WERAM Information

Tag Content
WERAM ID WERAM-Hos-0119
Ensembl Protein ID ENSP00000253008.2
Uniprot Accession Q9H4Q4; PRD12_HUMAN; A3KFK9
Genbank Protein ID NP_067632.2
Protein Name PR domain zinc finger protein 12
Genbank Nucleotide ID NM_021619.2
Gene Name PRDM12;PFM9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130711.3 ENST00000253008.2 ENSP00000253008.2
Details
Type Family Domain Substrates AA References (PMIDs)
HMT RIZ SET H3K9 K 25537518
Status Reviewed
Classification
Type Family E-value Score Start End
HMT RIZ 3.60e-47 161.6 87 203
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Involved in the positive regulation of histone H3-K9 dimethylation.
Domain Profile
  HMT RIZ
            RIZ.txt   2 evelaessipkeglgvyakkkiekgekfGPfvGekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnvArskeeqNLaal 93 
                        ev +a+ssip+eglg+++k++i++g+++GPf+G++ ++e+v+ ++n++l+we+++++g+v+y++Das+e++++W++y+++Ar+++eqNL+++
  ENSP00000253008.2  87 EVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVV 178
                        7899**************************************************************************************** PP
            RIZ.txt  94 qineqifYktikdIepdeELLvwyk 118
                        qi+++ifYk+i++I+pd+ELLvwy+
  ENSP00000253008.2 179 QIGTSIFYKAIEMIPPDQELLVWYG 203
                        ************************6 PP
Protein Sequence
(Fasta)		MMGSVLPAEA LVLKTGLKAP GLALAEVITS DILHSFLYGR WRNVLGEQLF EDKSHHASPK 60
TAFTAEVLAQ SFSGEVQKLS SLVLPAEVII AQSSIPGEGL GIFSKTWIKA GTEMGPFTGR 120
VIAPEHVDIC KNNNLMWEVF NEDGTVRYFI DASQEDHRSW MTYIKCARNE QEQNLEVVQI 180
GTSIFYKAIE MIPPDQELLV WYGNSHNTFL GIPGVPGLEE DQKKNKHEDF HPADSAAGPA 240
GRMRCVICHR GFNSRSNLRS HMRIHTLDKP FVCRFCNRRF SQSSTLRNHV RLHTGERPYK 300
CQVCQSAYSQ LAGLRAHQKS ARHRPPSTAL QAHSPALPAP HAHAPALAAA AAAAAAAAAH 360
HLPAMVL 367
Nucleotide Sequence
(Fasta)		CCCGCCCACC TCCCCCGTCG GCCCGGCCGT CCCCCGGCGC CGGGGAGCTC CGGGCCGCCC 60
ATGATGGGCT CCGTGCTCCC GGCTGAGGCC CTGGTGCTCA AGACCGGGCT GAAGGCGCCG 120
GGACTGGCGC TGGCCGAGGT TATCACCTCC GACATCCTGC ACAGCTTCCT GTACGGCCGC 180
TGGCGCAACG TGCTCGGGGA GCAGCTCTTC GAGGACAAGA GCCACCACGC CAGCCCCAAG 240
ACAGCCTTCA CCGCCGAGGT GCTGGCGCAG TCCTTCTCCG GCGAAGTGCA GAAGCTGTCC 300
AGCCTGGTGC TGCCTGCGGA GGTGATCATC GCTCAGAGCT CCATCCCTGG CGAGGGCCTC 360
GGCATCTTCT CCAAGACGTG GATCAAGGCG GGAACCGAGA TGGGCCCCTT CACCGGCCGC 420
GTGATCGCCC CGGAGCACGT GGACATCTGC AAGAACAACA ACCTCATGTG GGAGGTGTTC 480
