WERAM Information

Tag Content
WERAM ID WERAM-Hos-0126
Ensembl Protein ID ENSP00000256398.8
Uniprot Accession Q9H9T3; ELP3_HUMAN; B4DE19; B4DIG1; E2QRI5; Q53G84; Q6AWB0; Q9BVF7; Q9NVZ1
Genbank Protein ID NP_001271151.1; NP_001271153.1; NP_001271154.1; NP_001271155.1; NP_060561.3; XP_006716417.1
Protein Name Elongator complex protein 3
Genbank Nucleotide ID NM_001284222.1; NM_001284224.1; NM_001284225.1; NM_001284226.1; NM_018091.5; XM_006716354.1
Gene Name ELP3;KAT9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134014.16 ENST00000256398.12 ENSP00000256398.8
ENSG00000134014.16 ENST00000380353.8 ENSP00000369711.4
ENSG00000134014.16 ENST00000521015.5 ENSP00000428449.1
ENSG00000134014.16 ENST00000524103.5 ENSP00000429180.1
ENSG00000134014.16 ENST00000537665.2 ENSP00000445558.1
Details
Type Family Domain Substrates AA References (PMIDs)
HAT ELP3 N-acetyltransferase H3K14; H4K8 K 12466527; 15902492
Status Reviewed
Classification
Type Family E-value Score Start End
HAT ELP3 2.80e-92 309 396 546
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).
Domain Profile
  HAT ELP3
           ELP3.txt   1 lkcrdvrtrevgiqeihhkvrpeqvelirrdyvanggwetflsyedpkqdiligllrlrkisektfrpelkgevsivrelhvygsvvpvasr 92 
                        ++crdvrtrevgiqeihhkvrp+qvel+rrdyvanggwetflsyedp+qdiligllrlrk+se+tfr+el g vsivrelhvygsvvpv+sr
  ENSP00000256398.8 396 IQCRDVRTREVGIQEIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSR 487
                        69****************************************************************************************** PP
           ELP3.txt  93 dpkkfqhqgfgtllleeaeriareehgsekiavisgvgtreyyrklgyeldgpymsksl 151
                        dp+kfqhqgfg+ll+eeaeriareehgs kiavisgvgtr+yyrk+gy+l+gpym+k+l
  ENSP00000256398.8 488 DPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKML 546
                        *********************************************************98 PP
Protein Sequence
(Fasta)		MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI 60
IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF 120
EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE 180
YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC 240
TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ 300
FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT 360
RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV 420
ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS 480
VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP 540
YMVKMLK 547
Nucleotide Sequence
(Fasta)		GAGAGACCAT CCACTTCCAC CCTTTCACTT AGGCTTCCTG GCGCAGCCTC TATCCAGGAA 60
CTCTGTCCCA TAGCTGTACT GCCCAGGTCG AGCTTTCTAA CCCCAAGATG CCACTCCGTT 120
CAGACGTTCC CATCCTCCAT CCCTGAGACC CGGGGCAGGA TCGCAGCCTA GGGGCCTCAC 180
