WERAM Information

Tag Content
WERAM ID WERAM-Scp-0012
Ensembl Protein ID SPAC29A4.20.1:pep
Uniprot Accession O14023; ELP3_SCHPO
Genbank Protein ID NP_594862.1
Protein Name Probable elongator complex protein 3
Genbank Nucleotide ID NM_001020291.2
Gene Name ELP3;SPAC29A4.20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC29A4.20 SPAC29A4.20.1 SPAC29A4.20.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HAT ELP3 N-acetyltransferase K 26223950
Status Reviewed
Classification
Type Family E-value Score Start End
HAT ELP3 4.80e-92 304 393 544
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Acts as catalytic subunit of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling (By similarity).
Domain Profile
  HAT ELP3
           ELP3.txt   1 lkcrdvrtrevgiqeihhkvrpeqvelirrdyvanggwetflsyedpkqdiligllrlrkisektfrpelkge.vsivrelhvygsvvpvas 91 
                        +kcrd+r+revg+qe+hhk++peqvel+rrdy+anggwetflsyedpkqdiligllrlr++s+kt+rpe++++ +s+vrelhvygs+vpv+s
  SPAC29A4.20.1:pep 393 TKCRDIRAREVGMQEVHHKIHPEQVELLRRDYTANGGWETFLSYEDPKQDILIGLLRLRQCSDKTYRPEFTSQpTSLVRELHVYGSAVPVHS 484
                        69***********************************************************************9****************** PP
           ELP3.txt  92 rdpkkfqhqgfgtllleeaeriareehgsekiavisgvgtreyyrklgyeldgpymsksl 151
                        rdpkkfqhqgfgtllleeaeria++ehgs+ki+visgvg+r+yy+klgy+ldgpymsk+l
  SPAC29A4.20.1:pep 485 RDPKKFQHQGFGTLLLEEAERIAKYEHGSKKISVISGVGVRKYYQKLGYTLDGPYMSKWL 544
                        **********************************************************97 PP
Protein Sequence
(Fasta)		MSTSSLAFLK AKACAEIVAE LIASENQNKV INLNALKMRI SKKHQLSESP RLTDIIAAIP 60
PDAYLKESLM RKLRAKPVRT ASGIAVVAVM CKPHRCPHIA MTGNVCVYCP GGPDSDFEYS 120
TQSYTGYEPT SMRAIRARYD PYEQARGRVE QLRSLGHTVD KVEYIIMGGT FMSLPESYRH 180
TFIANLHNAL SGATTEDLDE AVKFSEQSET KCVGITIETR PDYCLDQHLD EMLRYGCTRL 240
EIGVQSVYED VARDTNRGHT VKAVCETFQL AKDTGYKVVT HMMPDLPNVG MERDIFQFQE 300
YFENPAFRTD GLKLYPTLVI RGTGLYELWK TGRYKNYTPN ALVDLIARIL ALVPPWTRIY 360
RIQRDIPMPL VSSGVETGNL RELALNRMRD LGTKCRDIRA REVGMQEVHH KIHPEQVELL 420
RRDYTANGGW ETFLSYEDPK QDILIGLLRL RQCSDKTYRP EFTSQPTSLV RELHVYGSAV 480
PVHSRDPKKF QHQGFGTLLL EEAERIAKYE HGSKKISVIS GVGVRKYYQK LGYTLDGPYM 540
SKWL 544
Nucleotide Sequence
(Fasta)		CAATTGGAGC AATTTGCTAG CCAACTTTTA GTTGCCTTTT GCCGCCATTT GGAAGGCATA 60
AAACAACTGT TTAATTAACA GACTAATAGA AATCACACCT GATTCTATTG TTCAGGAACA 120
TGTCGACTTC CAGTTTGGCC TTTTTAAAGG CCAAAGCTTG TGCAGAAATT GTTGCTGAGC 180
TGATTGCCTC TGAAAATCAA AACAAGGTCA TCAATTTGAA TGCTTTGAAA ATGAGAATAT 240
CAAAAAAACA TCAATTATCG GAGTCCCCCC GCCTGACCGA CATTATTGCT GCAATTCCAC 300
CAGATGCCTA CCTTAAAGAA TCGTTGATGA GGAAACTAAG AGCGAAACCA GTACGTACCG 360
CCTCTGGTAT AGCAGTTGTT GCAGTGATGT GCAAACCTCA TAGATGTCCA CACATTGCCA 420
TGACAGGAAA CGTTTGTGTT TACTGTCCGG GTGGACCTGA TTCAGATTTT GAATACTCGA 480
CACAGTCGTA CACTGGTTAT GAACCAACTA GTATGCGTGC GATTCGCGCT CGTTATGATC 540
