WERAM Information


Tag Content
WERAM ID WERAM-Art-0083
Ensembl Protein ID AT3G44750.1
Uniprot Accession Q9FVE6; HDT1_ARATH; O22238
Genbank Protein ID NP_566872.1
Protein Name Histone deacetylase HDT1
Genbank Nucleotide ID NM_114344.3
Gene Name HDT1;HD2A;HDA3;At3g44750;T32N15.8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT3G44750 AT3G44750.1 AT3G44750.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC HD2 H3K9 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC HD2 2.00e-86 315
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for histone H3 'Lys-9' deacetylation. Involved in rRNA gene silencing in nucleolar dominance. Seems to be implicated in the regulation of genes involved in seeds development.
Domain Profile
  HDAC HD2

Query: 1   MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST 60
MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST
Sbjct: 1 MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST 60
Query: 61 ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYSXXXXXXXXXXXXXXXXX 120
ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYS
Sbjct: 61 ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYSEEEEEEEEEVPAGNAAK 120
Query: 121 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPTPKKPASSKKRANEXXX 180
PTPKKPASSKKRANE
Sbjct: 121 AVAKPKAKPAEVKPAVDDEEDESDSDGMDEDDSDGEDSEEEEPTPKKPASSKKRANETTP 180
Query: 181 XXXXXXXXXXXXXXXQKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK 240
QKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK
Sbjct: 181 KAPVSAKKAKVAVTPQKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK 240
Query: 241 HAAAK 245
HAAAK
Sbjct: 241 HAAAK 245

Protein Sequence
(Fasta)
MEFWGIEVKS GKPVTVTPEE GILIHVSQAS LGECKNKKGE FVPLHVKVGN QNLVLGTLST 60
ENIPQLFCDL VFDKEFELSH TWGKGSVYFV GYKTPNIEPQ GYSEEEEEEE EEVPAGNAAK 120
AVAKPKAKPA EVKPAVDDEE DESDSDGMDE DDSDGEDSEE EEPTPKKPAS SKKRANETTP 180
KAPVSAKKAK VAVTPQKTDE KKKGGKAANQ SPKSASQVSC GSCKKTFNSG NALESHNKAK 240
HAAAK 245
Nucleotide Sequence
(Fasta)
TCTTACATTT TCAGCTGCTC ATAAACCCTA AAAATCCTCT CTTTTTCTCA ACCTTGATTC 60
TTAGCCATGG AGTTCTGGGG AATTGAAGTT AAATCAGGAA AGCCAGTTAC AGTGACTCCT 120
GAAGAAGGCA TTCTTATCCA CGTTTCTCAG GCATCGCTTG GAGAATGTAA AAACAAGAAG 180
GGAGAGTTTG TGCCTTTACA TGTAAAGGTT GGGAACCAGA ACTTGGTTCT GGGAACTCTA 240
TCGACTGAGA ACATCCCTCA GCTTTTCTGT GATTTGGTAT TCGACAAGGA GTTTGAGCTT 300
TCTCACACTT GGGGAAAAGG AAGTGTTTAC TTTGTTGGAT ACAAAACTCC CAACATTGAG 360
CCACAAGGCT ATTCTGAGGA AGAAGAGGAA GAAGAGGAAG AAGTTCCTGC TGGGAATGCT 420
GCCAAGGCTG TAGCTAAACC AAAGGCTAAG CCTGCAGAAG TGAAGCCAGC TGTTGATGAT 480
GAAGAGGATG AGTCTGATTC TGACGGAATG GATGAAGATG ATTCTGATGG TGAGGATTCT 540
GAGGAAGAAG AGCCTACACC TAAGAAGCCT GCATCAAGCA AGAAGAGAGC TAATGAAACT 600
ACCCCTAAAG CACCTGTGTC AGCAAAGAAG GCGAAAGTAG CAGTTACTCC TCAGAAAACA 660
GATGAGAAGA AGAAAGGGGG AAAGGCTGCA AACCAGAGCC CAAAGTCGGC CAGTCAAGTC 720
TCATGTGGTT CATGCAAGAA GACTTTCAAC TCAGGGAATG CACTTGAGTC TCACAACAAG 780
GCCAAGCACG CTGCTGCCAA GTGAAGTGGT TTCTTATTAG AGCTTGTGAT TTCTATGGAA 840
TTTTGCCTGT AGTCTTTATG AAACCTTCGG ATTTTCTTAT ATTTTCTTTT GATAACAAGA 900
GTCTTAATGA AAGAGAGCCA GTTGGAGTCT TATTACCACT ATATTTCAAC ATTCTATCTT 960
GGCTCAAATG TGTTAATTTT AGATTCACGT TTTCACCA 999
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--

