WERAM Information

Tag Content
WERAM ID WERAM-Hos-0101
Ensembl Protein ID ENSP00000358605.1
Uniprot Accession O75940; SPF30_HUMAN; B2RA27; D3DRB1; Q5T3K6
Genbank Protein ID NP_005862.1
Protein Name Survival of motor neuron-related-splicing factor 30
Genbank Nucleotide ID NM_005871.3
Gene Name SMNDC1;SMNR;SPF30
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119953.12 ENST00000369592.1 ENSP00000358605.1
ENSG00000119953.12 ENST00000369603.9 ENSP00000358616.4
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3R17me2a R 21172665
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 2.40e-12 49.2 73 129
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Necessary for spliceosome assembly. Overexpression causes apoptosis.
Domain Profile
  Me_Reader Tudor
          Tudor.txt   2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqy 62 
                        +kvG++++a ws+dG++Y+++i    ++++ ++ + +i++ ++++ +++ L++ +++ e +
  ENSP00000358605.1  73 WKVGDKCMAVWSEDGQCYEAEI----EEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGR 129
                        9*********************....*****************************999876 PP
Protein Sequence
(Fasta)		MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS 60
SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAG YGNAEVTPLL 120
NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ 180
FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ 238
Nucleotide Sequence
(Fasta)		TCCCGAGGTG AAGCGGAGGC CCAAGGCTGA GGAGCCCGCC TCGCCGGAGA CGCCCAGGCG 60
CTGGCCCTGG ATCCCGGAGC CACGGCCGTC TCTCAGCCAG AGCTGAGCCT CGGCGGCCCG 120
GCCGGCGCTG GCCTCCGTGC GGCGGCGGCA AACACGGCCC GCAGGGGACC GGGTCGGGTG 180
GGGCTGGGCG CCGCGCGGCT CCCTGTGGAG CCTGCCTGTT GGAGCGCGGC GGGGCTCCGG 240
CGGTGGTCTT GGAGCTGGCG TGTGGATTTC CACGTCCGAA TGATCGAGTT GTGGCGGGCT 300
TTGAGATGTC AGAGGATTTA GCAAAGCAGC TGGCAAGCTA CAAAGCTCAG CTCCAGCAAG 360
TTGAAGCTGC ATTATCTGGA AATGGAGAAA ATGAAGATTT GCTAAAATTG AAGAAAGATT 420
TACAAGAAGT TATAGAACTA ACCAAAGACC TTCTGTCAAC TCAACCTTCT GAGACGCTTG 480
CAAGTTCAGA CAGTTTTGCT TCTACTCAAC CTACTCATTC ATGGAAAGTA GGAGACAAGT 540
GTATGGCAGT CTGGAGTGAA GATGGACAGT GTTATGAAGC GGAGATTGAG GAGATAGATG 600
AAGAAAATGG CACCGCTGCA ATCACCTTTG CTGGTTATGG CAATGCTGAA GTGACTCCAC 660
TGTTGAACCT CAAGCCTGTA GAAGAAGGAA GGAAGGCAAA GGAGGACAGT GGCAACAAAC 720
CCATGTCAAA AAAAGAAATG ATTGCCCAGC AGCGTGAATA TAAAAAGAAG AAAGCTTTGA 780
AAAAAGCTCA GAGAATAAAA GAACTTGAGC AGGAAAGAGA GGACCAGAAA GTGAAATGGC 840
AACAATTCAA CAACAGAGCC TATTCTAAAA ACAAAAAAGG CCAGGTAAAG AGGAGTATTT 900
TTGCTTCACC TGAGAGTGTG ACTGGTAAAG TTGGAGTAGG AACCTGTGGA ATTGCTGATA 960
AACCTATGAC ACAATATCAA GATACCTCTA AATACAATGT CAGGCATTTG ATGCCTCAAT 1020
AATCAGAAAA ACTGTTGGAT TTCATCTCTG CAGGGCTTTA CATTTACCTT TTTATCCTTA 1080
TATTTTTCTA AAGGTAAATT ATTTGTTAGA 1111
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
--
Interpro

