| Tag |
Content |
| WERAM ID |
WERAM-Ran-0024 |
| Ensembl Protein ID |
ENSRNOP00000004224.4 |
| Uniprot Accession |
B1WC68; HDAC8_RAT
|
| Genbank Protein ID |
NP_001119845.2
|
| Protein Name |
Histone deacetylase 8 |
| Genbank Nucleotide ID |
NM_001126373.2
|
| Gene Name |
HDAC8 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
26395029; 26365275
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
1.60e-140 |
468.6 |
17 |
323 |
|
| Organism |
Rattus norvegicus |
| NCBI Taxa ID |
10116 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity).
|
| Domain Profile |
HDAC Class-I
class-1.txt 4 ayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedc 92
+y+y+++ +++++++ +++pkr+s++h+L+ +y+l+k+++ivkpk as+ee+++fh+++y+++l+kv++e +e+++ ++ ++++g+dc
ENSRNOP00000004224.4 17 VYIYSPE--YVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHP-DSIEYGLGYDC 102
6888888..8899**************************************************************99.6789******* PP
class-1.txt 93 PvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyt 181
P ++g+f+y+++i+G++++aa++L+++++++ainw+GG+hhakk+easGfcy+nD vl+il+l++k++r+ly+d+dlhhGDgve+af++
ENSRNOP00000004224.4 103 PATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSF 191
***************************************************************************************** PP
class-1.txt 182 tdrvmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnls 270
t++vmtvs+hk++++ffPgtGd+sdvg +kg+yy+vnvP++dgi+De+y++i++sv+++v++af+P+avvlq+GaD++agD++++fn++
ENSRNOP00000004224.4 192 TSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT 280
***************************************************************************************** PP
class-1.txt 271 ikghaecvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
g+++c+k+v +++l++l+lGGGGY+l+n+aRcwty+t+v+l
ENSRNOP00000004224.4 281 PVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVIL 323
*****************************************97 PP
|
Protein Sequence
(Fasta) | MEIPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK 60
VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI 120
TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH 180
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY 240
YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI 300
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH 360
RIQQILNYIK GNLKHVV 377Protein Fasta Sequence
>ENSRNOP00000004224.4|HDAC8|Rattus norvegicus
MEIPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV |
Nucleotide Sequence
(Fasta) | GTAGGGCAAC AAGGCTGGTT ACTTTTGACC GTGCTACTTG TGTCATGAAA AAAATCGATC 60
CCAATTGGCA GTTATTTGGC TTTTATATCT GTCAGGCCCC CCTTTTGAAC TGTTGTCATT 120
AATAGAATGT TCCTAATCTG GATGGGCCCA TCCATCCCCG CAGTTGGACG AGGGACTAGG 180
GAAACTGTCT CCAGCGATCT AAATAGGAGG GAATGTTGAC TAGGGAGCAC CGCTGGGGCC 240
GAACAGAGGA GCAGGAACCG GAGCTCAGGC TGAGTCTGAA AACTGTTGGC TCCAGACTTT 300
GGCTCGGGGA CGATTGGAAG TAGGAGATGG AGATACCAGA GGAACCCGCC AATAGTGGGC 360
ATTCGCTACC CCCGGTTTAT ATTTACAGTC CCGAGTATGT CAGCATCTGC GATTCCCTTG 420
TGAAGGTCCC CAAACGGGCC AGTATGGTTC ACTCTCTGAT CGAAGCATAT GCCCTGCATA 480
AACAAATGAG GATAGTGAAG CCCAAAGTGG CCTCCATGGA GGAGATGGCC ACCTTCCACA 540
CTGATGCCTA TCTTCAACAT CTCCAGAAGG TCAGCCAAGA AGGGGATGAG GACCATCCAG 600
ACTCCATAGA ATATGGACTA GGTTATGACT GCCCAGCCAC AGAAGGGATA TTTGACTATG 660
CAGCAGCTAT AGGAGGAGGT ACAATCACAG CTGCCCAGTG CCTGATTGAC GGGAAGTGTA 720
AAGTAGCCAT TAACTGGTCT GGAGGGTGGC ATCATGCAAA GAAAGATGAA GCATCTGGTT 780
TCTGTTATCT CAATGATGCT GTCCTAGGAA TATTACGATT GCGACGGAAA TTTGACCGGA 840
TTCTCTATGT GGACTTGGAT CTACACCATG GAGATGGTGT AGAAGATGCC TTCAGTTTTA 900
CATCTAAAGT TATGACTGTG TCCCTGCACA AGTTCTCTCC AGGATTTTTC CCAGGAACAG 960
GTGACATGTC TGATGTTGGC CTGGGGAAAG GACGGTACTA CAGTGTCAAT GTGCCCATTC 1020
AGGATGGCAT CCAGGATGAG AAGTACTATC ACATCTGTGA AAGTGTACTA AAGGAAGTAT 1080
ACCAGGCCTT CAATCCGAAG GCAGTGGTTC TACAGCTGGG AGCAGATACC ATTGCTGGAG 1140
ATCCAATGTG CTCCTTTAAC ATGACACCAG TGGGAATTGG CAAGTGTCTG AAGTATGTCC 1200
TTCAGTGGCA GTTGGCAACT CTGATTTTAG GAGGAGGAGG CTACAACCTT GCCAACACGG 1260
CTCGTTGCTG GACATACTTG ACCGGGGTCA TCCTAGGGAA AACACTATCC TCTGAGATCC 1320
CAGATCATGA GTTTTTCACA GCATATGGTC CTGATTATGT GCTGGAAATC ACGCCAAGCT 1380
GCCGGCCAGA CCGCAATGAG CCCCATCGAA TCCAGCAAAT CCTCAACTAC ATCAAAGGGA 1440
ATCTGAAGCA TGTGGTCTAG TTGACAAAAA GAGATCAAGT TTCCAGAGCT GGGCAGAACC 1500
CATAATGAAG ACAGTGTGTT GATGCAAGCA GTTTGTGGGA TTTGTGACTG CAGGGGAAAT 1560
TTGGAAGAAA TTACTTCCTG AAAATTTCCA AGGGGCACCA AGTGGCAGCT GGCCTCCTGG 1620
GGTGAGGAGG CAGACACCTC AGAGCCAGGC CTAGGGGGAA AGAGGGAGAT ATCCAGTGTT 1680
GAATGTGTCT TATTTTAAAA CACAAACACT GTTTTTAATG TTTCAAAATT ATTTTTAAGC 1740
AAGTTGGGGG AATAATTTTA TCTTTATAAA GGGGACAAGT CAGGAGCTGC AGTCAAGTGG 1800
AGCTGGGTAG GGGAACAGCA GATGGGCAGG TTTGGACCTC AGGGCCATTT AGATAGAGAC 1860
ACATCGGGGA GGGGTGTCAG CAGACTGGGA GGTAAAGAGG AGTCTACCAC TTTTGTTTTG 1920
GTACTATGCA CTCAAGTTGT TCTTAATAAA ATTTTTGAAA CTCTA
1966Nucleotide Fasta Sequence
