| Tag |
Content |
| WERAM ID |
WERAM-Art-0148 |
| Ensembl Protein ID |
AT5G63110.1 |
| Uniprot Accession |
Q9FML2; HDA6_ARATH; Q9FVE5
|
| Genbank Protein ID |
NP_201116.1
|
| Protein Name |
Histone deacetylase 6 |
| Genbank Nucleotide ID |
NM_125705.3
|
| Gene Name |
HDA6;RPD3B;At5g63110;MDC12.7 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689639; 26704384
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
7.10e-163 |
542.3 |
19 |
332 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity (PubMed:11340181, PubMed:12486004, PubMed:15037732, PubMed:16648464). Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). Binds to KNAT1, KNAT2, and KNATM chromatin (PubMed:23271976). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this effect seems to bee independent of the histone deacetylase activity (PubMed:11340181, PubMed:12486004, PubMed:15037732, PubMed:16648464). Part of the AS1 repressor complex to regulate the KNOX expression in leaf development (PubMed:23271976). Binds to KNAT1, KNAT2, and KNATM chromatin (PubMed:23271976).
|
| Domain Profile |
HDAC Class-I
class-1.txt 1 kkvayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae..elskelkkfnvgedcPvfd 96
++v+y+y++++g+y+ygq+hpmkp+r++++h+L+++y+l+++lei +p+ a+a+++ +fhs ey++fl +v+pe++ + +++l++fnvgedcPvfd
AT5G63110.1 19 RRVSYFYEPTIGDYYYGQGHPMKPHRIRMAHSLIIHYHLHRRLEISRPSLADASDIGRFHSPEYVDFLASVSPESMGdpSAARNLRRFNVGEDCPVFD 116
589************************************************************************99445559*************** PP
class-1.txt 97 glfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmtvsfhkyg 194
glf++c++++G+s+ aa kLn+++adiainw GGlhhakkseasGfcyvnDivl+ilellk++krvlyidid+hhGDgveeafyttdrvmtvsfhk+g
AT5G63110.1 117 GLFDFCRASAGGSIGAAVKLNRQDADIAINWGGGLHHAKKSEASGFCYVNDIVLGILELLKMFKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKFG 214
************************************************************************************************** PP
class-1.txt 195 eeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvkfvksfnlpllvlG 292
+ ffPgtG+++dvgaekgkyya+nvPl+dg+dDes++++f+++i+kv+e+++PeavvlqcGaDsl+gDrlg+fnls+kgha+c++f++s+n+pl+vlG
AT5G63110.1 215 D-FFPGTGHIRDVGAEKGKYYALNVPLNDGMDDESFRSLFRPLIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSYNVPLMVLG 311
*.************************************************************************************************ PP
class-1.txt 293 GGGYtlrnvaRcwtyetavvl 313
GGGYt+rnvaRcw+yetav++
AT5G63110.1 312 GGGYTIRNVARCWCYETAVAV 332
******************986 PP
|
Protein Sequence
(Fasta) | MEADESGISL PSGPDGRKRR VSYFYEPTIG DYYYGQGHPM KPHRIRMAHS LIIHYHLHRR 60
LEISRPSLAD ASDIGRFHSP EYVDFLASVS PESMGDPSAA RNLRRFNVGE DCPVFDGLFD 120
FCRASAGGSI GAAVKLNRQD ADIAINWGGG LHHAKKSEAS GFCYVNDIVL GILELLKMFK 180
