WERAM Information

Tag Content
WERAM ID WERAM-Art-0112
Ensembl Protein ID AT4G38130.1
Uniprot Accession O22446; HDA19_ARATH; Q0WWG3; Q9SZL3
Genbank Protein ID NP_195526.1
Protein Name Histone deacetylase 19
Genbank Nucleotide ID NM_119974.3
Gene Name HDA19;HD1;RPD3A;At4g38130;F20D10.250
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT4G38130 AT4G38130.1 AT4G38130.1
AT4G38130 AT4G38130.2 AT4G38130.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-I Histone deacetylase H2A; H2B; H3; H4 K 26704384; 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-I 2.40e-165 550.5 17 328
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous floral organ identity genes (PubMed:23034631).
Domain Profile
  HDAC Class-I
  class-1.txt   1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdgl 98 
                  +kv+y+yd++vg+y+ygq+hpmkp+r+++th L+ +ygl ++++++kp  a+ ++l++fh+++y++fl++++pe++++ +++lk+fnvgedcPvfdgl
  AT4G38130.1  17 RKVCYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARDRDLCRFHADDYVSFLRSITPETQQDQIRQLKRFNVGEDCPVFDGL 114
                  589*********************************************************************************************** PP
  class-1.txt  99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
                  +++cq+++G+s+ ++ kLn++ +diainwaGGlhhakk+easGfcyvnDivlailellk+h+rvly+did+hhGDgveeafy+tdrvmtvsfhk+g+ 
  AT4G38130.1 115 YSFCQTYAGGSVGGSVKLNHGLCDIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLKQHERVLYVDIDIHHGDGVEEAFYATDRVMTVSFHKFGD- 211
                  *************************************************************************************************. PP
  class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
                  +fPgtG+++d+g ++gkyy++nvPl+dgidDesy+ +fk+++ kv+e+f+P avvlqcGaDsl+gDrlg+fnlsikghaecvkf++sfn+pll+lGGG
  AT4G38130.1 212 YFPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGGG 309
                  ************************************************************************************************** PP
  class-1.txt 295 GYtlrnvaRcwtyetavvl 313
                  GYt+rnvaRcw+yet+v+l
  AT4G38130.1 310 GYTIRNVARCWCYETGVAL 328
                  ****************986 PP
Protein Sequence
(Fasta)		MDTGGNSLAS GPDGVKRKVC YFYDPEVGNY YYGQGHPMKP HRIRMTHALL AHYGLLQHMQ 60
VLKPFPARDR DLCRFHADDY VSFLRSITPE TQQDQIRQLK RFNVGEDCPV FDGLYSFCQT 120
YAGGSVGGSV KLNHGLCDIA INWAGGLHHA KKCEASGFCY VNDIVLAILE LLKQHERVLY 180
