| Tag |
Content |
| WERAM ID |
WERAM-Hos-0174 |
| Ensembl Protein ID |
ENSP00000295757.3 |
| Uniprot Accession |
Q96DB2; HDA11_HUMAN; B4DDK1; Q9H6I7; Q9H6X3; Q9NTC9
|
| Genbank Protein ID |
NP_001129513.1; NP_079103.2; XP_011532437.1
|
| Protein Name |
Histone deacetylase 11 |
| Genbank Nucleotide ID |
NM_001136041.2; NM_024827.3; XM_011534135.1
|
| Gene Name |
HDAC11;HDA11 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-IV |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-IV |
7.80e-169 |
562.8 |
31 |
317 |
| HDAC |
Class-I |
4.70e-25 |
91.1 |
26 |
310 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
|
| Domain Profile |
HDAC Class-IV
class-4.txt 1 leklhpfdaskwkkvikflkeeklledealveareaskedllvvhtrkylkslksslkvatiteiplvaflpnflvqrkvlrplrlqagGti 92
leklhpfda+kw+kvi+flkeekll+d++lveareas+edllvvhtr+yl++lk+s++vatiteip+v+flpnflvqrkvlrplr+q+gGti
ENSP00000295757.3 31 LEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTI 122
79****************************************************************************************** PP
class-4.txt 93 laaklaverGwainvGGGfhhcsserGGGfcayaditlaikflferlkaisrviiidldahqGnGherdfaddkrvyildvynreiypkdrv 184
+a+klaverGwainvGGGfhhcss+rGGGfcayaditlaikflfer+++isr++iidldahqGnGherdf+ddkrvyi+dvynr+iyp+dr+
ENSP00000295757.3 123 MAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF 214
******************************************************************************************** PP
class-4.txt 185 akeairrkvelesgtedeeylekleralkkslqefepdlvvynaGtdvleGdrlGalkispegivkrdevvfrlvrakdipivmvtsGGyqk 276
ak+airrkvele+gted+eyl+k+er++kkslqe+ pd+vvynaGtd+leGdrlG+l+isp+givkrde+vfr+vr +++pi+mvtsGGyqk
ENSP00000295757.3 215 AKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQK 306
******************************************************************************************** PP
class-4.txt 277 rsarviadsil 287
r+ar+iadsil
ENSP00000295757.3 307 RTARIIADSIL 317
*********95 PP
HDAC Class-I
class-1.txt 11 vgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflk.kvepenaeelskelkkfnvgedcPvfdglfey 101
++ + ++ hp ++ + +++ + +l + +v++++as e+ll +h+ y++ lk + + + +e++ + + v ++
ENSP00000295757.3 26 ITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKwSFAVATITEIPPVIFLP----NFLVQRKVLRP 113
5555566778888889999999999999999999999*****************99998244556666666544333....34455566666 PP
class-1.txt 102 cqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellk...khkrvlyididlhhGDgveeafyttdrvmtvsf 190
++ tG+++ a kL e+ ain GG+hh ++ Gfc Di lai l +r + id+d h G+g e f +rv + +
ENSP00000295757.3 114 LRTQTGGTIMAG-KLA-VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFErveGISRATIIDLDAHQGNGHERDFMDDKRVYIMDV 203
