| Tag |
Content |
| WERAM ID |
WERAM-Sac-0039 |
| Ensembl Protein ID |
YNL330C |
| Uniprot Accession |
P32561; RPD3_YEAST; D6W0L7
|
| Genbank Protein ID |
NP_014069.1
|
| Protein Name |
Histone deacetylase RPD3 |
| Genbank Nucleotide ID |
NM_001183168.1
|
| Gene Name |
Rpd3;MOF6;REC3;SDI2;SDS6;YNL330C;N0305 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
8.70e-165 |
546.2 |
19 |
330 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Is involved in rDNA and telomere silencing and in double strand breaks repair. Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2. The RPD3 complexes regulate also chromosomal replication timing. |
Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Is involved in rDNA and telomere silencing and in double strand breaks repair. Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2. The RPD3 complexes regulate also chromosomal replication timing.
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvfdgl 98
++vay+yd dvg+y yg++hpmkp+r++++h+L++nygl+kk+ei+++k a+++e+++fh++eyi+fl++v+p+n e +++e+ kfnvg+dcPvfdgl
YNL330C 19 RRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGL 116
589*********************************************************************************************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkygee 196
+eyc++++G+s+e+a++Ln++++d+a+n+aGGlhhakkseasGfcy+nDivl+i+ell++h+rvlyidid+hhGDgveeafyttdrvmt+sfhkyge
YNL330C 117 YEYCSISGGGSMEGAARLNRGKCDVAVNYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGE- 213
*************************************************************************************************. PP
class-1.txt 197 ffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlGGG 294
ffPgtG+l+d+g++ gk+yavnvPl+dgidD +y+++f++vi+k++e+++P+avvlqcG+Dsl+gDrlg+fnls++gha+cv++vksf +p++v+GGG
YNL330C 214 FFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGG 311
************************************************************************************************** PP
class-1.txt 295 GYtlrnvaRcwtyetavvl 313
GYt+rnvaR+w++et++++
YNL330C 312 GYTMRNVARTWCFETGLLN 330
***************9975 PP
|
Protein Sequence
(Fasta) | MVYEATPFDP ITVKPSDKRR VAYFYDADVG NYAYGAGHPM KPHRIRMAHS LIMNYGLYKK 60
MEIYRAKPAT KQEMCQFHTD EYIDFLSRVT PDNLEMFKRE SVKFNVGDDC PVFDGLYEYC 120
SISGGGSMEG AARLNRGKCD VAVNYAGGLH HAKKSEASGF CYLNDIVLGI IELLRYHPRV 180
LYIDIDVHHG DGVEEAFYTT DRVMTCSFHK YGEFFPGTGE LRDIGVGAGK NYAVNVPLRD 240
GIDDATYRSV FEPVIKKIME WYQPSAVVLQ CGGDSLSGDR LGCFNLSMEG HANCVNYVKS 300
FGIPMMVVGG GGYTMRNVAR TWCFETGLLN NVVLDKDLPY NEYYEYYGPD YKLSVRPSNM 360
FNVNTPEYLD KVMTNIFANL ENTKYAPSVQ LNHTPRDAED LGDVEEDSAE AKDTKGGSQY 420
ARDLHVEHDN EFY 433Protein Fasta Sequence
>YNL330C|Rpd3;MOF6;REC3;SDI2;SDS6;YNL330C;N0305|Saccharomyces cerevisiae
MVYEATPFDPITVKPSDKRRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVNYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDKDLPYNEYYEYYGPDYKLSVRPSNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLNHTPRDAEDLGDVEEDSAEAKDTKGGSQYARDLHVEHDNEFY |
Nucleotide Sequence
(Fasta) | ATGGTATATG AAGCAACACC TTTTGATCCG ATCACGGTCA AGCCAAGCGA TAAAAGACGC 60
GTTGCATATT TTTACGATGC AGACGTTGGG AACTATGCAT ATGGAGCAGG TCACCCGATG 120
AAGCCGCATA GAATAAGAAT GGCACATTCC CTTATTATGA ATTATGGCTT GTACAAGAAG 180
ATGGAAATTT ACAGAGCTAA GCCGGCAACG AAACAAGAAA TGTGTCAGTT CCATACTGAT 240
GAATACATTG ATTTTTTATC GAGGGTTACT CCAGATAATT TAGAAATGTT TAAAAGAGAA 300
AGTGTCAAGT TTAATGTCGG AGATGATTGT CCTGTCTTTG ATGGGCTCTA TGAGTACTGT 360
AGCATATCTG GTGGTGGCTC TATGGAAGGA GCTGCTCGTC TGAATAGAGG CAAATGTGAT 420
