| Tag |
Content |
| WERAM ID |
WERAM-Hos-0153 |
| Ensembl Protein ID |
ENSP00000362674.3 |
| Uniprot Accession |
Q9BY41; HDAC8_HUMAN; A6ND12; A6ND61; A6NET3; A6NJR3; A8MQ62; B4DKN0; B4DV22; Q86VC8; Q9NP76; Q9NYH4
|
| Genbank Protein ID |
NP_001159890.1; NP_001159891.1; NP_001159892.1; NP_001159894.1; NP_001159920.1; NP_060956.1
|
| Protein Name |
Histone deacetylase 8 |
| Genbank Nucleotide ID |
NM_001166418.1; NM_001166419.1; NM_001166420.1; NM_001166422.1; NM_001166448.1; NM_018486.2
|
| Gene Name |
HDAC8;HDACL1;CDA07 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
3.80e-139 |
465.9 |
17 |
323 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
|
| Domain Profile |
HDAC Class-I
class-1.txt 4 ayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedcPvf 95
+y+y+++ +++++++ +++pkr+s++h+L+ +y+l+k+++ivkpk as+ee+++fh+++y+++l+kv++e +++++ ++ ++++g+dcP +
ENSP00000362674.3 17 VYIYSPE--YVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHP-DSIEYGLGYDCPAT 105
6889888..8899**************************************************************99.6789********** PP
class-1.txt 96 dglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyttdrvmt 187
+g+f+y+++i+Ga+++aa++L+++++++ainw+GG+hhakk+easGfcy+nD vl+il+l++k++r+ly+d+dlhhGDgve+af++t++vmt
ENSP00000362674.3 106 EGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMT 197
******************************************************************************************** PP
class-1.txt 188 vsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghaecvk 279
vs+hk++++ffPgtGd+sdvg +kg+yy+vnvP++dgi+De+y++i++sv+++v++af+P+avvlq+GaD++agD++++fn++ g+++c+k
ENSP00000362674.3 198 VSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLK 289
******************************************************************************************** PP
class-1.txt 280 fvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
++ +++l++l+lGGGGY+l+n+aRcwty+t+v+l
ENSP00000362674.3 290 YILQWQLATLILGGGGYNLANTARCWTYLTGVIL 323
********************************97 PP
|
Protein Sequence
(Fasta) | MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK 60
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI 120
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH 180
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY 240
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI 300
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH 360
RIQQILNYIK GNLKHVV 377Protein Fasta Sequence
>ENSP00000362674.3|HDAC8;HDACL1;CDA07|Homo sapiens
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV |
Nucleotide Sequence
(Fasta) | AAATGGCCCC GTAGGGCAAC AAGGATGGTT AGTTTTGACC CTACTTATTT GTGCCATAAA 60
