| Tag |
Content |
| WERAM ID |
WERAM-Sac-0053 |
| Ensembl Protein ID |
YPR068C |
| Uniprot Accession |
Q12214; HOS1_YEAST; D6W472
|
| Genbank Protein ID |
NP_015393.1
|
| Protein Name |
Histone deacetylase HOS1 |
| Genbank Nucleotide ID |
NM_001184165.1
|
| Gene Name |
HOS1;YPR068C;YP9499.23C |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
25288980
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
2.60e-125 |
416.6 |
23 |
391 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
|
| Domain Profile |
HDAC Class-I
class-1.txt 23 kpkrlsltheLvlnyglskkle.ivkpkkasaeellkfhseeyieflkkvepe 74
++ +lt +L+ +y+l ++++ +++ a++++ll+fhs+ yi++l + + +
YPR068C 23 NHQKSQLTYSLINAYDLLQHFDeVLTFPYARKDDLLEFHSKSYIDYLINGRFN 75
34678899************972556678999**************9876655 PP
class-1.txt 15 hygqkhpmkpkrlsltheLv......lnyglskkleivkpkkasaeellkfhs..eeyieflkkvepenae....els..kelkkfnvgedcPvfdgl 98
++++pm+++++s+++eL+ ++y++s++l++++++++ ++++l++++ e+++++++++e+++++ +++ +e+k++n++ dcP+f++l
YPR068C 79 AQDVNNPMVESKWSELSELAdnwnekIDYNPSQDLQRFTTRENLYNYYLNHSQalENNMDCINNSEVPTNDkptdTYIlnSETKQYNLEGDCPIFSYL 176
56889**********************************************99999**********9999867664435589**************** PP
class-1.txt 99 feycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellk.khkrvlyididlhhGDgveeafyttdrvmtvsfhkyge 195
++ycq+itGa+l+ +++L+ +e+ i+inw+GG+hha+k++asGfcy+nD+vl i++l+k k+++++y+d+dlhhGDgve+af+++++++t+s+h y++
YPR068C 177 PMYCQVITGATLNLLDHLSPTERLIGINWDGGRHHAFKQRASGFCYINDVVLLIQRLRKaKLNKITYVDFDLHHGDGVEKAFQYSKQIQTISVHLYEP 274
***********************************************************99************************************* PP
class-1.txt 196 effPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae.cvkfvksf.nlpllvl 291
+ffPgtG+lsd++++k+ +vn+Plk+g+dD+++e i++++++++ie++ePea++++cG+D+l gDr++e++l+i+g+++ +++++ks+ ++++++l
YPR068C 275 GFFPGTGSLSDSRKDKN---VVNIPLKHGCDDNYLELIASKIVNPLIERHEPEALIIECGGDGLLGDRFNEWQLTIRGLSRiIINIMKSYpRAHIFLL 369
*****************...*************************************************************889************** PP
class-1.txt 292 GGGGYtlrnvaRcwtyetavvl 313
GGGGY++ ++R++ty+t++v+
YPR068C 370 GGGGYNDLLMSRFYTYLTWCVT 391
********************97 PP
|
Protein Sequence
(Fasta) | MSKLVISTSI FQSQVADLLP CNNHQKSQLT YSLINAYDLL QHFDEVLTFP YARKDDLLEF 60
HSKSYIDYLI NGRFNKMMAQ DVNNPMVESK WSELSELADN WNEKIDYNPS QDLQRFTTRE 120
