WERAM Information

Tag Content
WERAM ID WERAM-Art-0130
Ensembl Protein ID AT5G26210.1
Uniprot Accession O81488; ALFL4_ARATH; Q0WWI3; Q2HIV6; Q8LBJ5
Genbank Protein ID NP_197993.1
Protein Name PHD finger protein ALFIN-LIKE 4
Genbank Nucleotide ID NM_122522.4
Gene Name ALFL4;AL4At5g26210;F9D12.13;T19G15_60
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G26210 AT5G26210.1 AT5G26210.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3/2 K 19154204
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 9.60e-13 48.9 200 250
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
Domain Profile
  Me_Reader PHD
      PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                  t C +Cg++++ ++++++Cd C++wfH+kCvk++  +++  k++ CpsC +
  AT5G26210.1 200 TQCGACGESYAADEFWICCDLCEMWFHGKCVKITPARAEHIKQYKCPSCSN 250
                  67********************************666664479******86 PP
Protein Sequence
(Fasta)		MEAGGAYNPR TVEEVFRDFK GRRAGMIKAL TTDVQEFFRL CDPEKENLCL YGHPNEHWEV 60
NLPAEEVPPE LPEPVLGINF ARDGMAEKDW LSLVAVHSDA WLLAVAFFFG ARFGFDKADR 120
KRLFNMVNDL PTIFEVVAGT AKKQGKDKSS VSNNSSNRSK SSSKRGSESR AKFSKPEPKD 180
DEEEEEEGVE EEDEDEQGET QCGACGESYA ADEFWICCDL CEMWFHGKCV KITPARAEHI 240
KQYKCPSCSN KRARS 255
Nucleotide Sequence
(Fasta)		AAATCCGCTT AATTGTTTTT GGGTCCGCCC TTTTTCTCTT TCACATCTTT CTTTCTCTCG 60
CAAACCCAAA TTCTCTCAGC GCCGGTCAAA TACTTGTCTC TCTCTCTCTC TCTCTTTCAC 120
TCTTGTCTTG TCTCCTTCGA AGCTGTTTGT TCTGTAAGAA AGATGGAAGC AGGTGGCGCG 180
TACAATCCAC GCACTGTTGA AGAGGTGTTT AGGGATTTTA AGGGTCGTAG AGCTGGCATG 240
ATTAAGGCTT TAACCACTGA TGTTCAGGAG TTTTTCCGAC TTTGTGATCC CGAAAAGGAG 300
AACCTTTGCC TTTACGGACA TCCAAATGAG CACTGGGAAG TGAATTTGCC AGCTGAAGAG 360
GTTCCTCCTG AGCTCCCAGA GCCTGTCTTG GGTATCAATT TTGCCAGAGA CGGGATGGCG 420
GAAAAGGATT GGTTGTCCCT TGTTGCTGTC CACAGTGATG CTTGGCTTCT TGCTGTTGCT 480
TTCTTTTTTG GAGCCAGGTT TGGATTTGAC AAAGCTGATA GGAAGAGGCT TTTCAATATG 540
GTGAATGACC TCCCAACAAT CTTTGAGGTT GTAGCTGGCA CTGCTAAGAA ACAAGGAAAA 600
GATAAGTCCT CTGTTTCCAA CAACAGCAGC AACAGATCCA AATCAAGCTC CAAGCGAGGA 660
TCTGAATCCC GTGCCAAGTT CTCAAAGCCG GAGCCGAAAG ATGATGAGGA GGAGGAAGAG 720
GAAGGTGTGG AAGAGGAGGA TGAGGATGAG CAAGGTGAAA CACAGTGTGG AGCATGTGGT 780
GAGAGCTATG CAGCTGATGA GTTCTGGATT TGCTGTGACC TCTGTGAGAT GTGGTTTCAT 840
GGAAAGTGTG TTAAGATAAC ACCAGCAAGA GCTGAGCACA TCAAGCAATA CAAGTGCCCT 900
TCTTGCAGCA ACAAAAGGGC TCGTTCCTAA ATTTGTTGAC CGCTCGCTTC TGTGTATCTA 960
CCTTTGCATA TGATGATGAA CAGCTTAACT GTTTGGTTTA GATCAGATTT GTCATATGGA 1020
