| Tag |
Content |
| WERAM ID |
WERAM-Cae-0006 |
| Ensembl Protein ID |
C08B11.2 |
| Uniprot Accession |
Q09440; HDA2_CAEEL
|
| Genbank Protein ID |
NP_495678.1
|
| Protein Name |
Putative histone deacetylase 2 |
| Genbank Nucleotide ID |
NM_063277.5
|
| Gene Name |
HDA-2;C08B11.2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
21573134
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
5.10e-146 |
486.8 |
30 |
341 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and forgaging (PubMed:21573134). |
Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and forgaging (PubMed:21573134).
|
| Domain Profile |
HDAC Class-I
class-1.txt 2 kvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeels.kelkkfnvgedcPvfdgl 98
+vay+y++dvg++hygq hpmkp+rl ++++Lv++y++ k +++v++ k +a++++ fh+e+y++fl++v+p+ +++ + l++fn+gedcP+f gl
C08B11.2 30 NVAYYYHKDVGHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAADISVFHTEDYVNFLQTVTPKLGLTMPdDVLRQFNIGEDCPIFAGL 127
79************************************************************************9999945789************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
++yc+l++G+s+e+a++Ln+k++di+inw GGlhhakkseasGfcyvnDivl+ilellk+hkrvlyidid+hhGDgv+eaf+++drvmtvsfh++g+
C08B11.2 128 WDYCTLYAGGSVEGARRLNHKMNDIVINWPGGLHHAKKSEASGFCYVNDIVLGILELLKYHKRVLYIDIDIHHGDGVQEAFNNSDRVMTVSFHRFGQ- 224
*************************************************************************************************. PP
class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
+fPg+G+++d+g++ gky+a+nvPl +i+De y k+f+svis v e f+Pea+vlqcG+Dsl++Drlg+f ls+++ha++vk+vks pl+vlGGG
C08B11.2 225 YFPGSGSIMDKGVGPGKYFAINVPLMAAIRDEPYLKLFESVISGVEENFNPEAIVLQCGSDSLCEDRLGQFALSFNAHARAVKYVKSLGKPLMVLGGG 322
************************************************************************************************** PP
class-1.txt 295 GYtlrnvaRcwtyetavvl 313
GYtlrnvaRcw+ et+v+l
C08B11.2 323 GYTLRNVARCWALETGVIL 341
*****************97 PP
|
Protein Sequence
(Fasta) | MSSDKFKLDT LFDDNDEIIE PDGADVKKRN VAYYYHKDVG HFHYGQLHPM KPQRLVVCND 60
LVVSYEMPKY MTVVESPKLD AADISVFHTE DYVNFLQTVT PKLGLTMPDD VLRQFNIGED 120
CPIFAGLWDY CTLYAGGSVE GARRLNHKMN DIVINWPGGL HHAKKSEASG FCYVNDIVLG 180
ILELLKYHKR VLYIDIDIHH GDGVQEAFNN SDRVMTVSFH RFGQYFPGSG SIMDKGVGPG 240
KYFAINVPLM AAIRDEPYLK LFESVISGVE ENFNPEAIVL QCGSDSLCED RLGQFALSFN 300
AHARAVKYVK SLGKPLMVLG GGGYTLRNVA RCWALETGVI LGLRMDDEIP GTSLYSHYFT 360
PRLLRPNLVP KMNDANSAAY LASIEKETLA CLRMIRGAPS VQMQNIVGIR LDEIEQIEEN 420