NLYNYYLNHS QALENNMDCI NNSEVPTNDK PTDTYILNSE TKQYNLEGDC PIFSYLPMYC 180
QVITGATLNL LDHLSPTERL IGINWDGGRH HAFKQRASGF CYINDVVLLI QRLRKAKLNK 240
ITYVDFDLHH GDGVEKAFQY SKQIQTISVH LYEPGFFPGT GSLSDSRKDK NVVNIPLKHG 300
CDDNYLELIA SKIVNPLIER HEPEALIIEC GGDGLLGDRF NEWQLTIRGL SRIIINIMKS 360
YPRAHIFLLG GGGYNDLLMS RFYTYLTWCV TKQFSNLRCG DNNSFQIDPF DVCDGDDSEQ 420
FIREHDLVEM YNEENYQYWI YEMEGSSRMK MLRNDNKDRD MVELMKFYEL Protein Fasta Sequence
>YPR068C|HOS1;YPR068C;YP9499.23C|Saccharomyces cerevisiae
MSKLVISTSIFQSQVADLLPCNNHQKSQLTYSLINAYDLLQHFDEVLTFPYARKDDLLEFHSKSYIDYLINGRFNKMMAQDVNNPMVESKWSELSELADNWNEKIDYNPSQDLQRFTTRENLYNYYLNHSQALENNMDCINNSEVPTNDKPTDTYILNSETKQYNLEGDCPIFSYLPMYCQVITGATLNLLDHLSPTERLIGINWDGGRHHAFKQRASGFCYINDVVLLIQRLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQTISVHLYEPGFFPGTGSLSDSRKDKNVVNIPLKHGCDDNYLELIASKIVNPLIERHEPEALIIECGGDGLLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYNDLLMSRFYTYLTWCVTKQFSNLRCGDNNSFQIDPFDVCDGDDSEQFIREHDLVEMYNEENYQYWIYEMEGSSRMKMLRNDNKDRDMVELMKFYEL |
Nucleotide Sequence
(Fasta) | ATGTCGAAAT TGGTCATATC AACGTCAATA TTTCAGTCTC AAGTAGCAGA TTTACTCCCA 60
TGTAACAATC ATCAAAAATC GCAGCTGACA TATTCCCTAA TAAACGCGTA CGATCTTCTC 120
CAGCACTTTG ACGAAGTGCT AACATTTCCC TACGCCAGAA AGGATGATCT GCTGGAGTTC 180
CATTCGAAAT CATATATCGA TTATTTGATA AATGGCAGAT TCAATAAAAT GATGGCACAA 240
GATGTAAATA ATCCCATGGT AGAGTCCAAA TGGAGTGAGT TGAGTGAATT GGCCGATAAT 300
TGGAACGAAA AAATCGACTA CAATCCATCG CAAGATCTTC AGAGATTCAC CACTAGAGAG 360
AATCTCTATA ATTATTATCT GAATCACTCA CAAGCGCTCG AAAATAATAT GGACTGTATT 420
AATAACAGTG AGGTGCCCAC CAATGATAAA CCAACAGATA CTTATATTTT AAATTCTGAA 480
ACAAAACAGT ATAATTTAGA GGGAGATTGC CCGATTTTTT CATACCTTCC TATGTACTGT 540
CAAGTTATTA CAGGTGCGAC TTTAAACTTG TTGGATCATC TATCGCCTAC AGAACGTCTT 600
ATCGGTATAA ATTGGGATGG TGGAAGACAT CATGCCTTTA AACAGAGGGC AAGCGGATTC 660
TGCTATATAA ATGACGTGGT ACTGTTAATA CAGAGATTGC GCAAAGCAAA GCTAAATAAA 720
ATCACGTACG TTGACTTCGA CTTGCATCAT GGTGACGGTG TAGAAAAGGC TTTCCAATAT 780
TCTAAACAAA TACAGACAAT TTCAGTACAT CTCTACGAGC CTGGTTTTTT TCCTGGAACT 840
GGTTCTTTAA GTGATTCAAG AAAGGATAAG AACGTGGTTA ATATTCCTTT AAAGCATGGT 900
TGTGATGACA ACTACTTGGA ATTGATCGCA TCCAAAATCG TCAATCCTCT AATAGAAAGA 960
CACGAACCTG AGGCCTTAAT AATTGAATGT GGTGGTGATG GGCTTCTGGG TGATAGATTC 1020
AATGAATGGC AGCTAACAAT ACGAGGGCTT TCTCGAATCA TCATAAATAT CATGAAAAGT 1080