CTTATGAACA GGCTAGAGGA CGTGTTGAGC AACTGCGGTC GTTAGGCCAC ACAGTCGATA 600
AAGTAGAATA CATTATCATG GGCGGTACCT TCATGTCATT ACCTGAATCC TACCGTCACA 660
CATTTATTGC TAATTTACAC AATGCTCTTT CAGGAGCTAC GACTGAAGAT TTAGATGAAG 720
CAGTCAAATT TTCTGAGCAA TCTGAGACAA AATGTGTTGG CATTACTATT GAGACGCGTC 780
CTGATTATTG CCTAGACCAA CATTTGGATG AAATGCTTCG TTACGGATGT ACTCGTTTGG 840
AAATTGGTGT CCAAAGTGTT TACGAGGATG TCGCCAGAGA CACCAATAGA GGACATACTG 900
TTAAAGCTGT GTGCGAAACA TTCCAGTTGG CTAAGGATAC TGGATACAAG GTGGTTACGC 960
ATATGATGCC TGATTTGCCT AATGTTGGTA TGGAAAGAGA TATATTCCAA TTTCAAGAGT 1020
ACTTTGAAAA CCCTGCATTC CGTACTGATG GTTTAAAGCT CTATCCTACA TTAGTTATTC 1080
GTGGTACTGG TTTATATGAA TTATGGAAAA CGGGAAGATA TAAAAACTAT ACCCCCAATG 1140
CCTTGGTGGA TCTTATTGCT AGAATTCTCG CTTTGGTACC TCCATGGACC CGTATTTACC 1200
GTATTCAAAG AGATATCCCA ATGCCGCTTG TAAGTTCAGG CGTAGAAACA GGAAATCTCA 1260
GAGAACTTGC TTTAAATAGA ATGCGAGATT TAGGCACAAA GTGTCGAGAC ATTCGTGCTC 1320
GTGAAGTAGG TATGCAAGAA GTGCATCATA AAATTCATCC TGAGCAAGTT GAATTACTTC 1380
GCCGAGACTA TACTGCTAAT GGCGGATGGG AAACGTTTTT ATCATATGAA GATCCCAAAC 1440
AAGATATCTT GATTGGTTTG TTACGACTTC GCCAATGTTC CGATAAGACA TATCGACCAG 1500
AATTTACTTC TCAGCCTACC TCACTTGTTC GCGAACTTCA CGTGTATGGC AGTGCCGTTC 1560
CTGTTCACAG TAGAGATCCG AAGAAGTTCC AACATCAAGG TTTTGGAACA TTACTTTTAG 1620
AAGAAGCCGA GCGGATAGCT AAGTATGAGC ATGGTAGTAA AAAGATCAGT GTAATTTCGG 1680
GTGTTGGCGT TCGAAAATAT TATCAAAAAT TGGGATACAC ATTGGATGGT CCTTACATGT 1740
CTAAATGGCT TTAGCCTCTA ATATAATTTT AAGACTACTT AAGTTTGTAT AAAATATCAT 1800
TTTTGGTTGG GTGTGTTAAA ATCTTTAATA TTAACTCAGT TCGCAAGTTT TTTGAGTTGT 1860
CGATTTGGGA TGTGTGCAAT TTCATATACT ATTTAATTTC GTGTATAAAA AGAGAAAAGT 1920
GTTTAATTAC TTTCCTCTTT ATTAGATGAA ATCTGAGGTG TAGTTAGACA TATATATGTA 1980
CCATTCTTTA CTAATATTCA TATTTTTTTG CGTTCTCTTT AGACAA 2027
Sequence Source Ensembl
Keyword

KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0813--Transport
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR006638--Elp3/MiaB/NifB
IPR000182--GNAT_dom
IPR005910--Hist_AcTrfase_ELP3
IPR032432--Radical_SAM_C
IPR007197--rSAM
IPR023404--rSAM_horseshoe
PROSITE

PS51186--GNAT
Pfam

PF00583--Acetyltransf_1
PF04055--Radical_SAM
PF16199--Radical_SAM_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033588--C:Elongator holoenzyme complex
GO:0004402--F:histone acetyltransferase activity
GO:0051536--F:iron-sulfur cluster binding
GO:0015031--P:protein transport
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0002098--P:tRNA wobble uridine modification
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0040 EEB09543 Schizosaccharomyces japonicus 93 0.0 1050
WERAM-Sac-0047 YPL086C Saccharomyces cerevisiae 79 0.0 892
WERAM-Pof-0019 ENSPFOP00000001740.2 Poecilia formosa 74 0.0 865
WERAM-Dar-0095 ENSDARP00000113240.2 Danio rerio 75 0.0 863
WERAM-Orla-0173 ENSORLP00000020285.1 Oryzias latipes 74 0.0 863