AACAATCGAT CCTAATTGAC AGCTATTTGG ACTTTTACAT CTGCCAAACC CTTTTCCTTG 120
AACTGTGGTC ACTAAATGAG GGGAGTCTGG TCTGGGAAGT CCCATCCATT CCTTCAATAG 180
GATGGGGAGC GGTGATAGTG TCTCCGGCGA TCTCAAGAAT AGGAGGGAAT GTTGACCAGG 240
GAGCACCGCT GCGGCCGATC AGAGGAGCAG GAACTGGAAC CCTGGCCGAG TCCGAAAAAA 300
GCCAGATCTG GAAGGTGGCT GCGGAACGGT TTTAAGCGGA AGATGGAGGA GCCGGAGGAA 360
CCGGCGGACA GTGGGCAGTC GCTGGTCCCG GTTTATATCT ATAGTCCCGA GTATGTCAGT 420
ATGTGTGACT CCCTGGCCAA GATCCCCAAA CGGGCCAGTA TGGTGCATTC TTTGATTGAA 480
GCATATGCAC TGCATAAGCA GATGAGGATA GTTAAGCCTA AAGTGGCCTC CATGGAGGAG 540
ATGGCCACCT TCCACACTGA TGCTTATCTG CAGCATCTCC AGAAGGTCAG CCAAGAGGGC 600
GATGATGATC ATCCGGACTC CATAGAATAT GGGCTAGGTT ATGACTGCCC AGCCACTGAA 660
GGGATATTTG ACTATGCAGC AGCTATAGGA GGGGCTACGA TCACAGCTGC CCAATGCCTG 720
ATTGACGGAA TGTGCAAAGT AGCAATTAAC TGGTCTGGAG GGTGGCATCA TGCAAAGAAA 780
GATGAAGCAT CTGGTTTTTG TTATCTCAAT GATGCTGTCC TGGGAATATT ACGATTGCGA 840
CGGAAATTTG AGCGTATTCT CTACGTGGAT TTGGATCTGC ACCATGGAGA TGGTGTAGAA 900
GACGCATTCA GTTTCACCTC CAAAGTCATG ACCGTGTCCC TGCACAAATT CTCCCCAGGA 960
TTTTTCCCAG GAACAGGTGA CGTGTCTGAT GTTGGCCTAG GGAAGGGACG GTACTACAGT 1020
GTAAATGTGC CCATTCAGGA TGGCATACAA GATGAAAAAT ATTACCAGAT CTGTGAAAGT 1080
GTACTAAAGG AAGTATACCA AGCCTTTAAT CCCAAAGCAG TGGTCTTACA GCTGGGAGCT 1140
GACACAATAG CTGGGGATCC CATGTGCTCC TTTAACATGA CTCCAGTGGG AATTGGCAAG 1200
TGTCTTAAGT ACATCCTTCA ATGGCAGTTG GCAACACTCA TTTTGGGAGG AGGAGGCTAT 1260
AACCTTGCCA ACACGGCTCG ATGCTGGACA TACTTGACCG GGGTCATCCT AGGGAAAACA 1320
CTATCCTCTG AGATCCCAGA TCATGAGTTT TTCACAGCAT ATGGTCCTGA TTATGTGCTG 1380
GAAATCACGC CAAGCTGCCG GCCAGACCGC AATGAGCCCC ACCGAATCCA ACAAATCCTC 1440
AACTACATCA AAGGGAATCT GAAGCATGTG GTCTAGTTGA CAGAAAGAGA TCAGGTTTCC 1500
AGAGCTGAGG AGTGGTGCCT ATAATGAAGA CAGCGTGTTT ATGCAAGCAG TTTGTGGAAT 1560
TTGTGACTGC AGGGAAAATT TGAAAGAAAT TACTTCCTGA AAATTTCCAA GGGGCATCAA 1620
GTGGCAGCTG GCTTCCTGGG GTGAAGAGGC AGGCACCCCA GAGTCCTCAA CTGGACCTAG 1680
GGGAAGAAGG AGATATCCCA CATTTAAAGT TCTTATTTAA AAAAACACAC ACACACAAAT 1740
GAAATTTTTA ATCTTTGAAA ATTATTTTTA AGCGAATTGG GGAGGGGAGT ATTTTAATCA 1800
TCTTAAATGA AACAGATCAG AAGCTGGATG AGAGCAGTCA CCAGTTTGTA GGGCAGGAGG 1860
CAGCTGACAG GCAGGGTTTG GGCCTCAGGA CCATCCAGGT GGAGCCCTGG GAGAGAGGGT 1920
ACTGATCAGC AGACTGGGAG GTGGGGAGAA GTCCGCTGGT GTTGTTTTAG TGTTATATAT 1980
CTTTGGTTTT TTTAATAAAA TCTTTGAAAA CCTA
2015Nucleotide Fasta Sequence
>ENSP00000362674.3|Class-I|Homo sapiens
