| Tag | Content | 
					
						| WERAM ID | WERAM-Hos-0075 | 
					
						| Ensembl Protein ID | ENSP00000468004.1 | 
					
						| Uniprot Accession | Q9UQL6; HDAC5_HUMAN; C9JFV9; O60340; O60528; Q96DY4 | 
					
						| Genbank Protein ID | NP_001015053.1; NP_005465.2; XP_005256961.1; XP_005256963.1 | 
					
						| Protein Name | Histone deacetylase 5 | 
					
						| Genbank Nucleotide ID | NM_001015053.1; NM_005474.4; XM_005256904.3; XM_005256906.3 | 
					
						| Gene Name | HDAC5;KIAA0600 | 
					
						| Ensembl Information |  | 
					
						| Details | 
				| Type | Family | Domain | Substrates | AA | References (PMIDs) |  
				| HDAC | Class-II | Histone deacetylase | H2A; H2B; H3; H4 | K | 18292778 | 
 | 
					
						| Status | Reviewed | 
					
						| Classification | 
							
								| Type | Family | E-value | Score | Start | End |  
						| HDAC | Class-II | 1.00e-147 | 493.9 | 130 | 1023 |  
						| HDAC | Class-I | 4.30e-29 | 104.4 | 703 | 992 |  | 
					
						| Organism | Homo sapiens | 
					
						| NCBI Taxa ID | 9606 | 
					
						| Functional Description (View)
 Functional Description
      Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. | 
					
						| Domain Profile |   HDAC Class-II 
         class-2.txt  13 hqaleenkekhpE.kpeRiqailsrlqeagllekleelkarkatkee 58 +++l  + +++ E + +R q+  ++l+++ l ++l+ l++++++ke+
 ENSP00000468004.1 130 QEMLAAKRQQELEqQRQREQQRQEELEKQRLEQQLLILRNKEKSKES 176
 34444444455551457888999999999999999999998888876 PP
 class-2.txt    2 aglvydekmlkhqaleenkekhpEkpeRiqailsrlqeagllekleelkarkatkeelqlvHseehvelletaeklekeeles....... 84
 +g+vyd+ mlkhq++++n++ hpE+++Riq+i+srlqe+gll+k+e++++rkat++e+q+vHse h+ l++t+ +l++++l+s
 ENSP00000468004.1  683 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTS-PLNRQKLDSkkllgpi 771
 79**********************************************************************9.**************** PP
 class-2.txt   85 ............ltvdsdsiylesksikaarlavGavlelvdkvlkgelkngfavvRPPGHHaeestamGFClfnnvavaakllqqklkv 162
 ++vdsd++++e++s++a+r+avG++lel++kv++gelkngfa++RPPGHHaeestamGFC+fn+va++akllqqkl+v
 ENSP00000468004.1  772 sqkmyavlpcggIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 861
 ****************************************************************************************** PP
 class-2.txt  163 kkilivDwDvHhGnGtqeifykdpkvlylSlHRydkgsffpesgsgavdevgegkgegfnvNvawnggl...mgdaeylaafrevvlpia 249
 k+livDwD+HhGnGtq++fy+dp+vly+SlHRyd+g+ffp  gsga++evg g+g+g+nvNvaw+gg+   +gd eyl+afr+vv+pia
 ENSP00000468004.1  862 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYNVNVAWTGGVdppIGDVEYLTAFRTVVMPIA 949
 *****************************************..*********************************************** PP
 class-2.txt  250 keFkPdlvlvsaGfDaaeg..dplgglsvtakcyatltkqllklaggrvvlvlEGGynlkaiaeaveavvkaLl 321
 +eF+Pd+vlvsaGfDa+eg  +plgg+svta+c+++lt+ql++laggrvvl+lEGG++l+ai++a+ea+v+aLl
 ENSP00000468004.1  950 HEFSPDVVLVSAGFDAVEGhlSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALL 1023
 *******************99***************************************************98 PP
 