TATCCTCGAG CGCACATATT CCTACTTGGA GGGGGTGGGT ACAACGATTT ACTAATGAGT 1140
AGATTTTATA CGTACTTGAC TTGGTGTGTT ACAAAGCAGT TTTCCAACTT AAGATGTGGT 1200
GACAATAATT CGTTCCAAAT CGATCCATTT GATGTCTGTG ATGGTGATGA TTCTGAACAA 1260
TTTATACGTG AACATGATCT TGTTGAAATG TATAATGAAG AGAACTATCA GTATTGGATA 1320
TATGAGATGG AAGGAAGTTC TCGAATGAAA ATGTTAAGGA ATGACAATAA GGATAGAGAT 1380
ATGGTCGAAC TTATGAAGTT TTACGAACTG TAA
1414Nucleotide Fasta Sequence
>YPR068C|Class-I|Saccharomyces cerevisiae
ATGTCGAAATTGGTCATATCAACGTCAATATTTCAGTCTCAAGTAGCAGATTTACTCCCATGTAACAATCATCAAAAATCGCAGCTGACATATTCCCTAATAAACGCGTACGATCTTCTCCAGCACTTTGACGAAGTGCTAACATTTCCCTACGCCAGAAAGGATGATCTGCTGGAGTTCCATTCGAAATCATATATCGATTATTTGATAAATGGCAGATTCAATAAAATGATGGCACAAGATGTAAATAATCCCATGGTAGAGTCCAAATGGAGTGAGTTGAGTGAATTGGCCGATAATTGGAACGAAAAAATCGACTACAATCCATCGCAAGATCTTCAGAGATTCACCACTAGAGAGAATCTCTATAATTATTATCTGAATCACTCACAAGCGCTCGAAAATAATATGGACTGTATTAATAACAGTGAGGTGCCCACCAATGATAAACCAACAGATACTTATATTTTAAATTCTGAAACAAAACAGTATAATTTAGAGGGAGATTGCCCGATTTTTTCATACCTTCCTATGTACTGTCAAGTTATTACAGGTGCGACTTTAAACTTGTTGGATCATCTATCGCCTACAGAACGTCTTATCGGTATAAATTGGGATGGTGGAAGACATCATGCCTTTAAACAGAGGGCAAGCGGATTCTGCTATATAAATGACGTGGTACTGTTAATACAGAGATTGCGCAAAGCAAAGCTAAATAAAATCACGTACGTTGACTTCGACTTGCATCATGGTGACGGTGTAGAAAAGGCTTTCCAATATTCTAAACAAATACAGACAATTTCAGTACATCTCTACGAGCCTGGTTTTTTTCCTGGAACTGGTTCTTTAAGTGATTCAAGAAAGGATAAGAACGTGGTTAATATTCCTTTAAAGCATGGTTGTGATGACAACTACTTGGAATTGATCGCATCCAAAATCGTCAATCCTCTAATAGAAAGACACGAACCTGAGGCCTTAATAATTGAATGTGGTGGTGATGGGCTTCTGGGTGATAGATTCAATGAATGGCAGCTAACAATACGAGGGCTTTCTCGAATCATCATAAATATCATGAAAAGTTATCCTCGAGCGCACATATTCCTACTTGGAGGGGGTGGGTACAACGATTTACTAATGAGTAGATTTTATACGTACTTGACTTGGTGTGTTACAAAGCAGTTTTCCAACTTAAGATGTGGTGACAATAATTCGTTCCAAATCGATCCATTTGATGTCTGTGATGGTGATGATTCTGAACAATTTATACGTGAACATGATCTTGTTGAAATGTATAATGAAGAGAACTATCAGTATTGGATATATGAGATGGAAGGAAGTTCTCGAATGAAAATGTTAAGGAATGACAATAAGGATAGAGATATGGTCGAACTTATGAAGTTTTACGAACTGTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0000118--C:histone deacetylase complex
GO:0004407--F:histone deacetylase activity
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558--F:protein deacetylase activity
GO:0070933--P:histone H4 deacetylation
GO:0034983--P:peptidyl-lysine deacetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0061587--P:transfer RNA gene-mediated silencing
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
