WERAM Information

Tag Content
WERAM ID WERAM-Art-0114
Ensembl Protein ID AT5G03740.1
Uniprot Accession Q9LZR5; HDT3_ARATH; Q9M4T4
Genbank Protein ID NP_195994.3
Protein Name Histone deacetylase HDT3
Genbank Nucleotide ID NM_120455.3
Gene Name HDT3;HD2C;At5g03740;F17C15_160;MED24.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G03740 AT5G03740.1 AT5G03740.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC HD2 H2A; H2B; H3; H4 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC HD2 1.00e-111 397
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Involved in the modulation of abscisic acid and stress-responsive genes.
Domain Profile
  HDAC HD2
Query: 1   MEFWGVEVKNGKPLHLDPGLDRLVHISQVALGESKNNVTEPIQLYVTVGSDKLLIGTLSH 60
           MEFWGVEVKNGKPLHLDPGLDRLVHISQVALGESKNNVTEPIQLYVTVGSDKLLIGTLSH
Sbjct: 1   MEFWGVEVKNGKPLHLDPGLDRLVHISQVALGESKNNVTEPIQLYVTVGSDKLLIGTLSH 60
Query: 61  EKFPQLSTEIVLERNFALSHTWKNGSVFFSGYKVDASDPEPEDLIDDQLEXXXXXXXXXX 120
           EKFPQLSTEIVLERNFALSHTWKNGSVFFSGYKVDASDPEPEDLIDDQLE          
Sbjct: 61  EKFPQLSTEIVLERNFALSHTWKNGSVFFSGYKVDASDPEPEDLIDDQLEAAGFKAAPKS 120
Query: 121 XXXQVNFQLPNEDVKAKQXXXXXXXXXXXXXXXXXXXXXXXXXXKVTAXXXXXXXXXXXX 180
              QVNFQLPNEDVKAKQ                          KVTA            
Sbjct: 121 AAKQVNFQLPNEDVKAKQDDDADGSEEDSSDDDDSENSGDEEEEKVTAESDSEEDDSSDD 180
Query: 181 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVTPQKTDSKKPHVHVATPHPSK 240
                                                FVTPQKTDSKKPHVHVATPHPSK
Sbjct: 181 EEDDSSEEETPKKPEEPKKRSAEPNSSKNPASNKKAKFVTPQKTDSKKPHVHVATPHPSK 240
Query: 241 QAGKNSGGGSTGETSKQQQTPKSAGAFGCKSCTRTFTSEMGLQSHTKAKHSAAA 294
           QAGKNSGGGSTGETSKQQQTPKSAGAFGCKSCTRTFTSEMGLQSHTKAKHSAAA
Sbjct: 241 QAGKNSGGGSTGETSKQQQTPKSAGAFGCKSCTRTFTSEMGLQSHTKAKHSAAA 294
Protein Sequence
(Fasta)		MEFWGVEVKN GKPLHLDPGL DRLVHISQVA LGESKNNVTE PIQLYVTVGS DKLLIGTLSH 60
EKFPQLSTEI VLERNFALSH TWKNGSVFFS GYKVDASDPE PEDLIDDQLE AAGFKAAPKS 120
AAKQVNFQLP NEDVKAKQDD DADGSEEDSS DDDDSENSGD EEEEKVTAES DSEEDDSSDD 180
EEDDSSEEET PKKPEEPKKR SAEPNSSKNP ASNKKAKFVT PQKTDSKKPH VHVATPHPSK 240
QAGKNSGGGS TGETSKQQQT PKSAGAFGCK SCTRTFTSEM GLQSHTKAKH SAAA 294
Nucleotide Sequence
(Fasta)		CACATCAACA CGCCCTAAAA CCGCTCTCGA GAGACGAATC GCTCTCAGCT TCTTCTAGAA 60
CCTTCTCCTT CTCCTTCGAC GCATCGTCGC CTTCAAGATC ACACTACCTC GCACAACAAT 120
GGAGTTCTGG GGTGTTGAAG TTAAGAATGG CAAACCACTT CACCTAGATC CTGGGCTAGA 180
CAGGCTCGTG CACATCTCTC AGGTTGCTTT GGGAGAGAGT AAGAACAATG TAACCGAACC 240
AATCCAGCTT TACGTGACTG TTGGATCGGA TAAGCTTCTC ATTGGAACGC TATCTCATGA 300
GAAGTTTCCT CAGCTGTCTA CGGAGATTGT CTTGGAAAGG AACTTTGCGC TGTCTCATAC 360
TTGGAAGAAT GGGAGCGTTT TCTTCTCTGG TTACAAAGTT GATGCATCTG ATCCCGAGCC 420
TGAGGATTTG ATTGATGATC AACTTGAGGC TGCTGGTTTC AAAGCTGCTC CGAAATCTGC 480
TGCGAAACAG GTGAACTTTC AGTTGCCAAA TGAAGATGTC AAAGCCAAGC AAGATGATGA 540
CGCTGACGGT AGTGAAGAAG ATTCTTCAGA TGATGATGAT AGTGAAAACT CTGGAGACGA 600
GGAGGAAGAG AAGGTTACTG CTGAATCTGA CAGTGAGGAA GATGACTCAT CAGACGACGA 660
AGAAGATGAC TCCTCAGAAG AGGAAACCCC AAAGAAGCCT GAAGAACCCA AGAAGAGGTC 720
TGCAGAACCC AACTCCTCCA AGAACCCTGC GTCCAACAAG AAGGCTAAGT TTGTAACTCC 780
TCAGAAAACA GATTCGAAGA AACCGCATGT CCATGTTGCA ACTCCTCATC CCTCAAAACA 840