 
   HDAC Class-I 
         class-1.txt  19 khpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae.............elskelkkfnvgedc.Pvfd 96 hp    r++ + + + + gl  k e+++ +ka+ +e++++hse y ++l   +p n +             ++   l   ++g d+  v +
 ENSP00000468004.1 703 VHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSE-YHTLLYGTSPLNRQkldskkllgpisqKMYAVLPCGGIGVDSdTVWN 793
 46677778888888888889999999999999999999988875.55666665555555344443444332222222222245556524677 PP
 class-1.txt  97 glfeyc..qlitGasleaakkLnkkead..iainwaGGlhhakkseasGfcyvnDivlailellkkhk..rvlyididlhhGDgveeafytt 182
 ++++ +  ++  G  le a k+  +e +   ai    G hha  s a Gfc+ n + ++   l++k++  +vl +d d+hhG+g ++afy+
 ENSP00000468004.1 794 EMHSSSavRMAVGCLLELAFKVAAGELKngFAIIRPPG-HHAEESTAMGFCFFNSVAITAKLLQQKLNvgKVLIVDWDIHHGNGTQQAFYND 884
 77765511456788899999998876652256655555.9******************9998888654449********************* PP
 class-1.txt 183 drvmtvsfhkyge.effPgtGdlsdvgaekgkyyavnvPlkdgid....DesyekifksviskvieafePeavvlqcGaDslag..Drlgef 267
 v+ +s+h+y++ +ffPg+G  ++vg + g  y vnv  + g+d    D +y + f++v+ ++ + f+P++v++  G D++ g   +lg +
 ENSP00000468004.1 885 PSVLYISLHRYDNgNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDppigDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGhlSPLGGY 976
 ***********8746************************99997666669********************************8733589*** PP
 class-1.txt 268 nlsikghaecvkfvks 283
 +++ + +++  + + +
 ENSP00000468004.1 977 SVTARCFGHLTRQLMT 992
 **99999987665554 PP
 
 
 | 
						| Protein Sequence (Fasta)
 | MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR 60 GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 120
 QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS 180
 TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL 240
 PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI 300
 TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ 360
 FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST 420
 SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS 480
 MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE 540
 LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED 600
 CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ 660
 SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE 720
 TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP 780
 CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM 840
 GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF 900
 FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS 960
 AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS 1020
 ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET 1080
 EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL 1122
 Protein Fasta Sequence
 >ENSP00000468004.1|HDAC5;KIAA0600|Homo sapiensMNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
 | 
					