7899*****876.554.45789*****************************99987222467999**********************98766 PP
class-1.txt 191 hkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae....cv 278
y+ + +Pg + + + v l+ g +D++y +++ i+k ++ + P++vv + G+D l gDrlg ++s g+ + +
ENSP00000295757.3 204 --YNRHIYPGDRFAK-QAIRR------KVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKrdelVF 286
..88889**964333.33333......489***********999**************************************9987666678 PP
class-1.txt 279 kfvksfnlpllvlGGGGYtlrnvaR 303
++v+ ++p+l++ GGY++r aR
ENSP00000295757.3 287 RMVRGRRVPILMVTSGGYQKRT-AR 310
99999*************9874.45 PP
|
Protein Sequence
(Fasta) | MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDSML 60
VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG 120
TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL 180
DAHQGNGHER DFMDDKRVYI MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER 240
NIKKSLQEHL PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRRVPILMVT 300
SGGYQKRTAR IIADSILNLF GLGLIGPESP SVSAQNSDTP LLPPAVP 347Protein Fasta Sequence
>ENSP00000295757.3|HDAC11;HDA11|Homo sapiens
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP |
Nucleotide Sequence
(Fasta) | GGCCTTCCTG CGGGCAGGCT CTCTGTGTCG CAACACTGGC GGGGCGGGCC AAATCGGCCA 60
GAGCTCTGCC CCCAGAGGAC GCGGCTAAGC CCGGGGGCGT GTCCTGGGCT GGCCCCACCC 120
GCGCCCCGCC CCGCCCCGCC CGGTCGCGGA GCTGCGGCCA GCTTTGGGAG GGCCGGCCCC 180
GGGATGCTAC ACACAACCCA GCTGTACCAG CATGTGCCAG AGACACGCTG GCCAATCGTG 240
TACTCGCCGC GCTACAACAT CACCTTCATG GGCCTGGAGA AGCTGCATCC CTTTGATGCC 300
GGAAAATGGG GCAAAGTGAT CAATTTCCTA AAAGAAGAGA AGCTTCTGTC TGACAGCATG 360
CTGGTGGAGG CGCGGGAGGC CTCGGAGGAG GACCTGCTGG TGGTGCACAC GAGGCGCTAT 420
CTTAATGAGC TCAAGTGGTC CTTTGCTGTT GCTACCATCA CAGAAATCCC CCCCGTTATC 480
TTCCTCCCCA ACTTCCTTGT GCAGAGGAAG GTGCTGAGGC CCCTTCGGAC CCAGACAGGA 540
GGAACCATAA TGGCGGGGAA GCTGGCTGTG GAGCGAGGCT GGGCCATCAA CGTGGGGGGT 600
GGCTTCCACC ACTGCTCCAG CGACCGTGGC GGGGGCTTCT GTGCCTATGC GGACATCACG 660
CTCGCCATCA AGTTTCTGTT TGAGCGTGTG GAGGGCATCT CCAGGGCTAC CATCATTGAT 720
CTTGATGCCC ATCAGGGCAA TGGGCATGAG CGAGACTTCA TGGACGACAA GCGTGTGTAC 780
ATCATGGATG TCTACAACCG CCACATCTAC CCAGGGGACC GCTTTGCCAA GCAGGCCATC 840
AGGCGGAAGG TGGAGCTGGA GTGGGGCACA GAGGATGATG AGTACCTGGA TAAGGTGGAG 900
AGGAACATCA AGAAATCCCT CCAGGAGCAC CTGCCCGACG TGGTGGTATA CAATGCAGGC 960
ACCGACATCC TCGAGGGGGA CCGCCTTGGG GGGCTGTCCA TCAGCCCAGC GGGCATCGTG 1020
AAGCGGGATG AGCTGGTGTT CCGGATGGTC CGTGGCCGCC GGGTGCCCAT CCTTATGGTG 1080
ACCTCAGGCG GGTACCAGAA GCGCACAGCC CGCATCATTG CTGACTCCAT ACTTAATCTG 1140
TTTGGCCTGG GGCTCATTGG GCCTGAGTCA CCCAGCGTCT CCGCACAGAA CTCAGACACA 1200