AAATGGCCCCGTAGGGCAACAAGGATGGTTAGTTTTGACCCTACTTATTTGTGCCATAAAAACAATCGATCCTAATTGACAGCTATTTGGACTTTTACATCTGCCAAACCCTTTTCCTTGAACTGTGGTCACTAAATGAGGGGAGTCTGGTCTGGGAAGTCCCATCCATTCCTTCAATAGGATGGGGAGCGGTGATAGTGTCTCCGGCGATCTCAAGAATAGGAGGGAATGTTGACCAGGGAGCACCGCTGCGGCCGATCAGAGGAGCAGGAACTGGAACCCTGGCCGAGTCCGAAAAAAGCCAGATCTGGAAGGTGGCTGCGGAACGGTTTTAAGCGGAAGATGGAGGAGCCGGAGGAACCGGCGGACAGTGGGCAGTCGCTGGTCCCGGTTTATATCTATAGTCCCGAGTATGTCAGTATGTGTGACTCCCTGGCCAAGATCCCCAAACGGGCCAGTATGGTGCATTCTTTGATTGAAGCATATGCACTGCATAAGCAGATGAGGATAGTTAAGCCTAAAGTGGCCTCCATGGAGGAGATGGCCACCTTCCACACTGATGCTTATCTGCAGCATCTCCAGAAGGTCAGCCAAGAGGGCGATGATGATCATCCGGACTCCATAGAATATGGGCTAGGTTATGACTGCCCAGCCACTGAAGGGATATTTGACTATGCAGCAGCTATAGGAGGGGCTACGATCACAGCTGCCCAATGCCTGATTGACGGAATGTGCAAAGTAGCAATTAACTGGTCTGGAGGGTGGCATCATGCAAAGAAAGATGAAGCATCTGGTTTTTGTTATCTCAATGATGCTGTCCTGGGAATATTACGATTGCGACGGAAATTTGAGCGTATTCTCTACGTGGATTTGGATCTGCACCATGGAGATGGTGTAGAAGACGCATTCAGTTTCACCTCCAAAGTCATGACCGTGTCCCTGCACAAATTCTCCCCAGGATTTTTCCCAGGAACAGGTGACGTGTCTGATGTTGGCCTAGGGAAGGGACGGTACTACAGTGTAAATGTGCCCATTCAGGATGGCATACAAGATGAAAAATATTACCAGATCTGTGAAAGTGTACTAAAGGAAGTATACCAAGCCTTTAATCCCAAAGCAGTGGTCTTACAGCTGGGAGCTGACACAATAGCTGGGGATCCCATGTGCTCCTTTAACATGACTCCAGTGGGAATTGGCAAGTGTCTTAAGTACATCCTTCAATGGCAGTTGGCAACACTCATTTTGGGAGGAGGAGGCTATAACCTTGCCAACACGGCTCGATGCTGGACATACTTGACCGGGGTCATCCTAGGGAAAACACTATCCTCTGAGATCCCAGATCATGAGTTTTTCACAGCATATGGTCCTGATTATGTGCTGGAAATCACGCCAAGCTGCCGGCCAGACCGCAATGAGCCCCACCGAATCCAACAAATCCTCAACTACATCAAAGGGAATCTGAAGCATGTGGTCTAGTTGACAGAAAGAGATCAGGTTTCCAGAGCTGAGGAGTGGTGCCTATAATGAAGACAGCGTGTTTATGCAAGCAGTTTGTGGAATTTGTGACTGCAGGGAAAATTTGAAAGAAATTACTTCCTGAAAATTTCCAAGGGGCATCAAGTGGCAGCTGGCTTCCTGGGGTGAAGAGGCAGGCACCCCAGAGTCCTCAACTGGACCTAGGGGAAGAAGGAGATATCCCACATTTAAAGTTCTTATTTAAAAAAACACACACACACAAATGAAATTTTTAATCTTTGAAAATTATTTTTAAGCGAATTGGGGAGGGGAGTATTTTAATCATCTTAAATGAAACAGATCAGAAGCTGGATGAGAGCAGTCACCAGTTTGTAGGGCAGGAGGCAGCTGACAGGCAGGGTTTGGGCCTCAGGACCATCCAGGTGGAGCCCTGGGAGAGAGGGTACTGATCAGCAGACTGGGAGGTGGGGAGAAGTCCGCTGGTGTTGTTTTAGTGTTATATATCTTTGGTTTTTTTAATAAAATCTTTGAAAACCTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0550--Obesity
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0000228--C:nuclear chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004407--F:histone deacetylase activity
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008134--F:transcription factor binding
GO:0006333--P:chromatin assembly or disassembly
GO:0016568--P:chromatin modification
GO:0031397--P:negative regulation of protein ubiquitination
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0071922--P:regulation of cohesin localization to chromatin
GO:0031647--P:regulation of protein stability
GO:0032204--P:regulation of telomere maintenance
GO:0007062--P:sister chromatid cohesion
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