						| Nucleotide Sequence (Fasta)
 | GACAGGGGCG CCTTCCCTAC AGGGATGCCG TTCTGAGTGC CTGACTGCCT CGCCCCGAAG 60 GATGGCCTCG GATGGGCATT AGAGGCACGG CGGCCCCGGG CTCCCGTCCC GTCCGTCTGT 120
 CTGTTATCGT CTGTCTCTCT TGACATCACC GCAGCTCCAC CCCCTCCCGT CCCAGCCCCC 180
 AACGCCAGCT TCCTGCAGGC CCAGAGCCGG CATGAACTCT CCCAACGAGT CGGATGGGAT 240
 GTCAGGTCGG GAACCATCCT TGGAAATCCT GCCGCGGACT TCTCTGCACA GCATCCCTGT 300
 GACAGTGGAG GTGAAGCCGG TGCTGCCAAG AGCCATGCCC AGTTCCATGG GGGGTGGGGG 360
 TGGAGGCAGC CCCAGCCCTG TGGAGCTACG GGGGGCTCTG GTGGGCTCTG TGGACCCCAC 420
 ACTGCGGGAG CAGCAACTGC AGCAGGAGCT CCTGGCGCTC AAGCAGCAGC AGCAGCTGCA 480
 GAAGCAGCTC CTGTTCGCTG AGTTCCAGAA ACAGCATGAC CACCTGACAA GGCAGCATGA 540
 GGTCCAGCTG CAGAAGCACC TCAAGCAGCA GCAGGAGATG CTGGCAGCCA AGCAGCAGCA 600
 GGAGATGCTG GCAGCCAAGC GGCAGCAGGA GCTGGAGCAG CAGCGGCAGC GGGAGCAGCA 660
 GCGGCAGGAA GAGCTGGAGA AGCAGCGGCT GGAGCAGCAG CTGCTCATCC TGCGGAACAA 720
 GGAGAAGAGC AAAGAGAGTG CCATTGCCAG CACTGAGGTA AAGCTGAGGC TCCAGGAATT 780
 CCTCTTGTCG AAGTCAAAGG AGCCCACACC AGGCGGCCTC AACCATTCCC TCCCACAGCA 840
 CCCCAAATGC TGGGGAGCCC ACCATGCTTC TTTGGACCAG AGTTCCCCTC CCCAGAGCGG 900
 CCCCCCTGGG ACGCCTCCCT CCTACAAACT GCCTTTGCCT GGGCCCTACG ACAGTCGAGA 960
 CGACTTCCCC CTCCGCAAAA CAGCCTCTGA ACCCAACTTG AAAGTGCGTT CAAGGCTAAA 1020
 ACAGAAGGTG GCTGAGCGGA GAAGCAGTCC CCTCCTGCGT CGCAAGGATG GGACTGTTAT 1080
 TAGCACCTTT AAGAAGAGAG CTGTTGAGAT CACAGGTGCC GGGCCTGGGG CGTCGTCCGT 1140
 GTGTAACAGC GCACCCGGCT CCGGCCCCAG CTCTCCCAAC AGCTCCCACA GCACCATCGC 1200
 TGAGAATGGC TTTACTGGCT CAGTCCCCAA CATCCCCACT GAGATGCTCC CTCAGCACCG 1260
 AGCCCTCCCT CTGGACAGCT CCCCCAACCA GTTCAGCCTC TACACGTCTC CTTCTCTGCC 1320
 CAACATCTCC CTAGGGCTGC AGGCCACGGT CACTGTCACC AACTCACACC TCACTGCCTC 1380
 CCCGAAGCTG TCGACACAGC AGGAGGCCGA GAGGCAGGCC CTCCAGTCCC TGCGGCAGGG 1440
 TGGCACGCTG ACCGGCAAGT TCATGAGCAC ATCCTCTATT CCTGGCTGCC TGCTGGGCGT 1500
 GGCACTGGAG GGCGACGGGA GCCCCCACGG GCATGCCTCC CTGCTGCAGC ATGTGCTGTT 1560
 GCTGGAGCAG GCCCGGCAGC AGAGCACCCT CATTGCTGTG CCACTCCACG GGCAGTCCCC 1620
 ACTAGTGACG GGTGAACGTG TGGCCACCAG CATGCGGACG GTAGGCAAGC TCCCGCGGCA 1680
