WERAM Information


Tag Content
WERAM ID WERAM-Art-0129
Ensembl Protein ID AT5G26040.2
Uniprot Accession Q944K3; HDA2_ARATH; Q3E940; Q8LRK7; Q9XH00
Genbank Protein ID NP_568480.2; NP_851078.1
Protein Name Histone deacetylase 2
Genbank Nucleotide ID NM_122505.3; NM_180747.2
Gene Name HDA2;At5g26040;T1N24.9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G26040 AT5G26040.2 AT5G26040.2
AT5G26040 AT5G26040.1 AT5G26040.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC Class-IV Histone deacetylase H2A; H2B; H3; H4 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC Class-IV 5.00e-153 509.4 89 374
HDAC Class-I 5.10e-26 92.8 76 364
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Domain Profile
  HDAC Class-IV

  class-4.txt   1 leklhpfdaskwkkvikflkeeklledealveareaskedllvvhtrkylkslksslkvatiteiplvaflpnflvqrkvlrplrlqagGtilaakla 98 
+eklhpfd+skw++v+kfl+++ +le++a+ve+ eask dllvvh+++yl+slkss++va+ite+++vaf+pnflvq+kvl+p+r+q+gGtilaakla
AT5G26040.2 89 IEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENYLNSLKSSATVARITEVAPVAFFPNFLVQQKVLYPFRKQVGGTILAAKLA 186
79************************************************************************************************ PP
class-4.txt 99 verGwainvGGGfhhcsserGGGfcayaditlaikflferlkaisrviiidldahqGnGherdfaddkrvyildvynreiypkdrvakeairrkvele 196
+erGwain+GGGfhhc++erGGGfca+adi+l+i+f+f rl+ isrv+iidldahqGnGhe+d+ dd+rvyild+yn+eiyp+d++a+++i++kve++
AT5G26040.2 187 TERGWAINIGGGFHHCTAERGGGFCAFADISLCIHFAFLRLR-ISRVMIIDLDAHQGNGHETDLGDDNRVYILDMYNPEIYPFDYRARRFIDQKVEVM 283
******************************************.******************************************************* PP
class-4.txt 197 sgtedeeylekleralkkslqefepdlvvynaGtdvleGdrlGalkispegivkrdevvfrlvrakdipivmvtsGGyqkrsarviadsil 287
sgt+++eyl+kl++al+ ++++f+p+lv+ynaGtd+l+Gd+lG lkisp+gi++rde+vfr++r+k+ip+vm+tsGGy+k+sarviadsi+
AT5G26040.2 284 SGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKISPDGITSRDEKVFRFAREKNIPLVMLTSGGYMKSSARVIADSIE 374
*****************************************************************************************95 PP

  HDAC Class-I

  class-1.txt   3 vayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenae.els..kelkkfnvgedcPvfdg 97 
+ y + d++ + +++ hp +++ + +++++ g ++ iv+p +as+ +ll +hse+y++ lk++ + e++ + +f v++ +
AT5G26040.2 76 IIYSSSYDISFMGIEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENYLNSLKSSATVARItEVApvAFFPNFLVQQ-----KV 168
5677788888899999**********999999999*******************************9876554431333112334444443.....45 PP
class-1.txt 98 lfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlail.ellk.khkrvlyididlhhGDgveeafyttdrvmtvsfhky 193
l+ + + + G+++ aa kL +e+ ain GG+hh ++ Gfc Di l i +l+ +rv+ id+d h G+g e + +rv + y
AT5G26040.2 169 LYPFRKQV-GGTILAA-KLA-TERGWAINIGGGFHHCTAERGGGFCAFADISLCIHfAFLRlRISRVMIIDLDAHQGNGHETDLGDDNRVYIL--DMY 261
88887766.5566544.554.57789***************************99634555599**************************986..568 PP
class-1.txt 194 geeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnlsikghae....cvkfvksfnlp 287
++e +P ++ v + g ++y + + + ++ + f+Pe v+ + G+D l gD+lg ++s +g+++ + +f ++ n+p
AT5G26040.2 262 NPEIYPF-------DYRARRFIDQKVEVMSGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKISPDGITSrdekVFRFAREKNIP 352
9977774.......444556667778888888777777777889999*******************************998643344999******** PP
class-1.txt 288 llvlGGGGYtlr 299
l++l GGY +
AT5G26040.2 353 LVMLTSGGYMKS 364
*********764 PP