WERAM-Pes-0176 ENSPSIP00000020589.1 Pelodiscus sinensis 76 0.0 862
WERAM-Tar-0031 ENSTRUP00000007288.1 Takifugu rubripes 74 0.0 860
WERAM-Asm-0096 ENSAMXP00000010004.1 Astyanax mexicanus 74 0.0 860
WERAM-Gaga-0154 ENSGALP00000026781.4 Gallus gallus 75 0.0 858
WERAM-Ten-0222 ENSTNIP00000022366.1 Tetraodon nigroviridis 74 0.0 855
WERAM-Anc-0112 ENSACAP00000010561.3 Anolis carolinensis 74 0.0 855
WERAM-Mod-0066 ENSMODP00000010748.1 Monodelphis domestica 73 0.0 851
WERAM-Ran-0091 ENSRNOP00000019262.6 Rattus norvegicus 73 0.0 844
WERAM-Drm-0040 FBpp0077129 Drosophila melanogaster 75 0.0 839
WERAM-Meg-0143 ENSMGAP00000014997.2 Meleagris gallopavo 73 0.0 839
WERAM-Leo-0166 ENSLOCP00000019667.1 Lepisosteus oculatus 74 0.0 838
WERAM-Nol-0182 ENSNLEP00000020133.1 Nomascus leucogenys 74 0.0 836
WERAM-Hos-0126 ENSP00000256398.8 Homo sapiens 74 0.0 835
WERAM-Aim-0003 ENSAMEP00000000138.1 Ailuropoda melanoleuca 74 0.0 834
WERAM-Dan-0089 ENSDNOP00000009022.3 Dasypus novemcinctus 74 0.0 834
WERAM-Bot-0033 ENSBTAP00000003541.4 Bos taurus 74 0.0 834
WERAM-Pat-0170 ENSPTRP00000034434.4 Pan troglodytes 74 0.0 833
WERAM-Chs-0193 ENSCSAP00000012007.1 Chlorocebus sabaeus 74 0.0 833
WERAM-Poa-0172 ENSPPYP00000020704.1 Pongo abelii 74 0.0 833
WERAM-Ptv-0074 ENSPVAP00000007055.1 Pteropus vampyrus 74 0.0 833
WERAM-Ova-0161 ENSOARP00000015996.1 Ovis aries 74 0.0 833
WERAM-Caf-0094 ENSCAFP00000012247.3 Canis familiaris 74 0.0 833
WERAM-Caj-0159 ENSCJAP00000028585.1 Callithrix jacchus 74 0.0 832
WERAM-Mam-0035 ENSMMUP00000006711.2 Macaca mulatta 74 0.0 832
WERAM-Mup-0009 ENSMPUP00000000960.1 Mustela putorius furo 74 0.0 832
WERAM-Eqc-0111 ENSECAP00000012517.1 Equus caballus 74 0.0 832
WERAM-Orc-0001 ENSOCUP00000000032.3 Oryctolagus cuniculus 73 0.0 831
WERAM-Fec-0168 ENSFCAP00000022256.1 Felis catus 74 0.0 828
WERAM-Cae-0049 ZK863.3 Caenorhabditis elegans 74 0.0 826
WERAM-Tas-0072 ENSTSYP00000007200.1 Tarsius syrichta 73 0.0 825
WERAM-Mum-0041 ENSMUSP00000022609.5 Mus musculus 72 0.0 825
WERAM-Cap-0041 ENSCPOP00000003379.2 Cavia porcellus 73 0.0 824
WERAM-Art-0140 AT5G50320.1 Arabidopsis thaliana 71 0.0 812
WERAM-Loa-0131 ENSLAFP00000012147.3 Loxodonta africana 72 0.0 799
WERAM-Otg-0004 ENSOGAP00000000206.2 Otolemur garnettii 78 0.0 786
WERAM-Mim-0112 ENSMICP00000010908.1 Microcebus murinus 79 0.0 784
WERAM-Fia-0138 ENSFALP00000011193.1 Ficedula albicollis 70 0.0 767
WERAM-Dio-0119 ENSDORP00000011706.1 Dipodomys ordii 78 0.0 759
WERAM-Tut-0037 ENSTTRP00000002753.1 Tursiops truncatus 67 0.0 741
WERAM-Ect-0111 ENSETEP00000012545.1 Echinops telfairi 64 0.0 715
WERAM-Lac-0054 ENSLACP00000007746.1 Latimeria chalumnae 74 7e-178 621
WERAM-Tub-0144 ENSTBEP00000015350.1 Tupaia belangeri 58 1e-166 583
WERAM-Gog-0054 ENSGGOP00000004714.2 Gorilla gorilla 70 1e-125 447
WERAM-Ict-0009 ENSSTOP00000000462.2 Ictidomys tridecemlineatus 77 4e-116 416
Created Date 25-Jun-2016