 TCGGCCCCTG AGCCGCACTC AGTCCTCACC GCTGCCGCAG AGTCCCCAGG CCCTGCAGCA 1740
 GCTGGTCATG CAACAACAGC ACCAGCAGTT CCTGGAGAAG CAGAAGCAGC AGCAGCTACA 1800
 GCTGGGCAAG ATCCTCACCA AGACAGGGGA GCTGCCCAGG CAGCCCACCA CCCACCCTGA 1860
 GGAGACAGAG GAGGAGCTGA CGGAGCAGCA GGAGGTCTTG CTGGGGGAGG GAGCCCTGAC 1920
 CATGCCCCGG GAGGGCTCCA CAGAGAGTGA GAGCACACAG GAAGACCTGG AGGAGGAGGA 1980
 CGAGGAAGAC GATGGGGAGG AGGAGGAGGA TTGCATCCAG GTTAAGGACG AGGAGGGCGA 2040
 GAGTGGTGCT GAGGAGGGGC CCGACTTGGA GGAGCCTGGT GCTGGATACA AAAAACTGTT 2100
 CTCAGATGCC CAGCCGCTGC AGCCTTTGCA GGTGTACCAG GCGCCCCTCA GCCTGGCCAC 2160
 TGTGCCCCAC CAGGCCCTGG GCCGTACCCA GTCCTCCCCT GCTGCCCCTG GGGGCATGAA 2220
 GAGCCCCCCA GACCAGCCCG TCAAGCACCT CTTCACCACA GGTGTGGTCT ACGACACGTT 2280
 CATGCTAAAG CACCAGTGCA TGTGCGGGAA CACACACGTG CACCCTGAGC ATGCTGGCCG 2340
 GATCCAGAGC ATCTGGTCCC GGCTGCAGGA GACAGGCCTG CTTAGCAAGT GCGAGCGGAT 2400
 CCGAGGTCGC AAAGCCACGC TAGATGAGAT CCAGACAGTG CACTCTGAAT ACCACACCCT 2460
 GCTCTATGGG ACCAGTCCCC TCAACCGGCA GAAGCTAGAC AGCAAGAAGT TGCTCGGCCC 2520
 CATCAGCCAG AAGATGTATG CTGTGCTGCC TTGTGGGGGC ATCGGGGTGG ACAGTGACAC 2580
 CGTGTGGAAT GAGATGCACT CCTCCAGTGC TGTGCGCATG GCAGTGGGCT GCCTGCTGGA 2640
 GCTGGCCTTC AAGGTGGCTG CAGGAGAGCT CAAGAATGGA TTTGCCATCA TCCGGCCCCC 2700
 AGGACACCAC GCCGAGGAAT CCACAGCCAT GGGATTCTGC TTCTTCAACT CTGTAGCCAT 2760
 CACCGCAAAA CTCCTACAGC AGAAGTTGAA CGTGGGCAAG GTCCTCATCG TGGACTGGGA 2820
 CATTCACCAT GGCAATGGCA CCCAGCAGGC GTTCTACAAT GACCCCTCTG TGCTCTACAT 2880
 CTCTCTGCAT CGCTATGACA ACGGGAACTT CTTTCCAGGC TCTGGGGCTC CTGAAGAGGT 2940
 TGGTGGAGGA CCAGGCGTGG GGTACAATGT GAACGTGGCA TGGACAGGAG GTGTGGACCC 3000
 CCCCATTGGA GACGTGGAGT ACCTTACAGC CTTCAGGACA GTGGTGATGC CCATTGCCCA 3060
 CGAGTTCTCA CCTGATGTGG TCCTAGTCTC CGCCGGGTTT GATGCTGTTG AAGGACATCT 3120
 GTCTCCTCTG GGTGGCTACT CTGTCACCGC CAGATGTTTT GGCCACTTGA CCAGGCAGCT 3180
 GATGACCCTG GCAGGGGGCC GGGTGGTGCT GGCCCTGGAG GGAGGCCATG ACTTGACCGC 3240
 CATCTGTGAT GCCTCTGAGG CTTGTGTCTC GGCTCTGCTC AGTGTAGAGC TGCAGCCCTT 3300
 GGATGAGGCA GTCTTGCAGC AAAAGCCCAA CATCAACGCA GTGGCCACGC TAGAGAAAGT 3360
 CATCGAGATC CAGAGCAAAC ACTGGAGCTG TGTGCAGAAG TTCGCCGCTG GTCTGGGCCG 3420