CCGCTGCTTC CCCCTGCAGT GCCCTGACCC TTGCTGCCCT GCCTGTCACG TGGCCCTGCC 1260
TATCCGCCCC TTAGTGCTTT TTGTTTTCTA ACCTCATGGG GTGGTGGAGG CAGCCTTCAG 1320
TGAGCATGGA GGGGCAGGGC CATCCCTGGC TGGGGCCTGG AGCTGGCCCT TCCTCTACTT 1380
TTCCCTGCTG GAAGCCAGAA GGGCTTGAGG CCTCTATGGG TGGGGGCAGA AGGCAGAGCC 1440
TGTGTCCCAG GGGGACCCAC ACGAAGTCAC CAGCCCATAG GTCCAGGGAG GCAGGCAGTT 1500
AACTGAGAAT TGGAGAGGAC AGGCTAGGTC CCAGGCACAG CGAGGGCCCT GGGCTTGGGG 1560
TGTTCTGGTT TTGAGAACGG CAGACCCAGG TCGGAGTGAG GAAGCTTCCA CCTCCATCCT 1620
GACTAGGCCT GCATCCTAAC TGGGCCTCCC TCCCTCCCCT TGGTCATGGG ATTTGCTGCC 1680
CTCTTTGCCC CAGAGCTGAA GAGCTATAGG CACTGGTGTG GATGGCCCAG GAGGTGCTGG 1740
AGCTAGGTCT CCAGGTGGGC CTGGTTCCCA GGCAGCAGGT GGGAACCCTG GGCCTGGATG 1800
TGAGGGGCGG TCAGGAAGGG GTACAGGTGG GTTCCCTCAT CTGGAGTTCC CCCTCAATAA 1860
AGCAAGGTCT GGACCTGCCT TCCCAGGCCC TTCTGTGGGG GTGAAGGTGG GGAAGGCCTG 1920
CGGCGCCCAG ATCACTGCCT TAGCAGTAGT CTTGCCTGTT CAGTGCAAGG GGCAGGTTTT 1980
GGGGGGAGGA ATTCTTAGCG CAAGGACGGG CCTCAGCCCT GTCGCCTCCA GGGGGCCGCT 2040
GACCCAGGTG GGGAGAGGGC AGAAGAAGGG TGGGGGACGT GGGCAGGCCA GGCTCACAGG 2100
TGGAAATCAG GGATGCAGGG TGGTGCCCAA GCCAGGTCCT GCAGGAACCC AGGCCCAGGG 2160
AGGGACCCAG ACACTGGTGA GGCGGGGCAG GGGTTCCTGG AGAGAGGGCA GCGAGGATCT 2220
CTATCCTGGC CTGGGGATTA TGAACATAGG TAGCCGGGGC AGGGCCCTGG GTGGGACTGT 2280
GGCCTCCACT GGCCTCACCA AAGTGCCTGG GCCCCAATCC TTCTCCATGC CCAGGGGCCC 2340
CAGGTGGGCC AGACCTCTGG CCTGTTCCTC AGCCCTACTC ATGGGGACAT TCAGGGACCT 2400
CCAGGAAGTG GGCGGGGGAG CATCCACCCC TGCTAGCCGG CAGCTGTGGC CCTGATCAAA 2460
TCAGGGGCTG GGGAGGGAAA GTGGGTCCAT TGAGGTGGCC CTGCTCCATC AGCCCCCTAC 2520
GGGACTTGTG TTCATTACAG TGAGGGGGTG CTCCCACTGT CTCCCGGCCT CCCTAATGCT 2580
CCCTCTGCTG CAGGGAGAAG GGTTCCAAGA TCACAAAATG TCAACAATGC TGGCCTCCTG 2640
GACCAGACCC CGAGGCTCTA ACAATGCACT CTGAGATCCC TACCCTTGCC GTTGGTCTCT 2700
GTCGCTGACT CGAGGCACCT AACATCCATT CACACCCAAC ACAGGCCAGC GACTTCTGGG 2760
GCTCAGCCAC AGACATGGTT TGTCACTGTT GAGCTTCTGT TCCTAGAGAA TCCTAGAGGC 2820
TTGATTGGCC CAGGCTGCTG TGTGTGCTGG AGGCAAAGAA TCCCTACCTC CTAGGGGTGA 2880
AAGGAAATGA AAATGGAAAG TTCTTGTAGC GCAAGGCCTG ACATGGGTAG CTGCTCAATA 2940
AATGCTAGTG TGTTATTTCA
2961Nucleotide Fasta Sequence
>ENSP00000295757.3|Class-I|Homo sapiens
GGCCTTCCTGCGGGCAGGCTCTCTGTGTCGCAACACTGGCGGGGCGGGCCAAATCGGCCAGAGCTCTGCCCCCAGAGGACGCGGCTAAGCCCGGGGGCGTGTCCTGGGCTGGCCCCACCCGCGCCCCGCCCCGCCCCGCCCGGTCGCGGAGCTGCGGCCAGCTTTGGGAGGGCCGGCCCCGGGATGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTACTCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAGAAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTTAATGAGCTCAAGTGGTCCTTTGCTGTTGCTACCATCACAGAAATCCCCCCCGTTATCTTCCTCCCCAACTTCCTTGTGCAGAGGAAGGTGCTGAGGCCCCTTCGGACCCAGACAGGAGGAACCATAATGGCGGGGAAGCTGGCTGTGGAGCGAGGCTGGGCCATCAACGTGGGGGGTGGCTTCCACCACTGCTCCAGCGACCGTGGCGGGGGCTTCTGTGCCTATGCGGACATCACGCTCGCCATCAAGTTTCTGTTTGAGCGTGTGGAGGGCATCTCCAGGGCTACCATCATTGATCTTGATGCCCATCAGGGCAATGGGCATGAGCGAGACTTCATGGACGACAAGCGTGTGTACATCATGGATGTCTACAACCGCCACATCTACCCAGGGGACCGCTTTGCCAAGCAGGCCATCAGGCGGAAGGTGGAGCTGGAGTGGGGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATACAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGGCATCGTGAAGCGGGATGAGCTGGTGTTCCGGATGGTCCGTGGCCGCCGGGTGCCCATCCTTATGGTGACCTCAGGCGGGTACCAGAAGCGCACAGCCCGCATCATTGCTGACTCCATACTTAATCTGTTTGGCCTGGGGCTCATTGGGCCTGAGTCACCCAGCGTCTCCGCACAGAACTCAGACACACCGCTGCTTCCCCCTGCAGTGCCCTGACCCTTGCTGCCCTGCCTGTCACGTGGCCCTGCCTATCCGCCCCTTAGTGCTTTTTGTTTTCTAACCTCATGGGGTGGTGGAGGCAGCCTTCAGTGAGCATGGAGGGGCAGGGCCATCCCTGGCTGGGGCCTGGAGCTGGCCCTTCCTCTACTTTTCCCTGCTGGAAGCCAGAAGGGCTTGAGGCCTCTATGGGTGGGGGCAGAAGGCAGAGCCTGTGTCCCAGGGGGACCCACACGAAGTCACCAGCCCATAGGTCCAGGGAGGCAGGCAGTTAACTGAGAATTGGAGAGGACAGGCTAGGTCCCAGGCACAGCGAGGGCCCTGGGCTTGGGGTGTTCTGGTTTTGAGAACGGCAGACCCAGGTCGGAGTGAGGAAGCTTCCACCTCCATCCTGACTAGGCCTGCATCCTAACTGGGCCTCCCTCCCTCCCCTTGGTCATGGGATTTGCTGCCCTCTTTGCCCCAGAGCTGAAGAGCTATAGGCACTGGTGTGGATGGCCCAGGAGGTGCTGGAGCTAGGTCTCCAGGTGGGCCTGGTTCCCAGGCAGCAGGTGGGAACCCTGGGCCTGGATGTGAGGGGCGGTCAGGAAGGGGTACAGGTGGGTTCCCTCATCTGGAGTTCCCCCTCAATAAAGCAAGGTCTGGACCTGCCTTCCCAGGCCCTTCTGTGGGGGTGAAGGTGGGGAAGGCCTGCGGCGCCCAGATCACTGCCTTAGCAGTAGTCTTGCCTGTTCAGTGCAAGGGGCAGGTTTTGGGGGGAGGAATTCTTAGCGCAAGGACGGGCCTCAGCCCTGTCGCCTCCAGGGGGCCGCTGACCCAGGTGGGGAGAGGGCAGAAGAAGGGTGGGGGACGTGGGCAGGCCAGGCTCACAGGTGGAAATCAGGGATGCAGGGTGGTGCCCAAGCCAGGTCCTGCAGGAACCCAGGCCCAGGGAGGGACCCAGACACTGGTGAGGCGGGGCAGGGGTTCCTGGAGAGAGGGCAGCGAGGATCTCTATCCTGGCCTGGGGATTATGAACATAGGTAGCCGGGGCAGGGCCCTGGGTGGGACTGTGGCCTCCACTGGCCTCACCAAAGTGCCTGGGCCCCAATCCTTCTCCATGCCCAGGGGCCCCAGGTGGGCCAGACCTCTGGCCTGTTCCTCAGCCCTACTCATGGGGACATTCAGGGACCTCCAGGAAGTGGGCGGGGGAGCATCCACCCCTGCTAGCCGGCAGCTGTGGCCCTGATCAAATCAGGGGCTGGGGAGGGAAAGTGGGTCCATTGAGGTGGCCCTGCTCCATCAGCCCCCTACGGGACTTGTGTTCATTACAGTGAGGGGGTGCTCCCACTGTCTCCCGGCCTCCCTAATGCTCCCTCTGCTGCAGGGAGAAGGGTTCCAAGATCACAAAATGTCAACAATGCTGGCCTCCTGGACCAGACCCCGAGGCTCTAACAATGCACTCTGAGATCCCTACCCTTGCCGTTGGTCTCTGTCGCTGACTCGAGGCACCTAACATCCATTCACACCCAACACAGGCCAGCGACTTCTGGGGCTCAGCCACAGACATGGTTTGTCACTGTTGAGCTTCTGTTCCTAGAGAATCCTAGAGGCTTGATTGGCCCAGGCTGCTGTGTGTGCTGGAGGCAAAGAATCCCTACCTCCTAGGGGTGAAAGGAAATGAAAATGGAAAGTTCTTGTAGCGCAAGGCCTGACATGGGTAGCTGCTCAATAAATGCTAGTGTGTTATTTCA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008134--F:transcription factor binding
GO:0016568--P:chromatin modification
GO:0016575--P:histone deacetylation
GO:0014003--P:oligodendrocyte development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