Interpro

IPR007087--Znf_C2H2

PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam
Gene Ontology

GO:0005730--C:nucleolus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0016568--P:chromatin modification
GO:0009294--P:DNA mediated transformation
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010162--P:seed dormancy process
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0089 fgenesh2_kg.5__ 872__ AT3G44750.1 Arabidopsis lyrata 95 3e-52 202
WERAM-Thc-0115 EOY33573 Theobroma cacao 65 1e-30 130
WERAM-Viv-0052 VIT_08s0007g03940.t01 Vitis vinifera 61 2e-30 129
WERAM-Pot-0109 POPTR_0009s15160.1 Populus trichocarpa 60 1e-29 127
WERAM-Sot-0008 PGSC0003DMT400006927 Solanum tuberosum 59 1e-28 123
WERAM-Brr-0103 Bra020209.1-P Brassica rapa 61 3e-28 122
WERAM-Sol-0107 Solyc09g009030.2.1 Solanum lycopersicum 59 3e-28 122
WERAM-Bro-0028 Bo2g024240.1 Brassica oleracea 60 7e-28 121
WERAM-Glm-0023 GLYMA03G34850.3 Glycine max 60 1e-26 117
WERAM-Mua-0063 GSMUA_Achr3P22840_001 Musa acuminata 59 4e-26 115
WERAM-Prp-0078 EMJ06874 Prunus persica 55 2e-25 113
WERAM-Zem-0158 GRMZM5G898314_P01 Zea mays 56 4e-24 108
WERAM-Sob-0059 Sb03g043350.1 Sorghum bicolor 53 5e-24 108
WERAM-Tra-0342 TRAES3BF048700110CFD_t1 Triticum aestivum 49 5e-24 108
WERAM-Sei-0085 Si022778m Setaria italica 56 7e-24 107
WERAM-Ors-0052 OS05T0597100-01 Oryza sativa 55 9e-24 107
WERAM-Ori-0055 BGIOSGA017430-PA Oryza indica 55 9e-24 107
WERAM-Orbr-0066 OB05G35770.1 Oryza brachyantha 54 5e-23 105
WERAM-Tru-0046 TRIUR3_21067-P1 Triticum urartu 50 8e-23 104
WERAM-Aet-0097 EMT09079 Aegilops tauschii 52 2e-22 102
WERAM-Met-0051 KEH38943 Medicago truncatula 52 6e-22 101
WERAM-Php-0037 PP1S183_93V6.3 Physcomitrella patens 48 9e-22 100
WERAM-Hov-0097 MLOC_70585.1 Hordeum vulgare 52 2e-20 96.7
WERAM-Orl-0054 KN539082.1_FGP007 Oryza longistaminata 52 2e-20 96.3
WERAM-Lep-0059 LPERR05G23920.1 Leersia perrieri 56 3e-20 95.9
WERAM-Orp-0054 OPUNC05G25830.1 Oryza punctata 56 4e-20 95.5
WERAM-Orb-0056 OBART05G28290.1 Oryza barthii 56 4e-20 95.5
WERAM-Orni-0013 ONIVA01G46280.1 Oryza nivara 47 7e-18 88.2
WERAM-Orr-0013 ORUFI01G44570.1 Oryza rufipogon 47 7e-18 88.2
WERAM-Brd-0043 BRADI2G14120.1 Brachypodium distachyon 49 2e-16 83.6
WERAM-Org-0014 ORGLA01G0351500.1 Oryza glaberrima 43 6e-14 75.1
WERAM-Sem-0061 EFJ07202 Selaginella moellendorffii 38 1e-12 70.9
WERAM-Amt-0052 ERN12770 Amborella trichopoda 62 2e-10 63.5
WERAM-Orgl-0013 OGLUM01G45450.3 Oryza glumaepatula 31 4e-09 58.9
Created Date 25-Jun-2016