VDIDIHHGDG VEEAFYATDR VMTVSFHKFG DYFPGTGHIQ DIGYGSGKYY SLNVPLDDGI 240
DDESYHLLFK PIMGKVMEIF RPGAVVLQCG ADSLSGDRLG CFNLSIKGHA ECVKFMRSFN 300
VPLLLLGGGG YTIRNVARCW CYETGVALGV EVEDKMPEHE YYEYFGPDYT LHVAPSNMEN 360
KNSRQMLEEI RNDLLHNLSK LQHAPSVPFQ ERPPDTETPE VDEDQEDGDK RWDPDSDMDV 420
DDDRKPIPSR VKREAVEPDT KDKDGLKGIM ERGKGCEVEV DESGSTKVTG VNPVGVEEAS 480
VKMEEEGTNK GGAEQAFPPK T 501
Nucleotide Sequence
(Fasta)		GTAAGTAGGC TACAGTTTCA GTCAGAGGTG AAAGAAAATC TGAAAGCAAA GCAGAGAGCA 60
GCTCCCTTCC CCTCGGCGAG GAGGAAGGAA GAAGAAAGCC AGAGAGAGAG AGAGAGATCA 120
TCGCAGCTTC TCCTCCGACC ATTTGACTGC GACTGTGATT ACAACACACC GTTGATCCTA 180
CGAAAAAGAG GTAATGGATA CTGGCGGCAA TTCGCTGGCG TCCGGACCTG ATGGTGTGAA 240
GAGGAAAGTT TGTTATTTCT ATGACCCTGA GGTCGGCAAT TACTACTATG GCCAAGGTCA 300
TCCCATGAAG CCCCATCGCA TCCGCATGAC CCATGCCCTC CTCGCTCACT ACGGTCTCCT 360
TCAGCATATG CAGGTTCTCA AGCCCTTCCC TGCCCGCGAC CGTGATCTCT GCCGCTTCCA 420
CGCCGACGAC TATGTCTCTT TTCTCCGCAG CATTACCCCT GAAACCCAGC AAGATCAGAT 480
TCGCCAACTT AAGCGCTTCA ATGTTGGTGA AGACTGTCCC GTCTTTGACG GCCTTTATTC 540
CTTTTGCCAG ACCTATGCTG GAGGATCTGT TGGTGGCTCT GTCAAGCTTA ACCACGGCCT 600
CTGCGATATT GCCATCAACT GGGCTGGTGG TCTCCATCAC GCTAAGAAGT GCGAGGCCTC 660
TGGCTTCTGT TACGTCAATG ATATCGTCTT AGCTATCCTA GAGCTCCTTA AGCAGCATGA 720
GCGTGTTCTT TATGTCGATA TTGATATCCA CCACGGGGAT GGAGTGGAGG AGGCATTTTA 780
TGCTACTGAC AGGGTTATGA CTGTCTCGTT TCATAAATTT GGTGATTACT TTCCCGGTAC 840
AGGTCACATT CAGGATATAG GTTATGGTAG CGGAAAGTAC TATTCTCTCA ATGTACCACT 900
GGATGATGGA ATCGATGATG AGAGCTATCA TCTGTTATTC AAGCCCATCA TGGGGAAAGT 960
TATGGAAATT TTCCGACCAG GGGCTGTGGT ATTGCAATGT GGTGCTGATT CATTGTCTGG 1020
TGATAGGTTG GGGTGCTTTA ATCTTTCAAT CAAAGGTCAT GCTGAGTGCG TCAAATTTAT 1080
GAGATCGTTC AATGTTCCCC TACTGCTCTT GGGTGGTGGT GGTTACACTA TCCGCAATGT 1140
TGCCCGTTGC TGGTGCTACG AGACTGGAGT TGCACTTGGA GTTGAAGTTG AAGACAAGAT 1200
GCCGGAGCAT GAATATTATG AATACTTTGG TCCAGACTAT ACACTTCACG TTGCTCCAAG 1260
TAACATGGAA AATAAGAATT CTCGTCAGAT GCTTGAAGAG ATTCGCAATG ACCTTCTCCA 1320
CAATCTCTCT AAGCTTCAGC ATGCTCCAAG TGTACCATTT CAGGAAAGAC CACCTGATAC 1380
AGAGACTCCC GAGGTTGATG AAGACCAAGA AGATGGGGAT AAAAGATGGG ATCCGGATTC 1440
AGACATGGAT GTTGATGATG ACCGTAAACC TATACCAAGC AGAGTAAAAA GAGAAGCTGT 1500
TGAACCAGAT ACAAAGGACA AGGATGGACT GAAAGGAATT ATGGAGCGTG GAAAAGGTTG 1560
TGAGGTGGAG GTGGATGAGA GTGGAAGCAC TAAGGTTACA GGAGTAAACC CAGTGGGAGT 1620
GGAGGAAGCA AGTGTGAAAA TGGAAGAGGA AGGAACAAAC AAGGGTGGGG CGGAGCAGGC 1680
GTTTCCTCCT AAAACATAAG ACTCGGAGCT TCTAATTTCT TGCTACTTTT TCTGTCTATC 1740