Protein Sequence
(Fasta)
MTHTRVISTW TELTRDLAIY LLFTFFAIKV FKFLFSCNRT SEISSFSMAT HPEALRRERI 60
LNSKLYFDVP LSKVSIIYSS SYDISFMGIE KLHPFDSSKW GRVCKFLVSD GFLEEKAIVE 120
PLEASKIDLL VVHSENYLNS LKSSATVARI TEVAPVAFFP NFLVQQKVLY PFRKQVGGTI 180
LAAKLATERG WAINIGGGFH HCTAERGGGF CAFADISLCI HFAFLRLRIS RVMIIDLDAH 240
QGNGHETDLG DDNRVYILDM YNPEIYPFDY RARRFIDQKV EVMSGTTTDE YLRKLDEALE 300
VASRNFQPEL VIYNAGTDIL DGDPLGLLKI SPDGITSRDE KVFRFAREKN IPLVMLTSGG 360
YMKSSARVIA DSIENLSRQG LIQTRPE 387
Nucleotide Sequence
(Fasta)
AACAAAAAAA ATATCTCACC GCTTCAGACC AAAAACTAAT GACACATACC CGAGTCATCT 60
CGACCTGGAC CGAGTTAACT CGCGACTTAG CTATTTACTT GCTCTTCACG TTTTTCGCAA 120
TCAAAGTCTT CAAATTTCTC TTCTCCTGTA ATCGAACCTC TGAAATATCA TCGTTTTCGA 180
TGGCGACTCA TCCCGAAGCT CTCCGACGAG AGCGAATTCT CAACAGTAAA CTCTACTTCG 240
ACGTTCCTCT TTCAAAGGTT TCGATTATCT ATTCATCGTC TTATGATATC TCGTTCATGG 300
GTATTGAGAA ATTGCACCCA TTTGATTCTT CCAAGTGGGG TAGAGTTTGC AAGTTCCTTG 360
TTTCAGATGG GTTTCTGGAG GAGAAAGCAA TTGTTGAGCC TCTTGAAGCT TCAAAGATTG 420
ATCTTTTAGT GGTACATTCT GAGAACTACT TAAACAGCTT GAAAAGCAGT GCCACTGTCG 480
CTAGGATCAC CGAGGTTGCA CCAGTTGCGT TTTTTCCGAA TTTTCTTGTG CAGCAGAAAG 540
TTCTTTACCC ATTCCGAAAG CAGGTTGGTG GGACGATTCT GGCAGCTAAA CTTGCAACAG 600
AACGTGGATG GGCGATAAAC ATTGGAGGAG GTTTTCATCA TTGTACTGCT GAAAGAGGAG 660
GCGGGTTTTG TGCTTTCGCT GATATTTCTC TCTGTATTCA CTTTGCGTTT CTTCGTCTGA 720
GAATCTCGAG GGTTATGATA ATAGATCTTG ATGCTCATCA AGGGAATGGC CATGAAACAG 780
ATCTCGGCGA TGACAACCGT GTTTACATTT TGGATATGTA CAATCCCGAG ATATACCCTT 840
TCGATTATAG AGCTAGGAGA TTTATCGATC AGAAAGTTGA GGTCATGAGC GGGACGACCA 900
CCGATGAGTA TTTGAGGAAA CTAGATGAAG CCCTTGAGGT TGCTTCGCGA AACTTCCAAC 960
CGGAGTTGGT AATTTACAAT GCTGGCACAG ACATATTAGA TGGTGACCCT CTGGGACTTC 1020
TAAAGATAAG CCCCGATGGC ATAACAAGTA GAGACGAGAA AGTCTTCAGA TTTGCAAGGG 1080
AGAAAAATAT TCCTCTTGTG ATGCTAACCT CAGGCGGGTA CATGAAGTCA AGCGCTAGAG 1140
TTATTGCGGA TTCCATTGAG AATCTCTCAC GGCAAGGGTT GATCCAGACA CGACCGGAAT 1200
AAGTCATATA GCCAAAGACA GAGTTTCTTT GTTTTGTGTT TGTGTATATT TGTATAGAGA 1260
GAGACCCTTA TGATGTGTTT GTCACCTTTT GTATATGTGT ACCTTTCCCT TGTTTAATTT 1320
ACTTGTAAGT TCAGTGTTGA AACGTATTCA AAAGCTTTAT ATTCTG 1367
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom

PROSITE
Pfam

PF00850--Hist_deacetyl

Gene Ontology

GO:0005634--C:nucleus
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0095 fgenesh2_kg.6__ 2585__ AT5G26040.2 Arabidopsis lyrata 96 0.0 748
WERAM-Bro-0132 Bo7g095520.1 Brassica oleracea 86 0.0 675
WERAM-Brr-0052 Bra009877.1-P Brassica rapa 90 6e-180 627
WERAM-Pot-0080 POPTR_0006s24640.1 Populus trichocarpa 73 4e-158 555
WERAM-Viv-0015 VIT_04s0008g00910.t01 Vitis vinifera 81 4e-154 541
WERAM-Glm-0229 GLYMA17G34770.1 Glycine max 78 5e-152 534
WERAM-Met-0014 AES59273 Medicago truncatula 77 2e-150 529
WERAM-Sol-0102 Solyc08g065350.2.1 Solanum lycopersicum 74 3e-148 521
WERAM-Thc-0103 EOY29884 Theobroma cacao 73 4e-148 521
WERAM-Orgl-0063 OGLUM06G20210.1 Oryza glumaepatula 73 5e-145 511
WERAM-Ors-0058 OS06T0571100-01 Oryza sativa 73 1e-144 509
WERAM-Orni-0064 ONIVA06G22840.1 Oryza nivara 73 1e-144 509
WERAM-Ori-0066 BGIOSGA021002-PA Oryza indica 73 1e-144 509
WERAM-Org-0062 ORGLA06G0157900.1 Oryza glaberrima 73 1e-144 509
WERAM-Orb-0065 OBART06G18360.1 Oryza barthii 73 1e-144 509
WERAM-Brd-0021 BRADI1G37510.1 Brachypodium distachyon 74 2e-144 509
WERAM-Orr-0066 ORUFI06G20130.1 Oryza rufipogon 73 3e-144 508
WERAM-Tra-0321 Traes_7DL_86EEFA04E.2 Triticum aestivum 73 1e-143 506
WERAM-Sei-0028 Si006784m Setaria italica 71 2e-141 499
WERAM-Mua-0015 GSMUA_Achr10P28050_001 Musa acuminata 76 4e-140 495
WERAM-Sob-0134 Sb10g022550.1 Sorghum bicolor 70 4e-139 491
WERAM-Zem-0011 GRMZM2G008425_P01 Zea mays 69 3e-138 488
WERAM-Tru-0023 TRIUR3_12206-P1 Triticum urartu 75 1e-132 469
WERAM-Orbr-0073 OB06G26590.1 Oryza brachyantha 69 7e-132 467
WERAM-Orm-0062 OMERI06G19350.1 Oryza meridionalis 68 2e-130 462
WERAM-Prp-0064 EMJ26901 Prunus persica 70 1e-129 459
WERAM-Aet-0055 EMT26973 Aegilops tauschii 64 2e-128 456
WERAM-Lep-0065 LPERR06G15640.1 Leersia perrieri 71 2e-126 449
WERAM-Php-0113 PP1S53_217V6.1 Physcomitrella patens 64 1e-124 443
WERAM-Sem-0048 EFJ15307 Selaginella moellendorffii 63 8e-120 427
WERAM-Sot-0090 PGSC0003DMT400076986 Solanum tuberosum 78 2e-107 386
WERAM-Tut-0131 ENSTTRP00000010611.1 Tursiops truncatus 59 1e-106 383
WERAM-Orn-0036 ENSONIP00000004088.1 Oreochromis niloticus 61 2e-106 383
WERAM-Pof-0112 ENSPFOP00000009813.1 Poecilia formosa 58 5e-106 381
WERAM-Orla-0136 ENSORLP00000016174.1 Oryzias latipes 58 2e-105 380
WERAM-Gaa-0111 ENSGACP00000014764.1 Gasterosteus aculeatus 61 2e-105 379
WERAM-Hov-0085 MLOC_6441.1 Hordeum vulgare 68 5e-105 378
WERAM-Xim-0081 ENSXMAP00000007517.1 Xiphophorus maculatus 58 5e-105 378
