WERAM Information

Tag Content
WERAM ID WERAM-Cae-0049
Ensembl Protein ID ZK863.3
Uniprot Accession Q23651; ELP3_CAEEL
Genbank Protein ID NP_506055.2
Protein Name Probable elongator complex protein 3
Genbank Nucleotide ID NM_073654.4
Gene Name ELPC-3;ZK863.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00014123 ZK863.3 ZK863.3
Details
Type Family Domain Substrates AA References (PMIDs)
HAT ELP3 N-acetyltransferase K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HAT ELP3 3.50e-93 310.3 392 542
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).
Domain Profile
  HAT ELP3
  ELP3.txt   1 lkcrdvrtrevgiqeihhkvrpeqvelirrdyvanggwetflsyedpkqdiligllrlrkisektfrpelkgevsivrelhvygsvvpvasrdpkkfqhqg 101
               lkcrdvrtrevgiqeih+kvrpe+velirrdy+anggwetf+syedpkqdiligllrlrkis+k++rpelkg+vs+vrelhvygsvv+va+rdpkkfqhqg
   ZK863.3 392 LKCRDVRTREVGIQEIHNKVRPEDVELIRRDYTANGGWETFISYEDPKQDILIGLLRLRKISDKAHRPELKGNVSVVRELHVYGSVVSVADRDPKKFQHQG 492
               59*************************************************************************************************** PP
  ELP3.txt 102 fgtllleeaeriareehgsekiavisgvgtreyyrklgyeldgpymsksl 151
               +g+ll+eeaeriareehgs+kiavisgvgtreyyrklgyeldgpymsk+l
   ZK863.3 493 YGSLLMEEAERIAREEHGSDKIAVISGVGTREYYRKLGYELDGPYMSKML 542
               ************************************************98 PP
Protein Sequence
(Fasta)		MDQKGSQRAL LAQTINEIVK LLIEAHNQKK DVNLNRLKCI VAQKNGLSFQ PKLVDIIAGV 60
PSDYKDSLLP KLKAKPVRTA SGIAVVAVMS KPHRCPHINF TGNICVYCPG GPDSDFEYST 120
QSYTGYEPTS MRAIRARYNP YLQTRGRLNQ LMQLGHSVDK VEFIVMGGTF MSLPEDYRDF 180
FIRNLHDALS GHTSASVEEA VAYSERSKMK CIGITIETRP DYCLPRHLND MLLYGCTRLE 240
IGVQSTYEDV ARDTNRGHTV KSVCETFHMA KDTGYKVVIH MMPDLPNVGL ERDKEQFLEL 300
FESPAFRPDG LKLYPTLVIR GTGLYELWKT GRYQSYPPSV LVDLIATILS LVPPWTRVYR 360
VQRDIPMPLV SSGVEHGNLR EHAMAKMKEL GLKCRDVRTR EVGIQEIHNK VRPEDVELIR 420
RDYTANGGWE TFISYEDPKQ DILIGLLRLR KISDKAHRPE LKGNVSVVRE LHVYGSVVSV 480
ADRDPKKFQH QGYGSLLMEE AERIAREEHG SDKIAVISGV GTREYYRKLG YELDGPYMSK 540
MLDSAAA 547
Nucleotide Sequence
(Fasta)		ATGGATCAGA AGGGTTCACA AAGAGCACTA CTGGCACAAA CAATAAATGA AATTGTCAAG 60
CTTCTTATTG AAGCTCACAA TCAAAAAAAG GATGTCAACT TGAATCGGCT GAAATGCATC 120
GTTGCTCAAA AGAATGGACT GAGTTTTCAA CCGAAACTCG TTGACATTAT CGCTGGAGTT 180
CCGTCCGATT ACAAAGACAG CCTTCTTCCA AAACTCAAGG CAAAACCAGT TCGAACTGCT 240
TCTGGAATTG CTGTTGTAGC AGTGATGAGC AAACCACATC GTTGTCCTCA CATCAATTTC 300
ACTGGAAACA TTTGTGTCTA TTGTCCCGGT GGGCCAGATT CTGATTTCGA GTATTCAACA 360
CAAAGTTACA CCGGTTATGA GCCTACAAGT ATGCGTGCAA TTCGTGCTAG ATATAACCCT 420
TATTTGCAAA CTCGTGGAAG ACTCAATCAA TTGATGCAAC TCGGACACTC AGTTGATAAA 480
GTTGAATTCA TCGTAATGGG AGGAACATTT ATGTCGCTGC CTGAAGATTA TCGAGACTTT 540
TTCATTCGAA ATCTACATGA TGCACTGAGT GGACATACAT CAGCGTCAGT TGAAGAAGCA 600