ERLQKSSKSS IEYEVGKVSE KMEEECFVEE DSKPPSFPPG QDPRRIGQYW GYDRSGLAPP 480
RSHSDVIEEA KYEDRDRRKD LNIPGIP 507Protein Fasta Sequence
>C08B11.2|HDA-2;C08B11.2|Caenorhabditis elegans
MSSDKFKLDTLFDDNDEIIEPDGADVKKRNVAYYYHKDVGHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAADISVFHTEDYVNFLQTVTPKLGLTMPDDVLRQFNIGEDCPIFAGLWDYCTLYAGGSVEGARRLNHKMNDIVINWPGGLHHAKKSEASGFCYVNDIVLGILELLKYHKRVLYIDIDIHHGDGVQEAFNNSDRVMTVSFHRFGQYFPGSGSIMDKGVGPGKYFAINVPLMAAIRDEPYLKLFESVISGVEENFNPEAIVLQCGSDSLCEDRLGQFALSFNAHARAVKYVKSLGKPLMVLGGGGYTLRNVARCWALETGVILGLRMDDEIPGTSLYSHYFTPRLLRPNLVPKMNDANSAAYLASIEKETLACLRMIRGAPSVQMQNIVGIRLDEIEQIEENERLQKSSKSSIEYEVGKVSEKMEEECFVEEDSKPPSFPPGQDPRRIGQYWGYDRSGLAPPRSHSDVIEEAKYEDRDRRKDLNIPGIP |
Nucleotide Sequence
(Fasta) | AAAATTGGCA AAAATATGTC ATCAGACAAG TTCAAACTAG ATACACTGTT CGATGATAAT 60
GATGAGATAA TCGAGCCAGA TGGAGCTGAT GTTAAAAAAA GAAATGTTGC ATATTATTAT 120
CATAAAGACG TCGGACATTT TCATTATGGC CAACTTCATC CAATGAAACC TCAACGGCTT 180
GTGGTGTGCA ACGATTTAGT AGTTTCCTAT GAAATGCCAA AATATATGAC AGTTGTTGAA 240
TCACCAAAGT TAGATGCTGC AGATATTTCT GTATTTCACA CTGAAGATTA CGTCAACTTT 300
CTGCAAACAG TGACACCGAA GCTCGGTCTT ACAATGCCTG ATGACGTTTT GAGGCAGTTT 360
AACATTGGAG AGGATTGTCC AATTTTCGCT GGACTTTGGG ATTACTGTAC TTTGTATGCT 420
GGTGGATCTG TTGAAGGTGC TCGACGATTG AATCATAAAA TGAATGATAT TGTGATTAAT 480
TGGCCTGGAG GACTTCATCA CGCCAAGAAA TCAGAAGCTT CAGGATTTTG CTATGTAAAC 540
GACATTGTGC TGGGAATTTT GGAGTTATTG AAATATCACA AACGAGTATT GTATATCGAC 600
ATTGACATTC ATCATGGTGA TGGTGTTCAG GAAGCATTCA ATAATTCTGA TCGAGTTATG 660
ACTGTGTCAT TTCATCGTTT TGGTCAATAT TTCCCAGGAT CTGGAAGTAT TATGGACAAA 720
GGTGTCGGTC CCGGAAAGTA TTTTGCGATT AATGTTCCCC TGATGGCTGC AATTCGAGAT 780
GAACCTTACT TAAAATTATT CGAGAGTGTT ATAAGTGGCG TTGAAGAAAA TTTTAATCCT 840
GAGGCAATTG TTCTTCAATG TGGTTCCGAT TCATTGTGTG AAGACAGACT TGGTCAATTT 900
GCTTTGTCAT TCAATGCACA TGCACGCGCA GTCAAATACG TGAAAAGTCT TGGAAAACCA 960
TTGATGGTCC TTGGTGGTGG TGGATATACA CTTAGAAATG TTGCGAGATG CTGGGCCCTT 1020
GAAACTGGAG TCATTTTAGG TCTTCGAATG GACGATGAAA TCCCTGGAAC ATCATTATAC 1080
TCGCACTATT TCACTCCACG ACTTCTTCGC CCAAATTTGG TTCCAAAAAT GAATGATGCT 1140
AATTCTGCGG CATATTTGGC TTCTATTGAA AAAGAAACGC TGGCATGTTT GAGAATGATT 1200
CGTGGAGCAC CATCAGTTCA AATGCAAAAT ATTGTTGGAA TCAGGCTCGA CGAAATTGAG 1260
CAAATCGAAG AAAATGAACG ACTACAAAAA TCATCAAAAT CTTCAATTGA ATATGAAGTT 1320
GGAAAAGTAT CAGAGAAAAT GGAAGAAGAA TGCTTTGTAG AAGAAGACTC AAAACCTCCA 1380
TCATTTCCAC CGGGTCAAGA TCCTCGTCGG ATTGGTCAGT ACTGGGGATA TGACAGGTCT 1440