GGGCCGCCTG CTACCCTGTT AGTTGCAACA CGGGGCGGGG CGTGGCTTTG TGCACGTCGG 240
CTTCCGGGAA GAGCTTTACG ATACATTGAC CGACATTTTA CGACAGGCGG GATTGTTTTG 300
TGGCTGTCAG CTTTCCCCGT GGTCTGAGTT TGTGGCTGCA TTTTTATCTC TGGTGGCTCT 360
GCTACGGCGG CGCAGAAATG AGGCAGAAGC GGAAAGGAGA TCTCAGCCCT GCTGAGCTGA 420
TGATGCTGAC TATAGGAGAT GTTATTAAAC AACTGATTGA AGCCCACGAG CAGGGGAAAG 480
ACATCGATCT AAATAAGGTG AAAACCAAGA CAGCTGCCAA ATATGGCCTT TCTGCCCAGC 540
CCCGCCTGGT GGATATCATT GCTGCCGTCC CTCCTCAGTA TCGCAAGGTC TTGATGCCCA 600
AGTTAAAGGC GAAACCCATC AGAACTGCTA GTGGGATTGC TGTCGTGGCT GTGATGTGCA 660
AACCCCACAG ATGTCCACAC ATCAGTTTTA CAGGAAATAT ATGTGTATAC TGCCCTGGTG 720
GACCTGATTC TGATTTTGAG TATTCCACCC AGTCTTACAC TGGCTATGAG CCAACCTCCA 780
TGAGAGCTAT CCGTGCCAGA TATGACCCTT TCCTACAGAC AAGACACCGA ATAGAACAGT 840
TAAAACAACT TGGTCATAGT GTGGATAAAG TGGAGTTTAT TGTGATGGGT GGAACGTTTA 900
TGGCCCTTCC AGAAGAATAC AGAGATTATT TTATTCGAAA TTTACATGAT GCCTTATCAG 960
GACATACTTC CAACAATATT TACGAGGCAG TCAAGTATTC TGAGAGAAGC CTCACAAAGT 1020
GTATTGGAAT TACTATTGAA ACCAGACCAG ATTACTGCAT GAAGCGACAT TTAAGTGACA 1080
TGTTGACCTA TGGCTGCACA AGGCTGGAGA TTGGGGTGCA GAGTGTTTAT GAAGATGTGG 1140
CTAGAGACAC CAACAGGGGC CACACTGTGA AGGCAGTGTG TGAGTCATTT CACCTGGCCA 1200
AAGATTCCGG TTTTAAAGTG GTGGCCCATA TGATGCCTGA CCTGCCAAAC GTGGGACTAG 1260
AAAGAGACAT TGAACAGTTC ACAGAGTTTT TTGAGAACCC TGCTTTTCGT CCCGATGGGC 1320
TGAAACTCTA TCCTACCCTG GTGATTCGTG GGACCGGGCT TTATGAGCTT TGGAAATCAG 1380
GAAGATATAA GAGTTACTCT CCTAGTGACC TGGTTGAATT GGTGGCTCGG ATCCTAGCCC 1440
TCGTGCCTCC ATGGACTCGA GTGTACCGAG TACAGAGGGA TATTCCAATG CCTTTAGTTA 1500
GCTCAGGAGT AGAGCATGGT AACCTGAGAG AGCTGGCACT TGCAAGAATG AAAGACCTCG 1560
GAATACAGTG TCGAGATGTG AGAACCAGAG AAGTTGGAAT CCAAGAAATT CATCACAAAG 1620
TACGGCCATA CCAGGTTGAA TTGGTAAGGA GAGATTATGT TGCAAATGGT GGCTGGGAAA 1680
CATTCTTGTC ATACGAAGAC CCAGATCAAG ACATTTTGAT TGGCCTCCTA CGATTACGCA 1740
AGTGTTCAGA AGAAACTTTC CGTTTCGAAT TGGGTGGAGG TGTCTCCATA GTACGAGAGC 1800
TGCATGTGTA TGGGAGTGTG GTCCCTGTGA GCAGCCGGGA TCCTACTAAA TTTCAGCATC 1860
AGGGATTTGG CATGCTGCTG ATGGAGGAAG CAGAAAGAAT AGCTAGAGAA GAACATGGGT 1920
CTGGGAAAAT CGCTGTGATA TCAGGGGTCG GCACCAGGAA TTATTATAGA AAGATCGGCT 1980
ACAGATTACA AGGCCCGTAC ATGGTGAAGA TGCTGAAATA ATGGCCACAC CAGTCCACTC 2040
TTCTGCAGTA TCCTCCCTGG CAGAACACGG AGAATCAGGA TTTCTTAAAT ACTCAACAGA 2100
GAGGCTGAGC AGAGCAAATG GGGGGCTTCA CCCTCATCCC GCAGCTGCAG AGACTGGAAA 2160
CTGCCTTCAA GGCCACGGCT GGTCATCTGC TGACCACACC CCAGATCCGC CCTCTCCTGC 2220
GTGCACCCCA AAAAATCACT TGCGTTTTTG AGGCTTAAAT CATCTATCCA GTTTCTACAT 2280
TTTGCATGAG GCCTGCAGGT GGCCTATTTT GACTCAGACG GTGAAAAAAG CAAATTAACT 2340
CATTTGGACA CCATAACTCA TGCAATAAAA CTGATTGTCA TTCGAGGAGC AAACTTAAGA 2400
GTAGTTTATT TATATACCCT GGGGACAGAA AGTCAGGTTG AAACAGGAAA ACCACCAGAC 2460
TCTAATCTCA GCCCTTTAAC GACATACGCA TTGGAGCGCA AGTTAGGAAA ATGAGCTTTT 2520
GTTTTCATGG AAATCATTCT GATTACAGTG CTGATGTTTA GAAATAAATA GCAGTGTGAC 2580
TGGGAAAGAG GAATTGCAGT TGTGGGGGTG TGAGCCTGGC AGCAGCCAGC CAGCAGCCTC 2640
TCCCAGGCGG GAGTCTACCA TCCGAGACGG CGATGACAAA GAGCTTCATT CCACATTCTT 2700
TGTTATCTCT ACTTCCCACC CTCTTGGCAA CTACAGAGCA GTGTGGGCAG CCCCAAGTGT 2760
GGTCCCCAGA GAGCGTTTGG CTTTCCTGTC TGTCTATCCT GAGCGGGTGG AGTCTCAGGT 2820
TGTGTGCCCC TAAATCAAGA TTTGCTTCCA CAGAAGCCAT TACTTGCAAT TTTTTTTTTT 2880
TTTCTGAGAA AGTCTCGCTG TGTCACCCAG GCTGGAGTGC AGTGGCGCAA TCTCACTGCA 2940
TCCTCCGCCT CCCGGGTTCA AGCGATTCTC CCGCCTCAGC CTCCTGAGTA GCTGGGATTA 3000
CAGGCACCCG CCGCTGCTAA TTTTTGTATT TTTAGTAGAG ATGGGGGTTT CACCATATTG 3060
GTCAGGCTGG TCTCGAACTC CTGACCTCAG GTGATCAACC CACCTTGGCC TCCCTAAATG 3120
CCGGGATTAC AGGCATGAGC CACCGCTCCC AGCCTTTGAT TTTTTAAGGT GGATTTTGGT 3180
TGTTATAAAT GGAGAAAGGT AAGAGTTCAA GTTCAACCCG TGTGTGAAAG CAAAACAATG 3240
GAAAACAGGA TTGGCTTCTT CAAAGGCTCC TCTTGTAGAA CTGCCTCTTT GAAATTTCGA 3300
GGTAATCTAC TTTGGAGACT CTGCCTGGAG AGGGTCAGTT CCTAAGTTAA AAGCATCGCT 3360
TAACCTTGGC TCCTGTGGCA TTTTACAAAG GTTTAAAGGA ATTGATTCCT CTGAAAGGGC 3420
CTGAAAATAA AAAGTCTTTA ACATACAAAG AA 3453
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR006638--Elp3/MiaB/NifB
IPR000182--GNAT_dom
IPR005910--Hist_AcTrfase_ELP3
IPR032432--Radical_SAM_C
IPR007197--rSAM
IPR023404--rSAM_horseshoe
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF04055--Radical_SAM
PF16199--Radical_SAM_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0005730--C:nucleolus
GO:0008023--C:transcription elongation factor complex
GO:0010484--F:H3 histone acetyltransferase activity
GO:0010485--F:H4 histone acetyltransferase activity
GO:0051536--F:iron-sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0008607--F:phosphorylase kinase regulator activity
GO:0007417--P:central nervous system development
GO:0043966--P:histone H3 acetylation
GO:0043967--P:histone H4 acetylation
GO:0001764--P:neuron migration
GO:0030335--P:positive regulation of cell migration
GO:0045859--P:regulation of protein kinase activity
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0002098--P:tRNA wobble uridine modification
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0170 ENSPTRP00000034434.4 Pan troglodytes 100 0.0 1132
WERAM-Chs-0193 ENSCSAP00000012007.1 Chlorocebus sabaeus 100 0.0 1132
WERAM-Poa-0172 ENSPPYP00000020704.1 Pongo abelii 100 0.0 1132
WERAM-Mam-0035 ENSMMUP00000006711.2 Macaca mulatta 100 0.0 1130
WERAM-Nol-0182 ENSNLEP00000020133.1 Nomascus leucogenys 99 0.0 1128
WERAM-Caj-0159 ENSCJAP00000028585.1 Callithrix jacchus 99 0.0 1128
WERAM-Orc-0001 ENSOCUP00000000032.3 Oryctolagus cuniculus 99 0.0 1125
WERAM-Eqc-0111 ENSECAP00000012517.1 Equus caballus 99 0.0 1121
