WERAM Information

Tag Content
WERAM ID WERAM-Art-0140
Ensembl Protein ID AT5G50320.1
Uniprot Accession Q93ZR1; ELP3_ARATH; Q9FK40
Genbank Protein ID NP_568725.1
Protein Name Elongator complex protein 3
Genbank Nucleotide ID NM_124412.2
Gene Name HAG3;ELP3;EAST1;ELO3;At5g50320;MXI22.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G50320 AT5G50320.1 AT5G50320.1
Details
Type Family Domain Substrates AA References (PMIDs)
HAT ELP3 N-acetyltransferase K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HAT ELP3 7.20e-90 299.7 414 564
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Histone acetyltransferase component of the large multiprotein complex Elongator that is involved in the regulation of transcription initiation and elongation (PubMed:20080602). May also have a methyltransferase activity (PubMed:20080602). Promotes organs development by modulating cell division rate (PubMed:20080602). Required for auxin distribution or signaling (PubMed:20080602). Required for meristem cell cycle activation at the time of germination (PubMed:23969312). Probably required for DNA replication-coupled histone acetylation (PubMed:22026817). Involved in tRNA wobble uridine modification (PubMed:20398216). Mediates the establishment of leaf polarity independently of AS2 and the ta-siRNA-related pathway (PubMed:21700721). Potential a-tubulin acetyltransferase (PubMed:22404109). Negatively regulates the expression of genes that participate in UV-B responses, such as DNA repair enzymes and enzymes that participate in sunscreen pigment biosynthesis (PubMed:25907565).
Domain Profile
  HAT ELP3
     ELP3.txt   1 lkcrdvrtrevgiqeihhkvrpeqvelirrdyvanggwetflsyedpkqdiligllrlrkisektfrpelkgevsivrelhvygsvvpvasrdpkkfq 98 
                  lkcrdvrtre+giq+ihhk++peqvel+rrdy+an+gwetflsyed++qdil+gllrlrk+++++++pel+g++s+vrelhvyg++vpv++rd++k+q
  AT5G50320.1 414 LKCRDVRTREAGIQDIHHKIKPEQVELVRRDYTANEGWETFLSYEDTRQDILVGLLRLRKCGKNVTCPELMGKCSVVRELHVYGTAVPVHGRDADKLQ 511
                  59************************************************************************************************ PP
     ELP3.txt  99 hqgfgtllleeaeriareehgsekiavisgvgtreyyrklgyeldgpymsksl 151
                  hqg+gtll+eeaeriar+eh+s+ki+visgvgtr+yyrklgyel+gpym+k+l
  AT5G50320.1 512 HQGYGTLLMEEAERIARREHRSNKIGVISGVGTRHYYRKLGYELEGPYMVKHL 564
                  ***************************************************97 PP
Protein Sequence
(Fasta)		MATAVVMNGE LKKQPRPGKG GYQGRGLTEE EARVRAISEI VSTMIERSHR NENVDLNAIK 60
TAACRKYGLA RAPKLVEMIA ALPDSERETL LPKLRAKPVR TASGIAVVAV MSKPHRCPHI 120