AAATGTTGCT AGTTAAGTTT CTGGAGTTGT TGTTGTTGTA AGCACTCCTC TGTTTTAGAG 1800
GATTGAGCAC GGATATGTAT TTATTCGTTG CATGTCTGAA TGATGATATG ATATGACAAG 1860
ACGAGCTATT CCTTTTGCTA TATATTTATT GATTGGGCCG 1901
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
PROSITE
Pfam

PF00850--Hist_deacetyl
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0009294--P:DNA mediated transformation
GO:0016573--P:histone acetylation
GO:0009861--P:jasmonic acid and ethylene-dependent systemic resistance
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009405--P:pathogenesis
GO:1902459--P:positive regulation of stem cell population maintenance
GO:2000026--P:regulation of multicellular organismal development
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0038 fgenesh1_pm.C_scaffold_7000002 Arabidopsis lyrata 98 0.0 977
WERAM-Brr-0202 Bra040131.1-P Brassica rapa 95 0.0 944
WERAM-Bro-0021 Bo1g151980.1 Brassica oleracea 95 0.0 923
WERAM-Thc-0026 EOX98961 Theobroma cacao 86 0.0 867
WERAM-Viv-0012 VIT_03s0038g04240.t01 Vitis vinifera 85 0.0 847
WERAM-Pot-0112 POPTR_0009s17200.1 Populus trichocarpa 85 0.0 838
WERAM-Sol-0120 Solyc09g091440.2.1 Solanum lycopersicum 81 0.0 809
WERAM-Prp-0056 EMJ02177 Prunus persica 85 0.0 807
WERAM-Glm-0156 GLYMA13G06010.3 Glycine max 81 0.0 800
WERAM-Sot-0088 PGSC0003DMT400076252 Solanum tuberosum 76 0.0 792
WERAM-Met-0084 KEH36404 Medicago truncatula 82 0.0 788
WERAM-Brd-0020 BRADI1G37290.1 Brachypodium distachyon 77 0.0 768
WERAM-Ors-0059 OS06T0583400-01 Oryza sativa 78 0.0 761
WERAM-Orb-0066 OBART06G19560.1 Oryza barthii 78 0.0 761
WERAM-Orp-0064 OPUNC06G17670.1 Oryza punctata 78 0.0 761
WERAM-Amt-0016 ERM94967 Amborella trichopoda 77 0.0 759
WERAM-Orr-0068 ORUFI06G20660.1 Oryza rufipogon 76 0.0 752
WERAM-Orgl-0064 OGLUM06G20570.1 Oryza glumaepatula 76 0.0 751
WERAM-Tra-0318 Traes_7DL_578CF3F0D.2 Triticum aestivum 83 0.0 749
WERAM-Sei-0069 Si016908m Setaria italica 79 0.0 744
WERAM-Ori-0039 BGIOSGA012324-PA Oryza indica 82 0.0 743
WERAM-Orbr-0074 OB06G27130.1 Oryza brachyantha 76 0.0 740
WERAM-Sob-0135 Sb10g022820.1 Sorghum bicolor 76 0.0 738
WERAM-Php-0088 PP1S351_29V6.1 Physcomitrella patens 83 0.0 736
WERAM-Orm-0063 OMERI06G19730.1 Oryza meridionalis 83 0.0 735
WERAM-Zem-0099 GRMZM2G172883_P01 Zea mays 75 0.0 721
WERAM-Aet-0051 EMT16627 Aegilops tauschii 74 0.0 719
WERAM-Orni-0065 ONIVA06G23170.1 Oryza nivara 77 0.0 719
WERAM-Lep-0066 LPERR06G16070.1 Leersia perrieri 78 0.0 706