GTTGCTGTCA ACTATGCGGG TGGTTTGCAT CATGCAAAAA AATCGGAAGC TTCTGGGTTT 480
TGTTATTTAA ATGACATAGT ACTGGGCATT ATTGAGCTAC TACGATACCA CCCCAGAGTT 540
CTGTATATTG ATATTGATGT GCACCATGGT GATGGTGTAG AGGAAGCGTT TTATACAACG 600
GATCGTGTCA TGACATGTTC TTTCCACAAA TATGGTGAGT TTTTCCCTGG CACAGGTGAA 660
CTGAGAGATA TAGGGGTGGG TGCAGGAAAA AACTACGCGG TCAATGTGCC ATTAAGAGAC 720
GGTATTGACG ATGCTACGTA TAGATCTGTG TTTGAACCTG TGATAAAAAA AATTATGGAA 780
TGGTATCAAC CTTCTGCTGT CGTGTTACAG TGTGGTGGGG ACTCCTTGTC CGGCGATCGT 840
CTTGGTTGCT TTAATCTTTC CATGGAAGGC CATGCTAATT GTGTAAACTA TGTGAAATCC 900
TTTGGGATCC CAATGATGGT TGTTGGTGGA GGAGGCTATA CTATGAGAAA TGTTGCAAGG 960
ACATGGTGCT TTGAAACAGG TCTACTAAAT AACGTTGTCT TGGATAAAGA TTTACCGTAC 1020
AATGAATATT ACGAATATTA CGGTCCAGAT TATAAGTTAA GTGTTAGACC TTCGAATATG 1080
TTCAATGTAA ATACTCCCGA ATATCTTGAC AAGGTAATGA CCAATATATT TGCTAATTTG 1140
GAAAACACAA AGTATGCCCC TAGTGTTCAG TTGAATCACA CACCTAGGGA TGCCGAAGAT 1200
TTGGGTGATG TTGAAGAAGA TTCTGCCGAG GCTAAAGATA CGAAGGGTGG TTCGCAATAT 1260
GCGAGGGACC TACATGTTGA GCATGACAAT GAATTCTATT GA
1303Nucleotide Fasta Sequence
>YNL330C|Class-I|Saccharomyces cerevisiae
ATGGTATATGAAGCAACACCTTTTGATCCGATCACGGTCAAGCCAAGCGATAAAAGACGCGTTGCATATTTTTACGATGCAGACGTTGGGAACTATGCATATGGAGCAGGTCACCCGATGAAGCCGCATAGAATAAGAATGGCACATTCCCTTATTATGAATTATGGCTTGTACAAGAAGATGGAAATTTACAGAGCTAAGCCGGCAACGAAACAAGAAATGTGTCAGTTCCATACTGATGAATACATTGATTTTTTATCGAGGGTTACTCCAGATAATTTAGAAATGTTTAAAAGAGAAAGTGTCAAGTTTAATGTCGGAGATGATTGTCCTGTCTTTGATGGGCTCTATGAGTACTGTAGCATATCTGGTGGTGGCTCTATGGAAGGAGCTGCTCGTCTGAATAGAGGCAAATGTGATGTTGCTGTCAACTATGCGGGTGGTTTGCATCATGCAAAAAAATCGGAAGCTTCTGGGTTTTGTTATTTAAATGACATAGTACTGGGCATTATTGAGCTACTACGATACCACCCCAGAGTTCTGTATATTGATATTGATGTGCACCATGGTGATGGTGTAGAGGAAGCGTTTTATACAACGGATCGTGTCATGACATGTTCTTTCCACAAATATGGTGAGTTTTTCCCTGGCACAGGTGAACTGAGAGATATAGGGGTGGGTGCAGGAAAAAACTACGCGGTCAATGTGCCATTAAGAGACGGTATTGACGATGCTACGTATAGATCTGTGTTTGAACCTGTGATAAAAAAAATTATGGAATGGTATCAACCTTCTGCTGTCGTGTTACAGTGTGGTGGGGACTCCTTGTCCGGCGATCGTCTTGGTTGCTTTAATCTTTCCATGGAAGGCCATGCTAATTGTGTAAACTATGTGAAATCCTTTGGGATCCCAATGATGGTTGTTGGTGGAGGAGGCTATACTATGAGAAATGTTGCAAGGACATGGTGCTTTGAAACAGGTCTACTAAATAACGTTGTCTTGGATAAAGATTTACCGTACAATGAATATTACGAATATTACGGTCCAGATTATAAGTTAAGTGTTAGACCTTCGAATATGTTCAATGTAAATACTCCCGAATATCTTGACAAGGTAATGACCAATATATTTGCTAATTTGGAAAACACAAAGTATGCCCCTAGTGTTCAGTTGAATCACACACCTAGGGATGCCGAAGATTTGGGTGATGTTGAAGAAGATTCTGCCGAGGCTAAAGATACGAAGGGTGGTTCGCAATATGCGAGGGACCTACATGTTGAGCATGACAATGAATTCTATTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000118--C:histone deacetylase complex
GO:0034399--C:nuclear periphery
GO:0033698--C:Rpd3L complex
GO:0032221--C:Rpd3S complex
GO:0070822--C:Sin3-type complex
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0045128--P:negative regulation of reciprocal meiotic recombination
GO:0016479--P:negative regulation of transcription from RNA polymerase I promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051038--P:negative regulation of transcription involved in meiotic cell cycle
GO:0016239--P:positive regulation of macroautophagy
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0034503--P:protein localization to nucleolar rDNA repeats
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117--P:regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0001302--P:replicative cell aging
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0061587--P:transfer RNA gene-mediated silencing
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
