAAATAT AAAGGCACAT 900
GGAGAATGCG TAAAATTTGT CAAATCATTT GGTCTACCAA TGCTAGTAGT GGGCGGTGGA 960
GGTTATACAC CTAGAAATGT ATCACGGCTT TGGACCTACG AGACAGGAAT TTTAAATGAT 1020
GTCTTGCTAC CAGAAGACAT CCCCGAAGAT ATCCCATTCC GGGACTCATT CGGGCCGGAT 1080
TATTCACTTT ATCCTATGTT AGATGACTTA TACGAAAACA AAAACAGTAA AAAACTACTG 1140
GAAGACATTA GAATACGATG TCTAGAAAAT ATCAGATACT TGCAAGGAGC ACCAAGTGTC 1200
AGAATGGATG CTGAATGCAT ACCGACACAA GATATAAGTG CCCTGACAGA AGAAGAGGAT 1260
AAAATCATTC AAGAAATGAA TGAAGAAACA GAAGCAGACA GTTCAAATAG GCTAGAAGAA 1320
ATGGAAAAAG AAAACAGTGG ATTGATTGCC TTTTCATAG
Nucleotide Fasta Sequence
>YGL194C|Class-I|Saccharomyces cerevisiae
ATGTCTGGAACATTTAGTTATGATGTGAAAACAAAGGAGAACGAACCATTATTTGAGTTTAATTCTGCTTATTCTCCCAGGGTATCGTATCATTTTAACTCCAAAGTTTCACATTACCATTATGGTGTTAAGCATCCAATGAAGCCGTTTCGGTTAATGCTAACGGATCACCTAGTTTCCTCTTATGGATTGCACAAGATTATGGACCTTTATGAAACAAGAAGCGCTACCAGAGACGAATTACTACAATTTCACTCGGAAGACTACGTGAATTTTCTCTCGAAGGTTTCACCAGAAAATGCAAACAAACTGCCCAGAGGCACACTTGAAAATTTTAACATTGGAGACGACTGTCCTATTTTTCAAAATTTATATGATTATACAACACTATACACTGGTGCGAGCCTTGACGCCACCAGGAAACTAATCAACAATCAATCGGACATAGCGATAAATTGGTCTGGTGGTCTTCATCATGCAAAAAAGAATAGTCCATCTGGGTTTTGCTATGTAAATGATATTGTGCTTTCTATTTTGAACTTATTACGATATCACCCAAGAATCCTTTATATCGATATCGACTTACATCACGGCGATGGTGTCCAGGAGGCATTTTACACCACAGATAGGGTCTTCACGTTGTCTTTTCATAAATATAATGGCGAATTTTTCCCAGGAACTGGTGATCTGACAGAAATTGGTTGCGACAAAGGAAAACATTTCGCATTAAATGTACCCCTAGAAGATGGCATAGATGACGACTCATATATAAACCTTTTCAAGTCAATTGTAGATCCTCTAATAATGACTTTCAAACCAACACTTATTGTCCAACAATGCGGTGCGGATTCCTTAGGTCATGATCGCTTAGGATGCTTCAATTTAAATATAAAGGCACATGGAGAATGCGTAAAATTTGTCAAATCATTTGGTCTACCAATGCTAGTAGTGGGCGGTGGAGGTTATACACCTAGAAATGTATCACGGCTTTGGACCTACGAGACAGGAATTTTAAATGATGTCTTGCTACCAGAAGACATCCCCGAAGATATCCCATTCCGGGACTCATTCGGGCCGGATTATTCACTTTATCCTATGTTAGATGACTTATACGAAAACAAAAACAGTAAAAAACTACTGGAAGACATTAGAATACGATGTCTAGAAAATATCAGATACTTGCAAGGAGCACCAAGTGTCAGAATGGATGCTGAATGCATACCGACACAAGATATAAGTGCCCTGACAGAAGAAGAGGATAAAATCATTCAAGAAATGAATGAAGAAACAGAAGCAGACAGTTCAAATAGGCTAGAAGAAATGGAAAAAGAAAACAGTGGATTGATTGCCTTTTCATAG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0034399--C:nuclear periphery
GO:0034967--C:Set3 complex
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0045129--F:NAD-independent histone deacetylase activity
GO:0006325--P:chromatin organization
GO:0016575--P:histone deacetylation
GO:0045835--P:negative regulation of meiotic nuclear division
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
