| Tag |
Content |
| WERAM ID |
WERAM-Mum-0132 |
| Ensembl Protein ID |
ENSMUSP00000043828.4 |
| Uniprot Accession |
Q91WA3; HDA11_MOUSE
|
| Genbank Protein ID |
NP_659168.1
|
| Protein Name |
Histone deacetylase 11 |
| Genbank Nucleotide ID |
NM_144919.2
|
| Gene Name |
HDAC11;HDA11 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-IV |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-IV |
1.80e-169 |
564 |
31 |
317 |
| HDAC |
Class-I |
1.90e-25 |
91.6 |
29 |
309 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
| Domain Profile |
HDAC Class-IV
class-4.txt 1 leklhpfdaskwkkvikflkeeklledealveareaskedllvvhtrkylkslksslkvatiteiplvaflpnflvqrkvlrplrlqag 89
leklhpfda+kw+kvi+flkeekll+d++lveareas+edllvvhtr+yl++lk+s++vatiteip+v+flpnflvqrkvlrplr+q+g
ENSMUSP00000043828.4 31 LEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFLVQRKVLRPLRTQTG 119
79*************************************************************************************** PP
class-4.txt 90 GtilaaklaverGwainvGGGfhhcsserGGGfcayaditlaikflferlkaisrviiidldahqGnGherdfaddkrvyildvynrei 178
Gti+a+klaverGwainvGGGfhhcss+rGGGfcayaditlaikflfer+++isr++iidldahqGnGherdf++dkrvyi+dvynr+i
ENSMUSP00000043828.4 120 GTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHI 208
***************************************************************************************** PP
class-4.txt 179 ypkdrvakeairrkvelesgtedeeylekleralkkslqefepdlvvynaGtdvleGdrlGalkispegivkrdevvfrlvrakdipiv 267
yp+dr+akeairrkvele+gtedeeylek+er++++slqe+ pd+vvynaGtdvleGdrlG+l+isp+givkrdevvfr+vra+dipi+
ENSMUSP00000043828.4 209 YPGDRFAKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPIL 297
***************************************************************************************** PP
class-4.txt 268 mvtsGGyqkrsarviadsil 287
mvtsGGyqkr+ar+iadsil
ENSMUSP00000043828.4 298 MVTSGGYQKRTARIIADSIL 317
******************95 PP
HDAC Class-I
class-1.txt 14 yhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkve.penaeelskelkkfnvgedcPvfdglfey 101
+ ++ hp ++ + +++ + +l + +v++++as e+ll +h+ y++ lk + + + +e++ + + v ++
ENSMUSP00000043828.4 29 MGLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFvVATITEIPPVIFL----PNFLVQRKVLRP 113
5556778888888888888888888888888999999999999999999999999865404455555543333....334455566666 PP
class-1.txt 102 cqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellk...khkrvlyididlhhGDgveeafyttdrvmt 187
++ tG+++ a kL e+ ain GG+hh ++ Gfc Di lai l +r + id+d h G+g e f +rv
