Tag |
Content |
WERAM ID |
WERAM-Art-0129 |
Ensembl Protein ID |
AT5G26040.2 |
Uniprot Accession |
Q944K3; HDA2_ARATH; Q3E940; Q8LRK7; Q9XH00 |
Genbank Protein ID |
NP_568480.2; NP_851078.1 |
Protein Name |
Histone deacetylase 2 |
Genbank Nucleotide ID |
NM_122505.3; NM_180747.2 |
Gene Name |
HDA2;At5g26040;T1N24.9 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDAC |
Class-IV |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26689639 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDAC |
Class-IV |
5.00e-153 |
509.4 |
89 |
374 |
HDAC |
Class-I |
5.10e-26 |
92.8 |
76 |
364 |
|
Organism |
Arabidopsis thaliana |
NCBI Taxa ID |
3702 |
Functional Description (View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
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Domain Profile |
HDAC Class-IV
class-4.txt 1 leklhpfdaskwkkvikflkeeklledealveareaskedllvvhtrkylkslksslkvatiteiplvaflpnflvqrkvlrplrlqagGtilaakla 98 +eklhpfd+skw++v+kfl+++ +le++a+ve+ eask dllvvh+++yl+slkss++va+ite+++vaf+pnflvq+kvl+p+r+q+gGtilaakla AT5G26040.2 89 IEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENYLNSLKSSATVARITEVAPVAFFPNFLVQQKVLYPFRKQVGGTILAAKLA 186 79************************************************************************************************ PP class-4.txt 99 verGwainvGGGfhhcsserGGGfcayaditlaikflferlkaisrviiidldahqGnGherdfaddkrvyildvynreiypkdrvakeairrkvele 196 +erGwain+GGGfhhc++erGGGfca+adi+l+i+f+f rl+ isrv+iidldahqGnGhe+d+ dd+rvyild+yn+eiyp+d++a+++i++kve++ AT5G26040.2 187 TERGWAINIGGGFHHCTAERGGGFCAFADISLCIHFAFLRLR-ISRVMIIDLDAHQGNGHETDLGDDNRVYILDMYNPEIYPFDYRARRFIDQKVEVM 283 ******************************************.******************************************************* PP class-4.txt 197 sgtedeeylekleralkkslqefepdlvvynaGtdvleGdrlGalkispegivkrdevvfrlvrakdipivmvtsGGyqkrsarviadsil 287 sgt+++eyl+kl++al+ ++++f+p+lv+ynaGtd+l+Gd+lG lkisp+gi++rde+vfr++r+k+ip+vm+tsGGy+k+sarviadsi+ AT5G26040.2 284 SGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKISPDGITSRDEKVFRFAREKNIPLVMLTSGGYMKSSARVIADSIE 374 *****************************************************************************************95 PP
HDAC Class-I
class-1.txt 3 vayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae.els..kelkkfnvgedcPvfdg 97 + y + d++ + +++ hp +++ + +++++ g ++ iv+p +as+ +ll +hse+y++ lk++ + e++ + +f v++ + AT5G26040.2 76 IIYSSSYDISFMGIEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENYLNSLKSSATVARItEVApvAFFPNFLVQQ-----KV 168 5677788888899999**********999999999*******************************9876554431333112334444443.....45 PP class-1.txt 98 lfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlail.ellk.khkrvlyididlhhGDgveeafyttdrvmtvsfhky 