WERAM-Leo-0143 ENSLOCP00000017300.1 Lepisosteus oculatus 58 7e-105 378
WERAM-Orc-0095 ENSOCUP00000008476.2 Oryctolagus cuniculus 59 2e-104 376
WERAM-Mam-0008 ENSMMUP00000001824.2 Macaca mulatta 59 4e-104 375
WERAM-Mup-0199 ENSMPUP00000017162.1 Mustela putorius furo 59 1e-103 374
WERAM-Paa-0195 ENSPANP00000003035.1 Papio anubis 59 1e-103 374
WERAM-Poa-0118 ENSPPYP00000014982.2 Pongo abelii 59 1e-103 374
WERAM-Orp-0063 OPUNC06G17220.1 Oryza punctata 74 1e-103 373
WERAM-Gog-0090 ENSGGOP00000007570.2 Gorilla gorilla 59 2e-103 373
WERAM-Chs-0115 ENSCSAP00000005710.1 Chlorocebus sabaeus 59 2e-103 373
WERAM-Anp-0099 ENSAPLP00000011801.1 Anas platyrhynchos 59 2e-103 373
WERAM-Hos-0174 ENSP00000295757.3 Homo sapiens 59 2e-103 373
WERAM-Pes-0146 ENSPSIP00000017189.1 Pelodiscus sinensis 58 2e-103 373
WERAM-Ptv-0049 ENSPVAP00000005253.1 Pteropus vampyrus 59 2e-103 372
WERAM-Ocp-0102 ENSOPRP00000009462.1 Ochotona princeps 58 3e-103 372
WERAM-Cap-0083 ENSCPOP00000005971.2 Cavia porcellus 59 3e-103 372
WERAM-Eqc-0015 ENSECAP00000002522.1 Equus caballus 58 4e-103 372
WERAM-Myl-0189 ENSMLUP00000015766.2 Myotis lucifugus 58 4e-103 372
WERAM-Aim-0104 ENSAMEP00000010054.1 Ailuropoda melanoleuca 58 4e-103 372
WERAM-Meg-0057 ENSMGAP00000005254.2 Meleagris gallopavo 58 6e-103 371
WERAM-Loa-0005 ENSLAFP00000000421.3 Loxodonta africana 58 8e-103 371
WERAM-Anc-0120 ENSACAP00000011278.3 Anolis carolinensis 59 1e-102 370
WERAM-Gaga-0055 ENSGALP00000008151.4 Gallus gallus 58 2e-102 370
WERAM-Bot-0074 ENSBTAP00000009482.5 Bos taurus 58 2e-102 370
WERAM-Sah-0048 ENSSHAP00000005466.1 Sarcophilus harrisii 59 4e-102 369
WERAM-Tag-0056 ENSTGUP00000003927.1 Taeniopygia guttata 59 5e-102 368
WERAM-Mod-0065 ENSMODP00000010728.2 Monodelphis domestica 61 6e-102 368
WERAM-Mae-0056 ENSMEUP00000005580.1 Macropus eugenii 59 6e-102 368
WERAM-Caf-0054 ENSCAFP00000006551.3 Canis familiaris 60 9e-102 367
WERAM-Fec-0086 ENSFCAP00000006953.3 Felis catus 60 9e-102 367
WERAM-Nol-0049 ENSNLEP00000005908.2 Nomascus leucogenys 60 9e-102 367
WERAM-Ran-0042 ENSRNOP00000008962.5 Rattus norvegicus 58 1e-101 367
WERAM-Mum-0132 ENSMUSP00000043828.4 Mus musculus 58 2e-101 367
WERAM-Dio-0089 ENSDORP00000009107.1 Dipodomys ordii 60 4e-101 365
WERAM-Otg-0083 ENSOGAP00000006490.2 Otolemur garnettii 59 6e-101 364
WERAM-Pem-0019 ENSPMAP00000002586.1 Petromyzon marinus 56 1e-99 360
WERAM-Dar-0190 ENSDARP00000109681.2 Danio rerio 57 9e-98 354
WERAM-Cis-0041 ENSCSAVP00000009072.1 Ciona savignyi 55 1e-94 343