WERAM-Sem-0132 EFJ35052 Selaginella moellendorffii 84 0.0 705
WERAM-Hov-0099 MLOC_71091.1 Hordeum vulgare 88 0.0 679
WERAM-Mua-0048 GSMUA_Achr2P19590_001 Musa acuminata 66 0.0 644
WERAM-Osl-0002 ABO94711 Ostreococcus lucimarinus 72 3e-176 615
WERAM-Org-0090 ORGLA08G0103000.1 Oryza glaberrima 61 2e-169 593
WERAM-Ran-0062 ENSRNOP00000012854.5 Rattus norvegicus 68 1e-166 583
WERAM-Mum-0093 ENSMUSP00000099657.4 Mus musculus 68 1e-166 583
WERAM-Ocp-0006 ENSOPRP00000000780.1 Ochotona princeps 68 2e-166 583
WERAM-Ova-0221 ENSOARP00000022517.1 Ovis aries 68 2e-166 583
WERAM-Bot-0118 ENSBTAP00000016877.5 Bos taurus 68 2e-166 583
WERAM-Anc-0033 ENSACAP00000004062.3 Anolis carolinensis 67 2e-166 583
WERAM-Gaga-0034 ENSGALP00000005212.3 Gallus gallus 68 2e-166 583
WERAM-Nol-0026 ENSNLEP00000003167.1 Nomascus leucogenys 68 3e-166 582
WERAM-Hos-0092 ENSP00000362649.3 Homo sapiens 68 3e-166 582
WERAM-Gog-0132 ENSGGOP00000011454.2 Gorilla gorilla 68 3e-166 582
WERAM-Orc-0030 ENSOCUP00000003186.2 Oryctolagus cuniculus 68 3e-166 582
WERAM-Otg-0072 ENSOGAP00000005101.2 Otolemur garnettii 68 3e-166 582
WERAM-Tag-0022 ENSTGUP00000001473.1 Taeniopygia guttata 68 3e-166 582
WERAM-Cap-0092 ENSCPOP00000006985.2 Cavia porcellus 68 3e-166 582
WERAM-Ptv-0152 ENSPVAP00000012567.1 Pteropus vampyrus 67 9e-166 580
WERAM-Loa-0056 ENSLAFP00000004079.2 Loxodonta africana 67 1e-165 580
WERAM-Mup-0173 ENSMPUP00000015122.1 Mustela putorius furo 67 2e-165 580
WERAM-Poa-0013 ENSPPYP00000001838.2 Pongo abelii 67 8e-165 577
WERAM-Dan-0175 ENSDNOP00000033349.1 Dasypus novemcinctus 68 9e-165 577
WERAM-Myl-0152 ENSMLUP00000012593.2 Myotis lucifugus 67 1e-164 577
WERAM-Caf-0116 ENSCAFP00000015619.3 Canis familiaris 67 1e-164 577
WERAM-Pof-0181 ENSPFOP00000015600.1 Poecilia formosa 68 1e-163 573
WERAM-Tar-0085 ENSTRUP00000016627.1 Takifugu rubripes 67 1e-163 573
WERAM-Xim-0061 ENSXMAP00000005239.1 Xiphophorus maculatus 67 1e-162 570
WERAM-Orla-0197 ENSORLP00000022529.1 Oryzias latipes 67 1e-162 570
WERAM-Aim-0087 ENSAMEP00000008076.1 Ailuropoda melanoleuca 67 2e-162 569
WERAM-Ten-0109 ENSTNIP00000012136.1 Tetraodon nigroviridis 67 4e-162 568
WERAM-Orn-0087 ENSONIP00000009730.1 Oreochromis niloticus 67 4e-162 568
WERAM-Gam-0033 ENSGMOP00000003469.1 Gadus morhua 68 4e-162 568
WERAM-Pes-0020 ENSPSIP00000004435.1 Pelodiscus sinensis 67 6e-162 568
WERAM-Dar-0035 ENSDARP00000051798.4 Danio rerio 66 8e-162 567
WERAM-Gaa-0093 ENSGACP00000012045.1 Gasterosteus aculeatus 67 1e-161 567