TTTGGTAATT TAGGAAGACA TTTTAGTTTT TTCATTGTTA CATTTTGGCG ATTGAAGGGA 1080
TAACTCTTTG TTTAGGGGTA ATGATCTTTT GCTCTGTTTT ATGTTTGTTT ATTAACATTC 1140
TTCAAACTCA ATCAAAAGTA TTTTGGTTAG TCTTAACA 1179
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR021998--Alfin
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12165--DUF3594
PF00628--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0139 scaffold_602752.1 Arabidopsis lyrata 94 7e-97 350
WERAM-Bro-0167 Bo9g011050.1 Brassica oleracea 89 3e-90 328
WERAM-Brr-0184 Bra036568.1-P Brassica rapa 89 2e-89 325
WERAM-Pot-0079 POPTR_0006s23990.1 Populus trichocarpa 82 9e-85 310
WERAM-Viv-0068 VIT_11s0016g01500.t01 Vitis vinifera 81 1e-82 303
WERAM-Glm-0179 GLYMA14G11400.1 Glycine max 79 3e-82 301
WERAM-Thc-0105 EOY30333 Theobroma cacao 81 5e-82 301
WERAM-Sol-0143 Solyc12g096040.1.1 Solanum lycopersicum 74 1e-80 296
WERAM-Prp-0082 EMJ27202 Prunus persica 80 1e-80 296
WERAM-Amt-0032 ERN11177 Amborella trichopoda 77 3e-79 291
WERAM-Mua-0134 GSMUA_Achr8P32300_001 Musa acuminata 71 2e-78 289
WERAM-Met-0013 KEH39913 Medicago truncatula 77 3e-78 288
WERAM-Orbr-0088 OB07G27390.1 Oryza brachyantha 70 9e-75 276
WERAM-Sei-0086 Si023009m Setaria italica 69 3e-74 275
WERAM-Sob-0124 Sb09g020610.1 Sorghum bicolor 68 4e-74 275
WERAM-Orr-0054 ORUFI05G17990.1 Oryza rufipogon 67 1e-73 273
WERAM-Sot-0014 PGSC0003DMT400012523 Solanum tuberosum 69 2e-73 272
WERAM-Zem-0014 GRMZM2G016817_P02 Zea mays 69 2e-73 272
WERAM-Lep-0053 LPERR05G13340.1 Leersia perrieri 63 9e-72 267
WERAM-Brd-0046 BRADI2G25120.1 Brachypodium distachyon 67 1e-71 266
WERAM-Ors-0008 OS01T0887700-01 Oryza sativa 69 2e-71 266
WERAM-Orp-0013 OPUNC01G38560.1 Oryza punctata 69 2e-71 266
WERAM-Orni-0011 ONIVA01G44710.1 Oryza nivara 69 2e-71 266
WERAM-Orm-0013 OMERI01G36760.1 Oryza meridionalis 69 2e-71 266
WERAM-Orgl-0011 OGLUM01G44060.1 Oryza glumaepatula 69 2e-71 266
WERAM-Org-0012 ORGLA01G0337500.1 Oryza glaberrima 69 2e-71 266
WERAM-Orb-0011 OBART01G39820.1 Oryza barthii 69 2e-71 266
WERAM-Ori-0060 BGIOSGA019887-PA Oryza indica 67 2e-71 266
WERAM-Hov-0037 MLOC_37761.1 Hordeum vulgare 67 2e-71 265
WERAM-Php-0090 PP1S371_53V6.1 Physcomitrella patens 68 2e-70 262
WERAM-Aet-0106 EMT19247 Aegilops tauschii 66 2e-70 262
WERAM-Tra-0074 Traes_2BS_9C7CA760D.1 Triticum aestivum 68 5e-69 258
WERAM-Sem-0105 EFJ23237 Selaginella moellendorffii 64 2e-68 256
WERAM-Orl-0043 KN538915.1_FGP008 Oryza longistaminata 69 2e-62 236
Created Date 25-Jun-2016