193 l+ + + + G+++ aa kL +e+ ain GG+hh ++ Gfc Di l i +l+ +rv+ id+d h G+g e + +rv + y AT5G26040.2 169 LYPFRKQV-GGTILAA-KLA-TERGWAINIGGGFHHCTAERGGGFCAFADISLCIHfAFLRlRISRVMIIDLDAHQGNGHETDLGDDNRVYIL--DMY 261 88887766.5566544.554.57789***************************99634555599**************************986..568 PP class-1.txt 194 geeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae....cvkfvksfnlp 287 ++e +P ++ v + g ++y + + + ++ + f+Pe v+ + G+D l gD+lg ++s +g+++ + +f ++ n+p AT5G26040.2 262 NPEIYPF-------DYRARRFIDQKVEVMSGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKISPDGITSrdekVFRFAREKNIP 352 9977774.......444556667778888888777777777889999*******************************998643344999******** PP class-1.txt 288 llvlGGGGYtlr 299 l++l GGY + AT5G26040.2 353 LVMLTSGGYMKS 364 *********764 PP
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Protein Sequence (Fasta) | MTHTRVISTW TELTRDLAIY LLFTFFAIKV FKFLFSCNRT SEISSFSMAT HPEALRRERI 60 LNSKLYFDVP LSKVSIIYSS SYDISFMGIE KLHPFDSSKW GRVCKFLVSD GFLEEKAIVE 120 PLEASKIDLL VVHSENYLNS LKSSATVARI TEVAPVAFFP NFLVQQKVLY PFRKQVGGTI 180 LAAKLATERG WAINIGGGFH HCTAERGGGF CAFADISLCI HFAFLRLRIS RVMIIDLDAH 240 QGNGHETDLG DDNRVYILDM YNPEIYPFDY RARRFIDQKV EVMSGTTTDE YLRKLDEALE 300 VASRNFQPEL VIYNAGTDIL DGDPLGLLKI SPDGITSRDE KVFRFAREKN IPLVMLTSGG 360 YMKSSARVIA DSIENLSRQG LIQTRPE 387Protein Fasta Sequence
>AT5G26040.2|HDA2;At5g26040;T1N24.9|Arabidopsis thaliana MTHTRVISTWTELTRDLAIYLLFTFFAIKVFKFLFSCNRTSEISSFSMATHPEALRRERILNSKLYFDVPLSKVSIIYSSSYDISFMGIEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENYLNSLKSSATVARITEVAPVAFFPNFLVQQKVLYPFRKQVGGTILAAKLATERGWAINIGGGFHHCTAERGGGFCAFADISLCIHFAFLRLRISRVMIIDLDAHQGNGHETDLGDDNRVYILDMYNPEIYPFDYRARRFIDQKVEVMSGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKISPDGITSRDEKVFRFAREKNIPLVMLTSGGYMKSSARVIADSIENLSRQGLIQTRPE
|
Nucleotide Sequence (Fasta) | AACAAAAAAA ATATCTCACC GCTTCAGACC AAAAACTAAT GACACATACC CGAGTCATCT 60 CGACCTGGAC CGAGTTAACT CGCGACTTAG CTATTTACTT GCTCTTCACG TTTTTCGCAA 120 TCAAAGTCTT CAAATTTCTC TTCTCCTGTA ATCGAACCTC TGAAATATCA TCGTTTTCGA 180 TGGCGACTCA TCCCGAAGCT CTCCGACGAG AGCGAATTCT CAACAGTAAA CTCTACTTCG 240 ACGTTCCTCT TTCAAAGGTT TCGATTATCT ATTCATCGTC TTATGATATC TCGTTCATGG 300 GTATTGAGAA ATTGCACCCA TTTGATTCTT CCAAGTGGGG TAGAGTTTGC AAGTTCCTTG 360 TTTCAGATGG GTTTCTGGAG GAGAAAGCAA TTGTTGAGCC TCTTGAAGCT TCAAAGATTG 420 ATCTTTTAGT GGTACATTCT GAGAACTACT TAAACAGCTT GAAAAGCAGT GCCACTGTCG 480 CTAGGATCAC CGAGGTTGCA CCAGTTGCGT TTTTTCCGAA TTTTCTTGTG CAGCAGAAAG 540 TTCTTTACCC ATTCCGAAAG CAGGTTGGTG GGACGATTCT GGCAGCTAAA CTTGCAACAG 600 AACGTGGATG GGCGATAAAC ATTGGAGGAG GTTTTCATCA TTGTACTGCT