Tag |
Content |
WERAM ID |
WERAM-Hos-0075 |
Ensembl Protein ID |
ENSP00000468004.1 |
Uniprot Accession |
Q9UQL6; HDAC5_HUMAN; C9JFV9; O60340; O60528; Q96DY4 |
Genbank Protein ID |
NP_001015053.1; NP_005465.2; XP_005256961.1; XP_005256963.1 |
Protein Name |
Histone deacetylase 5 |
Genbank Nucleotide ID |
NM_001015053.1; NM_005474.4; XM_005256904.3; XM_005256906.3 |
Gene Name |
HDAC5;KIAA0600 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-II |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-II |
1.00e-147 |
493.9 |
130 |
1023 |
HDAC |
Class-I |
4.30e-29 |
104.4 |
703 |
992 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
|
Domain Profile |
HDAC Class-II
class-2.txt 13 hqaleenkekhpE.kpeRiqailsrlqeagllekleelkarkatkee 58 +++l + +++ E + +R q+ ++l+++ l ++l+ l++++++ke+ ENSP00000468004.1 130 QEMLAAKRQQELEqQRQREQQRQEELEKQRLEQQLLILRNKEKSKES 176 34444444455551457888999999999999999999998888876 PP class-2.txt 2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles....... 84 +g+vyd+ mlkhq++++n++ hpE+++Riq+i+srlqe+gll+k+e++++rkat++e+q+vHse h+ l++t+ +l++++l+s ENSP00000468004.1 683 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTS-PLNRQKLDSkkllgpi 771 79**********************************************************************9.**************** PP class-2.txt 85 ............ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkv 162 ++vdsd++++e++s++a+r+avG++lel++kv++gelkngfa++RPPGHHaeestamGFC+fn+va++akllqqkl+v ENSP00000468004.1 772 sqkmyavlpcggIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 861 ****************************************************************************************** PP class-2.txt 163 kkilivDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvlpia 249 k+livDwD+HhGnGtq++fy+dp+vly+SlHRyd+g+ffp gsga++evg g+g+g+nvNvaw+gg+ +gd eyl+afr+vv+pia ENSP00000468004.1 862 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYNVNVAWTGGVdppIGDVEYLTAFRTVVMPIA 949 *****************************************..*********************************************** PP class-2.txt 250 keFkPdlvlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLl 321 +eF+Pd+vlvsaGfDa+eg +plgg+svta+c+++lt+ql++laggrvvl+lEGG++l+ai++a+ea+v+aLl ENSP00000468004.1 950 HEFSPDVVLVSAGFDAVEGhlSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALL 1023 *******************99***************************************************98 PP
HDAC Class-I
class-1.txt 19 khpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae.............elskelkkfnvgedc.Pvfd 96 hp r++ + + + + gl k e+++ +ka+ +e++++hse y ++l +p n + ++ l ++g d+ v + ENSP00000468004.1 703 VHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSE-YHTLLYGTSPLNRQkldskkllgpisqKMYAVLPCGGIGVDSdTVWN 793 46677778888888888889999999999999999999988875.55666665555555344443444332222222222245556524677 PP class-1.txt 97 glfeyc..qlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellkkhk..rvlyididlhhGDgveeafytt 182 ++++ + ++ G le a k+ +e + ai G hha s a Gfc+ n + ++ l++k++ +vl +d d+hhG+g ++afy+ ENSP00000468004.1 794 EMHSSSavRMAVGCLLELAFKVAAGELKngFAIIRPPG-HHAEESTAMGFCFFNSVAITAKLLQQKLNvgKVLIVDWDIHHGNGTQQAFYND 884 77765511456788899999998876652256655555.9******************9998888654449********************* PP class-1.txt 183 drvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDslag..Drlgef 267 v+ +s+h+y++ +ffPg+G ++vg + g y vnv + g+d D +y + f++v+ ++ + f+P++v++ G D++ g +lg + ENSP00000468004.1 885 PSVLYISLHRYDNgNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDppigDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGhlSPLGGY 976 ***********8746************************99997666669********************************8733589*** PP class-1.txt 268 nlsikghaecvkfvks 283 +++ + +++ + + + ENSP00000468004.1 977 SVTARCFGHLTRQLMT 992 **99999987665554 PP