GGCGGGTAAG AATTCTGGTG GAGGCAGCAC TGGAGAGACA TCGAAGCAGC AGCAGACACC 900
GAAGTCTGCA GGAGCGTTTG GGTGCAAGTC GTGCACCAGA ACCTTTACTT CGGAAATGGG 960
ATTGCAGTCT CACACAAAGG CCAAACACAG TGCAGCTGCT TGAGAAGAAG AAGCAGCATG 1020
ATGACTACTC TCTATAATAT CTACTCTAGA ACTTTGATGT CTTTTGGTAC TTAAATCTGG 1080
AACTTGCGAG TGAGCCAGTT TTAGTTGGTC TTTTTTTTCA GGCATTTCTT CCTGTTTAAC 1140
TTTATCGTTT TGGTAGCTGA AACTGTGCTA AACCTTTGTT TGTGTTTAGT GGTATGGATA 1200
TTAAGTCTTT TTGTAGACTT TTCTAGTGAA AATCTACATT TG 1243
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR007087--Znf_C2H2
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam
Gene Ontology

GO:0005730--C:nucleolus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0016568--P:chromatin modification
GO:0007275--P:multicellular organism development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009737--P:response to abscisic acid
GO:0009651--P:response to salt stress
GO:0009414--P:response to water deprivation
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0026 fgenesh1_pg.C_scaffold_6000249 Arabidopsis lyrata 70 6e-53 204
WERAM-Bro-0186 Bo9g181760.1 Brassica oleracea 61 3e-36 149
WERAM-Brr-0050 Bra009513.1-P Brassica rapa 55 1e-35 147
WERAM-Viv-0052 VIT_08s0007g03940.t01 Vitis vinifera 51 2e-29 126
WERAM-Thc-0115 EOY33573 Theobroma cacao 56 1e-28 124
WERAM-Glm-0023 GLYMA03G34850.3 Glycine max 53 1e-26 117
WERAM-Pot-0048 POPTR_0004s20020.1 Populus trichocarpa 53 1e-26 117
WERAM-Sol-0131 Solyc10g085560.1.1 Solanum lycopersicum 54 2e-26 117
WERAM-Sot-0024 PGSC0003DMT400021644 Solanum tuberosum 53 3e-26 116
WERAM-Orbr-0066 OB05G35770.1 Oryza brachyantha 53 4e-25 112
WERAM-Ors-0052 OS05T0597100-01 Oryza sativa 51 2e-24 110
WERAM-Ori-0055 BGIOSGA017430-PA Oryza indica 51 2e-24 110
WERAM-Sob-0127 Sb09g026730.1 Sorghum bicolor 51 1e-22 103
WERAM-Sei-0085 Si022778m Setaria italica 52 3e-22 102
WERAM-Zem-0062 GRMZM2G100146_P01 Zea mays 52 9e-22 101
WERAM-Prp-0077 EMJ03579 Prunus persica 49 1e-21 101
WERAM-Met-0051 KEH38943 Medicago truncatula 48 1e-21 100
WERAM-Mua-0063 GSMUA_Achr3P22840_001 Musa acuminata 47 2e-21 100
WERAM-Tru-0046 TRIUR3_21067-P1 Triticum urartu 48 4e-21 99.4
WERAM-Tra-0342 TRAES3BF048700110CFD_t1 Triticum aestivum 48 2e-20 97.1
WERAM-Aet-0097 EMT09079 Aegilops tauschii 48 5e-20 95.5
WERAM-Hov-0097 MLOC_70585.1 Hordeum vulgare 51 7e-20 95.1
WERAM-Lep-0059 LPERR05G23920.1 Leersia perrieri 49 3e-19 92.8
WERAM-Orl-0054 KN539082.1_FGP007 Oryza longistaminata 48 7e-19 91.7
WERAM-Orb-0056 OBART05G28290.1 Oryza barthii 47 1e-17 87.4
WERAM-Orp-0054 OPUNC05G25830.1 Oryza punctata 47 1e-17 87.4
WERAM-Org-0014 ORGLA01G0351500.1 Oryza glaberrima 45 3e-16 83.2
WERAM-Php-0037 PP1S183_93V6.3 Physcomitrella patens 41 7e-16 81.6
WERAM-Brd-0043 BRADI2G14120.1 Brachypodium distachyon 49 2e-15 80.1
WERAM-Orni-0013 ONIVA01G46280.1 Oryza nivara 41 3e-15 79.7
WERAM-Orr-0013 ORUFI01G44570.1 Oryza rufipogon 41 3e-15 79.7
WERAM-Amt-0052 ERN12770 Amborella trichopoda 49 6e-11 65.5
WERAM-Orm-0014 OMERI01G38240.2 Oryza meridionalis 44 8e-10 61.6
WERAM-Orgl-0013 OGLUM01G45450.3 Oryza glumaepatula 33 4e-09 59.3
WERAM-Sem-0061 EFJ07202 Selaginella moellendorffii 31 3e-08 56.2
Created Date 25-Jun-2016