 GTCCCTGCGA GAGGCCCAAG CAGGTGAGAC CGAGGAGGCC GAGACTGTGA GCGCCATGGC 3480
 CTTGCTGTCG GTGGGGGCCG AGCAGGCCCA GGCTGCGGCA GCCCGGGAAC ACAGCCCCAG 3540
 GCCGGCAGAG GAGCCCATGG AGCAGGAGCC TGCCCTGTGA CGCCCCGGCC CCCATCCCTC 3600
 TGGGCTTCAC CATTGTGATT TTGTTTATTT TTTCTATTAA AAACAAAAAG TCACACATTC 3660
 AA
 3663
 Nucleotide Fasta Sequence
 >ENSP00000468004.1|Class-I|Homo sapiensGACAGGGGCGCCTTCCCTACAGGGATGCCGTTCTGAGTGCCTGACTGCCTCGCCCCGAAGGATGGCCTCGGATGGGCATTAGAGGCACGGCGGCCCCGGGCTCCCGTCCCGTCCGTCTGTCTGTTATCGTCTGTCTCTCTTGACATCACCGCAGCTCCACCCCCTCCCGTCCCAGCCCCCAACGCCAGCTTCCTGCAGGCCCAGAGCCGGCATGAACTCTCCCAACGAGTCGGATGGGATGTCAGGTCGGGAACCATCCTTGGAAATCCTGCCGCGGACTTCTCTGCACAGCATCCCTGTGACAGTGGAGGTGAAGCCGGTGCTGCCAAGAGCCATGCCCAGTTCCATGGGGGGTGGGGGTGGAGGCAGCCCCAGCCCTGTGGAGCTACGGGGGGCTCTGGTGGGCTCTGTGGACCCCACACTGCGGGAGCAGCAACTGCAGCAGGAGCTCCTGGCGCTCAAGCAGCAGCAGCAGCTGCAGAAGCAGCTCCTGTTCGCTGAGTTCCAGAAACAGCATGACCACCTGACAAGGCAGCATGAGGTCCAGCTGCAGAAGCACCTCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCAGCAGCAGGAGATGCTGGCAGCCAAGCGGCAGCAGGAGCTGGAGCAGCAGCGGCAGCGGGAGCAGCAGCGGCAGGAAGAGCTGGAGAAGCAGCGGCTGGAGCAGCAGCTGCTCATCCTGCGGAACAAGGAGAAGAGCAAAGAGAGTGCCATTGCCAGCACTGAGGTAAAGCTGAGGCTCCAGGAATTCCTCTTGTCGAAGTCAAAGGAGCCCACACCAGGCGGCCTCAACCATTCCCTCCCACAGCACCCCAAATGCTGGGGAGCCCACCATGCTTCTTTGGACCAGAGTTCCCCTCCCCAGAGCGGCCCCCCTGGGACGCCTCCCTCCTACAAACTGCCTTTGCCTGGGCCCTACGACAGTCGAGACGACTTCCCCCTCCGCAAAACAGCCTCTGAACCCAACTTGAAAGTGCGTTCAAGGCTAAAACAGAAGGTGGCTGAGCGGAGAAGCAGTCCCCTCCTGCGTCGCAAGGATGGGACTGTTATTAGCACCTTTAAGAAGAGAGCTGTTGAGATCACAGGTGCCGGGCCTGGGGCGTCGTCCGTGTGTAACAGCGCACCCGGCTCCGGCCCCAGCTCTCCCAACAGCTCCCACAGCACCATCGCTGAGAATGGCTTTACTGGCTCAGTCCCCAACATCCCCACTGAGATGCTCCCTCAGCACCGAGCCCTCCCTCTGGACAGCTCCCCCAACCAGTTCAGCCTCTACACGTCTCCTTCTCTGCCCAACATCTCCCTAGGGCTGCAGGCCACGGTCACTGTCACCAACTCACACCTCACTGCCTCCCCGAAGCTGTCGACACAGCAGGAGGCCGAGAGGCAGGCCCTCCAGTCCCTGCGGCAGGGTGGCACGCTGACCGGCAAGTTCATGAGCACATCCTCTATTCCTGGCTGCCTGCTGGGCGTGGCACTGGAGGGCGACGGGAGCCCCCACGGGCATGCCTCCCTGCTGCAGCATGTGCTGTTGCTGGAGCAGGCCCGGCAGCAGAGCACCCTCATTGCTGTGCCACTCCACGGGCAGTCCCCACTAGTGACGGGTGAACGTGTGGCCACCAGCATGCGGACGGTAGGCAAGCTCCCGCGGCATCGGCCCCTGAGCCGCACTCAGTCCTCACCGCTGCCGCAGAGTCCCCAGGCCCTGCAGCAGCTGGTCATGCAACAACAGCACCAGCAGTTCCTGGAGAAGCAGAAGCAGCAGCAGCTACAGCTGGGCAAGATCCTCACCAAGACAGGGGAGCTGCCCAGGCAGCCCACCACCCACCCTGAGGAGACAGAGGAGGAGCTGACGGAGCAGCAGGAGGTCTTGCTGGGGGAGGGAGCCCTGACCATGCCCCGGGAGGGCTCCACAGAGAGTGAGAGCACACAGGAAGACCTGGAGGAGGAGGACGAGGAAGACGATGGGGAGGAGGAGGAGGATTGCATCCAGGTTAAGGACGAGGAGGGCGAGAGTGGTGCTGAGGAGGGGCCCGACTTGGAGGAGCCTGGTGCTGGATACAAAAAACTGTTCTCAGATGCCCAGCCGCTGCAGCCTTTGCAGGTGTACCAGGCGCCCCTCAGCCTGGCCACTGTGCCCCACCAGGCCCTGGGCCGTACCCAGTCCTCCCCTGCTGCCCCTGGGGGCATGAAGAGCCCCCCAGACCAGCCCGTCAAGCACCTCTTCACCACAGGTGTGGTCTACGACACGTTCATGCTAAAGCACCAGTGCATGTGCGGGAACACACACGTGCACCCTGAGCATGCTGGCCGGATCCAGAGCATCTGGTCCCGGCTGCAGGAGACAGGCCTGCTTAGCAAGTGCGAGCGGATCCGAGGTCGCAAAGCCACGCTAGATGAGATCCAGACAGTGCACTCTGAATACCACACCCTGCTCTATGGGACCAGTCCCCTCAACCGGCAGAAGCTAGACAGCAAGAAGTTGCTCGGCCCCATCAGCCAGAAGATGTATGCTGTGCTGCCTTGTGGGGGCATCGGGGTGGACAGTGACACCGTGTGGAATGAGATGCACTCCTCCAGTGCTGTGCGCATGGCAGTGGGCTGCCTGCTGGAGCTGGCCTTCAAGGTGGCTGCAGGAGAGCTCAAGAATGGATTTGCCATCATCCGGCCCCCAGGACACCACGCCGAGGAATCCACAGCCATGGGATTCTGCTTCTTCAACTCTGTAGCCATCACCGCAAAACTCCTACAGCAGAAGTTGAACGTGGGCAAGGTCCTCATCGTGGACTGGGACATTCACCATGGCAATGGCACCCAGCAGGCGTTCTACAATGACCCCTCTGTGCTCTACATCTCTCTGCATCGCTATGACAACGGGAACTTCTTTCCAGGCTCTGGGGCTCCTGAAGAGGTTGGTGGAGGACCAGGCGTGGGGTACAATGTGAACGTGGCATGGACAGGAGGTGTGGACCCCCCCATTGGAGACGTGGAGTACCTTACAGCCTTCAGGACAGTGGTGATGCCCATTGCCCACGAGTTCTCACCTGATGTGGTCCTAGTCTCCGCCGGGTTTGATGCTGTTGAAGGACATCTGTCTCCTCTGGGTGGCTACTCTGTCACCGCCAGATGTTTTGGCCACTTGACCAGGCAGCTGATGACCCTGGCAGGGGGCCGGGTGGTGCTGGCCCTGGAGGGAGGCCATGACTTGACCGCCATCTGTGATGCCTCTGAGGCTTGTGTCTCGGCTCTGCTCAGTGTAGAGCTGCAGCCCTTGGATGAGGCAGTCTTGCAGCAAAAGCCCAACATCAACGCAGTGGCCACGCTAGAGAAAGTCATCGAGATCCAGAGCAAACACTGGAGCTGTGTGCAGAAGTTCGCCGCTGGTCTGGGCCGGTCCCTGCGAGAGGCCCAAGCAGGTGAGACCGAGGAGGCCGAGACTGTGAGCGCCATGGCCTTGCTGTCGGTGGGGGCCGAGCAGGCCCAGGCTGCGGCAGCCCGGGAACACAGCCCCAGGCCGGCAGAGGAGCCCATGGAGCAGGAGCCTGCCCTGTGACGCCCCGGCCCCCATCCCTCTGGGCTTCACCATTGTGATTTTGTTTATTTTTTCTATTAAAAACAAAAAGTCACACATTCAA
 | 
					