|
Protein Sequence (Fasta) | MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR 60 GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 120 QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS 180 TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL 240 PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI 300 TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ 360 FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST 420 SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS 480 MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE 540 LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED 600 CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ 660 SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE 720 TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP 780 CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM 840 GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF 900 FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS 960 AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS 1020 ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET 1080 EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL 1122Protein Fasta Sequence
>ENSP00000468004.1|HDAC5;KIAA0600|Homo sapiens MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
|
Nucleotide Sequence (Fasta) | GACAGGGGCG CCTTCCCTAC AGGGATGCCG TTCTGAGTGC CTGACTGCCT CGCCCCGAAG 60 GATGGCCTCG GATGGGCATT AGAGGCACGG CGGCCCCGGG CTCCCGTCCC GTCCGTCTGT 120 CTGTTATCGT CTGTCTCTCT TGACATCACC GCAGCTCCAC CCCCTCCCGT CCCAGCCCCC 180 AACGCCAGCT TCCTGCAGGC CCAGAGCCGG CATGAACTCT CCCAACGAGT CGGATGGGAT 240 GTCAGGTCGG GAACCATCCT TGGAAATCCT GCCGCGGACT TCTCTGCACA GCATCCCTGT 300 GACAGTGGAG GTGAAGCCGG TGCTGCCAAG AGCCATGCCC AGTTCCATGG GGGGTGGGGG 360 TGGAGGCAGC CCCAGCCCTG TGGAGCTACG GGGGGCTCTG GTGGGCTCTG TGGACCCCAC 420 ACTGCGGGAG CAGCAACTGC AGCAGGAGCT CCTGGCGCTC AAGCAGCAGC AGCAGCTGCA 480 GAAGCAGCTC CTGTTCGCTG AGTTCCAGAA ACAGCATGAC CACCTGACAA GGCAGCATGA 540 GGTCCAGCTG CAGAAGCACC TCAAGCAGCA GCAGGAGATG CTGGCAGCCA AGCAGCAGCA 600 GGAGATGCTG GCAGCCAAGC GGCAGCAGGA GCTGGAGCAG CAGCGGCAGC GGGAGCAGCA 660 GCGGCAGGAA GAGCTGGAGA AGCAGCGGCT GGAGCAGCAG CTGCTCATCC TGCGGAACAA 720 GGAGAAGAGC AAAGAGAGTG CCATTGCCAG CACTGAGGTA AAGCTGAGGC TCCAGGAATT 780 CCTCTTGTCG AAGTCAAAGG AGCCCACACC AGGCGGCCTC AACCATTCCC TCCCACAGCA 840 CCCCAAATGC TGGGGAGCCC ACCATGCTTC TTTGGACCAG AGTTCCCCTC CCCAGAGCGG 900 CCCCCCTGGG ACGCCTCCCT CCTACAAACT GCCTTTGCCT GGGCCCTACG ACAGTCGAGA 960 CGACTTCCCC CTCCGCAAAA CAGCCTCTGA ACCCAACTTG AAAGTGCGTT CAAGGCTAAA 1020 ACAGAAGGTG GCTGAGCGGA GAAGCAGTCC CCTCCTGCGT CGCAAGGATG GGACTGTTAT 1080 TAGCACCTTT AAGAAGAGAG CTGTTGAGAT CACAGGTGCC GGGCCTGGGG CGTCGTCCGT 1140 GTGTAACAGC GCACCCGGCT CCGGCCCCAG CTCTCCCAAC AGCTCCCACA GCACCATCGC 1200 TGAGAATGGC TTTACTGGCT CAGTCCCCAA CATCCCCACT GAGATGCTCC CTCAGCACCG 1260 AGCCCTCCCT CTGGACAGCT CCCCCAACCA GTTCAGCCTC TACACGTCTC CTTCTCTGCC 1320 CAACATCTCC CTAGGGCTGC AGGCCACGGT CACTGTCACC AACTCACACC TCACTGCCTC 1380 CCCGAAGCTG TCGACACAGC AGGAGGCCGA GAGGCAGGCC CTCCAGTCCC TGCGGCAGGG 1440 TGGCACGCTG ACCGGCAAGT TCATGAGCAC ATCCTCTATT CCTGGCTGCC TGCTGGGCGT 1500 GGCACTGGAG GGCGACGGGA GCCCCCACGG GCATGCCTCC CTGCTGCAGC ATGTGCTGTT 1560 GCTGGAGCAG GCCCGGCAGC AGAGCACCCT CATTGCTGTG CCACTCCACG GGCAGTCCCC 1620 ACTAGTGACG GGTGAACGTG TGGCCACCAG CATGCGGACG GTAGGCAAGC TCCCGCGGCA 1680 TCGGCCCCTG AGCCGCACTC AGTCCTCACC GCTGCCGCAG