GTAGCTTATT CTGAAAGGTC TAAAATGAAA TGTATTGGAA TCACTATTGA AACTCGTCCT 660
GATTATTGTC TACCCCGTCA TCTGAACGAT ATGCTTCTCT ATGGATGTAC AAGACTAGAA 720
ATCGGTGTCC AGTCGACCTA CGAAGATGTT GCACGTGATA CGAATAGAGG TCATACTGTA 780
AAATCGGTGT GCGAGACATT TCACATGGCA AAGGATACTG GATACAAAGT TGTCATTCAC 840
ATGATGCCAG ATCTCCCTAA TGTTGGTCTA GAACGAGACA AGGAACAATT TCTGGAACTT 900
TTTGAAAGTC CAGCCTTCCG ACCTGACGGT CTGAAGCTGT ACCCAACATT GGTCATTCGT 960
GGAACAGGAC TATATGAGTT GTGGAAAACT GGAAGATATC AAAGTTATCC ACCATCAGTT 1020
CTTGTTGATT TGATTGCTAC TATCTTATCA TTAGTTCCGC CATGGACACG TGTGTATCGA 1080
GTGCAAAGAG ATATCCCCAT GCCATTAGTA TCTTCAGGCG TTGAACATGG AAATCTTCGT 1140
GAACATGCGA TGGCAAAAAT GAAAGAACTC GGTTTGAAAT GTCGAGACGT TCGAACGAGA 1200
GAAGTTGGAA TTCAAGAGAT TCATAATAAA GTTCGTCCTG AAGATGTGGA GCTCATTAGG 1260
CGAGATTACA CAGCAAATGG TGGTTGGGAG ACGTTTATCT CTTATGAGGA TCCGAAACAA 1320
GACATTCTTA TTGGACTTCT TCGATTGAGA AAAATTTCAG ATAAAGCCCA TCGGCCAGAG 1380
TTGAAGGGTA ATGTGTCAGT GGTTCGCGAG TTGCATGTAT ACGGATCCGT CGTTTCGGTA 1440
GCGGATCGTG ATCCCAAGAA GTTCCAGCAT CAAGGATACG GTTCACTTTT GATGGAAGAA 1500
GCTGAAAGGA TAGCCAGAGA AGAACATGGA TCCGATAAAA TCGCAGTCAT CTCGGGCGTT 1560
GGAACTCGAG AGTACTACCG TAAACTTGGA TACGAGCTGG ATGGTCCTTA TATGAGCAAG 1620
ATGCTCGACT CTGCTGCAGC TTAATTTTTC ATTACTGTTC TTGTTATTAA TGTTTTTTGT 1680
TGGTTCGGTA TTTTTCGTTT TTCATCATAA AACAATGTTT TTTTG 1726
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR006638--Elp3/MiaB/NifB
IPR000182--GNAT_dom
IPR005910--Hist_AcTrfase_ELP3
IPR032432--Radical_SAM_C
IPR007197--rSAM
IPR023404--rSAM_horseshoe
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF04055--Radical_SAM
PF16199--Radical_SAM_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0008023--C:transcription elongation factor complex
GO:0004402--F:histone acetyltransferase activity
GO:0051536--F:iron-sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0008607--F:phosphorylase kinase regulator activity
GO:0048598--P:embryonic morphogenesis
GO:0008355--P:olfactory learning
GO:0048599--P:oocyte development
GO:0045859--P:regulation of protein kinase activity
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
GO:0006412--P:translation
GO:0002098--P:tRNA wobble uridine modification
GO:0040025--P:vulval development
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gaga-0154 ENSGALP00000026781.4 Gallus gallus 81 0.0 923
WERAM-Anc-0112 ENSACAP00000010561.3 Anolis carolinensis 81 0.0 922
WERAM-Pes-0176 ENSPSIP00000020589.1 Pelodiscus sinensis 81 0.0 920
WERAM-Asm-0096 ENSAMXP00000010004.1 Astyanax mexicanus 80 0.0 919
WERAM-Orla-0173 ENSORLP00000020285.1 Oryzias latipes 80 0.0 915
WERAM-Tar-0031 ENSTRUP00000007288.1 Takifugu rubripes 80 0.0 915
WERAM-Mod-0066 ENSMODP00000010748.1 Monodelphis domestica 80 0.0 914