ATTGNICVYC PGGPDSDFEY STQSYTGYEP TSMRAIRARY NPYVQARSRI DQLKRLGHSV 180
DKVEFILMGG TFMSLPAEYR DFFIRNLHDA LSGHTSANVE EAVAYSEHSA TKCIGMTIET 240
RPDYCLGPHL RQMLIYGCTR LEIGVQSTYE DVARDTNRGH TVAAVADCFC LAKDAGFKVV 300
AHMMPDLPNV GVERDMESFK EFFESPSFRA DGLKIYPTLV IRGTGLYELW KTGRYRNYPP 360
EQLVDIVARI LSMVPPWTRV YRVQRDIPMP LVTSGVEKGN LRELALARMD DLGLKCRDVR 420
TREAGIQDIH HKIKPEQVEL VRRDYTANEG WETFLSYEDT RQDILVGLLR LRKCGKNVTC 480
PELMGKCSVV RELHVYGTAV PVHGRDADKL QHQGYGTLLM EEAERIARRE HRSNKIGVIS 540
GVGTRHYYRK LGYELEGPYM VKHLL 565
Nucleotide Sequence
(Fasta)		GCTATTTTCC CGTAATTTTG GTCTGAGGTT TTGGTGACGA TGGCGACGGC GGTAGTGATG 60
AACGGCGAGC TGAAAAAGCA ACCTCGGCCA GGTAAAGGCG GCTATCAGGG CCGTGGATTA 120
ACTGAAGAAG AAGCTCGAGT TCGCGCCATA TCGGAGATTG TTAGCACCAT GATTGAGCGT 180
TCACACCGCA ACGAGAATGT TGACCTAAAC GCAATTAAAA CCGCCGCTTG CCGGAAATAC 240
GGCCTAGCAC GTGCGCCTAA GCTCGTGGAG ATGATTGCTG CGCTTCCTGA TTCAGAGAGA 300
GAGACTCTTC TCCCGAAGCT CCGTGCCAAA CCGGTTCGAA CAGCTTCAGG GATCGCCGTT 360
GTGGCGGTTA TGTCGAAGCC TCATAGGTGC CCGCATATAG CTACGACGGG GAATATATGC 420
GTTTATTGTC CCGGTGGACC TGACTCTGAC TTTGAGTATA GTACTCAGTC TTACACTGGA 480
TATGAGCCTA CCAGCATGCG AGCTATTCGA GCCAGGTACA ATCCATATGT TCAGGCAAGA 540
AGCAGGATAG ATCAGCTGAA GCGGTTGGGT CACAGTGTAG ATAAGGTTGA GTTCATTTTG 600
ATGGGAGGTA CTTTCATGTC ACTGCCTGCT GAGTATCGGG ATTTCTTCAT ACGGAATCTT 660
CATGATGCTT TATCAGGACA CACTTCTGCC AACGTTGAAG AGGCAGTTGC TTACTCTGAA 720
CATAGTGCAA CTAAATGCAT TGGGATGACA ATTGAAACGA GGCCAGATTA CTGCCTTGGA 780
CCTCATTTAC GACAAATGCT GATTTACGGT TGCACCCGGC TAGAGATAGG TGTCCAGAGC 840
ACATATGAAG ATGTTGCCCG TGACACAAAT AGAGGTCATA CTGTTGCTGC TGTAGCTGAC 900
TGCTTCTGCT TGGCTAAAGA TGCTGGTTTC AAGGTGGTTG CACATATGAT GCCTGATCTT 960
CCTAATGTTG GGGTTGAGAG AGACATGGAA AGTTTCAAGG AGTTTTTCGA GAGCCCATCT 1020
TTTAGAGCAG ATGGGTTAAA AATATATCCC ACCCTTGTGA TCCGTGGAAC TGGACTTTAT 1080
GAACTATGGA AAACTGGGAG GTACCGAAAT TATCCACCTG AGCAGCTTGT GGATATAGTT 1140
GCAAGGATTC TCTCCATGGT ACCTCCATGG ACACGTGTAT ATAGAGTTCA GCGTGATATT 1200
CCTATGCCTC TGGTTACGTC AGGGGTAGAA AAAGGAAATC TTCGTGAACT GGCTCTAGCC 1260
AGAATGGATG ACTTGGGCCT TAAATGCCGT GATGTCCGTA CTCGTGAAGC TGGAATTCAG 1320
GACATTCATC ATAAAATTAA GCCAGAACAA GTAGAGCTTG TGCGTCGTGA TTACACTGCC 1380
AATGAAGGTT GGGAGACGTT CCTTTCTTAT GAAGATACAC GCCAGGACAT TCTTGTTGGA 1440
TTGCTACGTT TGCGAAAATG CGGGAAGAAT GTAACGTGTC CAGAACTCAT GGGAAAGTGT 1500
TCTGTTGTCC GTGAGCTTCA TGTATACGGA ACAGCTGTAC CAGTTCATGG TCGAGATGCT 1560
GATAAGTTGC AACATCAGGG CTATGGTACA CTTCTGATGG AAGAAGCAGA GAGGATTGCT 1620
AGAAGAGAAC ATCGATCTAA CAAAATCGGT GTGATTTCTG GTGTAGGAAC CAGACATTAC 1680
TACAGAAAGT TGGGTTATGA ATTGGAAGGT CCTTACATGG TGAAGCATCT TCTTTGAAAT 1740