WERAM-Sus-0082 ENSSSCP00000012372.2 Sus scrofa 55 6e-93 338
WERAM-Fia-0001 ENSFALP00000000041.1 Ficedula albicollis 60 5e-92 335
WERAM-Lac-0082 ENSLACP00000010626.1 Latimeria chalumnae 53 2e-89 326
WERAM-Gam-0017 ENSGMOP00000001513.1 Gadus morhua 52 1e-88 324
WERAM-Cii-0063 ENSCINP00000027979.2 Ciona intestinalis 55 2e-87 320
WERAM-Mim-0127 ENSMICP00000012962.1 Microcebus murinus 52 2e-86 317
WERAM-Asm-0175 ENSAMXP00000017267.1 Astyanax mexicanus 62 2e-86 316
WERAM-Ova-0011 ENSOARP00000001712.1 Ovis aries 51 1e-83 307
WERAM-Dan-0117 ENSDNOP00000014714.2 Dasypus novemcinctus 59 6e-80 295
WERAM-Ict-0088 ENSSTOP00000009419.2 Ictidomys tridecemlineatus 58 7e-80 295
WERAM-Drm-0083 FBpp0084109 Drosophila melanogaster 50 8e-80 294
WERAM-Cae-0036 C35A5.9 Caenorhabditis elegans 45 2e-75 280
WERAM-Prc-0001 ENSPCAP00000000121.1 Procavia capensis 46 6e-73 271
WERAM-Chr-0007 EDP00102 Chlamydomonas reinhardtii 49 7e-71 265
WERAM-Pat-0124 ENSPTRP00000025262.3 Pan troglodytes 60 2e-66 249
WERAM-Orl-0079 KN539689.1_FGP004 Oryza longistaminata 57 3e-59 226
WERAM-Chh-0019 ENSCHOP00000001858.1 Choloepus hoffmanni 37 6e-45 179
WERAM-Tub-0108 ENSTBEP00000012162.1 Tupaia belangeri 56 2e-44 177
WERAM-Ect-0025 ENSETEP00000001831.1 Echinops telfairi 39 5e-44 176
WERAM-Amt-0062 ERN16364 Amborella trichopoda 69 1e-42 171
WERAM-Ora-0107 ENSOANP00000020314.1 Ornithorhynchus anatinus 58 2e-39 160
WERAM-Caj-0177 ENSCJAP00000031023.1 Callithrix jacchus 56 1e-34 144
WERAM-Tar-0078 ENSTRUP00000015330.1 Takifugu rubripes 31 7e-30 129
WERAM-Osl-0037 ABP00055 Ostreococcus lucimarinus 31 9e-27 118
WERAM-Cym-0025 CMQ158CT Cyanidioschyzon merolae 30 2e-22 103
WERAM-Xet-0128 ENSXETP00000044353.3 Xenopus tropicalis 25 5e-20 96.3
WERAM-Asg-0010 AAS51704 Ashbya gossypii 26 2e-19 94.4
WERAM-Miv-0013 MVLG_01994T0 Microbotryum violaceum 26 8e-19 92.0
WERAM-Scp-0016 SPAC3G9.07c.1:pep Schizosaccharomyces pombe 27 1e-17 88.2
WERAM-Tas-0086 ENSTSYP00000008784.1 Tarsius syrichta 24 1e-16 84.7
WERAM-Scj-0003 EEB05565 Schizosaccharomyces japonicus 26 1e-16 84.7
WERAM-Pug-0033 EFP89819 Puccinia graminis 28 2e-16 84.3
WERAM-Mel-0007 EGF99116 Melampsora laricipopulina 27 3e-16 83.6
WERAM-Cag-0018 CAG60803 Candida glabrata 24 5e-16 82.8
WERAM-Caa-0015 KGT70099 Candida albicans 27 9e-16 82.0
WERAM-Kll-0020 CAG99415 Kluyveromyces lactis 23 1e-15 82.0
WERAM-Vip-0110 ENSVPAP00000010202.1 Vicugna pacos 24 1e-15 81.6
WERAM-Lab-0007 EDR12637 Laccaria bicolor 31 2e-15 80.9
WERAM-Trr-0017 EGR48353 Trichoderma reesei 33 4e-15 80.1
Created Date 25-Jun-2016