RVLYIDIDVH HGDGVEEAFY TTDRVMTVSF HKFGDFFPGT GHIRDVGAEK GKYYALNVPL 240
NDGMDDESFR SLFRPLIQKV MEVYQPEAVV LQCGADSLSG DRLGCFNLSV KGHADCLRFL 300
RSYNVPLMVL GGGGYTIRNV ARCWCYETAV AVGVEPDNKL PYNEYFEYFG PDYTLHVDPS 360
PMENLNTPKD MERIRNTLLE QLSGLIHAPS VQFQHTPPVN RVLDEPEDDM ETRPKPRIWS 420
GTATYESDSD DDDKPLHGYS CRGGATTDRD STGEDEMDDD NPEPDVNPPS S 471Protein Fasta Sequence
>AT5G63110.1|HDA6;RPD3B;At5g63110;MDC12.7|Arabidopsis thaliana
MEADESGISLPSGPDGRKRRVSYFYEPTIGDYYYGQGHPMKPHRIRMAHSLIIHYHLHRRLEISRPSLADASDIGRFHSPEYVDFLASVSPESMGDPSAARNLRRFNVGEDCPVFDGLFDFCRASAGGSIGAAVKLNRQDADIAINWGGGLHHAKKSEASGFCYVNDIVLGILELLKMFKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKFGDFFPGTGHIRDVGAEKGKYYALNVPLNDGMDDESFRSLFRPLIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSYNVPLMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNEYFEYFGPDYTLHVDPSPMENLNTPKDMERIRNTLLEQLSGLIHAPSVQFQHTPPVNRVLDEPEDDMETRPKPRIWSGTATYESDSDDDDKPLHGYSCRGGATTDRDSTGEDEMDDDNPEPDVNPPSS |
Nucleotide Sequence
(Fasta) | GTGCCCACAA CTCCTAGTAA TGACTTTCTC AGGCATTGTT GACACAAATT TTGCTCTGAG 60
TAAAACTTGG GAATAGAGAG AGACTCTGAG TGAGAGAGAG ATTCTGAGTG AGAGACGGAG 120
ATGGAGGCAG ACGAAAGCGG CATCTCTCTG CCGTCGGGAC CCGACGGACG TAAGCGGCGA 180
GTCAGTTACT TCTACGAGCC GACGATCGGA GACTACTACT ACGGTCAAGG CCACCCGATG 240
AAGCCTCACC GGATCCGTAT GGCTCATAGC CTAATCATTC ACTATCACCT CCACCGTCGC 300
TTAGAAATCA GTCGCCCTAG CCTCGCTGAC GCCTCCGATA TCGGCCGATT CCATTCGCCG 360
GAGTATGTTG ACTTCCTCGC TTCCGTTTCG CCGGAATCTA TGGGCGATCC TTCCGCTGCA 420
CGAAACCTAA GGCGATTCAA TGTCGGTGAG GATTGTCCTG TCTTCGACGG ACTTTTTGAT 480
TTTTGCCGTG CTTCCGCCGG AGGTTCTATT GGTGCTGCCG TCAAATTAAA CAGACAGGAC 540
GCTGATATCG CTATCAATTG GGGCGGTGGG CTTCACCATG CTAAGAAAAG CGAGGCTTCT 600
GGGTTTTGCT ATGTAAACGA CATCGTGCTA GGGATTCTGG AGTTGCTCAA GATGTTTAAG 660
CGGGTTCTCT ACATAGATAT TGATGTCCAC CATGGAGATG GAGTGGAAGA AGCGTTTTAC 720
ACCACTGATA GAGTTATGAC TGTTTCTTTC CACAAATTTG GGGACTTTTT CCCAGGAACT 780
GGTCACATAA GAGATGTTGG CGCTGAAAAA GGGAAATACT ATGCTCTAAA TGTTCCACTA 840
AACGATGGTA TGGACGATGA AAGTTTCCGC AGCTTGTTTA GACCTCTTAT CCAGAAGGTT 900
ATGGAAGTGT ATCAGCCAGA GGCAGTTGTT CTTCAGTGTG GTGCTGACTC CTTAAGTGGT 960
GATCGGTTGG GTTGCTTCAA CTTATCAGTC AAGGGTCACG CTGATTGCCT TCGGTTCTTA 1020
AGATCTTACA ACGTTCCTCT CATGGTGTTG GGTGGTGGAG GGTATACTAT TCGAAATGTT 1080
GCCCGTTGCT GGTGTTATGA GACTGCAGTT GCTGTTGGAG TAGAGCCGGA CAACAAACTC 1140
CCTTACAATG AGTATTTTGA GTATTTCGGC CCAGATTATA CGCTTCATGT CGACCCAAGT 1200
CCTATGGAGA ATTTAAACAC GCCCAAAGAT ATGGAGAGGA TAAGGAACAC GTTGCTGGAA 1260
CAACTTTCGG GACTAATACA CGCACCTAGC GTCCAGTTTC AGCACACACC ACCAGTCAAT 1320
CGAGTTTTGG ACGAGCCGGA AGATGACATG GAGACAAGAC CAAAACCTCG CATCTGGAGT 1380
GGAACTGCGA CTTATGAATC AGACAGTGAC GATGATGATA AACCTCTTCA TGGTTACTCA 1440
TGTCGTGGTG GCGCAACTAC GGACAGGGAC TCTACCGGTG AAGATGAAAT GGATGACGAT 1500