GGATTGGCTC CACCGAGAAG TCACTCGGAT GTTATTGAAG AAGCAAAATA TGAAGATCGC 1500
GACAGACGAA AAGATCTCAA TATTCCCGGA ATTCCGTAAC TTTCCATGTA ATTAATGATT 1560
AAACACTGTG ATGAATTTGT CAAAAATCTT TTCTGTGTTG GTTTTCAGTA TTTCCGATTT 1620
TATATTGTTT TCTGTTGCAT GATCTCTAAA TTTCTCAAGT AATAAACCAA ATTTCAGA
1679Nucleotide Fasta Sequence
>C08B11.2|Class-I|Caenorhabditis elegans
AAAATTGGCAAAAATATGTCATCAGACAAGTTCAAACTAGATACACTGTTCGATGATAATGATGAGATAATCGAGCCAGATGGAGCTGATGTTAAAAAAAGAAATGTTGCATATTATTATCATAAAGACGTCGGACATTTTCATTATGGCCAACTTCATCCAATGAAACCTCAACGGCTTGTGGTGTGCAACGATTTAGTAGTTTCCTATGAAATGCCAAAATATATGACAGTTGTTGAATCACCAAAGTTAGATGCTGCAGATATTTCTGTATTTCACACTGAAGATTACGTCAACTTTCTGCAAACAGTGACACCGAAGCTCGGTCTTACAATGCCTGATGACGTTTTGAGGCAGTTTAACATTGGAGAGGATTGTCCAATTTTCGCTGGACTTTGGGATTACTGTACTTTGTATGCTGGTGGATCTGTTGAAGGTGCTCGACGATTGAATCATAAAATGAATGATATTGTGATTAATTGGCCTGGAGGACTTCATCACGCCAAGAAATCAGAAGCTTCAGGATTTTGCTATGTAAACGACATTGTGCTGGGAATTTTGGAGTTATTGAAATATCACAAACGAGTATTGTATATCGACATTGACATTCATCATGGTGATGGTGTTCAGGAAGCATTCAATAATTCTGATCGAGTTATGACTGTGTCATTTCATCGTTTTGGTCAATATTTCCCAGGATCTGGAAGTATTATGGACAAAGGTGTCGGTCCCGGAAAGTATTTTGCGATTAATGTTCCCCTGATGGCTGCAATTCGAGATGAACCTTACTTAAAATTATTCGAGAGTGTTATAAGTGGCGTTGAAGAAAATTTTAATCCTGAGGCAATTGTTCTTCAATGTGGTTCCGATTCATTGTGTGAAGACAGACTTGGTCAATTTGCTTTGTCATTCAATGCACATGCACGCGCAGTCAAATACGTGAAAAGTCTTGGAAAACCATTGATGGTCCTTGGTGGTGGTGGATATACACTTAGAAATGTTGCGAGATGCTGGGCCCTTGAAACTGGAGTCATTTTAGGTCTTCGAATGGACGATGAAATCCCTGGAACATCATTATACTCGCACTATTTCACTCCACGACTTCTTCGCCCAAATTTGGTTCCAAAAATGAATGATGCTAATTCTGCGGCATATTTGGCTTCTATTGAAAAAGAAACGCTGGCATGTTTGAGAATGATTCGTGGAGCACCATCAGTTCAAATGCAAAATATTGTTGGAATCAGGCTCGACGAAATTGAGCAAATCGAAGAAAATGAACGACTACAAAAATCATCAAAATCTTCAATTGAATATGAAGTTGGAAAAGTATCAGAGAAAATGGAAGAAGAATGCTTTGTAGAAGAAGACTCAAAACCTCCATCATTTCCACCGGGTCAAGATCCTCGTCGGATTGGTCAGTACTGGGGATATGACAGGTCTGGATTGGCTCCACCGAGAAGTCACTCGGATGTTATTGAAGAAGCAAAATATGAAGATCGCGACAGACGAAAAGATCTCAATATTCCCGGAATTCCGTAACTTTCCATGTAATTAATGATTAAACACTGTGATGAATTTGTCAAAAATCTTTTCTGTGTTGGTTTTCAGTATTTCCGATTTTATATTGTTTTCTGTTGCATGATCTCTAAATTTCTCAAGTAATAAACCAAATTTCAGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000118--C:histone deacetylase complex
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003714--F:transcription corepressor activity
GO:0016568--P:chromatin modification
GO:0042262--P:DNA protection
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045138--P:nematode male tail tip morphogenesis
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