WERAM-Dar-0095 ENSDARP00000113240.2 Danio rerio 80 0.0 914
WERAM-Pof-0019 ENSPFOP00000001740.2 Poecilia formosa 79 0.0 911
WERAM-Ten-0222 ENSTNIP00000022366.1 Tetraodon nigroviridis 79 0.0 909
WERAM-Ran-0091 ENSRNOP00000019262.6 Rattus norvegicus 80 0.0 906
WERAM-Leo-0166 ENSLOCP00000019667.1 Lepisosteus oculatus 80 0.0 900
WERAM-Meg-0143 ENSMGAP00000014997.2 Meleagris gallopavo 79 0.0 895
WERAM-Caj-0159 ENSCJAP00000028585.1 Callithrix jacchus 80 0.0 889
WERAM-Hos-0126 ENSP00000256398.8 Homo sapiens 80 0.0 888
WERAM-Pat-0170 ENSPTRP00000034434.4 Pan troglodytes 80 0.0 888
WERAM-Chs-0193 ENSCSAP00000012007.1 Chlorocebus sabaeus 80 0.0 888
WERAM-Poa-0172 ENSPPYP00000020704.1 Pongo abelii 80 0.0 888
WERAM-Mam-0035 ENSMMUP00000006711.2 Macaca mulatta 80 0.0 887
WERAM-Nol-0182 ENSNLEP00000020133.1 Nomascus leucogenys 80 0.0 887
WERAM-Orc-0001 ENSOCUP00000000032.3 Oryctolagus cuniculus 80 0.0 886
WERAM-Eqc-0111 ENSECAP00000012517.1 Equus caballus 80 0.0 886
WERAM-Bot-0033 ENSBTAP00000003541.4 Bos taurus 80 0.0 886
WERAM-Drm-0040 FBpp0077129 Drosophila melanogaster 80 0.0 885
WERAM-Aim-0003 ENSAMEP00000000138.1 Ailuropoda melanoleuca 80 0.0 885
WERAM-Ptv-0074 ENSPVAP00000007055.1 Pteropus vampyrus 80 0.0 885
WERAM-Mup-0009 ENSMPUP00000000960.1 Mustela putorius furo 80 0.0 885
WERAM-Dan-0089 ENSDNOP00000009022.3 Dasypus novemcinctus 80 0.0 884
WERAM-Caf-0094 ENSCAFP00000012247.3 Canis familiaris 80 0.0 884
WERAM-Ova-0161 ENSOARP00000015996.1 Ovis aries 80 0.0 882
WERAM-Cap-0041 ENSCPOP00000003379.2 Cavia porcellus 80 0.0 881
WERAM-Mum-0041 ENSMUSP00000022609.5 Mus musculus 79 0.0 880
WERAM-Fec-0168 ENSFCAP00000022256.1 Felis catus 80 0.0 880
WERAM-Tas-0072 ENSTSYP00000007200.1 Tarsius syrichta 80 0.0 879
WERAM-Loa-0131 ENSLAFP00000012147.3 Loxodonta africana 79 0.0 851
WERAM-Art-0140 AT5G50320.1 Arabidopsis thaliana 75 0.0 847
WERAM-Scp-0012 SPAC29A4.20.1:pep Schizosaccharomyces pombe 74 0.0 844
WERAM-Fia-0138 ENSFALP00000011193.1 Ficedula albicollis 76 0.0 823
WERAM-Scj-0040 EEB09543 Schizosaccharomyces japonicus 74 0.0 821
WERAM-Otg-0004 ENSOGAP00000000206.2 Otolemur garnettii 83 0.0 817
WERAM-Mim-0112 ENSMICP00000010908.1 Microcebus murinus 83 0.0 817
WERAM-Sac-0047 YPL086C Saccharomyces cerevisiae 75 0.0 812
WERAM-Dio-0119 ENSDORP00000011706.1 Dipodomys ordii 74 0.0 803
WERAM-Tut-0037 ENSTTRP00000002753.1 Tursiops truncatus 74 0.0 791
WERAM-Ect-0111 ENSETEP00000012545.1 Echinops telfairi 70 0.0 766
WERAM-Lac-0054 ENSLACP00000007746.1 Latimeria chalumnae 80 0.0 668
WERAM-Tub-0144 ENSTBEP00000015350.1 Tupaia belangeri 65 0.0 642
WERAM-Gog-0054 ENSGGOP00000004714.2 Gorilla gorilla 79 5e-140 495
WERAM-Ict-0009 ENSSTOP00000000462.2 Ictidomys tridecemlineatus 82 3e-119 426
Created Date 25-Jun-2016