AATGAGGATG GCACGGTGCG CTACTTCATC GATGCCAGCC AGGAGGACCA CCGGAGCTGG 540
ATGACCTACA TCAAGTGTGC ACGTAACGAA CAGGAGCAGA ACCTGGAGGT GGTCCAGATC 600
GGCACCAGCA TCTTCTACAA GGCCATTGAG ATGATCCCAC CTGACCAGGA ACTGCTGGTG 660
TGGTACGGAA ACTCACACAA CACCTTCCTG GGGATCCCAG GTGTGCCCGG GCTAGAGGAG 720
GACCAGAAAA AGAACAAGCA TGAGGACTTC CACCCGGCGG ACTCGGCGGC TGGCCCCGCG 780
GGCCGCATGC GATGCGTCAT CTGCCACCGC GGCTTCAACT CGCGCAGCAA CCTGCGCTCG 840
CACATGCGCA TCCACACGCT GGACAAGCCC TTCGTGTGCC GCTTCTGCAA CCGCCGCTTC 900
AGCCAGTCGT CCACGCTGCG CAACCACGTG CGCCTGCACA CGGGCGAGCG CCCCTACAAG 960
TGCCAGGTGT GCCAGAGCGC CTACTCGCAG CTGGCCGGCC TGCGCGCCCA CCAGAAGAGC 1020
GCGCGGCACC GGCCGCCCAG CACCGCGCTG CAGGCACACT CGCCCGCGCT GCCCGCCCCG 1080
CACGCGCACG CGCCCGCGCT CGCCGCCGCC GCCGCCGCCG CCGCCGCCGC CGCCGCGCAC 1140
CACCTGCCGG CCATGGTGCT GTGAGCGCGC CCGCGCCCCC GCCGGGCCCC GCGCGCTCCT 1200
GGGTCCCCGG CACCCCGGCC CCGCAGCGCG ACTCGCCCTC CAGCCCCAAC CCCCGGCCCG 1260
GCGCCGCCGC GGAGCCCCGC GCGCTGGGGT TGCGCCCCGG AGGCGGATCT CAGGCACCCC 1320
CGCCTTGGCC CGTGTCGCAG ATGAGGACAC TGAGGGCGGC GTCCCTCACC CAGGCCACGC 1380
AGCTGGTGCG GCTGTTCGGC CGCCTCCTCT GGGAGGGGGT CCCCCTGCCT GGCCTCGCCC 1440
CCGAGTCTCC CTGCTGCTGT AGAGCCGGGC GCCCAGGCCG GCATCCCCCT CGTGGGTGGC 1500
AGGAGAGCGG ACTTAGAGCC CCCGAGGGCC CCTCAGCAGA GGAAGGGGAG TCCCCTCCTC 1560
CGCCACCGAG AGTCCTGTGC TTCGGAATGA AGGGAGGGCG ACCTCCTTGT CCGGGTGTGG 1620
TCGGGCGCGG GGGTTGTGGG GGCGCCATCT CCTCTTCCGG CCCCTGGGAC TGGTGTCCTG 1680
AAGTGTCGGG AGTCCTTACG CAACCTTGAC ATGTGCGGGC TACTGGGGTC CATCGGCAGC 1740
GGGAAGAGAC CCGGAGAGAT GCATCTTCTG GGCCCTTCTC TCCTTTAGGC CAGCTTACCC 1800
CCAAACCTGG CTCCTGGGGA CGGATGAGGA AGGAGCTCTT TGCAGTGCAC CAGGCACGTT 1860
GAGAGTGGAG GCACAATGGA AATCCTCTGT GGGACCCCGA GCAAGACCCT GCACCTCTTT 1920
GGGCCTCAGT TTCCCCATCT GTAAAATGAA GGAGTTGGAC CAATGCCCCC TCCCCTTCAG 1980
CTGTGACATC GTGCCTGGGA AGGCGAAATA TACCCCCAGC CCCTTCCAAC ACACACACTC 2040
CAGCGAGAGG AGGGCAAGAC TGGAACCGCT GCCCGAGAGG TTAAGGTGGC TTCTGTGGCC 2100
ACGAAGCGCT TCCGAGCTGT GCCCAGTCCC GGGAATTCCG CCCAGTCTGC CCACACTTCC 2160
CTCGGTCCCT GCCCGTTTCC TCAAATTCGG GCCGTGCGCG CCCTCTGGTG TCGCCTCTCA 2220
CACTTTGCAG TCATTTACCA GGATTCCCGT AGGGCGTTTT GTAAAATAAA CTATAATATT 2280
AATGAAAAGT ATAAAATGTA TAGAGTTTTC AAGAAACTGC GTTCTACTTC CAGAAGATGG 2340
TCACTTTAAC CTTGTAAATA TTTATCTAAA ATGATATTTA CAAAACTGTA ATATATTATT 2400
ATTTGATTGT ATATGTACAA CTGTAAATAC ATTTGTACCT CTCTTGTATT CTAAAATAAA 2460
AATTACTTGG AACATT 2477