ENSMUSP00000043828.4 114 LRTQTGGTIMAG-KLA-VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFErveGISRATIIDLDAHQGNGHERDFMGDKRVYI 200
7899****9876.554.45788*****************************99987222467999**********************98 PP
class-1.txt 188 vsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae 276
+ + y+ + +Pg ++ v l+ g +De+y + +++ +++ ++ + P++vv + G+D l gDrlg ++s g+ +
ENSMUSP00000043828.4 201 MDV--YNRHIYPGDRFAKEAIRR-------KVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVK 280
766..88889**97655554443.......479************99*99***********************************9976 PP
class-1.txt 277 ....cvkfvksfnlpllvlGGGGYtlrnva 302
+ ++v+ +++p+l++ GGY++r a
ENSMUSP00000043828.4 281 rdevVFRVVRAHDIPILMVTSGGYQKRT-A 309
56656799****************9874.4 PP
|
Protein Sequence
(Fasta) | MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML 60
VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 120
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 180
DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER 240
NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT 300
SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP 347Protein Fasta Sequence
>ENSMUSP00000043828.4|HDAC11;HDA11|Mus musculus
MPHATQLYQHVPEKRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNLHDLGLIGPEFPCVSAQNSGIPLLSCAVP |
Nucleotide Sequence
(Fasta) | ATTGGGTGCT TCTCCTTGGC CGGCGCCGGT CCGGTCGTCT GTGACGCAGC TGCAGGCCAG 60
AGCTCCACCT CCAGCTCCCA GCGCCATGGA GGCGTGTGTT CTGCGTAGGC CCTGCCTCTT 120
GCACCCCTCC CACCCCTCCC GGTGCGGAGT GGCGTCCAGA GCAGGCAGGG CCGGCTGCGG 180
GATGCCTCAC GCAACACAGC TGTACCAGCA TGTACCAGAG AAACGCTGGC CCATCGTGTA 240
CTCACCACGT TACAACATCA CCTTCATGGG CCTGGAGAAG CTGCACCCCT TTGATGCTGG 300
GAAATGGGGC AAGGTGATCA ACTTCCTGAA AGAAGAGAAG CTGCTGTCCG ATGGCATGCT 360
GGTGGAGGCT CGGGAGGCCT CGGAGGAGGA CCTGCTGGTG GTGCACACGA GGCGCTATCT 420
CAACGAGCTG AAGTGGTCCT TTGTGGTGGC TACCATCACT GAGATCCCCC CGGTCATCTT 480
TCTTCCCAAC TTCCTTGTGC AGAGGAAGGT GCTGAGGCCC CTGCGGACCC AGACTGGAGG 540
CACCATCATG GCAGGGAAGC TGGCTGTGGA GCGAGGCTGG GCCATCAATG TTGGTGGTGG 600
CTTCCACCAC TGCTCCAGTG ACCGTGGTGG GGGCTTCTGT GCCTATGCAG ACATCACACT 660
GGCTATCAAG TTCCTGTTTG AACGCGTGGA AGGCATCTCC AGAGCCACCA TCATTGATCT 720
CGATGCCCAC CAGGGCAATG GGCATGAGCG AGACTTCATG GGTGACAAGC GAGTATACAT 780
CATGGATGTT TACAACCGCC ACATCTACCC TGGGGATCGC TTTGCTAAAG AGGCCATCAG 840
GCGGAAGGTG GAATTGGAGT GGGGCACAGA AGATGAGGAA TATCTGGAGA AGGTGGAGAG 900
GAATGTCAGG AGGTCCCTCC AGGAGCACCT GCCTGACGTG GTGGTGTACA ACGCTGGCAC 960
GGACGTGCTG GAGGGAGACC GCCTCGGGGG GCTGTCCATC AGCCCAGCGG GCATTGTGAA 1020