						| Sequence Source | Ensembl | 
					
						| Keyword | KW-0007--AcetylationKW-0025--Alternative splicing
 KW-0156--Chromatin regulator
 KW-0181--Complete proteome
 KW-0963--Cytoplasm
 KW-0378--Hydrolase
 KW-0479--Metal-binding
 KW-0539--Nucleus
 KW-0597--Phosphoprotein
 KW-0621--Polymorphism
 KW-1185--Reference proteome
 KW-0678--Repressor
 KW-0804--Transcription
 KW-0805--Transcription regulation
 KW-0832--Ubl conjugation
 KW-0862--Zinc
 --
 
 | 
					
						| Interpro | IPR000286--His_deacetylseIPR023801--His_deacetylse_dom
 IPR024643--Hist_deacetylase_Gln_rich_N
 IPR017320--Histone_deAcase_II_euk
 IPR030703--Histone_deacetylase_5
 
 | 
					
						| PROSITE |  | 
					
						| Pfam | PF12203--HDAC4_GlnPF00850--Hist_deacetyl
 
 | 
					
						| Gene Ontology | GO:0005737--C:cytoplasmGO:0005794--C:Golgi apparatus
 GO:0000118--C:histone deacetylase complex
 GO:0005654--C:nucleoplasm
 GO:0005634--C:nucleus
 GO:0003682--F:chromatin binding
 GO:0001047--F:core promoter binding
 GO:0004407--F:histone deacetylase activity
 GO:0042826--F:histone deacetylase binding
 GO:0046872--F:metal ion binding
 GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
 GO:0033558--F:protein deacetylase activity
 GO:0005080--F:protein kinase C binding
 GO:0070491--F:repressing transcription factor binding
 GO:0001025--F:RNA polymerase III transcription factor binding
 GO:0008134--F:transcription factor binding
 GO:0042113--P:B cell activation
 GO:0030183--P:B cell differentiation
 GO:0032869--P:cellular response to insulin stimulus
 GO:0071222--P:cellular response to lipopolysaccharide
 GO:0016568--P:chromatin modification
 GO:0006325--P:chromatin organization
 GO:0006338--P:chromatin remodeling
 GO:0006342--P:chromatin silencing
 GO:0016575--P:histone deacetylation
 GO:0006954--P:inflammatory response
 GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis
 GO:0010832--P:negative regulation of myotube differentiation
 GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
 GO:0045892--P:negative regulation of transcription, DNA-templated
 GO:0030182--P:neuron differentiation
 GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
 GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
 GO:0006476--P:protein deacetylation
 GO:0040029--P:regulation of gene expression, epigenetic
 GO:0010830--P:regulation of myotube differentiation
 GO:0043393--P:regulation of protein binding
 GO:0014823--P:response to activity
 GO:0042220--P:response to cocaine
 GO:0042493--P:response to drug
 GO:0006351--P:transcription, DNA-templated
 
 | 
					
						| Orthology |  | 
					
						| Created Date | 25-Jun-2016 |