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0818--Triplet repeat expansion
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001214--SET_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
IPR017126--Znf_PRDM12
PROSITE

PS50280--SET
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00096--zf-C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008168--F:methyltransferase activity
GO:0022008--P:neurogenesis
GO:1900111--P:positive regulation of histone H3-K9 dimethylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0178 ENSPTRP00000036745.1 Pan troglodytes 100 0.0 693
WERAM-Chs-0179 ENSCSAP00000010875.1 Chlorocebus sabaeus 100 0.0 691
WERAM-Paa-0213 ENSPANP00000018834.1 Papio anubis 100 0.0 691
WERAM-Poa-0186 ENSPPYP00000022077.1 Pongo abelii 100 0.0 690
WERAM-Ptv-0010 ENSPVAP00000001423.1 Pteropus vampyrus 99 0.0 686
WERAM-Otg-0085 ENSOGAP00000006760.2 Otolemur garnettii 99 0.0 684
WERAM-Gog-0123 ENSGGOP00000010306.2 Gorilla gorilla 99 0.0 684
WERAM-Ran-0059 ENSRNOP00000012234.3 Rattus norvegicus 98 0.0 683
WERAM-Mum-0228 ENSMUSP00000109098.2 Mus musculus 98 0.0 683
WERAM-Sus-0037 ENSSSCP00000006110.2 Sus scrofa 99 0.0 681
WERAM-Ict-0060 ENSSTOP00000005349.2 Ictidomys tridecemlineatus 99 0.0 680
WERAM-Bot-0192 ENSBTAP00000032579.2 Bos taurus 98 0.0 679
WERAM-Loa-0078 ENSLAFP00000005864.3 Loxodonta africana 97 0.0 677
WERAM-Ocp-0088 ENSOPRP00000007941.1 Ochotona princeps 98 0.0 675
WERAM-Dan-0173 ENSDNOP00000030867.1 Dasypus novemcinctus 98 0.0 674
WERAM-Caj-0218 ENSCJAP00000038158.1 Callithrix jacchus 98 0.0 669
WERAM-Mod-0098 ENSMODP00000015165.2 Monodelphis domestica 95 0.0 662
WERAM-Sah-0180 ENSSHAP00000018820.1 Sarcophilus harrisii 95 0.0 656
WERAM-Cap-0072 ENSCPOP00000005323.2 Cavia porcellus 98 0.0 654
WERAM-Pes-0052 ENSPSIP00000007299.1 Pelodiscus sinensis 93 0.0 647
WERAM-Fia-0018 ENSFALP00000001507.1 Ficedula albicollis 93 0.0 642
WERAM-Meg-0059 ENSMGAP00000005346.1 Meleagris gallopavo 93 0.0 641
WERAM-Gaga-0041 ENSGALP00000006182.3 Gallus gallus 93 0.0 641
WERAM-Lac-0168 ENSLACP00000019977.1 Latimeria chalumnae 91 0.0 635
WERAM-Aim-0182 ENSAMEP00000017138.1 Ailuropoda melanoleuca 93 0.0 633
WERAM-Asm-0075 ENSAMXP00000007875.1 Astyanax mexicanus 88 2e-174 608
WERAM-Dar-0018 ENSDARP00000015394.5 Danio rerio 87 5e-173 604
WERAM-Orc-0078 ENSOCUP00000007120.2 Oryctolagus cuniculus 94 8e-172 600
WERAM-Leo-0047 ENSLOCP00000006545.1 Lepisosteus oculatus 84 4e-170 594
WERAM-Caf-0210 ENSCAFP00000030461.2 Canis familiaris 98 5e-170 594
WERAM-Orla-0069 ENSORLP00000008922.1 Oryzias latipes 85 1e-167 586
WERAM-Xim-0064 ENSXMAP00000005547.1 Xiphophorus maculatus 83 5e-167 584
WERAM-Gaa-0177 ENSGACP00000022065.1 Gasterosteus aculeatus 84 1e-166 582
WERAM-Pof-0242 ENSPFOP00000019968.2 Poecilia formosa 83 1e-166 582
WERAM-Tar-0225 ENSTRUP00000047797.1 Takifugu rubripes 84 8e-166 580
WERAM-Ten-0104 ENSTNIP00000011876.1 Tetraodon nigroviridis 84 1e-164 576
WERAM-Gam-0121 ENSGMOP00000012620.1 Gadus morhua 83 4e-164 574
WERAM-Orn-0028 ENSONIP00000003595.1 Oreochromis niloticus 81 8e-164 573
WERAM-Mae-0037 ENSMEUP00000003491.1 Macropus eugenii 84 5e-162 567
WERAM-Anp-0104 ENSAPLP00000012181.1 Anas platyrhynchos 82 8e-156 546
WERAM-Ova-0077 ENSOARP00000008071.1 Ovis aries 81 7e-153 537
WERAM-Myl-0140 ENSMLUP00000011265.2 Myotis lucifugus 96 1e-144 509
WERAM-Tut-0169 ENSTTRP00000014364.1 Tursiops truncatus 85 3e-136 482
WERAM-Nol-0140 ENSNLEP00000015220.1 Nomascus leucogenys 100 8e-134 474
WERAM-Fec-0217 ENSFCAP00000016661.1 Felis catus 90 5e-133 471
WERAM-Ect-0066 ENSETEP00000007192.1 Echinops telfairi 97 2e-128 456
WERAM-Xet-0008 ENSXETP00000002850.3 Xenopus tropicalis 92 2e-123 439
WERAM-Eqc-0024 ENSECAP00000004143.1 Equus caballus 96 4e-101 365
WERAM-Mup-0145 ENSMPUP00000012594.1 Mustela putorius furo 98 6e-65 245
WERAM-Tag-0067 ENSTGUP00000004826.1 Taeniopygia guttata 95 2e-63 240
WERAM-Anc-0161 ENSACAP00000014909.3 Anolis carolinensis 34 6e-42 169
WERAM-Mim-0073 ENSMICP00000007053.1 Microcebus murinus 34 3e-34 143
WERAM-Soa-0070 ENSSARP00000006897.1 Sorex araneus 46 9e-31 131
WERAM-Vip-0075 ENSVPAP00000006917.1 Vicugna pacos 30 4e-24 109
WERAM-Ora-0122 ENSOANP00000023793.3 Ornithorhynchus anatinus 27 8e-22 102
WERAM-Chh-0063 ENSCHOP00000006916.1 Choloepus hoffmanni 29 1e-21 101
WERAM-Prc-0123 ENSPCAP00000010913.1 Procavia capensis 30 2e-21 100
WERAM-Tub-0069 ENSTBEP00000008639.1 Tupaia belangeri 25 3e-19 93.2
WERAM-Mam-0029 ENSMMUP00000005026.2 Macaca mulatta 35 3e-18 90.1
WERAM-Ere-0093 ENSEEUP00000009413.1 Erinaceus europaeus 37 4e-18 89.7
WERAM-Dio-0079 ENSDORP00000007870.1 Dipodomys ordii 26 5e-18 89.4
WERAM-Tas-0102 ENSTSYP00000010720.1 Tarsius syrichta 40 9e-18 88.6
WERAM-Pem-0105 ENSPMAP00000010842.1 Petromyzon marinus 32 1e-17 88.2
Created Date 25-Jun-2016