AGTCCCCAGG CCCTGCAGCA 1740 GCTGGTCATG CAACAACAGC ACCAGCAGTT CCTGGAGAAG CAGAAGCAGC AGCAGCTACA 1800 GCTGGGCAAG ATCCTCACCA AGACAGGGGA GCTGCCCAGG CAGCCCACCA CCCACCCTGA 1860 GGAGACAGAG GAGGAGCTGA CGGAGCAGCA GGAGGTCTTG CTGGGGGAGG GAGCCCTGAC 1920 CATGCCCCGG GAGGGCTCCA CAGAGAGTGA GAGCACACAG GAAGACCTGG AGGAGGAGGA 1980 CGAGGAAGAC GATGGGGAGG AGGAGGAGGA TTGCATCCAG GTTAAGGACG AGGAGGGCGA 2040 GAGTGGTGCT GAGGAGGGGC CCGACTTGGA GGAGCCTGGT GCTGGATACA AAAAACTGTT 2100 CTCAGATGCC CAGCCGCTGC AGCCTTTGCA GGTGTACCAG GCGCCCCTCA GCCTGGCCAC 2160 TGTGCCCCAC CAGGCCCTGG GCCGTACCCA GTCCTCCCCT GCTGCCCCTG GGGGCATGAA 2220 GAGCCCCCCA GACCAGCCCG TCAAGCACCT CTTCACCACA GGTGTGGTCT ACGACACGTT 2280 CATGCTAAAG CACCAGTGCA TGTGCGGGAA CACACACGTG CACCCTGAGC ATGCTGGCCG 2340 GATCCAGAGC ATCTGGTCCC GGCTGCAGGA GACAGGCCTG CTTAGCAAGT GCGAGCGGAT 2400 CCGAGGTCGC AAAGCCACGC TAGATGAGAT CCAGACAGTG CACTCTGAAT ACCACACCCT 2460 GCTCTATGGG ACCAGTCCCC TCAACCGGCA GAAGCTAGAC AGCAAGAAGT TGCTCGGCCC 2520 CATCAGCCAG AAGATGTATG CTGTGCTGCC TTGTGGGGGC ATCGGGGTGG ACAGTGACAC 2580 CGTGTGGAAT GAGATGCACT CCTCCAGTGC TGTGCGCATG GCAGTGGGCT GCCTGCTGGA 2640 GCTGGCCTTC AAGGTGGCTG CAGGAGAGCT CAAGAATGGA TTTGCCATCA TCCGGCCCCC 2700 AGGACACCAC GCCGAGGAAT CCACAGCCAT GGGATTCTGC TTCTTCAACT CTGTAGCCAT 2760 CACCGCAAAA CTCCTACAGC AGAAGTTGAA CGTGGGCAAG GTCCTCATCG TGGACTGGGA 2820 CATTCACCAT GGCAATGGCA CCCAGCAGGC GTTCTACAAT GACCCCTCTG TGCTCTACAT 2880 CTCTCTGCAT CGCTATGACA ACGGGAACTT CTTTCCAGGC TCTGGGGCTC CTGAAGAGGT 2940 TGGTGGAGGA CCAGGCGTGG GGTACAATGT GAACGTGGCA TGGACAGGAG GTGTGGACCC 3000 CCCCATTGGA GACGTGGAGT ACCTTACAGC CTTCAGGACA GTGGTGATGC CCATTGCCCA 3060 CGAGTTCTCA CCTGATGTGG TCCTAGTCTC CGCCGGGTTT GATGCTGTTG AAGGACATCT 3120 GTCTCCTCTG GGTGGCTACT CTGTCACCGC CAGATGTTTT GGCCACTTGA CCAGGCAGCT 3180 GATGACCCTG GCAGGGGGCC GGGTGGTGCT GGCCCTGGAG GGAGGCCATG ACTTGACCGC 3240 CATCTGTGAT GCCTCTGAGG CTTGTGTCTC GGCTCTGCTC AGTGTAGAGC TGCAGCCCTT 3300 GGATGAGGCA GTCTTGCAGC AAAAGCCCAA CATCAACGCA GTGGCCACGC TAGAGAAAGT 3360 CATCGAGATC CAGAGCAAAC ACTGGAGCTG TGTGCAGAAG TTCGCCGCTG GTCTGGGCCG 3420 GTCCCTGCGA GAGGCCCAAG CAGGTGAGAC CGAGGAGGCC GAGACTGTGA GCGCCATGGC 3480 CTTGCTGTCG GTGGGGGCCG AGCAGGCCCA GGCTGCGGCA GCCCGGGAAC ACAGCCCCAG 3540 GCCGGCAGAG GAGCCCATGG AGCAGGAGCC TGCCCTGTGA CGCCCCGGCC CCCATCCCTC 3600 TGGGCTTCAC CATTGTGATT TTGTTTATTT TTTCTATTAA AAACAAAAAG TCACACATTC 3660 AA
3663Nucleotide Fasta Sequence
>ENSP00000468004.1|Class-I|Homo sapiens GACAGGGGCGCCTTCCCTACAGGGATGCCGTTCTGAGTGCCTGACTGCCTCGCCCCGAAGGATGGCCTCGGATGGGCATTAGAGGCACGGCGGCCCCGGGCTCCCGTCCCGTCCGTCTGTCTGTTATCGTCTGTCTCTCTTGACATCACCGCAGCTCCACCCCCTCCCGTCCCAGCCCCCAACGCCAGCTTCCTGCAGGCCCAGAGCCGGCATGAACTCTCCCAACGAGTCGGATGGGATGTCAGGTCGGGAACCATCCTTGGAAATCCTGCCGCGGACTTCTCTGCACAGCATCCCTGTGACAGTGGAGGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCTGGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCTCCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGAAGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGTAAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATGCTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCCTGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGTGGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGCCGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGGCTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCTCTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCTGTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTATTCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCAGGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGACGGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCATGCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAGGCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCGGGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCAGGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGCCCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCCTGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTTCATGCTAAAGCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCGGATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCTGCTTAGCAAGTGCGAGCGGATCCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCTGCTCTATGGGACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCCCATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGGCATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGAGCTGGCCTTCAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTGCTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGACATTCACCATGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGGCTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCCCCCCATTGGAGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTTTGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCTGATGACCCTGGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCTCAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGTCATCGAGATCCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGCCGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAGGCCGGCAGAGGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTAAAAACAAAAAGTCACACATTCAA
|
Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0378--Hydrolase KW-0479--Metal-binding KW-0539--Nucleus KW-0597--Phosphoprotein KW-0621--Polymorphism KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0862--Zinc --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom IPR024643--Hist_deacetylase_Gln_rich_N IPR017320--Histone_deAcase_II_euk IPR030703--Histone_deacetylase_5
|
PROSITE |
|
Pfam |
PF12203--HDAC4_Gln PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0005794--C:Golgi apparatus GO:0000118--C:histone deacetylase complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0003682--F:chromatin binding GO:0001047--F:core promoter binding GO:0004407--F:histone deacetylase activity GO:0042826--F:histone deacetylase binding GO:0046872--F:metal ion binding GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558--F:protein deacetylase activity GO:0005080--F:protein kinase C binding GO:0070491--F:repressing transcription factor binding GO:0001025--F:RNA polymerase III transcription factor binding GO:0008134--F:transcription factor binding GO:0042113--P:B cell activation GO:0030183--P:B cell differentiation GO:0032869--P:cellular response to insulin stimulus GO:0071222--P:cellular response to lipopolysaccharide GO:0016568--P:chromatin modification GO:0006325--P:chromatin organization GO:0006338--P:chromatin remodeling GO:0006342--P:chromatin silencing GO:0016575--P:histone deacetylation GO:0006954--P:inflammatory response GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis GO:0010832--P:negative regulation of myotube differentiation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0030182--P:neuron differentiation GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0006476--P:protein deacetylation GO:0040029--P:regulation of gene expression, epigenetic GO:0010830--P:regulation of myotube differentiation GO:0043393--P:regulation of protein binding GO:0014823--P:response to activity GO:0042220--P:response to cocaine GO:0042493--P:response to drug GO:0006351--P:transcription, DNA-templated
|
Orthology |
|
Created Date |
25-Jun-2016 |