GAGGGATGAA GTGGTTTTCC GCGTGGTCCG AGCCCATGAT ATACCCATCC TCATGGTGAC 1080
CTCGGGTGGG TACCAGAAGC GCACAGCCCG TATTATCGCC GACTCCATCC TCAACTTGCA 1140
TGACCTGGGG CTCATTGGGC CTGAGTTTCC CTGCGTCTCG GCACAGAACT CGGGCATCCC 1200
CCTGCTTTCC TGTGCTGTGC CTTGACGGCT ACTCACAGAA CATTGTCATA CCTGCCCCCC 1260
CACCCCATCC ACCCGCCCAC CCGCCTGTGT TTGTTGCTGT GAAGACAGCT GCCAGTGAGT 1320
GTGGAGGGGC AGGAAGAGCA GGAGCCAGCC TTGCTGGCCA CTCCTCCACT CCCCACCAGG 1380
TGCCCAAGGG TCTCTGGGCC TTTGGGGTGG AAGAGCTGAG TCCCAGGGAG GAGCCCATGT 1440
GGGAAGCAGG CAGGCCATCA AGAGTCAGGG AGGACAGCTT AGCTCCAGCC ACAGGGAGGG 1500
GCCTCTGGAG TAGAGTCGTT TGCTGTTCAT ATCAGCAGAA GAAGGGCCCT CCCCGACCTG 1560
GTTGGCTTAC TTCCTCACTT TAGTCTGGAG AGGTCCCCTC CTGGACGTTG GTGCCTGTGG 1620
GTCTGAGGAG TTTCCATAGC CAGCCTCCAG GGGGCACTGG GTTCTCAGCT AACAGGTAGT 1680
AGTCCTGGTA TGGATTGGGA GGCCTAAGGA AGAAGGAAGC TGGGATTCTC CAGTTTGGGT 1740
TCCCCTCAAT AAGTCAAGGT CCAGACAGAC CTGTTTTTCC AAGCTCCCCC TATGATGATG 1800
GGGTTGAACA CTGAGGATGC CCAAGGCCCC CAACTTATCT CCTCTGTTCA GCATGAAAAC 1860
ACGTTTGGGA TGAGTGTTTA GCTCAGGAGT GACCCTCCAA ACTGGAGTTT TTAAGGGGCT 1920
GCTGACCAGG ATGGAGAGAA GGCAAGGCCC TGCAGATAGA AATGAGATGG AGGCTGGTGG 1980
CCAAGCTAGT CCTAGGTGGG GCTTGCTAGA GGGAGGGCAG CGAAGGTAAC ATCTAGGTAC 2040
AGTGGCCCCA CAGACCTTGA GTGAGCTACA ATCTCCATTG GGCTCACCCA AAGTGCCCAA 2100
TTTTCATCTT TGTCTGTGGC CCCAAGGTCT ACCTGCCCTC TGGCCATTTG ACCCTGAAGG 2160
GACAGCCAGG GCCCTCCGTG ACGTAGGCAG GAAAGCAGCC ACCCCTAGCC AGAGATTGGC 2220
AGCATAACCA AGGGCACAGG GGTAAGAGGA TGTGGGCCAG CTGGGTTTCC TCCTGCCCTG 2280
GATCTGCTCC AACTACAGGA CTCATATTCA TTACCATGTG GGGGTATTCC CACAGCCTTC 2340
ATAGTGTCCT TCATACTCCC TCTGCTGGAG TCGGGAGGAT GCCAGAGTCA CCAGTTGTCT 2400
AAACCACTGA CCTGGACCAG ACCCCACAGT ACTAATAGTG CAGCACCACA CCCCTCTGTC 2460
ATGGCCTCTT TGCCTCTGAC TGGAGGTACC TCCCAGGACA TTGGGGAGTG GTGACAGCAC 2520
AGTTTGTCAT TGTGGAGTTT GTCTGAGTGC CATTCAGGCT CCAGGTTGTT GCTGTGTGTT 2580
CTGAGGTAGA CAGACCTGCC TCCTGAGGAC CACTGGAAAT AAAGATTCAA AATTCACCAA 2640
TCCAGACACT TAA
2654Nucleotide Fasta Sequence
>ENSMUSP00000043828.4|Class-I|Mus musculus
ATTGGGTGCTTCTCCTTGGCCGGCGCCGGTCCGGTCGTCTGTGACGCAGCTGCAGGCCAGAGCTCCACCTCCAGCTCCCAGCGCCATGGAGGCGTGTGTTCTGCGTAGGCCCTGCCTCTTGCACCCCTCCCACCCCTCCCGGTGCGGAGTGGCGTCCAGAGCAGGCAGGGCCGGCTGCGGGATGCCTCACGCAACACAGCTGTACCAGCATGTACCAGAGAAACGCTGGCCCATCGTGTACTCACCACGTTACAACATCACCTTCATGGGCCTGGAGAAGCTGCACCCCTTTGATGCTGGGAAATGGGGCAAGGTGATCAACTTCCTGAAAGAAGAGAAGCTGCTGTCCGATGGCATGCTGGTGGAGGCTCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTCAACGAGCTGAAGTGGTCCTTTGTGGTGGCTACCATCACTGAGATCCCCCCGGTCATCTTTCTTCCCAACTTCCTTGTGCAGAGGAAGGTGCTGAGGCCCCTGCGGACCCAGACTGGAGGCACCATCATGGCAGGGAAGCTGGCTGTGGAGCGAGGCTGGGCCATCAATGTTGGTGGTGGCTTCCACCACTGCTCCAGTGACCGTGGTGGGGGCTTCTGTGCCTATGCAGACATCACACTGGCTATCAAGTTCCTGTTTGAACGCGTGGAAGGCATCTCCAGAGCCACCATCATTGATCTCGATGCCCACCAGGGCAATGGGCATGAGCGAGACTTCATGGGTGACAAGCGAGTATACATCATGGATGTTTACAACCGCCACATCTACCCTGGGGATCGCTTTGCTAAAGAGGCCATCAGGCGGAAGGTGGAATTGGAGTGGGGCACAGAAGATGAGGAATATCTGGAGAAGGTGGAGAGGAATGTCAGGAGGTCCCTCCAGGAGCACCTGCCTGACGTGGTGGTGTACAACGCTGGCACGGACGTGCTGGAGGGAGACCGCCTCGGGGGGCTGTCCATCAGCCCAGCGGGCATTGTGAAGAGGGATGAAGTGGTTTTCCGCGTGGTCCGAGCCCATGATATACCCATCCTCATGGTGACCTCGGGTGGGTACCAGAAGCGCACAGCCCGTATTATCGCCGACTCCATCCTCAACTTGCATGACCTGGGGCTCATTGGGCCTGAGTTTCCCTGCGTCTCGGCACAGAACTCGGGCATCCCCCTGCTTTCCTGTGCTGTGCCTTGACGGCTACTCACAGAACATTGTCATACCTGCCCCCCCACCCCATCCACCCGCCCACCCGCCTGTGTTTGTTGCTGTGAAGACAGCTGCCAGTGAGTGTGGAGGGGCAGGAAGAGCAGGAGCCAGCCTTGCTGGCCACTCCTCCACTCCCCACCAGGTGCCCAAGGGTCTCTGGGCCTTTGGGGTGGAAGAGCTGAGTCCCAGGGAGGAGCCCATGTGGGAAGCAGGCAGGCCATCAAGAGTCAGGGAGGACAGCTTAGCTCCAGCCACAGGGAGGGGCCTCTGGAGTAGAGTCGTTTGCTGTTCATATCAGCAGAAGAAGGGCCCTCCCCGACCTGGTTGGCTTACTTCCTCACTTTAGTCTGGAGAGGTCCCCTCCTGGACGTTGGTGCCTGTGGGTCTGAGGAGTTTCCATAGCCAGCCTCCAGGGGGCACTGGGTTCTCAGCTAACAGGTAGTAGTCCTGGTATGGATTGGGAGGCCTAAGGAAGAAGGAAGCTGGGATTCTCCAGTTTGGGTTCCCCTCAATAAGTCAAGGTCCAGACAGACCTGTTTTTCCAAGCTCCCCCTATGATGATGGGGTTGAACACTGAGGATGCCCAAGGCCCCCAACTTATCTCCTCTGTTCAGCATGAAAACACGTTTGGGATGAGTGTTTAGCTCAGGAGTGACCCTCCAAACTGGAGTTTTTAAGGGGCTGCTGACCAGGATGGAGAGAAGGCAAGGCCCTGCAGATAGAAATGAGATGGAGGCTGGTGGCCAAGCTAGTCCTAGGTGGGGCTTGCTAGAGGGAGGGCAGCGAAGGTAACATCTAGGTACAGTGGCCCCACAGACCTTGAGTGAGCTACAATCTCCATTGGGCTCACCCAAAGTGCCCAATTTTCATCTTTGTCTGTGGCCCCAAGGTCTACCTGCCCTCTGGCCATTTGACCCTGAAGGGACAGCCAGGGCCCTCCGTGACGTAGGCAGGAAAGCAGCCACCCCTAGCCAGAGATTGGCAGCATAACCAAGGGCACAGGGGTAAGAGGATGTGGGCCAGCTGGGTTTCCTCCTGCCCTGGATCTGCTCCAACTACAGGACTCATATTCATTACCATGTGGGGGTATTCCCACAGCCTTCATAGTGTCCTTCATACTCCCTCTGCTGGAGTCGGGAGGATGCCAGAGTCACCAGTTGTCTAAACCACTGACCTGGACCAGACCCCACAGTACTAATAGTGCAGCACCACACCCCTCTGTCATGGCCTCTTTGCCTCTGACTGGAGGTACCTCCCAGGACATTGGGGAGTGGTGACAGCACAGTTTGTCATTGTGGAGTTTGTCTGAGTGCCATTCAGGCTCCAGGTTGTTGCTGTGTGTTCTGAGGTAGACAGACCTGCCTCCTGAGGACCACTGGAAATAAAGATTCAAAATTCACCAATCCAGACACTTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008134--F:transcription factor binding
GO:0016568--P:chromatin modification
GO:0016575--P:histone deacetylation
GO:0014003--P:oligodendrocyte development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