TATGTTTACT TAAAAACCAA ATTCGTAAAA TCTTTATGTT GAACTAGTGA GATTAATCCC 1800
TTGTGGTATC ATTTTGCTCT TTAAATTTTC ATAGTCAAAA AGTTGAGAAA ACGGCTAATT 1860
CCTTCACGAA CTATGGCGAT TTTGTAAGAT TAATCTGTAA TGCGTACACA TGTTGCTAAG 1920
TTTTACAGAA TTTTGCATCC AAAAACGCCT GAACTAAAAT CATCATTCAT CACTTCCACT 1980
TGTAAGCAAA AGATGTTCAC ATCATCTAAA ATAAACCTTC GAAAACTACA AATTAACCGA 2040
AGATTGACTT GGCTCTTCGT TGTAGTCTAG ATCCATGAAC TCAAATCCTT CATCTGATGT 2100
GTTCCGATTC TTCGGTCTTA TATACTCCAC CCCAACATTA CCACACTTCC TCGTATTGTG 2160
TCCAATTACA CCACATCTGC CACAACGAAC AATCCTTCCC TCTCTCGTAA CTTTGGTTAC 2220
CTTCACTGGA GGAGACTCTT GCACTTCCTT TTTCCTTTTA GGATTCTTAC TTCTCTCCTC 2280
ATGAAACTCC ACAGAAGAAT CAGGGCTTGA G 2312
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0927--Auxin signaling pathway
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0819--tRNA processing
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR006638--Elp3/MiaB/NifB
IPR000182--GNAT_dom
IPR005910--Hist_AcTrfase_ELP3
IPR032432--Radical_SAM_C
IPR007197--rSAM
IPR023404--rSAM_horseshoe
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF04055--Radical_SAM
PF16199--Radical_SAM_C
Gene Ontology

GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0000123--C:histone acetyltransferase complex
GO:0005719--C:nuclear euchromatin
GO:0005634--C:nucleus
GO:0008023--C:transcription elongation factor complex
GO:0004402--F:histone acetyltransferase activity
GO:0051536--F:iron-sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0009734--P:auxin-activated signaling pathway
GO:0008283--P:cell proliferation
GO:0009294--P:DNA mediated transformation
GO:0016573--P:histone acetylation
GO:0035265--P:organ growth
GO:0010928--P:regulation of auxin mediated signaling pathway
GO:2000025--P:regulation of leaf formation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0010084--P:specification of organ axis polarity
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0002098--P:tRNA wobble uridine modification
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gaga-0154 ENSGALP00000026781.4 Gallus gallus 74 0.0 808
WERAM-Tar-0031 ENSTRUP00000007288.1 Takifugu rubripes 74 0.0 804
WERAM-Pof-0019 ENSPFOP00000001740.2 Poecilia formosa 74 0.0 804
WERAM-Anc-0112 ENSACAP00000010561.3 Anolis carolinensis 74 0.0 804
WERAM-Pes-0176 ENSPSIP00000020589.1 Pelodiscus sinensis 75 0.0 803
WERAM-Leo-0166 ENSLOCP00000019667.1 Lepisosteus oculatus 74 0.0 803
WERAM-Mod-0066 ENSMODP00000010748.1 Monodelphis domestica 74 0.0 802
WERAM-Drm-0040 FBpp0077129 Drosophila melanogaster 73 0.0 802
WERAM-Dar-0095 ENSDARP00000113240.2 Danio rerio 75 0.0 801