WERAM-Tut-0167 ENSTTRP00000014262.1 Tursiops truncatus 64 1e-161 566
WERAM-Cii-0014 ENSCINP00000005410.3 Ciona intestinalis 64 2e-161 566
WERAM-Drm-0018 FBpp0073173 Drosophila melanogaster 64 3e-161 565
WERAM-Chs-0011 ENSCSAP00000016960.1 Chlorocebus sabaeus 68 1e-160 563
WERAM-Asm-0120 ENSAMXP00000012237.1 Astyanax mexicanus 66 2e-160 563
WERAM-Pat-0210 ENSPTRP00000060659.1 Pan troglodytes 68 2e-160 563
WERAM-Anp-0136 ENSAPLP00000014652.1 Anas platyrhynchos 66 2e-160 563
WERAM-Sus-0201 ENSSSCP00000023024.1 Sus scrofa 65 2e-160 563
WERAM-Meg-0047 ENSMGAP00000004521.2 Meleagris gallopavo 67 4e-160 562
WERAM-Leo-0014 ENSLOCP00000002993.1 Lepisosteus oculatus 68 4e-160 561
WERAM-Eqc-0125 ENSECAP00000014039.1 Equus caballus 67 1e-159 560
WERAM-Xet-0037 ENSXETP00000011480.3 Xenopus tropicalis 67 1e-159 560
WERAM-Ect-0064 ENSETEP00000006883.1 Echinops telfairi 65 3e-159 558
WERAM-Mod-0165 ENSMODP00000022264.3 Monodelphis domestica 65 5e-159 558
WERAM-Fia-0139 ENSFALP00000011453.1 Ficedula albicollis 65 5e-159 558
WERAM-Ict-0111 ENSSTOP00000011457.2 Ictidomys tridecemlineatus 65 6e-159 558
WERAM-Paa-0030 ENSPANP00000015145.1 Papio anubis 65 6e-159 558
WERAM-Tru-0006 TRIUR3_03674-P1 Triticum urartu 86 8e-159 557
WERAM-Fec-0156 ENSFCAP00000015379.2 Felis catus 64 3e-154 542
WERAM-Sah-0134 ENSSHAP00000014467.1 Sarcophilus harrisii 57 7e-154 541
WERAM-Ere-0068 ENSEEUP00000005465.1 Erinaceus europaeus 65 1e-153 540
WERAM-Cae-0005 C53A5.3 Caenorhabditis elegans 62 7e-153 538
WERAM-Cym-0014 CMJ129CT Cyanidioschyzon merolae 65 2e-151 533
WERAM-Tas-0085 ENSTSYP00000008588.1 Tarsius syrichta 65 4e-151 532
WERAM-Asni-0020 CADANGAP00005938 Aspergillus niger 57 1e-150 530
WERAM-Asf-0020 CADAFLAP00008921 Aspergillus flavus 61 2e-150 529
WERAM-Coi-0024 EAS33504 Coccidioides immitis 61 3e-150 529
WERAM-Scs-0023 EDO03342 Sclerotinia sclerotiorum 59 6e-150 528
WERAM-Asn-0024 CADANIAP00005952 Aspergillus nidulans 60 2e-149 526
WERAM-Asc-0037 CADACLAP00008612 Aspergillus clavatus 58 2e-149 526
WERAM-Trv-0003 EHK19072 Trichoderma virens 59 3e-149 525
WERAM-Asfu-0015 CADAFUAP00003503 Aspergillus fumigatus 58 5e-149 525
WERAM-Lac-0087 ENSLACP00000011092.1 Latimeria chalumnae 61 2e-148 523
WERAM-Map-0015 MAPG_05105T0 Magnaporthe poae 59 3e-148 522
WERAM-Gag-0026 GGTG_08607T0 Gaeumannomyces graminis 59 3e-148 522
WERAM-Ved-0020 EGY15146 Verticillium dahliae 51 4e-148 522
Created Date 25-Jun-2016