IPR010304--Survival_motor_neuron
IPR002999--Tudor
PROSITE

PS50304--TUDOR
Pfam

PF06003--SMN
Gene Ontology

GO:0015030--C:Cajal body
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0044822--F:poly(A) RNA binding
GO:0006915--P:apoptotic process
GO:0006397--P:mRNA processing
GO:0000375--P:RNA splicing, via transesterification reactions
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0026 ENSPPYP00000003078.1 Pongo abelii 100 7e-120 426
WERAM-Paa-0147 ENSPANP00000020975.1 Papio anubis 100 7e-120 426
WERAM-Pat-0022 ENSPTRP00000005182.3 Pan troglodytes 100 7e-120 426
WERAM-Nol-0168 ENSNLEP00000018780.1 Nomascus leucogenys 100 7e-120 426
WERAM-Mup-0020 ENSMPUP00000002068.1 Mustela putorius furo 100 7e-120 426
WERAM-Mam-0060 ENSMMUP00000010218.1 Macaca mulatta 100 7e-120 426
WERAM-Gog-0116 ENSGGOP00000009828.2 Gorilla gorilla 100 7e-120 426
WERAM-Chs-0056 ENSCSAP00000001485.1 Chlorocebus sabaeus 100 7e-120 426
WERAM-Caj-0197 ENSCJAP00000034639.1 Callithrix jacchus 100 7e-120 426
WERAM-Aim-0064 ENSAMEP00000005552.1 Ailuropoda melanoleuca 100 7e-120 426
WERAM-Loa-0129 ENSLAFP00000012022.2 Loxodonta africana 99 1e-119 425
WERAM-Mod-0084 ENSMODP00000013212.2 Monodelphis domestica 100 2e-119 425
WERAM-Ova-0100 ENSOARP00000010198.1 Ovis aries 99 2e-119 425
WERAM-Otg-0012 ENSOGAP00000000511.2 Otolemur garnettii 99 2e-119 425
WERAM-Bot-0005 ENSBTAP00000000722.2 Bos taurus 99 2e-119 425
WERAM-Sus-0214 ENSSSCP00000026180.1 Sus scrofa 99 2e-119 425
WERAM-Ict-0061 ENSSTOP00000005452.2 Ictidomys tridecemlineatus 99 2e-119 425
WERAM-Tub-0111 ENSTBEP00000012421.1 Tupaia belangeri 99 2e-119 424
WERAM-Mum-0066 ENSMUSP00000025997.5 Mus musculus 100 3e-119 424
WERAM-Orc-0076 ENSOCUP00000007040.2 Oryctolagus cuniculus 99 5e-119 424
WERAM-Dan-0107 ENSDNOP00000012705.2 Dasypus novemcinctus 100 6e-119 423
WERAM-Ocp-0134 ENSOPRP00000014013.1 Ochotona princeps 99 7e-119 423
WERAM-Fec-0182 ENSFCAP00000025256.1 Felis catus 99 8e-119 423
WERAM-Ran-0098 ENSRNOP00000020539.5 Rattus norvegicus 99 1e-118 422
WERAM-Caf-0119 ENSCAFP00000015780.3 Canis familiaris 100 1e-118 422
WERAM-Soa-0056 ENSSARP00000005482.1 Sorex araneus 98 3e-118 421
WERAM-Myl-0175 ENSMLUP00000014580.1 Myotis lucifugus 98 6e-118 420
WERAM-Ora-0017 ENSOANP00000002552.2 Ornithorhynchus anatinus 98 1e-117 419
WERAM-Cap-0079 ENSCPOP00000005709.2 Cavia porcellus 92 5e-113 404
WERAM-Tag-0132 ENSTGUP00000010931.1 Taeniopygia guttata 96 9e-111 396
WERAM-Fia-0037 ENSFALP00000002401.1 Ficedula albicollis 96 9e-111 396
WERAM-Gaga-0089 ENSGALP00000013929.4 Gallus gallus 96 1e-110 396
WERAM-Anc-0058 ENSACAP00000005857.1 Anolis carolinensis 95 3e-109 391
WERAM-Pes-0113 ENSPSIP00000013643.1 Pelodiscus sinensis 98 4e-109 390
WERAM-Sah-0170 ENSSHAP00000017892.1 Sarcophilus harrisii 99 1e-102 369
WERAM-Vip-0036 ENSVPAP00000003145.1 Vicugna pacos 99 2e-102 368
WERAM-Dio-0058 ENSDORP00000005294.1 Dipodomys ordii 89 6e-101 363
WERAM-Lac-0064 ENSLACP00000008810.1 Latimeria chalumnae 84 3e-98 354
WERAM-Leo-0124 ENSLOCP00000015205.1 Lepisosteus oculatus 84 3e-95 345
WERAM-Anp-0034 ENSAPLP00000003829.1 Anas platyrhynchos 96 1e-94 343
WERAM-Meg-0112 ENSMGAP00000011207.2 Meleagris gallopavo 95 9e-92 333
WERAM-Prc-0158 ENSPCAP00000015111.1 Procavia capensis 99 4e-90 327
WERAM-Chh-0026 ENSCHOP00000002599.1 Choloepus hoffmanni 99 1e-89 326
WERAM-Orn-0003 ENSONIP00000000550.1 Oreochromis niloticus 76 1e-89 326