GAAAGAGGAG 660 GCGGGTTTTG TGCTTTCGCT GATATTTCTC TCTGTATTCA CTTTGCGTTT CTTCGTCTGA 720 GAATCTCGAG GGTTATGATA ATAGATCTTG ATGCTCATCA AGGGAATGGC CATGAAACAG 780 ATCTCGGCGA TGACAACCGT GTTTACATTT TGGATATGTA CAATCCCGAG ATATACCCTT 840 TCGATTATAG AGCTAGGAGA TTTATCGATC AGAAAGTTGA GGTCATGAGC GGGACGACCA 900 CCGATGAGTA TTTGAGGAAA CTAGATGAAG CCCTTGAGGT TGCTTCGCGA AACTTCCAAC 960 CGGAGTTGGT AATTTACAAT GCTGGCACAG ACATATTAGA TGGTGACCCT CTGGGACTTC 1020 TAAAGATAAG CCCCGATGGC ATAACAAGTA GAGACGAGAA AGTCTTCAGA TTTGCAAGGG 1080 AGAAAAATAT TCCTCTTGTG ATGCTAACCT CAGGCGGGTA CATGAAGTCA AGCGCTAGAG 1140 TTATTGCGGA TTCCATTGAG AATCTCTCAC GGCAAGGGTT GATCCAGACA CGACCGGAAT 1200 AAGTCATATA GCCAAAGACA GAGTTTCTTT GTTTTGTGTT TGTGTATATT TGTATAGAGA 1260 GAGACCCTTA TGATGTGTTT GTCACCTTTT GTATATGTGT ACCTTTCCCT TGTTTAATTT 1320 ACTTGTAAGT TCAGTGTTGA AACGTATTCA AAAGCTTTAT ATTCTG
1367Nucleotide Fasta Sequence
>AT5G26040.2|Class-I|Arabidopsis thaliana AACAAAAAAAATATCTCACCGCTTCAGACCAAAAACTAATGACACATACCCGAGTCATCTCGACCTGGACCGAGTTAACTCGCGACTTAGCTATTTACTTGCTCTTCACGTTTTTCGCAATCAAAGTCTTCAAATTTCTCTTCTCCTGTAATCGAACCTCTGAAATATCATCGTTTTCGATGGCGACTCATCCCGAAGCTCTCCGACGAGAGCGAATTCTCAACAGTAAACTCTACTTCGACGTTCCTCTTTCAAAGGTTTCGATTATCTATTCATCGTCTTATGATATCTCGTTCATGGGTATTGAGAAATTGCACCCATTTGATTCTTCCAAGTGGGGTAGAGTTTGCAAGTTCCTTGTTTCAGATGGGTTTCTGGAGGAGAAAGCAATTGTTGAGCCTCTTGAAGCTTCAAAGATTGATCTTTTAGTGGTACATTCTGAGAACTACTTAAACAGCTTGAAAAGCAGTGCCACTGTCGCTAGGATCACCGAGGTTGCACCAGTTGCGTTTTTTCCGAATTTTCTTGTGCAGCAGAAAGTTCTTTACCCATTCCGAAAGCAGGTTGGTGGGACGATTCTGGCAGCTAAACTTGCAACAGAACGTGGATGGGCGATAAACATTGGAGGAGGTTTTCATCATTGTACTGCTGAAAGAGGAGGCGGGTTTTGTGCTTTCGCTGATATTTCTCTCTGTATTCACTTTGCGTTTCTTCGTCTGAGAATCTCGAGGGTTATGATAATAGATCTTGATGCTCATCAAGGGAATGGCCATGAAACAGATCTCGGCGATGACAACCGTGTTTACATTTTGGATATGTACAATCCCGAGATATACCCTTTCGATTATAGAGCTAGGAGATTTATCGATCAGAAAGTTGAGGTCATGAGCGGGACGACCACCGATGAGTATTTGAGGAAACTAGATGAAGCCCTTGAGGTTGCTTCGCGAAACTTCCAACCGGAGTTGGTAATTTACAATGCTGGCACAGACATATTAGATGGTGACCCTCTGGGACTTCTAAAGATAAGCCCCGATGGCATAACAAGTAGAGACGAGAAAGTCTTCAGATTTGCAAGGGAGAAAAATATTCCTCTTGTGATGCTAACCTCAGGCGGGTACATGAAGTCAAGCGCTAGAGTTATTGCGGATTCCATTGAGAATCTCTCACGGCAAGGGTTGATCCAGACACGACCGGAATAAGTCATATAGCCAAAGACAGAGTTTCTTTGTTTTGTGTTTGTGTATATTTGTATAGAGAGAGACCCTTATGATGTGTTTGTCACCTTTTGTATATGTGTACCTTTCCCTTGTTTAATTTACTTGTAAGTTCAGTGTTGAAACGTATTCAAAAGCTTTATATTCTG
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0378--Hydrolase KW-0539--Nucleus KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation --
|
Interpro |
IPR000286--His_deacetylse IPR023801--His_deacetylse_dom
|
PROSITE |
|
Pfam |
PF00850--Hist_deacetyl
|
Gene Ontology |
GO:0005634--C:nucleus GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |