WERAM Information

Tag Content
WERAM ID WERAM-Drm-0040
Ensembl Protein ID FBpp0077129
Uniprot Accession Q9VQZ6; ELP3_DROME
Genbank Protein ID NP_608834.1
Protein Name Probable elongator complex protein 3
Genbank Nucleotide ID NM_134990.3
Gene Name ELP3;CG15433
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0031604 FBtr0077439 FBpp0077129
Details
Type Family Domain Substrates AA References (PMIDs)
HAT ELP3 N-acetyltransferase H3K9 K 20626565
Status Reviewed
Classification
Type Family E-value Score Start End
HAT ELP3 2.60e-93 310.7 398 548
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).
Domain Profile
  HAT ELP3
     ELP3.txt   1 lkcrdvrtrevgiqeihhkvrpeqvelirrdyvanggwetflsyedpkqdiligllrlrkisektfrpelkgevsivrelhvygsvvpvasrdpkkfq 98 
                  ++crdvrtrevgiqeih+kvrp+++elirrdyvanggwetflsyedp+qdil+gllrlrk+s +tfrpelkge+sivrelhvygsvvpv++rdp+kfq
  FBpp0077129 398 TTCRDVRTREVGIQEIHNKVRPYEIELIRRDYVANGGWETFLSYEDPEQDILVGLLRLRKCSPDTFRPELKGECSIVRELHVYGSVVPVNARDPTKFQ 495
                  58************************************************************************************************ PP
     ELP3.txt  99 hqgfgtllleeaeriareehgsekiavisgvgtreyyrklgyeldgpymsksl 151
                  hqgfg+ll+eeaeriareehgs+k+avisgvgtr+yyrk+gy+ldgpymsks+
  FBpp0077129 496 HQGFGMLLMEEAERIAREEHGSTKLAVISGVGTRNYYRKMGYQLDGPYMSKSI 548
                  ***************************************************98 PP
Protein Sequence
(Fasta)		MKAKKKLGVG LSRQERQVLV IGEIIQELLK AHEAKKDVNL NRMKSLVASK YGLDSSPRLV 60
DIIAAVPQDA KKILLPKLRA KPIRTASGIA VVAVMCKPHR CPHINMTGNI CVYCPGGPDS 120
DFEYSTQSYT GYEPTSMRAI RSRYDPFLQT RHRVEQLKQL GHSVDKVEFI VMGGTFMCLP 180
EEYRDYFIRN LHDALSGHSS ANVAEAVRYS EKSRTKCIGI TIETRPDYCL KRHISDMLSY 240
GCTRLEIGVQ SVYEDVARDT NRGHTVRAVC ESFQLGKDAG YKIVTHMMPD LPNVDFERDI 300
EQFIEYFENP AFRSDGLKIY PTLVIRGTGL YELWKTGRYK SYPPSMLVDL VAKILALVPP 360
WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTTC RDVRTREVGI QEIHNKVRPY 420
EIELIRRDYV ANGGWETFLS YEDPEQDILV GLLRLRKCSP DTFRPELKGE CSIVRELHVY 480
GSVVPVNARD PTKFQHQGFG MLLMEEAERI AREEHGSTKL AVISGVGTRN YYRKMGYQLD 540
GPYMSKSIEE NN 552
Nucleotide Sequence
(Fasta)		CTATTGGTCG GTCGATAACC GAATCAAAAC AAGTGCTGCT AACTTCACAC GTGCAGTTTA 60
TGTGATATTC ATCAGCAAAA TGAAGGCAAA AAAGAAGTTG GGCGTGGGAT TGAGCCGCCA 120
GGAACGACAG GTGCTCGTCA TCGGGGAGAT CATTCAGGAG CTGCTGAAGG CGCACGAAGC 180
CAAAAAGGAT GTAAACCTTA ATCGGATGAA ATCATTGGTG GCCTCCAAAT ATGGACTGGA 240
CAGTTCGCCG CGCCTGGTCG ACATAATTGC TGCCGTGCCG CAGGACGCCA AAAAAATTCT 300
GCTTCCAAAG CTGAGGGCAA AGCCCATTCG CACAGCAAGT GGCATCGCCG TGGTCGCCGT 360
CATGTGCAAG CCGCATCGTT GTCCGCACAT CAATATGACC GGCAATATAT GCGTCTATTG 420
TCCCGGCGGA CCGGACAGCG ACTTTGAGTA CTCGACACAG TCGTACACAG GCTACGAGCC 480
GACCTCGATG CGAGCCATCC GGTCGCGGTA CGATCCTTTT CTTCAGACCC GACACCGCGT 540
TGAACAGCTG AAGCAGCTGG GACACAGTGT GGACAAGGTG GAGTTCATCG TAATGGGCGG 600
TACGTTCATG TGCCTGCCGG AGGAGTACCG CGACTACTTT ATCCGCAACC TACACGACGC 660
CCTCTCCGGC CACAGCAGCG CCAATGTGGC GGAAGCCGTA CGCTACTCGG AGAAGTCACG 720
CACAAAGTGC ATTGGCATCA CCATAGAAAC AAGGCCAGAT TACTGCCTAA AGCGGCACAT 780
ATCGGATATG CTTAGCTATG GTTGCACCCG GCTGGAAATC GGTGTGCAAT CGGTTTACGA 840
AGACGTGGCC AGGGATACGA ACCGCGGACA CACGGTGCGA GCGGTGTGCG AGAGCTTCCA 900
GCTGGGCAAG GATGCTGGCT ATAAGATCGT GACGCACATG ATGCCTGATC TTCCCAATGT 960
TGACTTTGAA CGCGACATCG AGCAGTTTAT CGAGTACTTT GAGAACCCTG CCTTCCGCTC 1020
TGACGGCCTA AAGATCTATC CCACGCTCGT CATTCGCGGC ACTGGTCTCT ACGAGTTATG 1080
GAAAACCGGG CGATATAAGT CATATCCGCC ATCCATGCTT GTGGACTTAG TGGCGAAGAT 1140
TTTGGCCCTT GTACCACCAT GGACGCGAGT GTACCGCGTA CAGCGCGACA TTCCCATGCC 1200
GCTTGTTAGT TCCGGCGTGG AACACGGAAA TCTCCGTGAA CTGGCGCTGG CCCGCATGAA 1260
GGATCTTGGA ACCACTTGCC GCGATGTTAG AACCCGCGAA GTTGGCATTC AGGAAATCCA 1320
CAACAAGGTG CGCCCTTACG AAATTGAGCT AATTCGTCGG GACTATGTGG CCAATGGCGG 1380
CTGGGAAACG TTCCTCTCAT ACGAAGATCC TGAACAGGAC ATTCTCGTAG GCCTTCTTAG 1440
GCTGCGAAAG TGCTCACCGG ATACCTTCCG CCCGGAACTG AAGGGCGAAT GCTCCATTGT 1500
GAGGGAGCTG CACGTATATG GCTCAGTCGT GCCGGTTAAT GCTAGGGATC CCACCAAGTT 1560
TCAGCACCAG GGCTTCGGTA TGTTGCTGAT GGAGGAGGCG GAGCGAATTG CTCGAGAGGA 1620
GCACGGCAGC ACAAAACTGG CGGTCATATC GGGAGTGGGC ACCAGAAACT ACTATCGCAA 1680
AATGGGATAC CAACTTGACG GACCCTACAT GTCAAAGAGC ATAGAAGAAA ATAACTAGGT 1740
ATAGCGTTAA ATGACTGTCT TGGTGGTATG TTGGAGGATT AAATATTTGT ATTTTATCAC 1800
GCTAGGAGCA GTAAGATTTC GCTACTTAAA ACTACTCTCT TAAATATATA CATTAATATA 1860
TAG 1864
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR006638--Elp3/MiaB/NifB
IPR000182--GNAT_dom
IPR005910--Hist_AcTrfase_ELP3
IPR032432--Radical_SAM_C
IPR007197--rSAM
IPR023404--rSAM_horseshoe
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF04055--Radical_SAM
PF16199--Radical_SAM_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0008023--C:transcription elongation factor complex
GO:0016407--F:acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0051536--F:iron-sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0008607--F:phosphorylase kinase regulator activity
GO:0048789--P:cytoskeletal matrix organization at active zone
GO:0030097--P:hemopoiesis
GO:0016573--P:histone acetylation
GO:0002168--P:instar larval development
GO:0007626--P:locomotory behavior
GO:0018394--P:peptidyl-lysine acetylation
GO:2000289--P:regulation of photoreceptor cell axon guidance
GO:0045859--P:regulation of protein kinase activity
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0019233--P:sensory perception of pain
GO:0030431--P:sleep
GO:0050808--P:synapse organization
GO:0051124--P:synaptic growth at neuromuscular junction
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pof-0019 ENSPFOP00000001740.2 Poecilia formosa 84 0.0 987
WERAM-Tar-0031 ENSTRUP00000007288.1 Takifugu rubripes 84 0.0 979
WERAM-Orla-0173 ENSORLP00000020285.1 Oryzias latipes 84 0.0 978
WERAM-Anc-0112 ENSACAP00000010561.3 Anolis carolinensis 84 0.0 977
WERAM-Asm-0096 ENSAMXP00000010004.1 Astyanax mexicanus 83 0.0 975
WERAM-Ten-0222 ENSTNIP00000022366.1 Tetraodon nigroviridis 83 0.0 974
WERAM-Gaga-0154 ENSGALP00000026781.4 Gallus gallus 84 0.0 974
WERAM-Dar-0095 ENSDARP00000113240.2 Danio rerio 85 0.0 974
WERAM-Pes-0176 ENSPSIP00000020589.1 Pelodiscus sinensis 84 0.0 970
WERAM-Mod-0066 ENSMODP00000010748.1 Monodelphis domestica 84 0.0 966
WERAM-Ran-0091 ENSRNOP00000019262.6 Rattus norvegicus 82 0.0 959
WERAM-Leo-0166 ENSLOCP00000019667.1 Lepisosteus oculatus 83 0.0 956
WERAM-Meg-0143 ENSMGAP00000014997.2 Meleagris gallopavo 82 0.0 948
WERAM-Caj-0159 ENSCJAP00000028585.1 Callithrix jacchus 83 0.0 941
WERAM-Mup-0009 ENSMPUP00000000960.1 Mustela putorius furo 82 0.0 941
WERAM-Nol-0182 ENSNLEP00000020133.1 Nomascus leucogenys 83 0.0 941
WERAM-Hos-0126 ENSP00000256398.8 Homo sapiens 82 0.0 940
WERAM-Pat-0170 ENSPTRP00000034434.4 Pan troglodytes 82 0.0 940
WERAM-Chs-0193 ENSCSAP00000012007.1 Chlorocebus sabaeus 82 0.0 940
WERAM-Poa-0172 ENSPPYP00000020704.1 Pongo abelii 82 0.0 940
WERAM-Eqc-0111 ENSECAP00000012517.1 Equus caballus 82 0.0 940
WERAM-Mam-0035 ENSMMUP00000006711.2 Macaca mulatta 82 0.0 939
WERAM-Aim-0003 ENSAMEP00000000138.1 Ailuropoda melanoleuca 82 0.0 938
WERAM-Ova-0161 ENSOARP00000015996.1 Ovis aries 82 0.0 938
WERAM-Bot-0033 ENSBTAP00000003541.4 Bos taurus 82 0.0 938
WERAM-Ptv-0074 ENSPVAP00000007055.1 Pteropus vampyrus 82 0.0 937
WERAM-Orc-0001 ENSOCUP00000000032.3 Oryctolagus cuniculus 82 0.0 937
WERAM-Mum-0041 ENSMUSP00000022609.5 Mus musculus 83 0.0 937
WERAM-Dan-0089 ENSDNOP00000009022.3 Dasypus novemcinctus 82 0.0 936
WERAM-Caf-0094 ENSCAFP00000012247.3 Canis familiaris 82 0.0 936
WERAM-Cap-0041 ENSCPOP00000003379.2 Cavia porcellus 82 0.0 931
WERAM-Fec-0168 ENSFCAP00000022256.1 Felis catus 81 0.0 930
WERAM-Tas-0072 ENSTSYP00000007200.1 Tarsius syrichta 83 0.0 929
WERAM-Loa-0131 ENSLAFP00000012147.3 Loxodonta africana 82 0.0 908
WERAM-Fia-0138 ENSFALP00000011193.1 Ficedula albicollis 80 0.0 889
WERAM-Cae-0049 ZK863.3 Caenorhabditis elegans 80 0.0 885
WERAM-Mim-0112 ENSMICP00000010908.1 Microcebus murinus 87 0.0 858
WERAM-Scp-0012 SPAC29A4.20.1:pep Schizosaccharomyces pombe 75 0.0 857
WERAM-Otg-0004 ENSOGAP00000000206.2 Otolemur garnettii 86 0.0 857
WERAM-Art-0140 AT5G50320.1 Arabidopsis thaliana 73 0.0 848
WERAM-Dio-0119 ENSDORP00000011706.1 Dipodomys ordii 77 0.0 847
WERAM-Tut-0037 ENSTTRP00000002753.1 Tursiops truncatus 77 0.0 846
WERAM-Sac-0047 YPL086C Saccharomyces cerevisiae 74 0.0 845
WERAM-Scj-0040 EEB09543 Schizosaccharomyces japonicus 74 0.0 839
WERAM-Ect-0111 ENSETEP00000012545.1 Echinops telfairi 71 0.0 811
WERAM-Lac-0054 ENSLACP00000007746.1 Latimeria chalumnae 83 0.0 701
WERAM-Tub-0144 ENSTBEP00000015350.1 Tupaia belangeri 66 0.0 675
WERAM-Gog-0054 ENSGGOP00000004714.2 Gorilla gorilla 80 6e-147 518
WERAM-Ict-0009 ENSSTOP00000000462.2 Ictidomys tridecemlineatus 86 4e-127 452
Created Date 25-Jun-2016