AACCCAGAGC CAGACGTGAA TCCTCCATCG TCTTAAACCA GCTTGATGGT TTGGTGTCTC 1560
TTTTGCCATA TGATAATGTC GGCAGATTTA AGAAACAAGT TAGGGGAATG AATGATTCTT 1620
TGATGTTTTT TCAGCAACCT TTTGAGTTCT GTGAAAACGC TGCATTGATT AGAACAGTGA 1680
CAACTGACTA GTATTTTGGC CCAAGTTAGA AAATCAGAAT ATGTGAAAAA TGCAAAGAAA 1740
CTTTTT
1747Nucleotide Fasta Sequence
>AT5G63110.1|Class-I|Arabidopsis thaliana
GTGCCCACAACTCCTAGTAATGACTTTCTCAGGCATTGTTGACACAAATTTTGCTCTGAGTAAAACTTGGGAATAGAGAGAGACTCTGAGTGAGAGAGAGATTCTGAGTGAGAGACGGAGATGGAGGCAGACGAAAGCGGCATCTCTCTGCCGTCGGGACCCGACGGACGTAAGCGGCGAGTCAGTTACTTCTACGAGCCGACGATCGGAGACTACTACTACGGTCAAGGCCACCCGATGAAGCCTCACCGGATCCGTATGGCTCATAGCCTAATCATTCACTATCACCTCCACCGTCGCTTAGAAATCAGTCGCCCTAGCCTCGCTGACGCCTCCGATATCGGCCGATTCCATTCGCCGGAGTATGTTGACTTCCTCGCTTCCGTTTCGCCGGAATCTATGGGCGATCCTTCCGCTGCACGAAACCTAAGGCGATTCAATGTCGGTGAGGATTGTCCTGTCTTCGACGGACTTTTTGATTTTTGCCGTGCTTCCGCCGGAGGTTCTATTGGTGCTGCCGTCAAATTAAACAGACAGGACGCTGATATCGCTATCAATTGGGGCGGTGGGCTTCACCATGCTAAGAAAAGCGAGGCTTCTGGGTTTTGCTATGTAAACGACATCGTGCTAGGGATTCTGGAGTTGCTCAAGATGTTTAAGCGGGTTCTCTACATAGATATTGATGTCCACCATGGAGATGGAGTGGAAGAAGCGTTTTACACCACTGATAGAGTTATGACTGTTTCTTTCCACAAATTTGGGGACTTTTTCCCAGGAACTGGTCACATAAGAGATGTTGGCGCTGAAAAAGGGAAATACTATGCTCTAAATGTTCCACTAAACGATGGTATGGACGATGAAAGTTTCCGCAGCTTGTTTAGACCTCTTATCCAGAAGGTTATGGAAGTGTATCAGCCAGAGGCAGTTGTTCTTCAGTGTGGTGCTGACTCCTTAAGTGGTGATCGGTTGGGTTGCTTCAACTTATCAGTCAAGGGTCACGCTGATTGCCTTCGGTTCTTAAGATCTTACAACGTTCCTCTCATGGTGTTGGGTGGTGGAGGGTATACTATTCGAAATGTTGCCCGTTGCTGGTGTTATGAGACTGCAGTTGCTGTTGGAGTAGAGCCGGACAACAAACTCCCTTACAATGAGTATTTTGAGTATTTCGGCCCAGATTATACGCTTCATGTCGACCCAAGTCCTATGGAGAATTTAAACACGCCCAAAGATATGGAGAGGATAAGGAACACGTTGCTGGAACAACTTTCGGGACTAATACACGCACCTAGCGTCCAGTTTCAGCACACACCACCAGTCAATCGAGTTTTGGACGAGCCGGAAGATGACATGGAGACAAGACCAAAACCTCGCATCTGGAGTGGAACTGCGACTTATGAATCAGACAGTGACGATGATGATAAACCTCTTCATGGTTACTCATGTCGTGGTGGCGCAACTACGGACAGGGACTCTACCGGTGAAGATGAAATGGATGACGATAACCCAGAGCCAGACGTGAATCCTCCATCGTCTTAAACCAGCTTGATGGTTTGGTGTCTCTTTTGCCATATGATAATGTCGGCAGATTTAAGAAACAAGTTAGGGGAATGAATGATTCTTTGATGTTTTTTCAGCAACCTTTTGAGTTCTGTGAAAACGCTGCATTGATTAGAACAGTGACAACTGACTAGTATTTTGGCCCAAGTTAGAAAATCAGAATATGTGAAAAATGCAAAGAAACTTTTT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0009941--C:chloroplast envelope
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0009793--P:embryo development ending in seed dormancy
GO:0016458--P:gene silencing
GO:0016575--P:histone deacetylation
GO:0016441--P:posttranscriptional gene silencing
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009737--P:response to abscisic acid
GO:0009651--P:response to salt stress
GO:0010431--P:seed maturation
GO:0006351--P:transcription, DNA-templated
GO:0010228--P:vegetative to reproductive phase transition of meristem
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