>ENSRNOP00000004224.4|Class-I|Rattus norvegicus
GTAGGGCAACAAGGCTGGTTACTTTTGACCGTGCTACTTGTGTCATGAAAAAAATCGATCCCAATTGGCAGTTATTTGGCTTTTATATCTGTCAGGCCCCCCTTTTGAACTGTTGTCATTAATAGAATGTTCCTAATCTGGATGGGCCCATCCATCCCCGCAGTTGGACGAGGGACTAGGGAAACTGTCTCCAGCGATCTAAATAGGAGGGAATGTTGACTAGGGAGCACCGCTGGGGCCGAACAGAGGAGCAGGAACCGGAGCTCAGGCTGAGTCTGAAAACTGTTGGCTCCAGACTTTGGCTCGGGGACGATTGGAAGTAGGAGATGGAGATACCAGAGGAACCCGCCAATAGTGGGCATTCGCTACCCCCGGTTTATATTTACAGTCCCGAGTATGTCAGCATCTGCGATTCCCTTGTGAAGGTCCCCAAACGGGCCAGTATGGTTCACTCTCTGATCGAAGCATATGCCCTGCATAAACAAATGAGGATAGTGAAGCCCAAAGTGGCCTCCATGGAGGAGATGGCCACCTTCCACACTGATGCCTATCTTCAACATCTCCAGAAGGTCAGCCAAGAAGGGGATGAGGACCATCCAGACTCCATAGAATATGGACTAGGTTATGACTGCCCAGCCACAGAAGGGATATTTGACTATGCAGCAGCTATAGGAGGAGGTACAATCACAGCTGCCCAGTGCCTGATTGACGGGAAGTGTAAAGTAGCCATTAACTGGTCTGGAGGGTGGCATCATGCAAAGAAAGATGAAGCATCTGGTTTCTGTTATCTCAATGATGCTGTCCTAGGAATATTACGATTGCGACGGAAATTTGACCGGATTCTCTATGTGGACTTGGATCTACACCATGGAGATGGTGTAGAAGATGCCTTCAGTTTTACATCTAAAGTTATGACTGTGTCCCTGCACAAGTTCTCTCCAGGATTTTTCCCAGGAACAGGTGACATGTCTGATGTTGGCCTGGGGAAAGGACGGTACTACAGTGTCAATGTGCCCATTCAGGATGGCATCCAGGATGAGAAGTACTATCACATCTGTGAAAGTGTACTAAAGGAAGTATACCAGGCCTTCAATCCGAAGGCAGTGGTTCTACAGCTGGGAGCAGATACCATTGCTGGAGATCCAATGTGCTCCTTTAACATGACACCAGTGGGAATTGGCAAGTGTCTGAAGTATGTCCTTCAGTGGCAGTTGGCAACTCTGATTTTAGGAGGAGGAGGCTACAACCTTGCCAACACGGCTCGTTGCTGGACATACTTGACCGGGGTCATCCTAGGGAAAACACTATCCTCTGAGATCCCAGATCATGAGTTTTTCACAGCATATGGTCCTGATTATGTGCTGGAAATCACGCCAAGCTGCCGGCCAGACCGCAATGAGCCCCATCGAATCCAGCAAATCCTCAACTACATCAAAGGGAATCTGAAGCATGTGGTCTAGTTGACAAAAAGAGATCAAGTTTCCAGAGCTGGGCAGAACCCATAATGAAGACAGTGTGTTGATGCAAGCAGTTTGTGGGATTTGTGACTGCAGGGGAAATTTGGAAGAAATTACTTCCTGAAAATTTCCAAGGGGCACCAAGTGGCAGCTGGCCTCCTGGGGTGAGGAGGCAGACACCTCAGAGCCAGGCCTAGGGGGAAAGAGGGAGATATCCAGTGTTGAATGTGTCTTATTTTAAAACACAAACACTGTTTTTAATGTTTCAAAATTATTTTTAAGCAAGTTGGGGGAATAATTTTATCTTTATAAAGGGGACAAGTCAGGAGCTGCAGTCAAGTGGAGCTGGGTAGGGGAACAGCAGATGGGCAGGTTTGGACCTCAGGGCCATTTAGATAGAGACACATCGGGGAGGGGTGTCAGCAGACTGGGAGGTAAAGAGGAGTCTACCACTTTTGTTTTGGTACTATGCACTCAAGTTGTTCTTAATAAAATTTTTGAAACTCTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0031397--P:negative regulation of protein ubiquitination
GO:0071922--P:regulation of cohesin localization to chromatin
GO:0031647--P:regulation of protein stability
GO:0032204--P:regulation of telomere maintenance
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007062--P:sister chromatid cohesion
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