WERAM-Dar-0116 ENSDARP00000038215.5 Danio rerio 79 2e-89 325
WERAM-Gaa-0098 ENSGACP00000012540.1 Gasterosteus aculeatus 76 8e-89 323
WERAM-Asm-0216 ENSAMXP00000020915.1 Astyanax mexicanus 76 9e-89 323
WERAM-Tar-0084 ENSTRUP00000016366.1 Takifugu rubripes 74 3e-87 318
WERAM-Orla-0056 ENSORLP00000007459.1 Oryzias latipes 76 2e-86 315
WERAM-Ten-0164 ENSTNIP00000016321.1 Tetraodon nigroviridis 75 3e-86 315
WERAM-Xim-0155 ENSXMAP00000012780.1 Xiphophorus maculatus 75 8e-86 313
WERAM-Pof-0213 ENSPFOP00000017186.1 Poecilia formosa 76 3e-85 311
WERAM-Gam-0182 ENSGMOP00000017798.1 Gadus morhua 77 2e-84 309
WERAM-Tut-0090 ENSTTRP00000007470.1 Tursiops truncatus 80 2e-84 309
WERAM-Tas-0066 ENSTSYP00000006045.1 Tarsius syrichta 80 2e-84 309
WERAM-Ere-0065 ENSEEUP00000005400.1 Erinaceus europaeus 79 7e-84 307
WERAM-Pem-0076 ENSPMAP00000008472.1 Petromyzon marinus 68 6e-76 281
WERAM-Ect-0134 ENSETEP00000015345.1 Echinops telfairi 53 2e-50 196
WERAM-Xet-0102 ENSXETP00000033649.2 Xenopus tropicalis 82 2e-49 192
WERAM-Mae-0094 ENSMEUP00000009229.1 Macropus eugenii 59 3e-47 185
WERAM-Drm-0076 FBpp0289146 Drosophila melanogaster 41 7e-25 111
WERAM-Mua-0136 GSMUA_Achr8P34180_001 Musa acuminata 31 6e-14 75.1
WERAM-Lab-0003 EDR15018 Laccaria bicolor 32 1e-13 73.9
WERAM-Pot-0055 POPTR_0004s23810.1 Populus trichocarpa 30 2e-13 73.2
WERAM-Prp-0076 EMJ24376 Prunus persica 29 6e-12 68.2
WERAM-Met-0118 KEH32747 Medicago truncatula 29 2e-11 67.0
WERAM-Lep-0085 LPERR08G00910.1 Leersia perrieri 30 2e-11 66.6
WERAM-Orbr-0094 OB08G10830.1 Oryza brachyantha 30 2e-11 66.2
WERAM-Sol-0019 Solyc01g103020.2.1 Solanum lycopersicum 29 4e-11 65.9
WERAM-Glm-0215 GLYMA17G00560.1 Glycine max 29 5e-11 65.1
WERAM-Brr-0132 Bra026585.1-P Brassica rapa 29 8e-11 64.7
WERAM-Art-0036 AT2G02570.1 Arabidopsis thaliana 29 9e-11 64.3
WERAM-Orr-0090 ORUFI08G00760.1 Oryza rufipogon 30 1e-10 63.5
WERAM-Orni-0085 ONIVA08G00730.1 Oryza nivara 30 1e-10 63.5
WERAM-Ori-0093 BGIOSGA027775-PA Oryza indica 30 1e-10 63.5
WERAM-Orgl-0084 OGLUM08G00790.1 Oryza glumaepatula 30 1e-10 63.5
WERAM-Org-0087 ORGLA08G0001000.1 Oryza glaberrima 30 1e-10 63.5
WERAM-Orb-0087 OBART08G00720.1 Oryza barthii 30 1e-10 63.5
WERAM-Sot-0061 PGSC0003DMT400053385 Solanum tuberosum 29 2e-10 63.5
WERAM-Sob-0098 Sb07g001010.1 Sorghum bicolor 29 2e-10 63.5
WERAM-Arl-0131 scaffold_500192.1 Arabidopsis lyrata 30 2e-10 63.2
WERAM-Zem-0007 GRMZM2G005737_P01 Zea mays 27 2e-10 62.8
WERAM-Mel-0026 EGG10984 Melampsora laricipopulina 31 4e-10 62.4
WERAM-Brd-0073 BRADI3G13410.3 Brachypodium distachyon 29 4e-10 62.0
WERAM-Sei-0072 Si017933m Setaria italica 29 2e-09 60.5
WERAM-Viv-0076 VIT_12s0035g01830.t01 Vitis vinifera 27 7e-09 58.2
WERAM-Bro-0128 Bo7g080510.1 Brassica oleracea 28 8e-09 58.2
WERAM-Chr-0026 EDP07443 Chlamydomonas reinhardtii 32 3e-08 56.2
WERAM-Orl-0027 KN538777.1_FGP011 Oryza longistaminata 30 8e-08 54.7
WERAM-Ors-0078 OS08T0109900-01 Oryza sativa 30 2e-07 53.1
WERAM-Put-0003 PTTG_02468P0 Puccinia triticina 30 3e-07 52.8
WERAM-Tra-0312 Traes_7BL_DB71F86C2.1 Triticum aestivum 28 4e-07 52.4
WERAM-Eqc-0118 ENSECAP00000013134.1 Equus caballus 48 4e-07 52.0
WERAM-Tru-0060 TRIUR3_24898-P1 Triticum urartu 28 6e-07 51.6
WERAM-Pug-0026 EFP86213 Puccinia graminis 29 8e-07 51.2
WERAM-Orp-0083 OPUNC08G00700.1 Oryza punctata 30 2e-06 50.1
WERAM-Ptv-0052 ENSPVAP00000005647.1 Pteropus vampyrus 50 3e-06 49.3
Created Date 25-Jun-2016