WERAM-Eqc-0111 ENSECAP00000012517.1 Equus caballus 74 0.0 801
WERAM-Ten-0222 ENSTNIP00000022366.1 Tetraodon nigroviridis 74 0.0 801
WERAM-Hos-0126 ENSP00000256398.8 Homo sapiens 74 0.0 801
WERAM-Asm-0096 ENSAMXP00000010004.1 Astyanax mexicanus 74 0.0 801
WERAM-Aim-0003 ENSAMEP00000000138.1 Ailuropoda melanoleuca 74 0.0 801
WERAM-Ptv-0074 ENSPVAP00000007055.1 Pteropus vampyrus 74 0.0 801
WERAM-Pat-0170 ENSPTRP00000034434.4 Pan troglodytes 74 0.0 801
WERAM-Chs-0193 ENSCSAP00000012007.1 Chlorocebus sabaeus 74 0.0 801
WERAM-Caj-0159 ENSCJAP00000028585.1 Callithrix jacchus 74 0.0 801
WERAM-Mup-0009 ENSMPUP00000000960.1 Mustela putorius furo 74 0.0 800
WERAM-Cae-0049 ZK863.3 Caenorhabditis elegans 75 0.0 800
WERAM-Poa-0172 ENSPPYP00000020704.1 Pongo abelii 74 0.0 800
WERAM-Bot-0033 ENSBTAP00000003541.4 Bos taurus 74 0.0 800
WERAM-Orla-0173 ENSORLP00000020285.1 Oryzias latipes 73 0.0 800
WERAM-Caf-0094 ENSCAFP00000012247.3 Canis familiaris 74 0.0 799
WERAM-Mam-0035 ENSMMUP00000006711.2 Macaca mulatta 74 0.0 799
WERAM-Ran-0091 ENSRNOP00000019262.6 Rattus norvegicus 73 0.0 799
WERAM-Orc-0001 ENSOCUP00000000032.3 Oryctolagus cuniculus 74 0.0 798
WERAM-Dan-0089 ENSDNOP00000009022.3 Dasypus novemcinctus 73 0.0 798
WERAM-Ova-0161 ENSOARP00000015996.1 Ovis aries 74 0.0 798
WERAM-Nol-0182 ENSNLEP00000020133.1 Nomascus leucogenys 74 0.0 797
WERAM-Fec-0168 ENSFCAP00000022256.1 Felis catus 74 0.0 795
WERAM-Mum-0041 ENSMUSP00000022609.5 Mus musculus 71 0.0 793
WERAM-Cap-0041 ENSCPOP00000003379.2 Cavia porcellus 73 0.0 793
WERAM-Tas-0072 ENSTSYP00000007200.1 Tarsius syrichta 73 0.0 790
WERAM-Meg-0143 ENSMGAP00000014997.2 Meleagris gallopavo 72 0.0 787
WERAM-Loa-0131 ENSLAFP00000012147.3 Loxodonta africana 73 0.0 775
WERAM-Scj-0040 EEB09543 Schizosaccharomyces japonicus 71 0.0 769
WERAM-Scp-0012 SPAC29A4.20.1:pep Schizosaccharomyces pombe 71 0.0 769
WERAM-Otg-0004 ENSOGAP00000000206.2 Otolemur garnettii 79 0.0 750
WERAM-Sac-0047 YPL086C Saccharomyces cerevisiae 69 0.0 749
WERAM-Fia-0138 ENSFALP00000011193.1 Ficedula albicollis 68 0.0 746
WERAM-Mim-0112 ENSMICP00000010908.1 Microcebus murinus 79 0.0 728
WERAM-Tut-0037 ENSTTRP00000002753.1 Tursiops truncatus 68 0.0 723
WERAM-Dio-0119 ENSDORP00000011706.1 Dipodomys ordii 69 0.0 720
WERAM-Gog-0054 ENSGGOP00000004714.2 Gorilla gorilla 65 0.0 676
WERAM-Ect-0111 ENSETEP00000012545.1 Echinops telfairi 65 0.0 666
WERAM-Lac-0054 ENSLACP00000007746.1 Latimeria chalumnae 73 8e-169 591
WERAM-Tub-0144 ENSTBEP00000015350.1 Tupaia belangeri 59 5e-164 575
WERAM-Ict-0009 ENSSTOP00000000462.2 Ictidomys tridecemlineatus 75 2e-103 374
Created Date 25-Jun-2016