WERAM-Ptv-0074 ENSPVAP00000007055.1 Pteropus vampyrus 99 0.0 1120
WERAM-Dan-0089 ENSDNOP00000009022.3 Dasypus novemcinctus 98 0.0 1120
WERAM-Caf-0094 ENSCAFP00000012247.3 Canis familiaris 99 0.0 1120
WERAM-Aim-0003 ENSAMEP00000000138.1 Ailuropoda melanoleuca 99 0.0 1120
WERAM-Bot-0033 ENSBTAP00000003541.4 Bos taurus 98 0.0 1118
WERAM-Mup-0009 ENSMPUP00000000960.1 Mustela putorius furo 98 0.0 1117
WERAM-Ova-0161 ENSOARP00000015996.1 Ovis aries 99 0.0 1113
WERAM-Ran-0091 ENSRNOP00000019262.6 Rattus norvegicus 97 0.0 1110
WERAM-Cap-0041 ENSCPOP00000003379.2 Cavia porcellus 99 0.0 1095
WERAM-Fec-0168 ENSFCAP00000022256.1 Felis catus 98 0.0 1093
WERAM-Tas-0072 ENSTSYP00000007200.1 Tarsius syrichta 98 0.0 1092
WERAM-Mum-0041 ENSMUSP00000022609.5 Mus musculus 93 0.0 1072
WERAM-Mod-0066 ENSMODP00000010748.1 Monodelphis domestica 95 0.0 1071
WERAM-Anc-0112 ENSACAP00000010561.3 Anolis carolinensis 92 0.0 1060
WERAM-Loa-0131 ENSLAFP00000012147.3 Loxodonta africana 97 0.0 1050
WERAM-Gaga-0154 ENSGALP00000026781.4 Gallus gallus 91 0.0 1050
WERAM-Pof-0019 ENSPFOP00000001740.2 Poecilia formosa 91 0.0 1048
WERAM-Orla-0173 ENSORLP00000020285.1 Oryzias latipes 91 0.0 1047
WERAM-Pes-0176 ENSPSIP00000020589.1 Pelodiscus sinensis 93 0.0 1047
WERAM-Asm-0096 ENSAMXP00000010004.1 Astyanax mexicanus 90 0.0 1045
WERAM-Tar-0031 ENSTRUP00000007288.1 Takifugu rubripes 90 0.0 1041
WERAM-Ten-0222 ENSTNIP00000022366.1 Tetraodon nigroviridis 89 0.0 1035
WERAM-Dar-0095 ENSDARP00000113240.2 Danio rerio 91 0.0 1031
WERAM-Leo-0166 ENSLOCP00000019667.1 Lepisosteus oculatus 91 0.0 1028
WERAM-Meg-0143 ENSMGAP00000014997.2 Meleagris gallopavo 89 0.0 1019
WERAM-Tut-0037 ENSTTRP00000002753.1 Tursiops truncatus 91 0.0 992
WERAM-Otg-0004 ENSOGAP00000000206.2 Otolemur garnettii 98 0.0 977
WERAM-Dio-0119 ENSDORP00000011706.1 Dipodomys ordii 90 0.0 971
WERAM-Mim-0112 ENSMICP00000010908.1 Microcebus murinus 99 0.0 955
WERAM-Ect-0111 ENSETEP00000012545.1 Echinops telfairi 85 0.0 950
WERAM-Drm-0040 FBpp0077129 Drosophila melanogaster 82 0.0 939
WERAM-Fia-0138 ENSFALP00000011193.1 Ficedula albicollis 84 0.0 937
WERAM-Cae-0049 ZK863.3 Caenorhabditis elegans 80 0.0 888
WERAM-Sac-0047 YPL086C Saccharomyces cerevisiae 74 0.0 856
WERAM-Scp-0012 SPAC29A4.20.1:pep Schizosaccharomyces pombe 74 0.0 853
WERAM-Art-0140 AT5G50320.1 Arabidopsis thaliana 74 0.0 849
WERAM-Scj-0040 EEB09543 Schizosaccharomyces japonicus 74 0.0 826
WERAM-Tub-0144 ENSTBEP00000015350.1 Tupaia belangeri 81 0.0 815
WERAM-Lac-0054 ENSLACP00000007746.1 Latimeria chalumnae 91 0.0 763
WERAM-Gog-0054 ENSGGOP00000004714.2 Gorilla gorilla 99 3e-180 629
WERAM-Ict-0009 ENSSTOP00000000462.2 Ictidomys tridecemlineatus 99 4e-153 538
Created Date 25-Jun-2016